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| 1 | Hepatic clearance measured with ^(99m)Tc-GSA single-photon emission computed tomography to estimate liver fibrosis显示文摘AIM: To evaluate the clinical utility of hepatic clearance(HC) measured with technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl human serum albumin(99mTc-GSA) single-photon emission computed tomography(SPECT) to estimate the degree of liver fibrosis.METHODS:Seventy-eight consecutive patients who underwent initial hepatectomy due to hepatocellular carcinoma were enrolled in this study.Indocyanine green clearance(ICG R15),quantitative indices estimated by 99mTc-GSA[the receptor index(LHL15 and HH15)and HC via SPECT analysis],and conventional liver function tests were performed before hepatectomy.Correlations among the quantitative indices for liver functional reserve,conventional liver function tests,andthe degree of liver fibrosis were evaluated.RESULTS:The degree of liver fibrosis was correlated with ICG R15,HH15,LHL15,and HC.HC showed the best correlation with conventional liver function tests.According to multivariate analysis,HC and LHL15 were significant independent predictors of severe fibrosis.HC was the most valuable index for predicting severe fibrosis.CONCLUSION:HC measured with 99mTc-GSA SPECT is a reliable index for assessing liver fibrosis before hepatectomy. | Masahiko Taniguchi Atsutaka Okizaki Kenji Watanabe Koji Imai Koichiro Uchida Takahiro Einama Noriyuki Shuke Naoyuki Miyokawa Hiroyuki Furukawa | 2014 | World Journal of Gastroenterology2014，20，44： | 11 |
| 2 | STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury显示文摘AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration. | Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 3 | Strength of plastic with various helical wheels meshed types of worms显示文摘 | Makoto Nomura Takao Koide Akio Ueda Yusuke Ishida Atsutaka Tamura | 2015 | 材料与冶金学报2015，14，3： | 2 |
| 4 | Synthesis of poly{[bis(diethynylphenyl)silylene]phenylene}s with highly heat-resistant properties and an application to conducting materials显示文摘 | Joji Ohshita Toshiyuki Iida Masaru Ikeda Taisuke Uemura Nobuaki Ohta Atsutaka Kunai | 2004 | Journal of Organometallic Chemistry2004，，9： | 1 |
| 5 | Synthesis of pol{ -phenylenes}s with highly heat-resistant properties 显示文摘 | Joji Ohshita Akihiro Shinpo Atsutaka Kunai | 1999 | Macromolecules1999，32，： | 1 |
| 6 | Aluminum Deoxidation Equilibrium of Molten Fe-Ni Alloy Coexisting with Alumina or Hereynite显示文摘 | Atsutaka Hayashi Takayuki Uenishi Hirotoshi Kandori | 2008 | ISIJ International2008，48，11： | 1 |
| 7 | Polymeric organosilicon systems synthesis of poly with highly conducting properties显示文摘 | Mitsuo Ishikawa Yutaka Hasegawa Atsutaka Kunai | 1990 | J Orgmet Chem1990，，381： | 1 |
| 8 | Synthesis of poly { phenylene}s with highly heat-resistant properties 显示文摘 | Ohshita Joji Shinpo Akihiro Kunai Atsutaka | 1999 | Macromolecules1999，32，7： | 1 |
| 9 | Impaired and imbalanced cellular immunological status assessed in advanced cancer patients and restoration of the T cell immune status by adoptive T-cell immunotherapy显示文摘 | Atsutaka Noguchi Toru Kaneko Keiko Naitoh Masashi Saito Kazuro Iwai Ryuji Maekawa Takashi Kamigaki Shigenori Goto | 2014 | International Immunopharmacology2014，，1： | 1 |
| 10 | Complex formation of CD23/surface immunoglobulin and CD23/CD81/MHC class Ⅱ on an EBV-transformed human B cell line and inferable role of tetraspanin显示文摘 | Higeko Kijimoto-Ochiai Atsutaka Noguchi Toshiyuki Ohnishi | 2004 | Microbiol Immunol2004，48，5： | 1 |
| 11 | Zoledronate-activated Vγ9γδ T cell-based immunotherapy is feasible and restores the impairment of γδ T cells in patients with solid tumors显示文摘 | Atsutaka Noguchi Toru Kaneko Takashi Kamigaki Katsunada Fujimoto Masanori Ozawa Masashi Saito Naoko Ariyoshi Shigenori Goto | 2011 | Cytotherapy2011，，1： | 1 |
| 12 | A Novel Paired Electrosynthesis of p-Benzoquinone and Hydroquinone from Benzene 显示文摘 | Sotaro Ito Ryuichi Katayama Atsutaka Kunai | 1989 | Tetrahedron Letters1989，30，： | 1 |
| 13 | 铜氧化物母体在正负偏压下的选择性易失和非易失绝缘-超导转变显示文摘Changing carrier density is one of the most remarkable but common aspects of unconventional superconductors.Both for understanding the mechanism of exotic superconductivity and for novel technological applications,this“semiconductor-like”property plays a crucial role.Usually,this can be achieved by chemical substitution.However,in the chemical substitution technique. | Atsutaka Maeda | 2021 | Science Bulletin2021，66，1： | 1 |
| 14 | Synthesis of poly { phenylene} s with highly heat - resistant properties 显示文摘 | OHSHITA J AKIHIRO S ATSUTAKA K | 1999 | Macromolecules1999，32，： | 1 |
| 15 | Complex formation of CD23/surface immunoglobulin and CD23/CD81/MHC class Ⅱ on an EBV-transformed human B cell line and inferable role of tetraspanin显示文摘 | Higeko Kijimoto-Ochiai Atsutaka Noguchi Toshiyuki Ohnishi | 2004 | Microbiol Immunol2004，48，5： | 1 |
| 16 | Protein mRNA by in Situ Hybridization in Brain and Placenta of Sheep显示文摘 | Atsutaka Kubosaki Aito Ueno Yasunobu Matsumoto | 2000 | Biochemical and Biophysical Research Communications2000，273，： | 1 |
| 17 | Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors显示文摘Background:Antiangiogenic tyrosine kinase inhibitors(TKIs)provide one of the few therapeutic options for effective treatment of hepatocellular carcinoma(HCC).However,patients with HCC often develop resistance toward antiangiogenic TKIs,and the underlying mechanisms are not understood.The aim of this study was to determine the mechanisms underlying antiangiogenic TKI resistance in HCC.Methods:We used an unbiased proteomic approach to define proteins that were responsible for the resistance to antiangiogenic TKIs in HCC patients.We evaluated the prognosis,therapeutic response,and serum insulin-like growth factor-binding protein-1(IGFBP-1)levels of 31 lenvatinib-treated HCC patients.Based on the array of results,a retrospective clinical study and preclinical experiments using mouse and human hepatoma cells were conducted.Additionally,in vivo genetic and pharmacological gain-and loss-of-function experiments were performed.Results:In the patient cohort,IGFBP-1 was identified as the signaling molecule with the highest expression that was inversely associated with overall survival.Mechanistically,antiangiogenic TKI treatment markedly elevated tumor IGFBP-1 levels via the hypoxia-hypoxia inducible factor signaling.IGFBP-1 stimulated angiogenesis through activation of the integrinα5β1-focal adhesion kinase pathway.Consequently,loss of IGFBP-1 and integrinα5β1 by genetic and pharmacological approaches re-sensitized HCC to lenvatinib treatment.Conclusions:Together,our data shed light onmechanisms underlying acquired resistance of HCC to antiangiogenic TKIs.Antiangiogenic TKIs induced an increase of tumor IGFBP-1,which promoted angiogenesis through activating the IGFBP-1-integrinα5β1 pathway.These data bolster the application of a new therapeutic concept by combining antiangiogenic TKIs with IGFBP-1 inhibitors. | Hiroyuki Suzuki Hideki Iwamoto Takahiro Seki Toru Nakamura Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Yasuko Imamura Takashi Niizeki Masahito Nakano Shigeo Shimose Tomotake Shirono Yu Noda Naoki Kamachi Miwa Sakai Kazutoyo Morita Masamichi Nakayama Tomoharu Yoshizumi Ryoko Kuromatsu Hirohisa Yano Yihai Cao Hironori Koga Takuji Torimura | 2023 | Cancer Communications2023，43，4： | 0 |
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