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| 1 | OsWRKY03, a rice transcriptional activator that functions in defense signaling pathway upstream of OsNPR1显示文摘WRKY family proteins are a class of plant specific transcription factors that involve in many stress response pathways. It has been shown that one Arabidopsis WRKY protein, AtWRKY29/22, is activated by MAP kinase signaling cascade and confers resistance to both bacterial and fungal pathogens. However, little is known about the biological roles of WRKY proteins in rice. In this study, we investigated the expression patterns of rice AtWRKY29/22 homolog, OsWRKY03, under different conditions, and also its possible role involved in plant defense. Our results showed that OsWRKY03 was up-regulated by several defense signaling molecules or different treatments. Further analysis revealed that the expres- sion of OsWRKY03 was light dependent. Transcriptional activation activity of OsWRKY03 was also demonstrated by yeast functional assay. Transient expression of OsWRKY03-GFP fusion protein in onion epidermis cells showed that OsWRKY03 was a nuclear localized protein. OsNPR1 as well as several other pathogenesis-related genes, such as OsPR1b, phenylalanine ammonia-lyase (ZB8) and peroxidase (POX22.3), were induced in OsWRKY03-overexpressing transgenic plants. These results indicated that OsWRKY03 is located upstream of OsNPR1 as a transcriptional activator in salicylic acid (SA)-dependent or jasmonic acid (JA)-dependent defense signaling cascades. | Xiao Qiang LIU Xian Quan BAI Qian QIAN Xiu Jie WANG Ming Sheng CHEN Cheng Cai CHU | 2005 | Cell Research2005，15，8： | 55 |
| 2 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 3 | Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach显示文摘瞄准:Nuciferine 是从莲花叶子提取的 aporphine 碱,它是在为重量损失的中国药用的植物的原料。在这研究,我们使用了一条网络药理学途径识别 nuciferine 和内在的 mechanisms.Methods 的反肿瘤活动:nuciferine 的药理学活动和机制通过目标侧面预言被识别,聚类用我们的繁体中文药(TCM ) 的分析和功能的丰富分析网络药理学站台。nuciferine 的反肿瘤活动被验证由在 vitro 并且在 vivo 实验。nuciferine 的反肿瘤机制通过网络目标分析被预言并且验证了由在 vitro experiments.Results:nuciferine 目标侧面与表明小径和生物功能被充实,包括 “脂肪分解酵素 activity” 的规定;, “对 nicotine” 的反应;并且 “房间 proliferation” 的规定;。目标侧面聚类结果建议了那 nuciferine 施加反肿瘤效果。在试验性的确认, nuciferine (0.8 mg/mL ) 显著地在 vitro 禁止了人的 neuroblastoma SY5Y 房间和老鼠 colorectal 癌症 CT26 房间的生存能力,并且 nuciferine (0.05 mg/mL ) 显著地在 vitro 压制了 6 根癌症房间线的侵略。nuciferine 的 Intraperitoneal 注射(9.5 mg/mL, ip,乘为 3 个星期的一个星期的 3 ) 显著地减少了在裸体老鼠的 SY5Y 和 CT26 肿瘤异种皮移植的重量。在 SY5Y 和 CT26 房间的网络目标分析和试验性的确认证明 nuciferine 的反肿瘤效果通过禁止在 SY5Y 和 CT26 cells.Conclusion 表明小径和 IL-1 层次的 PI3K-AKT 被调停:由使用一个 TCM 网络药理学方法, nuciferine 在 vitro 并且在 vivo 对人的 neuroblastoma 和老鼠 colorectal 癌症作为一个反肿瘤代理人被识别,通过禁止表明小径和 IL-1 层次的 PI3K-AKT。 | Quan QI Rui LI Hui-ying LI Yu-bing CAO Ming BAI Xiao-jing FAN Shu-yan WANG Bo ZHANG Shao LI | 2016 | Acta Pharmacologica Sinica2016，37，7： | 23 |
| 4 | Nickel-exposed Workers in China: A Cohort Study显示文摘There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a | BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying | 2014 | Biomedical and Environmental Sciences2014，27，3： | 20 |
| 5 | Combination of serum inhibin B and follicle-stimulating hormone levels can not improve the diagnostic accuracy on testicular sperm extraction outcomes in Chinese non-obstructive azoospermic men显示文摘 | HUANG Xiang BAI Quan YAN Li-ying ZHANG Qiu-fang GENG Li QIAO Jie | 2012 | Chinese Medical Journal2012，，16： | 17 |
| 6 | 铬铁矿预富集和上地幔部分熔融关系的实验研究显示文摘用合成地幔岩为原始材料,在温度1225°C和严格控制氧分压10^(-5)-10^(-12)atm条件下,对上地幔部分熔融作用与铬铁矿预富集关系进行实验研究。实验结果表明:(1)在达到稳态熔融结构时,5%-8%的玄武质硅酸盐熔体主要赋存在矿物三联点之间,它为铬元素从地幔岩中萃取运移和预富集提供了先决条件;(2)在部分熔融过程中原岩的尖晶石和辉石(铬透辉石和顽火辉石)提供的铬元素相结合,形成了富铬尖晶石和铬铁矿(Cr_2O_3可达38%-47%)。上地幔部分熔融作用不仅控制了上地幔岩石类型演化(二辉橄榄岩→方辉橄榄岩→纯橄榄岩),同时它对铬铁矿的预富集起着关键作用。 | 金振民 Quan Bai D.L.Kohlstedt 金淑燕 | 1996 | 地质论评1996，42，5： | 16 |
| 7 | Experimental Research on the Propagation Process of Continuous Rotating Detonation Wave显示文摘In order to study the propagation mechanism of continuous rotating detonation wave,the H2/air continuous rotating detonation engine ignited by tangentially installed H2/O2pre-detonation tube is studied experimentally using a tilt slot injector structure.The experimental results show that the stable rotating detonation wave can be gained successfully with the equivalent ratio of 0.93.The propagation frequency and velocity of rotating detonation wave range from 5200 to 5500 Hz and from 1518.5 to 1606.1 m/s,respectively.Three propagation modes,such as rotation,reversal and bifurcation,of detonation wave are verified through the analysis of propagation mechanism of rotating detonation wave. | Quan ZHENG Chun-sheng WENG Qiao-dong BAI | 2013 | Defence Technology(防务技术)2013，9，4： | 16 |
| 8 | New Method to Improve Dynamic Stiffness of Electro-hydraulic Servo Systems显示文摘Most current researches working on improving stiffness focus on the application of control theories.But controller in closed-loop hydraulic control system takes effect only after the controlled position is deviated,so the control action is lagged.Thus dynamic performance against force disturbance and dynamic load stiffness can't be improved evidently by advanced control algorithms.In this paper,the elementary principle of maintaining piston position unchanged under sudden external force load change by charging additional oil is analyzed.On this basis,the conception of raising dynamic stiffness of electro hydraulic position servo system by flow feedforward compensation is put forward.And a scheme using double servo valves to realize flow feedforward compensation is presented,in which another fast response servo valve is added to the regular electro hydraulic servo system and specially utilized to compensate the compressed oil volume caused by load impact in time.The two valves are arranged in parallel to control the cylinder jointly.Furthermore,the model of flow compensation is derived,by which the product of the amplitude and width of the valve's pulse command signal can be calculated.And determination rules of the amplitude and width of pulse signal are concluded by analysis and simulations.Using the proposed scheme,simulations and experiments at different positions with different force changes are conducted.The simulation and experimental results show that the system dynamic performance against load force impact is largely improved with decreased maximal dynamic position deviation and shortened settling time.That is,system dynamic load stiffness is evidently raised.This paper proposes a new method which can effectively improve the dynamic stiffness of electro-hydraulic servo systems. | BAI Yanhong QUAN Long | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 9 |
| 9 | Effects of total pressures and equivalence ratios on kerosene/air rotating detonation engines using a paralleling CE/SE method显示文摘In this paper,the kerosene/air rotating detonation engines(RDE)are numerically investigated,and the emphasis is laid on the effects of total pressures and equivalence ratios on the operation characteristics of RDE including the initiation,instabilities,and propulsive performance.A hybrid MPI t OpenMP parallel computing model is applied and it is proved to be able to obtain a more effective parallel performance on high performance computing(HPC)systems.A series of cases with the total pressure of 1 MPa,1.5 MPa,2 MPa,and the equivalence ratio of 0.9,1,1.4 are simulated.On one hand,the total pressure shows a significant impact on the instabilities of rotating detonation waves.The instability phenomenon is observed in cases with low total pressure(1 MPa)and weakened with the increase of the total pressure.The total pressure has a small impact on the detonation wave velocity and the specific impulse.On the other hand,the equivalence ratio shows a negligible influence on the instabilities,while it affects the ignition process and accounts for the detonation velocity deficit.It is more difficult to initiate rotating detonation waves directly in the lean fuel operation condition.Little difference was observed in the thrust with different equivalence ratios of 0.9,1,and 1.4.The highest specific impulse was obtained in the lean fuel cases,which is around 2700 s.The findings could provide insights into the understanding of the operation characteristics of kerosene/air RDE. | Fang Wang Chun-sheng Weng Yu-wen Wu Qiao-dong Bai Quan Zheng Han Xu | 2021 | Defence Technology(防务技术)2021，17，6： | 7 |
| 10 | Design of freeform geometries in a MEMS accelerometer with a mechanical motion preamplifier based on a genetic algorithm显示文摘This paper describes a novel,semiautomated design methodology based on a genetic algorithm(GA)using freeform geometries for microelectromechanical systems(MEMS)devices.The proposed method can design MEMS devices comprising freeform geometries and optimize such MEMS devices to provide high sensitivity,large bandwidth,and large fabrication tolerances.The proposed method does not require much computation time or memory.The use of freeform geometries allows more degrees of freedom in the design process,improving the diversity and performance of MEMS devices.A MEMS accelerometer comprising a mechanical motion amplifier is presented to demonstrate the effectiveness of the design approach.Experimental results show an improvement in the product of sensitivity and bandwidth by 100%and a sensitivity improvement by 141%compared to the case of a device designed with conventional orthogonal shapes.Furthermore,excellent immunities to fabrication tolerance and parameter mismatch are achieved. | Chen Wang Xiaoxiao Song Weidong Fang Fang Chen Ioannis Zeimpekis Yuan Wang Aojie Quan Jian Bai Huafeng Liu Gerold Schropfer Chris Welham Michael Kraft | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 11 | Preparation of imprinted monolithic column under molecular crowding conditions显示文摘分子的拥挤是一个新概念与更大的能力和选择获得分子地印的聚合物(MIP ) 。在这个工作,分子的拥挤代理人第一被用于 MIP 整体的列的准备。一个新聚合系统基于包围的分子的拥挤被开发准备印 enrofloxacin 的独块巨石,它聚苯乙烯和 tetrahydrofuran 是镇静的。结果证明在分子的拥挤的条件下面的整体的 MIP 与 3.03 的一个印的因素为 enrofloxacin 介绍了好分子的识别。 | Xiao Xia Li Xin Liu Li Hong Bai Hong Quan Duan Yan Ping Huang Zhao Sheng Liu | 2011 | Chinese Chemical Letters2011，22，8： | 6 |
| 12 | The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats显示文摘Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other vital organs [1] . However, few studies | BAI Ya Na MA Li WANG Qiu Ying PU Hong Quan ZHANG Xiao Pei WU Xi Jiang XUAN Xiao Qiang CHENG Ning | 2013 | Biomedical and Environmental Sciences2013，26，7： | 5 |
| 13 | Prevalence of Metabolic Syndrome in Chinese Nickel-exposed Workers显示文摘The prevalence of metabolic syndrome(MS was investigated in Chinese nickel-exposed workers A total of 35 104 subjects were enrolled in this study.The age-adjusted prevalence of MS,BMI≥25diabetes,hypertension,and abnormal lipid was13.9%,29.5%,12.8%,27.5%,and 47.1%respectively.The prevalence of BMI≥25hyperglycemia,and hypertension increased | YANG Ai Min BAI Ya Na PU Hong Quan ZHENG Tong Zhang CHENG Ning LI Juan Sheng LI Hai Yan ZHANG Ya Wei DING Jiao SU Hui REN Xiao Wei HU Xiao Bin | 2014 | Biomedical and Environmental Sciences2014，27，6： | 5 |
| 14 | Sensitivity of runoff to climatic variability in the northern and southern slopes of the Middle Tianshan Mountains,China显示文摘Temperature and precipitation play an important role in the distribution of intra-annual runoff by influencing the timing and contribution of different water sources.In the northern and southern slopes of the Middle Tianshan Mountains in China,the water sources of rivers are similar;however,the proportion and dominance of water sources contributing to runoff are different.Using the Manas River watershed in the northern slope and the Kaidu River watershed in the southern slope of the Middle Tianshan Mountains as case studies,we investigated the changes in annual runoff under climate change.A modified hydrological model was used to simulate runoff in the Kaidu River and Manas River watersheds.The results indicated that runoff was sensitive to precipitation variation in the southern slope and to temperature variation in the northern slope of the Middle Tianshan Mountains.Variations in temperature and precipitation substantially influence annual and seasonal runoff.An increase in temperature did not influence the volume of spring runoff;but it resulted in earlier spring peaks with higher levels of peak flow.Damages caused by spring peak flow from both slopes of the Middle Tianshan Mountains should be given more attention in future studies. | ZHANG Feiyun BAI Lei LI Lanhai WANG Quan | 2016 | Journal of Arid Land2016，8，5： | 4 |
| 15 | A Retrospective Cohort Mortality Study in Jinchang,the Largest Nickel Production Enterprise in China显示文摘Nickel is an essential trace metal used in the occupational setting,resulting in both occupational and nonoccupational exposures to individuals at varying levels.Exposure to nickel has been associated with several toxicities and the International Agency for Research on Cancer has concluded that there is sufficient evidence in humans associating exposure to nickel | MA Li BAI Ya Na PU Hong Quan HE Jie Bryan A.Bassig DAI Min ZHANG Ya Wei ZHENG Tong Zhang CHENG Ning | 2014 | Biomedical and Environmental Sciences2014，27，7： | 4 |
| 16 | Architecture and critical technologies of space information networks显示文摘Focusing on its main requirements and challenges and by analyzing the characteristics of different space platforms,an overall architecture for space information networks is proposed based on national strategic planning and the present development status of associated technologies.Furthermore,the core scientific problems that need to be solved are expounded.In addition,the primary considerations and a preliminary integrated demonstration environment for verification of key technologies are presented. | YU Quan WANG Jingchao BAI Lin | 2016 | Journal of Communications and Information Networks2016，1，3： | 4 |
| 17 | Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair显示文摘Directional axon regeneration and remyelination are crucial for repair of spinal cord injury(SCI),but existing treatments do not effectively promote those processes.Here,we propose a strategy for construction of niche-specific spinal white matter-like tissue(WMLT)using decellularized optic nerve(DON)loaded with neurotrophin-3(NT-3)-overexpressing oligodendrocyte precursor cells.A rat model with a white matter defect in the dorsal spinal cord of the T10 segment was used.The WMLT transplantation group showed significant improvement in coordinated motor functions compared with the control groups.WMLT transplants integrated well with host spinal cord white matter,effectively addressing several barriers to directional axonal regeneration and myelination during SCI repair.In WMLT,laminin was found to promote development of oligodendroglial lineage(OL)cells by binding to laminin receptors.Interestingly,laminin could also guide linear axon regeneration via interactions with specific integrins on the axon surface.The WMLT developed here utilizes the unique microstructure and bioactive matrix of DON to create a niche rich in laminin,NT-3 and OL cells to achieve significant structural repair of SCI.Our protocol can help to promote research on repair of nerve injury and construction of neural tissues and organoids that form specific cell niches. | Bi-Qin Lai Yu-Rong Bai Wei-Tao Han Bao Zhang Shu Liu Jia-Hui Sun Jia-Lin Liu Ge Li Xiang Zeng Ying Ding Yuan-Huan Ma Ling Zhang Zheng-Hong Chen Jun Wang Yuan Xiong Jin-Hua Wu Qi Quan Ling-Yan Xing Hong-Bo Zhang Yuan-Shan Zeng | 2022 | Bioactive Materials2022，7，5： | 3 |
| 18 | Influence of Pre-injection Control Parameters on Main-injection Fuel Quantity for an Electronically Controlled Double-valve Fuel Injection System of Diesel Engine显示文摘一个模拟模型一电子地控制了二个螺线管阀门燃料注射系统因为一台柴油机引擎在 AMESim 环境被建立。模型的精确性与试验性的数据通过比较被验证。在不同控制模式下面的主要注射的数量上的注射前控制参数的影响被分析。在喷洒控制阀门模式,主要注射的燃料数量逐渐地减少然后因为多注射居住时间的增加,到达稳定的水平。在针控制阀门模式,主要注射的燃料数量与升起的多注射居住时间增加;这效果在高速度的革命和大主要注射的脉搏宽度变得更明显。注射前脉搏宽度没在二个控制模式下面在主要注射的数量上有明显的影响;在主要注射的数量的变化在 1 mm3 的范围。 | Enzhe Song Liyun Fan Chao Chen Quan Dong Xiuzhen Yun Bai | 2013 | Journal of Marine Science and Application2013，12，3： | 3 |
| 19 | Heavy Metal Assessment among Chinese Nonferrous Metal-exposed Workers from the Jinchang Cohort Study显示文摘Environmental exposure to heavy metals has been linked to a wide range of human health hazards.We detected the levels of 15 metals in urine samples from 500 representative sub-samples in an ongoing occupational cohort study(Jinchang Cohort)to directly evaluate metal exposure levels.Fifteen metals,namely As,Ba,Be,Cd,Cs,Cr,Co,Cu,Pb,Mn,Ni,Se,Tl,U,and Zn,were detected by inductively coupled plasma quadruple mass spectrometry.The results showed that median creatinine adjustment and geometric mean urinary metal levels were higher in the heavy metal-exposed group,except Se and Zn,than other reported general or occupational populations.Further studies should address the effects of heavy metals on human health. | YANG Ai Min CHENG Zhi Yuan PU Hong Quan CHENG Ning LI Hai Yan LIU Si Min DING Jiao LI Juan Sheng HU Xiao Bin REN Xiao Wei ZHENG Tong Zhang BAI Ya Na | 2017 | Biomedical and Environmental Sciences2017，30，7： | 2 |
| 20 | Dielectric properties of barium zirconate titanate (BZT) ceramics tailored by different donors for high voltage applications显示文摘 | Jian Quan Qi Bai Bo Liu Hu Yong Tian Han Zou Zhen Xing Yue Long Tu Li | 2012 | Solid State Sciences2012，，10： | 2 |
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