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| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 3 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 4 | Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients显示文摘AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined. | Andreas Teufel Markus Wrns Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 5 | Semiautomated 3D Root Segmentation and Evaluation Based on X-Ray CT Imagery显示文摘Background.Computed X-ray tomography(CTX)is a high-end nondestructive approach for the visual assessment of root architecture in soil.Nevertheless,in order to evaluate high-resolution CTX data of root architectures,manual segmentation of the depicted root systems from large-scale volume data is currently necessary,which is both time consuming and error prone.The duration of such a segmentation is of importance,especially for time-resolved growth analysis,where several instances of a plant need to be segmented and evaluated.Specifically,in our application,the contrast between soil and root data varies due to different growth stages and watering situations at the time of scanning.Additionally,the root system itself is expanding in length and in the diameter of individual roots.Objective.For semiautomated and robust root system segmentation from CTX data,we propose the RootForce approach,which is an extension of Frangi’s“multi-scale vesselness”method and integrates a 3D local variance.It allows a precise delineation of roots with diameters down to severalμm in pots with varying diameters.Additionally,RootForce is not limited to the segmentation of small below-ground organs,but is also able to handle storage roots with a diameter larger than 40 voxels.Results.Using CTX volume data of full-grown bean plants as well as time-resolved(3D+time)growth studies of cassava plants,RootForce produces similar(and much faster)results compared to manual segmentation of the regarded root architectures.Furthermore,RootForce enables the user to obtain traits not possible to be calculated before,such as total root volume(Vroot),total root length(Lroot),root volume over depth,root growth angles(θmin,θmean,andθmax),root surrounding soil density Dsoil,or form fraction F.Discussion.The proposed RootForce tool can provide a higher efficiency for the semiautomatic high-throughput assessment of the root architectures of different types of plants from large-scale CTX.Furthermore,for all datasets within a growth experiment,only a single set of parameters is needed.Thus,the proposed tool can be used for a wide range of growth experiments in the field of plant phenotyping. | Stefan Gerth Joelle Claußen Anja Eggert Norbert Wörlein Michael Waininger Thomas Wittenberg Norman Uhlmann | 2021 | Plant Phenomics2021，3，1： | 2 |
| 6 | Zero forcing and minimum mean-square-error equalization for multiuser detection in code-division multiple-access channels显示文摘 | ANJA K GHASSAN K K PAUL W B | 1996 | IEEE Transactions on Vehicular Technology1996，45，2： | 1 |
| 7 | Comparative characteristics of mesen-chymal stem cells from human bone marrow,adipose tissue,and umbili-cal cord blood显示文摘 | Frederik W Anja S | 2005 | Experimental Hematology2005，33，： | 1 |
| 8 | Approximating the Finite-Time Ruin Probability Under Interest Force显示文摘 | RUUD BREKELMANS ANJA DE W AEGENAERE | 2001 | Mathematics and Economics2001，29，： | 1 |
| 9 | Molec- ular profiling and predictive value of cir- culating tumor cells in patients with meta-static breast cancer:an option for monito- ring response to breast cancer related ther- apies 显示文摘 | Mitra T Bahriye A Anja W | 2009 | Breast Cancer Research & Treatment2009，115，3： | 1 |
| 10 | Duplications In- volving a Conserved Regulatory Element Downstream of BMP2 Are Associated with Brachydactyly Type A2显示文摘 | Katafina Dathe Klans W Kjaer Anja Brehm | 2009 | The American Journal of Human Genetics2009，84，4： | 1 |
| 11 | Reproducibility of Immunohistochemical Scoring for Epidermal Growth Factor Receptor Expression in Non-Small Cell Lung Cancer: Round Robin Test显示文摘 | R?schoff Josef Kerr Keith M Grote Hans J Middel Peter von Heydebreck Anja Alves Ven?ncio A Baldus Stephan E B?ttner Reinhard Carvalho Lina Fink Ludger Jochum Wolfram Lo Anthony W I L?pez-R?os Fernando Marx Alexander Molina Thierry J Olszews | 2013 | Archives of Pathology & Laboratory Medicine2013，，9： | 1 |
| 12 | On the relations among work value orienta- tions, psychological need satisfaction and job outcomes: A self- determination theory approach 显示文摘 | Maarten V Bart N Christopher P Niemiec Bart S Hans D W Anja V B | 2007 | Journal of Occupational and Organizational Psychology2007，，80： | 1 |
| 13 | CpG motifs are efficient adjuvants for DNA cancer vaccines 显示文摘 | Achim S Christine W Anja Z | 2004 | J Invest Dermatol2004，123，： | 1 |
| 14 | Vitamin D receptor deficient mice fail to develop experimental allergic asthma显示文摘 | Anja W Veronika W Brett D | 2008 | J Immunol2008，173，： | 1 |
| 15 | Angiotensin Ⅱ -induced reactive oxygen specied and the kidney 显示文摘 | Anja S Gunter W | 2007 | J Am Soc Nephrol2007，18，： | 1 |
| 16 | Methylprednisolone Therapy in Deceased Donors Reduces Inflammation in the Donor Liver and Improves Outcome After Liver Transplantation: A Prospective Randomized Controlled Trial显示文摘 | Katja Kotsch Frank Ulrich Anja Reutzel-Selke Andreas Pascher W Faber P Warnick S Hoffman M Francuski C Kunert O Kuecuek G Schumacher C Wesslau A Lun S Kohler S Weiss S G. Tullius P Neuhaus Johann Pratschke | 2008 | Annals of Surgery2008，，6： | 1 |
| 17 | Fluid therapy in septic shock显示文摘 | EMANUEL P R ANJA K J LAURA E W | 2010 | Curr Opin Crit Care2010，16，： | 1 |
| 18 | Comparative characteristics of mesenchymal stem cells from human bone marrow,adipose tissue,and umbilical cord blood显示文摘 | Wolfgang W Frederik W Anja S | 2005 | Exp Hematology2005，33，： | 1 |
| 19 | Molecular Analysis of Hereditary Nonpolyposis Colorectal Cancer in the United States:High Mutation Detection Rate among Clinically Selected Families and Characterization of an American Founder Genomic Deletion of the MSH2 Gene显示文摘 | Anja W Alicia B Juul TW | 2003 | An Am J Hum Genet2003，72，5： | 1 |
| 20 | Accelerated Mitochondrial Adenosine Diphosphate/Adenosine Triphosphate Transport Improves Hypertension - Induced Heart Disease 显示文摘 | Thomas W Carsten T Anja SK | 2007 | Circulation2007，115，6： | 1 |
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