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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | Furazolidone-based triple therapy for H pylori gastritis in children显示文摘AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients with upper digestive symptoms suffi ciently severe to warrant endoscopic investigation. H pylori status was defined based both on histology and on positive 13C-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and 13C-urea breath test. Further clinical evaluation was performed 7 d, 2 and 6 mo after the treatment. RESULTS: Thirty-eight patients (24 females, 14 males) were included. Their age ranged from 4 to 17.8 (mean 10.9 ± 3.7) years. On intent-to-treat analysis (n = 38), the eradication rate of H pylori was 73.7% (95% CI, 65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI, 78.5%-91%). All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate effi cacy in H pylori treatment. The eradicationrate seems to be higher in patients with duodenal ulcer. | Elisabete Kawakami Rodrigo Strehl Machado Silvio Kazuo Ogata Marini Langner Erika Fukushima Anna Paula Carelli Vania Cláudia Guimares Bonucci Francy Reis Silva Patrício | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 3 | Rhegmatogenous Retinal Detachment in Phakic Eyes After Posterior Chamber Phakic Intraocular Lens Implantation for Severe Myopia显示文摘 | Vicente Martínez-Castillo Anna Boixadera Alicia Verdugo Daniel Elíes Andrés Coret José García-Arumí | 2005 | Ophthalmology2005，，4： | 1 |
| 4 | Analysis of microRNAs in pancreatic fine-needle aspirates can classify benign and malig- nant tissues显示文摘 | Anna ES Martina D Hayward SE | 2008 | Clin Chem2008，54，10： | 1 |
| 5 | Evalution of tracheal intubation difficulty in patients with cervical spine immobilization:fiberoptic versus conventional laryngoscopy显示文摘 | Anna BP Tejbir SS | 1999 | Anesthesiology1999，91，： | 1 |
| 6 | Pectic acids in the production of wood containing paper 显示文摘 | Kenneth ES Anna CS Jeffrey WT | 1998 | TAPPI J1998，81，7： | 1 |
| 7 | Nutritional,rheological and sensory properties of butter processed with different mixtures of cow and sheep milk cream显示文摘This study assessed the quality parameters and consumer perception and behavior of butter processed with different ratios of cow and sheep milk cream.Cow milk cream butter(CMCB)showed lower moisture content and higher fat content,smaller fat globules,and higher concentrations of long-chain saturated fatty acids and monounsaturated fatty acids,resulting in improved potential health indices.In addition,CMCB showed yellow color,little salt,and butter taste as the main sensory characteristics,resulting in grateful and good digestibility perceptions.Sheep milk cream addition improved the rheological properties of the products(lower viscosity,consistency index,and rigidity(J0),and higher fluidity and viscoelastic behavior(J1)),mainly due to the increased concentrations of short-chain and medium-chain saturated fatty acids and polyunsaturated fatty acids.However,sheep milk cream butter(SMCB)was characterized by a greasy and striking aroma,with a lower perception of good digestibility and good appearance,and a higher bitter taste.The association of cow and sheep milk cream could be an exciting option to obtain products with improved fatty acid profiles,health indices,and yet maintain desired rheological and sensory properties.The formulation with 60%sheep milk cream and 40%cow milk cream would be the suggested combination. | Renata S Dias Celso F.Balthazar Rodrigo N.Cavalcanti Louise A.Sobral Jessica F.Rodrigues Roberto P.CNeto Maria Inˆes B.Tavares Ana Paula B.Ribeiro Renato Grimaldi Celso Sant’Anna Erick A.Esmerino Tatiana C.Pimentel Marcia Cristina Silva Adriano G.Cruz | 2022 | Food Bioscience2022，46，2： | 1 |
| 8 | Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis显示文摘 | Harish Nair Eric AF Simo?es Igor Rudan Bradford D Gessner Eduardo Azziz-Baumgartner Jian Shayne F Zhang Daniel R Feikin Grant A Mackenzie Jennifer C Moi?si Anna Roca Henry C Baggett Syed MA Zaman Rosalyn J Singleton Marilla G Lucero Aruna Chandran Angela | 2013 | The Lancet2013，，： | 1 |
| 9 | The effect of exercise training on disease progression,fitness,quality of life,and mental health in people living with HIV on antiretroviral therapy:a systematic review显示文摘Background:Exercise has been associated with improvements in adverse physiological and psychological effects of long-term antiretroviral therapy(ART)in people living with HIV(PLWH).Aim:To summarizes the findings on the effects of aerobic or resistance training alone or combined aerobic and resistance exercise training(CARET)on disease progression,fitness,physical functioning,mental health,and quality of life(QOL)in PLWH receiving ART.A systematic search of articles was performed in several databases,and 20 articles that met inclusion criteria were summarized.Relevance for patients:Aerobic exercise was associated with improvements in aerobic capacity,QOL,and depressive symptoms,while resistance training improved strength.CARET was related to improved aerobic fitness,strength,physical functioning,QOL,and self-efficacy.At least one of the exercise interventions resulted in improvements in CD4+cell count and HIV RNA viral load.Moreover,another study showed that HIV-specific biomarkers remained unchanged in the exercise intervention group,while they significantly worsened in the non-exercise group.In general,in spite of their well-known benefits,exercise programs have not been extensively utilized or widely recognized as viable therapeutic treatment options for this patient population.Knowing the possible health benefits of increasing physical activity level is important to better recommend exercise programs.However,the prescription must be done carefully and on an individual basis.Additional studies investigating the efficiency and effectiveness of different exercise training regimens for PLWH are needed. | Johanna Lopez Erika Richardson Eduard Tiozzo Laura Lantigua Camilo Martinez George Abreut Troy Prendergast Steven E.Atlas Andrew R.Pangilinan Serena M.Ferris Ana H.Martinez Janet Konefal Judi Woolger Anna M.Ray Herbert G.Sim?es Carmen S.G.Campbell John E.Lewis | 2015 | Journal of Clinical & Translational Research2015，1，3： | 0 |
| 10 | Status of bariatric endoscopy–what does the surgeon need to know? A review显示文摘BACKGROUND Obesity is a chronic and multifactorial disease with a variety of potential treatment options available.Currently,there are several multidisciplinary therapeutic options for its management,including conservative,endoscopic,and surgical treatment.AIM To clarify indications,technical aspects,and outcomes of bariatric endoscopy.METHODS Narrative review of current literature based on electronic databases including MEDLINE(PubMed),Cochrane Library,and SciELO.RESULTS Bariatric endoscopy is in constant development and comprises primary and revisional treatment options as well as management of surgical complications.Various devices act upon different mechanisms of action,which may be individualized to each patient.Despite favorable results for the endoscopic treatment of obesity,prospective randomized studies with long-term follow-up are required to fully validate primary and revisional endoscopic therapies.Regarding the management of bariatric surgery complications,endoscopic therapy may be considered the procedure of choice in a variety of situations.Still,as there is no standardized algorithm,local experience should be considered in decision-making.CONCLUSION The treatment of patients with obesity is complex,and a multidisciplinary approach is essential.Bariatric endoscopy has shown impressive results both in the treatment of obesity and its surgical complications,and therefore,must be part of the armamentarium in the fight against this disease. | Diogo Turiani Hourneaux de Moura Anna Carolina Batista Dantas Igor Braga Ribeiro Thomas R McCarty Flávio Roberto Takeda Marco Aurelio Santo Sergio Carlos Nahas Eduardo Guimarães Hourneaux de Moura | 2022 | World Journal of Gastrointestinal Surgery2022，14，2： | 0 |
| 11 | Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern worldwide.In that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and remedy.AIM To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease outcomes.METHODS This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian hospital.RESULTS The patients had a median age of 65.60±15.78 years.Dyspnea was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the patients.At least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with death.Nausea and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective factor.CONCLUSION This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected individuals.The associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features. | Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior Maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo | 2023 | World Journal of Clinical Cases2023，11，8： | 0 |
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