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| 1 | Platelet count/spleen diameter ratio to predict esophageal varices in Mexican patients with hepatic cirrhosis显示文摘AIM:To validate whether the platelet count/spleen size ratio can be used to predict the presence of esophageal varices in Mexican patients with hepatic cirrhosis.METHODS:This was an analytical cross-sectional study to validate the diagnostic test for hepatic cirrhosis and was performed between February 2010 and December 2011.Patients with a diagnosis of hepatic cirrhosis were included and stratified using their ChildPugh score.Biochemical parameters were evaluated,and ultrasound was used to measure the longest diameter of the spleen.The platelet count/spleen diameter ratio was calculated and analyzed to determine whether it can predict the presence of esophageal varices.Upper gastrointestinal endoscopy was used as the gold standard.Sensitivity and specificity,positive and negative predictive values,and positive and negative likelihood ratios were determined,with the cutoff points determined by receiver-operating characteristic curves.RESULTS:A total of 91 patients were included.The mean age was 53.75±12 years;50(54.9%)were men,and 41(45.0%)women.The etiology of cirrhosis included alcohol in 48(52.7%),virally induced in24(26.3%),alcoholism plus hepatitis C virus in three(3.2%),cryptogenic in nine(9.8%),and primary biliary cirrhosis in seven(7.6%).Esophageal varices were present in 73(80.2%)patients.Child-Pugh classification,17(18.6%)patients were classified as class A,37(40.6%)as class B,and 37(40.6%)as class C.The platelet count/spleen diameter ratio to detect esophageal varices independent of the grade showed using a cutoff value of≤884.3,had 84%sensitivity,70%specificity,and positive and negative predictive values of 94%and 40%,respectively.CONCLUSION:Our results suggest that the platelet count/spleen diameter ratio may be a useful tool for detecting esophageal varices in patients with hepatic cirrhosis. | Alejandro González-Ojeda Gabino Cervantes-Guevara Manuela Chávez-Sánchez Carlos Dávalos-Cobián Susana Ornelas-Cázares Michel Dassaejv Macías-Amezcua Mariana Chávez-Tostado Kenia Militzi Ramírez-Campos Anaís del Rocío Ramírez-Arce Clotilde Fuentes-Orozco | 2014 | World Journal of Gastroenterology2014，20，8： | 18 |
| 2 | Predictive clinical features of cardioembolic infarction in patients aged 85 years and older显示文摘Objective To assess predictive clinical factors of cardioembolic infarction in very old patients(85 years of age and older).Methods Prospective hospital-based stroke registry('The Sagrat Cor Hospital of Barcelona Stroke Registry')is an acute-care teaching hospital in Barcelona,Catalonia,Spain.From 956 first-ever cardioembolic stroke patients included in the stroke registry over a 24-year period,639 were younger than 85 years of age and 317 were 85 years or older(mean age:88.9 years).Demographics,clinical characteristics,risk factors and early outcome were compared.Predictors of cardioembolic infarction in the oldest age group were assessed by multivariate analyses.Results In a logistic regression model based on demographics,risk factors,clinical features and complications,female gender(odds ratio[OR]=1.74,95%confidence interval[CI]:1.27–2.39),heart failure(OR=2.27,95%CI:1.46–3.56),altered consciousness(OR=1.76,95%CI:1.28–2.42),and infectious complications(OR=2.01,95%CI:1.39–2.91)were predictors of cardioembolic stroke in the oldest age group.By contrast,heavy smoking,heart valve disease,hypertension,headache,early seizures,sensory deficit,and involvement of the posterior cerebral artery were independently associated with cardioembolic stroke in the younger group.Conclusions Identification of a differential clinical profile of cardioembolic stroke between patients aged 85 years or more and those younger than 85 years helps clinicians to the optimal management of ischemic infarction in the oldest segment of the population. | Ana Maria Carbajo-García Jonatan Cortés AdriàArboix Joan Massons Laura Díez Enric Vergés Jordi Arboix-Alió Luís García-Eroles | 2019 | Journal of Geriatric Cardiology2019，16，11： | 3 |
| 3 | Coronary physiology assessment in the catheterization laboratory显示文摘Physicians cannot rely solely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischemia. Instead, sound knowledge of coronary vascular physiology and of the methods currently available for its characterization can improve the diagnostic and prognostic accuracy of invasive assessment of the coronary circulation, and help improve clinical decision-making. In this article we summarize the current methods available for a thorough assessment of coronary physiology. | Felipe Díez-delhoyo Enrique Gutiérrez-Ibanes Gerard Loughlin Ricardo Sanz-Ruiz María Eugenia Vázquez-álvarez Fernando Sarnago-Cebada Rocío Angulo-Llanos Ana Casado-Plasencia Jaime Elízaga Francisco Fernández Avilés Diáz | 2015 | World Journal of Cardiology2015，7，9： | 2 |
| 4 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 5 | Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment显示文摘根据相关性,脆弱和认知缺陷与 atrial 纤维性颤动(AF ) 考虑老病人的临床的侧面和管理的 BackgroundAvailable 数据是少见的。学习的目的是根据相关性分析 biodemographic 数据,临床的侧面和 antithrombotic 治疗,吗在patients.MethodsCross部分的老 AF 和学习在 75 年与 3 个月在 Spain.ResultsA 在内部药部门出席了的口头的抗凝剂对待的连续 AF 病人执行了的多中心的脆弱和认知缺陷 837 总计病人( 83.0 ???????????????????吗???????????????????￡?? | Jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando José Ruiz Laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao Carmen Suárez | 2018 | Journal of Geriatric Cardiology2018，15，4： | 2 |
| 6 | Influence of the sea rush Juncus martitimus on metal concentration and speciation in estuarine sediment colonized by the plant显示文摘 | Marisa C RAlmeida Ana P Mucha Teresa M S D Vasconce- los | 2004 | Environmental Science and Technology2004，38，： | 1 |
| 7 | Nosocomial necrotizing enterocoli- tis outbreaks:epidemiology and control measures 显示文摘 | Boccia D Stofli 1 l ana S el al | 2001 | FUR J Peril- air2001，160，6： | 1 |
| 8 | Sensitive chemiluminescent immunoassay of triclopyr by digital image analysis显示文摘 | Aurora N. Díaz Francisco G. Sánchez Enrique N. Baro Ana F.G. Díaz Alfonso Aguilar Manuel Algarra | 2012 | Talanta2012，，： | 1 |
| 9 | Optimising monitoring in the management of Crohn’s disease: A physician’s perspective显示文摘 | Pavol Papay Ana Ignjatovic Konstantinos Karmiris Heda Amarante Pal Milheller Brian Feagan Geert D’Haens Philippe Marteau Walter Reinisch Andreas Sturm Flavio Steinwurz Laurence Egan Julián Panés Edouard Louis Jean-Frédéric Colombel Remo Panaccione | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 10 | A spare parts model with cold-standby redundancy on system level 显示文摘 | Karin S S D Nicole P E Ana I B | 2011 | Computers : Operations Research2011，38，7： | 1 |
| 11 | Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation显示文摘 | Ana Maria Sánchez Sophie Malagarie-Cazenave Nuria Olea Diana Vara Antonio Chiloeches Inés Díaz-Laviada | 2007 | Apoptosis2007，，11： | 1 |
| 12 | Liquid phase dehydration of D-xylose in the presence of keggin-type heteropolyacids显示文摘 | ANA S D MARTYN P ANABELA | 2005 | Applied Catalysis A:General2005，285，： | 1 |
| 13 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 14 | Polymorphisms in exons 6 and 7 of the ABO locus and their association with venous thrombosis in young Brazilian patients显示文摘 | Sabrina G Paiva Adriano P Sabino Maria G Carvalho Daniel D Ribeiro Karina B Gomes Mariana S Santos Marina S Oliveira Geralda G Lages Luci MS Dusse Ana Paula Fernandes | 2009 | Blood Coagulation & Fibrinolysis2009，，2： | 1 |
| 15 | The nucleolus as a genomic safe harbor for strong gene expression in Nannochloropsis oceanica显示文摘Microalgae are used in food and feed,and they are considered a potential feedstock for sustainably pro-duced chemicals and biofuel.However,production of microalgal-derived chemicals is not yet economically feasible.Genetic engineering could bridge the gap to industrial application and facilitate the production of novel products from microalgae.Here,we report the discovery of a novel gene expression system in the oleaginous microalga Nannochloropsis that exploits the highly efficient transcriptional activity of RNA po-lymerase I and an internal ribosome entry site for translation.We identified the nucleolus as a genomic safe harbor for Pol I transcription and used it to construct transformant strains with consistently strong trans-gene expression.The new expression system provides an outstanding tool for genetic and metabolic en-gineering of microalgae and thus will probably make substantial contributions to microalgal research. | Christian Südfeld Ana Pozo-Rodríguez Sara A.Manjavacas Díez RenéH.Wijffels Maria J.Barbosa Sarah D'Adamo | 2022 | Molecular Plant2022，15，2： | 1 |
| 16 | Extraction and Clean-up Preocedure for Analysis of Organochlorine Pesticide Residues in Ethoxylated Lanolin显示文摘 | LUCIANA P MIRIAM S ANA P d O S | 2000 | J II Farmaco2000，55，： | 1 |
| 17 | Arabidopsis and tobacco plants ectopically expressing the soybean antiquitin-like ALDH7 gene display enhanced tolerance to drought,salinity,and oxidative stress显示文摘 | Simone M R Maxuel O A Ana P S G Fabio M D Maria C B P Elizabeth P B F | | 0，，： | 1 |
| 18 | Phylogeography and population genetic structure of the Talas tuco-tuco (Ctenomys talarum): integrating demographic and habitat histories显示文摘 | Mora Mat?as S Cutrera Ana P Lessa Enrique P Vassallo Aldo I D’Anatro Alejandro Mapelli Fernando J | 2013 | Journal of Mammalogy2013，，2： | 1 |
| 19 | Stability design criteria for steel column splices显示文摘 | Girao Coelho Ana M Simao Pedro D Bijlaard Frans S K | 2010 | Journal of Constructional Steel Research2010，66，10： | 1 |
| 20 | Deactivation by Coke of a Catalyst Based on a SAPO-34 in the Transformation of Methanol into Olefins 显示文摘 | Andres T A Ana E S D C Ana G G | 1999 | Journal of Chemical Technology and Biotechnology1999，74，4： | 1 |
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