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| 1 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder 显示文摘 | Bourns E Camilleri M Burton D | 2001 | Gastroenterology2001，120，2： | 1 |
| 3 | Deep-UVRaman spectroscopic analysis of structure and dissolution rates of silica-rich sodium borosilicate glasses显示文摘 | Windisch C F Pierce E M Burton S D | 2011 | Journal of non-crystalline solids2011，357，10： | 1 |
| 4 | Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, pruealopride, in healthy humans 显示文摘 | Bouras E Camilleri M Burton D | 1999 | Gut1999，44，5： | 1 |
| 5 | Functional reorganization and stability of somatosensory-motor corti- cal topography in a tetraplegic subject with late recovery 显示文摘 | Corbetta M Burton H Sinclair R J Conturo TE Akbudak E McDonald JW | 2002 | Proc Natl Acad Sci U S A2002，99，17： | 1 |
| 6 | The internal consistency, stability, and accuracy of the discrete,compatible formulation of Lagrangian hydrodynamics显示文摘 | Bauer A L Burton D E Caramana E J Loubere R Shashkov M J Whalen P P | 2006 | J Comput Phys2006，218，： | 1 |
| 7 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 8 | Port-access coronary artery bypass grafting:technique and comparative results显示文摘 | SUTHERLAND S E BURTON H G | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 9 | Simulation of heat transfer in injection molds显示文摘 | T E Burton M Rezayat | 1987 | Computers in Engineering1987，2，： | 1 |
| 10 | Characterization of the genes encoding the cytosolic and plastidial forms of ADP- glucose pyrophosphorylase ha wheat endosperm 显示文摘 | Burton R A Johnson P E Beckles D M | 2002 | Plant Physiol2002，130，： | 1 |
| 11 | A boundary integral formulation for complex three-dimensional geometries显示文摘 | M Rezayat T E Burton | 1990 | International Journal for Numerical Methods in Engineering1990，29，2： | 1 |
| 12 | Malignant gliomas显示文摘 | BURTON E C M D PRADOS | 2000 | Curr Treat Options Oncol2000，1，5： | 1 |
| 13 | Port-access coronary artery bypass grafting: technique and comparative results显示文摘 | Groh M A Sutherland S E Burton H G | 1999 | Ann Thorac Surg1999，68，4： | 1 |
| 14 | Patterns of cerebral atrophy in dementia with lewy bodies using voxel-based morphometry显示文摘 | Burton E J Karas G Paling S M | 2002 | NeuroImage2002，17，2： | 1 |
| 15 | Prucalopride accelerates gastrointestinal and colonic in patients with constipation without a rectal evacuation disorder显示文摘 | Bouras E Camilleri M Burton D Thomforde G Burton D McKinzie S Zinsmeister A | 2001 | Gastrodenterology2001，120，2： | 1 |
| 16 | Interstitial pulmonary edema in children and adolescents with diabetic ketoacidosis显示文摘 | HOFFMAN W H LOCKAMITH J P BURTON E M | 1998 | J Diab Comp1998，12，： | 1 |
| 17 | Nitric oxide reductasetargeted real-time PCR quantification of denitrifier populations in soil显示文摘 | Dandie C E Miller M N Burton D L | 2007 | Applied and Environmental Microbiology2007，73，13： | 1 |
| 18 | Regional mapping of the creatine kinase b ( CKBB ) gene in rabbit ( Oryctolagus cuniculus ) and man using a rat cDNA probe显示文摘 | MAHoNEY C E PICCiANO S R BURTON K M | 1988 | Cytogenet Cell Genet1988，48，3： | 1 |
| 19 | A boundary - integral formulation for complex three - dimensional geometries 显示文摘 | REZAYAT M BURTON T E | 1990 | International Journal for Numerical Methods in Engerinerring1990，29，： | 1 |
| 20 | Histamine2 receptor antagonists standard therapy for acid-peptic disease ( first of two parts) 显示文摘 | FELDMAN M BURTON M E | 1990 | N Engl J Med1990，323，： | 1 |
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