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1Long-term frequency-stabilized optical frequency comb based on a turnkey Ti:sapphire mode-locked laser显示文摘We report a long-term frequency-stabilized optical frequency comb at 530–1100 nm based on a turnkey Ti:sapphire modelocked laser.With the help of a digital controller,turnkey operation is realized for the Ti:sapphire mode-locked laser.Under optimized design of the laser cavity,the laser can be mode-locked over a month,limited by the observation time.The combination of a fast piezo and a slow one inside the Ti:sapphire mode-locked laser allows us to adjust the cavity length with moderate bandwidth and tuning range,enabling robust locking of the repetition rate(f_(r)) to a hydrogen maser.By combining a fast analog feedback to pump current and a slow digital feedback to an intracavity wedge and the pump power of the Ti:sapphire mode-locked laser,the carrier envelope offset frequency(f_(ceo)) of the comb is stabilized.We extend the continuous frequency-stabilized time of the Ti:sapphire optical frequency comb to five days.The residual jitters of f;and f;are 0.08 m Hz and 2.5 m Hz at 1 s averaging time,respectively,satisfying many applications demanding accuracy and short operation time for optical frequency combs.杨广 师浩森 姚远 于洪浮 蒋燕义 Albrecht Bartels 马龙生 2021Chinese Optics Letters2021,19,12:2
2Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt显示文摘BACKGROUND Segmental intrahepatic cholestasis caused by transjugular intrahepatic portosystemic shunt(TIPS)(SIC-T),is a rare complication of this technique and only referred by case reports.Thus,we conducted a systematic,retrospective analysis to provide evidence regarding prevalence and consequences of this TIPS-induced bile duct compression.AIM To assess prevalence and outcome of SIC-T in a large TIPS-cohort.METHODS In this retrospective cohort study,we screened the institutional databases for all consecutive patients that were treated by TIPS-placement or TIPS-revision between January 2005 and August 2013.We analyzed radiologic images for signs of biliary congestion.Cases that were indicative of SIC-T were reviewed by two independent radiologists and additional patient data was collected.Descriptive statistics of patient demographics,indications for TIPS and procedural details were registered.Logistic regression analysis was performed to identify predictors for the development of SIC-T.RESULTS We analyzed 135 cirrhotic patients who underwent TIPS(mean age 55 years,79%male gender).Etiology of cirrhosis was alcohol in most cases and indications for TIPS were mainly refractory ascites and recurrent variceal bleeding.TIPS revision was necessary in 31 patients.We identified 4 cases(2.9%)of SIC-T in direct proximity of the TIPS-stent.Diagnosis was confirmed by CT-scan,MRI or endoscopic retrograde cholangio pancreaticography(ERCP).In two patients TIPS was implanted via the right and in one through the medial hepatic vein.One patient received TIPS-prolongation by multiple revisions.Most patients were asymptomatic but one cholangitic abscess necessitated a transhepatic drain.Logistic regression analysis identified TIPS-placement other than from medial hepatic vein to right portal vein as risk factor(OR 21.0)for SIC-T.CONCLUSION SIC-T ads to(mostly late)complications in the interventional treatment of cirrhotic portal hypertensions and can lead to cholangitic abscesses.Patients,particularly with multiple interventions,should be screened for SIC-T.Julian Nikolaus Bucher Marcus Hollenbach Steffen Strocka Gereon Gaebelein Michael Moche Thorsten Kaiser Michael Bartels Albrecht Hoffmeister 2019World Journal of Gastroenterology2019,25,43:2
3Optical frequency synthesis and comparison with uncertainty at the 10-19 level显示文摘MA Long-sheng BI Zhi-yi BARTELS ALBRECHT 2004Science2004,303,5665:1
4K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas显示文摘Dong-Anh Khuong-Quang Pawel Buczkowicz Patricia Rakopoulos Xiao-Yang Liu Adam Fontebasso Eric Bouffet Ute Bartels Steffen Albrecht Jeremy Schwartzentruber Louis Letourneau Mathieu Bourgey Guillaume Bourque Alexandre Montpetit Genevieve Bourret Pierre Lepa 2012Acta Neuropathologica2012,,3:1
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