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| 1 | Association between TNF-a and IL-1β genotypes vs Helicobacter pylori infection in Indonesia显示文摘AIM:To investigate the correlation between the Helicobacter pylori(H.pylori)infection and host genetic background of healthy populations in Indonesia.METHODS:In March 2007,epidemiological studies were undertaken on the general population of a city in Indonesia(Mataram,Lombok).The participants included 107 men and 187 women,whose ages ranged from6 to 74 years old,with an average age of 34.0(±14.4)(±SD).The H.pylori of subject by UBT method determination,and through the polymerase chain reaction with confronting two-pair primers(PCR-CTPP)method parsing the single nucleotide polymorphism of interleukin(IL)-8,IL-4,IL-1β,CD14,tumor necrosis factor(TNF-a)and tyrosine-protein phosphates non-receptor type 11(PTPN11)genotypes.The experimental data were analyzed by the statistical software SAS.RESULTS:The H.pylori infection rates in the healthy Indonesian population studied were 8.4%for men and12.8%for women;no obvious differences were noted for H.pylori infection rates by sex or age.TC genotypes of IL-4,TC and CC genotypes of TNF-a,and GA genotypes of PTPN11,were higher in frequency.Both CC and TC genotype of TNF-a T-1031C loci featured higher expressions in the healthy Indonesian population Indonesia studied of(OR=1.99;95%CI:0.67-5.89)and(OR=1.66;95%CI:0.73-3.76),respectively.C allele of IL-1βT-31C gene locus was at a higher risk(OR=1.11;95%CI:0.70-1.73)of H.pylori infection,but no statistical significance was found in our study.CONCLUSION:We reveal that the association between the TNF-a and IL-1βgenotypes may be the susceptibility of H.pylori in the studied population. | Yang Zhao Jing-Wen Wang Tsutomu Tanaka Akihiro Hosono Ryosuke Ando Shinkan Tokudome Soeripto FX Ediati Triningsih Tegu Triono Suwignyo Sumoharjo EY Wenny Astuti Achwan Stephanus Gunawan Yu-Min Li | 2013 | World Journal of Gastroenterology2013，19，46： | 5 |
| 2 | Efficacy of endoluminal gastroplication in Japanese patients with proton pump inhibitor-resistant,non-erosive esophagitis显示文摘AIM:To evaluate the efficacy,safety,and long-term outcomes of endoluminal gastroplication(ELGP) in patients with proton pump inhibitor(PPI)-resistant,nonerosive reflux disease(NERD).METHODS:The subjects were NERD patients,diagnosed by upper endoscopy before PPI use,who had symptoms such as heartburn or reflux sensations two or more times a week even after 8 wk of full-dose PPI treatment.Prior to ELGP,while continuing full-dose PPI medication,patients' symptoms and quality of life(QOL) were assessed using the questionnaire for the diagnosis of reflux disease,the frequency scale for symptoms of gastro-esophageal reflux disease(FSSG),gastrointestinal symptoms rating scale,a 36-item short-form.In addition,24-h esophageal pH monitoring or 24-h intraesophageal pH/impedance(MII-pH) monitoring was performed.The Bard EndoCinch TM was used for ELGP,and 2 or 3 plications were made.After ELGP,all acid reducers were temporarily discontinued,and medication was resumed depending on the development and severity of symptoms.Three mo after ELGP,symptoms,QOL,pH or MII-pH monitoring,number of plications,and PPI medication were evaluated.Further,symptoms,number of plications,and PPI medication were evaluated 12 mo after ELGP to investigate long-term effects.RESULTS:The mean FSSG score decreased significantly from before ELGP to 3 and 12 mo after ELGP(19.1 ± 10.5 to 10.3 ± 7.4 and 9.3 ± 9.9,P < 0.05,respectively).The total number of plications decreased gradually at 3 and 12 mo after ELGP(2.4 ± 0.8 to 1.2 ± 0.8 and 0.8 ± 1.0,P < 0.05,respectively).The FSSG scores in cases with no remaining plications and in cases with one or more remaining plications were 4.4 and 2.7,respectively,after 3 mo,and 2.0 and 2.8,respectively,after 12 mo,showing no correlation to plication loss.On pH monitoring,there was no difference in the percent time pH < 4 from before ELGP to 3 mo after.Impedance monitoring revealed no changes in the number of reflux episodes or the symptom index for reflux events from before ELGP to 3 mo after,but the symptom sensitivity index decreased significantly 3 mo after ELGP(16.1 ± 12.9 to 3.9 ± 8.3,P < 0.01).At 3 mo after ELGP,6 patients(31.6%) had reduced their PPI medication by 50% or more,and 11 patients(57.9%) were able to discontinue PPI medication altogether.After 12 mo,3 patients(16.7%) were able to reduce the amount of PPI medication by 50% or more,and 12 patients(66.7%) were able to discontinue PPI medication altogether.A high percentage of cases with remaining plications had discontinued PPIs medication after 3 mo,but there was no difference after 12 mo.No serious complications were observed in this study.CONCLUSION:ELGP was safe,resulted in significant improvement in subjective symptoms,and allowed less medication to be used over the long term in patients with PPI-refractory NERD. | Kentaro Tokudome Yasushi Funaki Makoto Sasaki Shinya Izawa Yasuhiro Tamura Akihito Iida Naotaka Ogasawara Toshihiro Konagaya Yoshifumi Tokura Kunio Kasugai | 2012 | World Journal of Gastroenterology2012，18，41： | 5 |
| 3 | 生命科学研究与时空两要素显示文摘五维的(四维时空加一维时间)宇宙,让世上事物各自披上特定的时空印迹。动态大千世界中的万物,它的静态不过是特定时空短暂的表象。认知万物的有效语言,就是时空。科学本身,就富含严谨的时空内涵。生命物质和无生命物质都由相同的结构单元——碳、氢、氧、氮、磷原子构建而成,唯一的重要区别就是这些原子在三维空间随时间变动的排列形式。时间和空间本属于宇宙,两者同时存在,不可分割地构成万物的自我和他我。万物在期间发生发展。 | 崔允文 邓一夫 李国君 Shinkan Tokudome | 2000 | 中国优生与遗传杂志2000，8，S1： | 4 |
| 4 | Inhibition of gastric perception of mild distention by omeprazole in volunteers显示文摘AIM:To evaluate the effects of omeprazole on gastric mechanosensitivity in humans. METHODS:A double lumen polyvinyl tube with a plastic bag was introduced into the stomach of healthy volunteers under fluorography and connected to a barostat device. Subjects were then positioned so they were sitting comfortably, and the minimal distending pressure (MDP) was determined after a 30-min adaptation period. Isobaric distensions were performed in stepwise increments of 2 mmHg (2 min each) starting from the MDP. Subjects were instructed to score feel-ings at the end of every step using a graphic rating scale:0, no perception; 1, weak/vague; 2, weak but significant; 3, moderate/vague; 4, moderate but signifi-cant; 5, severe discomfort; and 6, unbearable pain. After this first test, subjects received omeprazole (20 mg, after dinner) once daily for 1 wk. A second test was performed on the last day of treatment. RESULTS:No adverse effects were observed. Mean MDP before and after treatment was 6.3 ± 0.3 mmHg and 6.2 ± 0.5 mmHg, respectively. One subject before and 2 after treatment did not reach a score of 6 at the maximum bag volume of 750 mL. After omeprazole, there was a significant increase in the distension pres-sure required to reach scores of 1 (P = 0.019) and 2 (P = 0.017) as compared to baseline. There were no changes in pressure required to reach the other scores after treatment. Two subjects before and one after omeprazole rated their abdominal feeling < 1 at MDP, and mean (± SE) abdominal discomfort scores at MDP were 0.13 ± 0.09 and 0.04 ± 0.04, respectively. Mean scores induced by each MDP + 2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 (mmHg) were 1.1 ± 0.3, 2.0 ± 0.4, 2.9 ± 0.5, 3.3 ± 0.4, 4.6 ± 0.3, 5.2 ± 0.3, 5.5 ± 0.2, 5.5 ± 0.3, 5.7 ± 0.3, and 5.4, respectively. After omepra-zole, abdominal feeling scores for the same incremental pressures over MDP were 0.3 ± 0.1, 0.8 ± 0.1, 2.0 ± 0.4, 2.8 ± 0.4, 3.8 ± 0.4, 4.6 ± 0.4, 4.9 ± 0.3, 5.4 ± 0.4, 5.2 ± 0.6, and 5.0 ± 1.0, respectively. A signif- icant decrease in feeling score was observed at intrabag pressures of MDP + 2 mmHg (P = 0.028) and + 4 mmHg (P = 0.013), respectively, after omeprazole. No significant score changes were observed at pres-sures ≥ MDP + 6 mmHg. CONCLUSION:Although the precise mechanisms are undetermined, the present study demonstrated that omeprazole decreases mechanosensitivity to mild gastric distension. | Akihito Iida Hiroshi Kaneko Toshihiro Konagaya Yasushi Funaki Kentaro Tokudome Shinya Izawa Yasuhiro Tamura Mari Mizuno Naotaka Ogasawara Makoto Sasaki Kunio Kasugai | 2012 | World Journal of Gastroenterology2012，18，39： | 3 |
| 5 | The cardiovascular action of hexarelin显示文摘Hexarelin,合成生长释放荷尔蒙的肽,能绑在并且在类似于它的自然模拟 ghrelin 的大脑激活生长荷尔蒙促泌素受体(GHSR ) 。然而,在心和血容器的 GHSR 的外部分发建议 hexarelin 可能在生长荷尔蒙版本和 neuroendocrine 效果以外有直接心血管的行动。而且, non-GHSR CD36 被表明了是为 hexarelin 的特定的心脏的受体;并且调停它的 cardioprotective 效果。什么时候与 ghrelin 相比, hexarelin 是化学上更稳定并且机能上地更多的有势力。因此,它可以是为一些心血管的条件的一个有希望的治疗学的代理人。在这简明评论,我们为 hexarelin 的心血管的行动讨论当前的证据。 | Yuanjie MAO Takeshi Tokudome Ichiro Kishimoto | 2014 | Journal of Geriatric Cardiology2014，11，3： | 3 |
| 6 | Super-hydrophilic and transparent thin films of TiO2 nanotube arrays by a hydrothermal reaction 显示文摘 | Miyauchi M Tokudome H | 2007 | Journal of Materials Chemistry2007，17，20： | 1 |
| 7 | One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction显示文摘 | Schwenke DO Tokudome T Kishimoto I | 2012 | Endocrinology2012，153，5： | 1 |
| 8 | Insulin resistance is a risk factor for the progression of chronic kidney disease显示文摘 | Kobayashi H Tokudome G Hara Y | 2009 | Clin Nephrol2009，71，： | 1 |
| 9 | Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hyper-trophy:interference between CNP and endothelin-1 signaling pathways显示文摘 | Tokudome T Horio T Soeki T | 2004 | Endocrinol2004，145，5： | 1 |
| 10 | Microscopic measurement of the facial nerve root exit zone from central glial myelin to peripheral Schwann cell myelin显示文摘 | Masto Tomii Hisashi Onpue Tokudome | 2003 | Neurosurg2003，99，： | 1 |
| 11 | Synthesis of high-silica and low-silica zeolite monoliths with trimodal pores显示文摘 | Tokudome Y Nakanishi K Kosaka S | 2010 | Microporous and Mesoporous Materials2010，132，3： | 1 |
| 12 | Direct effect of high glucose and insuline on protein synthesis in cultured cardiac myocytes and DNA and collagen synthesis in cardiac fibroblasts显示文摘 | Tokudome T Horio T Yoshihara F | 2004 | Metabolism2004，53，6： | 1 |
| 13 | Electron Field Emission from TiO2 Nanotube Arrays Synthesized by Hydrothermal Reaction 显示文摘 | MIYAUCHI M TOKUDOME H TODA Y | 2006 | Applied Physics Letters2006，89，4： | 1 |
| 14 | 查看详情显示文摘 | Miyauchi M Tokudome H Toda Y Kamiya T Hosono H | | 0，，： | 1 |
| 15 | Sensitive detection of myocardial contraction abnormality in chronic hemodialysis patients by ultrasonic tissue characterization with integrated backscatter显示文摘 | Mizushige K Tokudome T Seki M | 2000 | Angiology2000，51，： | 1 |
| 16 | Direct effects of high glu-cose and insulin on protein synthesis in cultured cardiac myocytes and DNA and collagen synthesis in cardiac fibroblasts显示文摘 | Tokudome T Horio T Yoshihara F | 2004 | Metab-olism2004，53，6： | 1 |
| 17 | Synthesis of monolithic AI203 with well-defined macropores and mesostructured skeletons via the sol-gel process accompanied by phase separation 显示文摘 | TOKUDOME Y FUJITA K NAKANISHI K | 2007 | Chemistry of materials2007，19，： | 1 |
| 18 | Endogenous ghrelin attenuates pressure overload - induced cardiac hypertrophy via a eholinergic anti - inflammatory pathway显示文摘 | Mao Y Tokudome T Kishimoto I | 2015 | Hypertension2015，65，6： | 1 |
| 19 | Super-hydrophilic and transparent thin films of TiO2 nanotube arrays by a hydrothermal reaction显示文摘 | Miyauchi M Tokudome H | | 0，，20： | 1 |
| 20 | Synthesis of mon- olithic A1203 with well-defined macropores and mesostruc- tured skeletons via the sol-gel process accompanied by phase separation显示文摘 | Tokudome Y Fujita K Nakanishi K | 2007 | Chemistry of Materials2007，19，14： | 1 |
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