|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype. | C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 3 | Recent advances in membrane bioreactors ( MBRs ) : Membrane fouling and membrane material 显示文摘 | Meng F G Chae S R Anja D | 2009 | Water Res2009，43，6： | 1 |
| 4 | Evidence for Behavioral Attractiveness of Methoxylated Aromatics in a Dynastid Scarab Beetle-Pollinated Araceae显示文摘 | Stefan D?tterl Anja David Wilhelm Boland Ilse Silberbauer-Gottsberger Gerhard Gottsberger | 2012 | Journal of Chemical Ecology2012，，12： | 1 |
| 5 | Transcription analysis of Arabidopsis membrane transporters and hormone pathways during developmental and in- duced leaf senescence显示文摘 | Van V D G Rainer S Anja S | 2006 | Plant Physiology2006，141，2： | 1 |
| 6 | Optimization of conditions for germination of cold-stored Arabidopsis thaliana pollen 显示文摘 | Firas B D Youssef C Anja G | 2009 | Plant Cell Rep2009，，28： | 1 |
| 7 | Aberrant hypomethylation of the cancer–testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia显示文摘 | Christina A. Ortmann Lewin Eisele Holger Nückel Ludger Klein-Hitpass Anja Führer Ulrich Dührsen Michael Zeschnigk | 2008 | Annals of Hematology2008，，10： | 1 |
| 8 | Effect of microgrooved poly-l-lactic (PLA) surfaces on prolifera- tion, cytoskeletal organization, and min- eralized matrix formation of rat bone mar- row cells显示文摘 | MATSUZAKA K WALBOOMERS F ANJA D R | 2000 | Clin Oral Impl Res2000，11，4： | 1 |
| 9 | A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model显示文摘 | Rolf P Anja S Ilse D | 2004 | Journal of Clinical Investigation2004，113，10： | 1 |
| 10 | Ecological tax reform in Denmark:history and social acceptability显示文摘 | JACOB K ANDERS L ANJA D | 2006 | Energy Policy2006，，34： | 1 |
| 11 | On the relations among work value orienta- tions, psychological need satisfaction and job outcomes: A self- determination theory approach 显示文摘 | Maarten V Bart N Christopher P Niemiec Bart S Hans D W Anja V B | 2007 | Journal of Occupational and Organizational Psychology2007，，80： | 1 |
| 12 | A micro-solid oxide fuel cell system as battery replacement 显示文摘 | Anja B H Beckel D Infortuna A | 2008 | Journal of Power Sources2008，177，： | 1 |
| 13 | Neutrophil gelatinase-associated iipocalin as a biomarker of acute kidney injury: a critical evalua tion of current status显示文摘 | Anja HF Michael H Prasad D | 2014 | Ann Clin Biochem2014，51，3： | 1 |
| 14 | A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction显示文摘 | Anja M. van der Laan Alexander Hirsch Lourens F.H.J. Robbers Robin Nijveldt Ingrid Lommerse Ronak Delewi Pieter A. van der Vleuten Bart J. Biemond Jaap Jan Zwaginga Wim J. van der Giessen Felix Zijlstra Albert C. van Rossum Carlijn Voermans C. Ellen van d | 2012 | American Heart Journal2012，，1： | 1 |
| 15 | Vitamin D receptor deficient mice fail to develop experimental allergic asthma显示文摘 | Anja W Veronika W Brett D | 2008 | J Immunol2008，173，： | 1 |
| 16 | Clinical research for patient empowerment-a qualitative approach on the improvement of heart health promotion in chronic illness显示文摘 | Christian M Anja M Christine D | 2008 | Med Sci Munit2008，14，7： | 1 |
| 17 | Functional and structural syntax networks in aging显示文摘 | Antonenko Daria Brauer Jens Meinzer Marcus Fengler Anja Kerti Lucia Friederici Angela D&Fl?el Agnes | 2013 | Neuro Image2013，83，： | 1 |
| 18 | Fluorescence Resonance Energy Transfer (FRET) and Competing Processes in Donor-Acceptor Substituted DNA Strands:A Comparative Study of Ensemble and Single-Molecule Data显示文摘 | Anja D Volker B Christian M | 2002 | Molecular Biotechnology2002，82，3： | 1 |
| 19 | Molecular darting and analysis of the gene encoding the thermostable penicillin G acylase from Alcaligenes faecalis显示文摘 | Raymond M D Verhaert Anja M | 1997 | Applied and environmental microbiology1997，63，9： | 1 |
| 20 | Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study显示文摘 | Anja Wagner Heiko Mahrholdt Thomas A Holly Michael D Elliott Matthias Regenfus Michele Parker Francis J Klocke Robert O Bonow Raymond J Kim Robert M Judd | 2003 | The Lancet2003，，9355： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员