|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in HCC.HBX might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in HCC.By mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of HCC.The accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major determinant.This article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets. | Ashraf Ali Hany Abdel-Hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid Zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，30： | 29 |
| 2 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 3 | 水热法制备Sn掺杂TiO2纳米颗粒及其丙酮传感器应用显示文摘二氧化钛因为其优异的灵敏度和物化稳定性,被认为是挥发性有机气体(volatile organic chemicals,VOCs)传感应用的潜在候选者之一。中通过水热法合成(1%~5 mol%)Sn掺杂多孔TiO2纳米颗粒。通过测试基于Sn掺杂TiO2纳米颗粒传感器对丙酮的气敏响应,研究其气敏性能,证明了Sn掺杂片状多孔TiO2纳米颗粒在气体传感器领域的潜在应用前景。例如,气敏测试结果表明:Sn-TiO2显著降低了工作温度,3 mol%Sn-对丙酮具有高响应(Rs^42.35),快速的响应(16 s),恢复时间(8 s),良好的选择性以及稳定性。通过XRD、XPS、EDS、SEM、TEM等手段对合成的Sn-TiO2纳米颗粒进行了结构和形貌表征,以了解和验证其传感机理,并在此基础上,讨论了一种合理的传感机制。 | 王哲 殷文强 谢利娟 于淳义 Azhar Ali Haidry | 2020 | 功能材料2020，51，11： | 7 |
| 4 | Two-Dimensional Materials in Large-Areas: Synthesis, Properties and Applications显示文摘Large-area and high-quality two-dimensional crystals are the basis for the development of the next-generation electronic and optical devices.The synthesis of two-dimensional materials in wafer scales is the first critical step for future technology uptake by the industries;however,currently presented as a significant challenge.Substantial efforts have been devoted to producing atomically thin two-dimensional materials with large lateral dimensions,controllable and uniform thicknesses,large crystal domains and minimum defects.In this review,recent advances in synthetic routes to obtain high-quality two-dimensional crystals with lateral sizes exceeding a hundred micrometres are outlined.Applications of the achieved large-area two-dimensional crystals in electronics and optoelectronics are summarised,and advantages and disadvantages of each approach considering ease of the synthesis,defects,grain sizes and uniformity are discussed. | Ali Zavabeti Azmira Jannat Li Zhong Azhar Ali Haidry Zhengjun Yao Jian Zhen Ou | 2020 | Nano-Micro Letters2020，12，5： | 4 |
| 5 | Genetic effects conferring heat tolerance in upland cotton(Gossypium hirsutum L.)显示文摘Background:Climate change and particularly global warming has emerged as an alarming threat to the crop productivity of field crops and exerted drastic effects on the cropping patterns.Production of cotton has been dropped down to one million bales from 1.4 million bales since 2015 in Pakistan due to the increase in temperature at critical growth stages,i.e.,flowering and boll formation.Keeping in view the importance of cotton in the country,this study was conducted to investigate the genetic effects conferring heat tolerance in six populations(P1,P2,F1,F2,BC1 and BC2)developed from cross-1 and cross-2,i.e.,VH-282×FH-142 and DNH-40×VH-259.Results:The results revealed that cross-1 performed better in heat stress as compared with cross-2 for majority of the traits recorded.Boll weight and ginning outturn(GO-T)were highly effected under heat stress and had negative correlation with Relative cell injury(RCI).Boll weight,fiber length,fiber strength and fiber fineness were under the control of non-additive gene action,whereas RCI was controlled by additive gene effects.Lower values of genetic advance coupled with higher values of broad sense heritability for these traits except RCI confirmed the role of non-additive genetic effects.Duplicate types of epistasis were recorded for fiber strength in cross-1 in normal condition.However,complementary type of non-allelic interaction was recorded for fiber strength under normal condition,fiber fineness and RCI under heat stressed condition in cross-1.Likewise,boll weight,GOT and fiber length in populations derived from cross-2 in normal condition were also under the influence of complementary type of non-allelic interaction.Significant differences among values of mid parent and better parent heterosis for boll weight in both normal and heat stress condition provided the opportunity to cotton breeders for utilization of this germplasm for improvement of this trait through exploitation of heterosis breeding.Conclusion:Cross-1 performed better in heat stress and could be utilized for development of heat tolerant cultivar.RCI was under the influence of additive gene action,so one can rely on this trait for screening of large number of accessions of cotton for heat stress.While other traits were predominantly controlled by non-additive gene action and selection based on these should be delayed in later generations. | SALMAN Muhammad ZIA Zia Ullah RANA Iqrar Ahmad MAQSOOD Rana Haroon AHMAD Saghir BAKHSH Ali AZHAR Muhammad Tehseen | 2019 | Journal of Cotton Research2019，2，1： | 2 |
| 6 | Role of SNPs in determining QTLs for major traits in cotton显示文摘A single nucleotide polymorphism is the simplest form of genetic variation among individuals and can induce minor changes in phenotypic,physiological and biochemical characteristics.This polymorphism induces various mutations that alter the sequence of a gene which can lead to observed changes in amino acids.Several assays have been developed for identification and validation of these markers.Each method has its own advantages and disadvantages but genotyping by sequencing is the most common and most widely used assay.These markers are also associated with several desirable traits like yield,fibre quality,boll size and genes respond to biotic and abiotic stresses in cotton.Changes in yield related traits are of interest to plant breeders.Numerous quantitative trait loci with novel functions have been identified in cotton by using these markers.This information can be used for crop improvement through molecular breeding approaches.In this review,we discuss the identification of these markers and their effects on gene function of economically important traits in cotton. | MAJEED Sajid RANA Iqrar Ahmad ATIF Rana Muhammad ALI Zulfiqar HINZE Lori AZHAR Muhammad Tehseen | 2019 | Journal of Cotton Research2019，2，1： | 2 |
| 7 | 巴基斯坦旁遮普中部仓鸮食性的季节性变化(英文)显示文摘在巴基斯坦对仓鸮食性的季节变化进行了研究。通过分析连续3年在6个地区搜集的2 360个仓鸮回吐食物团,发现其食物主要是小型哺乳动物(95.6 %)。其中,家(Suncus murinus)有最高的比例,达65.6%(冬季最多78%,夏季最少27%)。就生物量而言,小型哺乳动物占仓鸮食物总生物量的99% 。 | Muhammad MAHMOOD-UL-HASSAN Mirza Azhar BEG Habib ALI | 2007 | 动物学报2007，53，3： | 1 |
| 8 | Structural,electrical,dielectric and magnetic properties of Mn-Nd substituted CoFeO_3 nano sized multiferroics显示文摘A series of Mn x Co_(1-x) Fe_(1-y) Nd_yO_3(where x=0.0–1.0 & y=0.0–0.1) multiferroic nanocrystals was synthesized via sol-gel auto-combustion technique. The structure was confirmed by X-ray diffraction(XRD)while morphology was investigated by scanning electron microscopy(SEM). The electrical resistivity was observed to increase from 2.14 * 10~7 to 8.77 * 10~9 Ω-cm and activation energy was found to increase from 0.64 to 0.75 e V, while the drift mobility decreased from 4.75 * 10^(-13) to 1.27 * 10^(-15)cm^2V^(-1)S^(-1) by the substitution of Mn and Nd contents. The dielectric constant, dielectric loss and dielectric loss factor decrease with frequency and Mn-Nd contents. The saturation magnetization was increased from 34 to 70 emu g^(-1) while the coercivity decreased from 705 to 262 Oe with the increase of substituents.The increase in electrical resistivity and saturation magnetization while decrease in dielectric parameters and coercivity make these nanomaterials suitable for applications in microwave devices and longitudinal magnetic recording media. | Abdul Aziz E.Ahmed Muhammad Naeem Ashiq Muhammad Azhar Khan Nazia Karamat Irshad Ali | 2016 | Progress in Natural Science:Materials International2016，26，4： | 1 |
| 9 | Correlation analysis of seed cotton yield with fiber characteristics in Gossypium hirsutum L显示文摘 | Azhar F M Naveed M Ali A | 2004 | International Journal of Agriculture and Biology2004，6，4： | 1 |
| 10 | The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia显示文摘 | Danish Saleheen Moazzam Zaidi Asif Rasheed Usman Ahmad Abdul Hakeem Muhammed Murtaza Waleed Kayani Azhar Faruqui Assadullah Kundi Khan Shah Zaman Zia Yaqoob Liaquat Ali Cheema Abdus Samad Syed Zahed Rasheed Nadeem Hayat Mallick Muhammad Azhar Rashid Jooma | 2009 | European Journal of Epidemiology2009，，6： | 1 |
| 11 | Optimizing the Highway Lifetime by Improving the Self Healing Capacity of Asphalt显示文摘 | Ali Azhar Butt Bjorn Birgisson NikiKringos | 2012 | Procedia-Social and Behavioral Sciences2012，48，： | 1 |
| 12 | HBV and HIV co‐infection: Prevalence and clinical outcomes in tertiary care hospital Malaysia显示文摘 | Ali Akhtar Amer Hayat Khan Syed Azhar Syed Sulaiman Chow Ting Soo Kashifullah Khan | 2016 | J. Med. Virol2016，，： | 1 |
| 13 | A flavonoid compound iso- lated from theartemisia plant, induces apoptosis and G2/M phase cellcycle arrest in human melanoma A375 cell 显示文摘 | Ali AS Azhar R Muhammad K | 2011 | Pharm Phar- maco2011，5，5： | 1 |
| 14 | Continuous production of dextran from immobilized cells of Leuconostoc mesenteroides KIBGE HA1 using acrylamide as a support显示文摘 | Qader Shah Ali Ul Aman Afsheen Azhar Abid | 2011 | Indian Journal of Microbiology2011，51，3： | 1 |
| 15 | Application of Response Surface Methodology for Modeling of Reactive Dye Removal from Solution Using Starch-montmorillonite/Polyaniline Nanocomposite显示文摘 | Ali Olad Fahimeh Farshi Azhar Maryam Shargh | 2014 | Polymer Engineering and Science2014，，54： | 1 |
| 16 | Correlation analysis of seed cotton yield with fiber characteristics in Gossypium hirsutum L 显示文摘 | Azhar F M Naveed M Ali A | 2004 | International Journal of Agriculture and Biology2004，6，4： | 1 |
| 17 | Pathogenicity of avian influenza virus H5N1 2007 isolates from Pakistan显示文摘 | Farhan Afzal Ali Saeed Muhammad Azhar Sharif Najma Ayub Shamsul Hassan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，，1： | 1 |
| 18 | 基于Fe_(3)O_(4)陶粒的密封舱微波辐射空气净化技术显示文摘着眼于开发满足生物安全性的密封舱空气净化技术,制备Fe_(3)O_(4)陶粒吸波材料,并探讨基于该吸波材料的微波辐射过程对不同种类生物气溶胶的灭活特性。验证实验显示:灭活效果随着微波辐射时间的延长而增强;微波辐射对不同种类生物气溶胶的灭活率依次为大肠杆菌>杂色曲霉菌>枯草芽孢杆菌>枯草芽孢杆菌孢子。分析发现:添加Fe_(3)O_(4)陶粒使微波辐射对生物气溶胶的灭活增强是微波热效应、非热效应以及O•和•OH的氧化作用共同所致;Fe_(3)O_(4)陶粒还可降低48.56%~59.23%的单位微波能耗。基于Fe_(3)O_(4)陶粒的微波辐射技术可有效用于我国载人航天器(含空间站)发射前的舱内空气净化除菌。 | 宋璐 李云飞 王灿 张郅巍 Azhar Ali LAGHARI 李国华 张磊 | 2021 | 航天器环境工程2021，38，1： | 1 |
| 19 | Optimizing the Highway Lifetime by Improving the Self-Healing Capacity of Asphalt显示文摘 | Ali Azhar Butt Bjorn Birgisson NikiKringos | 2012 | Procedia-Social and Behavioral Sciences2012，48，： | 1 |
| 20 | Tylophora hirsuta L. leaf extract attenuates alloxan-induced diabetes in mice by suppressing oxidative stress and α-amylase显示文摘Objective:To evaluate the antidiabetic potential of leaf extracts of Tylophora hirsuta(T.hirsuta).Methods:The methanolic and ethyl acetate extracts of T.hirsuta leaves were analyzed by high pressure liquid chromatography.In vitro antioxidant activity was determined by ferric ion reduction,1,1-diphenyl-2-picrylhydrazyl,and hydrogen peroxide scavenging methods.In vitro alpha amylase(α-amylase)inhibitory activity of the plant extracts was assessed.In vivo antidiabetic potential was determined in alloxan-induced diabetic mice to assess glycated hemoglobin(HbA1c),oral glucose tolerance,serum amylase,lipid profile,fasting blood glucose,and body weight.Histopathological lesions of the pancreas,liver and kidney were observed.Oxidative stress biomarkers such as superoxide dismutase,catalase and peroxidase were also determined.Results:Quercetin,chlorogenic acid,p-coumaric acid,and m-coumaric acid were found in the plant extracts.The methanolic plant extract exhibited higher in vitro antioxidant activities than the ethyl acetate extract.Moreover,methanolic plant extract exhibited(83.90±1.56)%α-amylase inhibitory activity at 3.2 mg/mL concentration.Animal study showed that the methanolic extract of T.hirsuta improved the levels of fasting blood glucose,HbA1c,serumα-amylase,lipid profile,liver function biomarkers,and kidney functions of diabetic mice.Moreover,the methanolic extract ameliorated diabetes-related oxidative stress by increasing superoxide dismutase and catalase activities and decreasing peroxidase and malondialdehyde levels.Histopathological examination showed that the plant extract had improved the integrity of pancreatic islets of Langerhans and reduced the pathological lesions in the liver and kidney of diabetic mice.Conclusions:The methanolic extract of T.hirsuta exhibits pronounced antidiabetic activity in mice through reduction of oxidative stress.The plant extract has several natural antioxidants such as phenolic acids.T.hirsuta extract could serve as a nutraceutical for managing diabetes mellitus. | Muhammad Furqan Akhtar Arsalan Shagufta Ammara Saleem Mirza Muhammad Faran Ashraf Baig Ali Sharif Azhar Rasul Mohamed M.Abdel-Daim | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员