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| 1 | Down-regulation of tyrosinase,TRP-1,TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma显示文摘Objective:To investigate the suitability of citrus-press cakes,by-products of the juice industry as a source for the whitening agents for cosmetic industry.Methods:Ethylacetate extracts of citrus-press cakes(CCE)were examined for their anti-melanogenic potentials in terms of the inhibition of melanin production and mechanisim of melanogenesis by using Western Blot analysis with tyrosinese,tyrosinase-related protein-1(TRP-1),TRP2,and microphthalmia-associated transcription factor(MITF)proteins.To apply the topical agents,citrus-press cakes was investigated the safety in human skin cell line.Finally flavonoid analysis of CCE was also determined by HPLC analysis.Results:Results indicated that CCE were shown to down-regulate melanin content in a dose-dependent pattern.The CCE inhibited tyrosinase,TRP-2,and MITF expressions in a dose-dependent manner.To test the applicability of CCE to human skin,we used MTT assay to assess the cytotoxic effects of CCE on human keratinocyte HaCaT cells.The CCE exhibited low cytotoxicity at 50μg/mL.Characterization of the citrus-press cakes for flavonoid contents using HPLC showed varied quantity of rutin,narirutin,and hesperidin.Conclusions:Considering the anti-melanogenic activity and human safety,CCE is considered as a potential anti-melanogenic agent and may be effective for topical application for treating hyperpigmentation disorders. | Sang Suk Kim Min-Jin Kim Young Hun Choi Byung Kuk Kim Kwang Sik Kim Kyung Jin Park Suk Man Park Nam Ho Lee Chang-Gu Hyun | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，8： | 7 |
| 2 | Long-term outcomes of laparoscopy-assisted distal gastrectomy for early gastric cancer: result of a randomized controlled trial (COACT 0301)显示文摘 | Young-Woo Kim Hong Man Yoon Young Ho Yun Byung Ho Nam Bang Wool Eom Yong Hae Baik Sang Eok Lee Yeji Lee Young-ae Kim Ji Yeon Park Keun Won Ryu | 2013 | Surgical Endoscopy2013，，11： | 3 |
| 3 | Intravenous iron supplementation may be superior to observation in acute isovolemic anemia after gastrectomy for cancer显示文摘AIM:To determine whether the application of postoperative intravenous(IV)-iron for acute isovolemic anemia after gastrectomy for cancer may be effective.METHODS:Among 2078 gastric cancer patients who underwent surgery between February 2007 and August2009 at the National Cancer Center Korea,368 patients developed post-operative anemia[hemoglobin-(Hb)-level<9 g/dL]within the first postoperative week.Patients requiring transfusions were excluded.IV-iron was administered to 63 patients(iron group).Sixty patients were observed without treatment(observation group).The clinical outcomes of the groups were compared concerning clinicopathologic data,morbidity,and changes in Hb levels using Fisher’s exact test,Student’s t-test and the Z-test.RESULTS:The initial Hb level was higher in the iron group than in the observation group(7.3±1.0 g/dL vs8.4±0.5 g/dL,P<0.001).The slope of the changes in the Hb level was significantly higher in the iron group than in the observation group(0.648±0.054 vs 0.349±0.038,P<0.001).The Hb level 1 and 3 mo postoperatively increased from 10.7±1.3 to 11.9±1.3g/dL in the iron group(P=0.033)and from 10.1±1.0to 10.8±1.4 g/dL in the observation group(P<0.001).The postoperative hospital stay was significantly longer in the iron group than in the observation group(10.5±6.8 d vs 7.6±5.5 d,P=0.011).There were no significant differences in the major and surgical complications between the groups(6.3%vs 13.3%,P=0.192;9.5%vs 3.3%,P=0.164).CONCLUSION:IV-iron supplementation may be an effective treatment for post-operative isovolemic postgastrectomy anemia and may be a better alternative than observation. | Hong Man Yoon Young-Woo Kim Byung Ho Nam Daniel Reim Bang Wool Eom Ji Yeon Park Keun Won Ryu | 2014 | World Journal of Gastroenterology2014，20，7： | 2 |
| 4 | HBV DNA and HBsAg Levels as Risk Predictors of Early and Late Recurrence after Curative Resection of HBV-related Hepatocellular Carcinoma显示文摘 | Won Sohn Yong-Han Paik Jong Man Kim Choon Hyuk Kwon Jae Won Joh Ju Yeon Cho Geum-Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Annals of Surgical Oncology2014，，7： | 2 |
| 5 | Assessment of factors affecting plasma BNP levels in patients with chronic atrial fibrillation and preserved left ventricular systolic function显示文摘 | Byung Jin Kim Sang Jun Hwang Ki Chul Sung Bum Soo Kim Jin Ho Kang Man Ho Lee Jung Ro Park | 2006 | International Journal of Cardiology2006，，2： | 1 |
| 6 | Design space optimization using a numerical design continuation method显示文摘 | Kim I L YONG KWAK BYUNG MAN | 2002 | International Journal for Numerical Methods in Engineering2002，3，8： | 1 |
| 7 | Conceptual and basic designs of the Mobile Harbor crane based on topology and shape optimiz- ation显示文摘 | In Gwun Jang Kyung-Soo Kim Byung Man Kwak | 2014 | Struct Multidisc Optim2014，，50： | 1 |
| 8 | Synthesis of dimethyl carbonate by vapor phase oxidative carbonylation of methanol over Cubased catalysts 显示文摘 | Man Seok Han Byung Gwon Lee Insuk Suh | 2001 | Joumal of Molecular Catalysis A: Chemical2001，170，： | 1 |
| 9 | Optimal stochastic design four-bar mechanism for tolerance and clearance显示文摘 | Je Ha Ruyu Byung Man Kwak | 1988 | Transactions of ASME1988，110，9： | 1 |
| 10 | Is the New Seventh AJCC/UICC Staging System Appropriate for Patients with Gastric Cancer?显示文摘 | Hong Man Yoon Keun Won Ryu Byung Ho Nam Soo Jeong Cho Sook Ryun Park Jong Yeul Lee Jun Ho Lee Myeong-Cherl Kook Il Ju Choi Young-Woo Kim | 2012 | Journal of the American College of Surgeons2012，，1： | 1 |
| 11 | Mass spectrometry based metabolomic approaches in urinary biomarker study of women’s cancers显示文摘 | Han Min Woo Kyung Mi Kim Man Ho Choi Byung Hwa Jung Jeongae Lee Gu Kong Seok Jin Nam Sunghoon Kim Sang Wook Bai Bong Chul Chung | 2008 | Clinica Chimica Acta2008，，1： | 1 |
| 12 | Risk Reduction of Adverse Effects Due to Di-(2-Ethylhexyl) Phthalate (DEHP) by Utilizing Microbial Degradation显示文摘 | Ji Hye Baek Man Bock Gu Byoung-In Sang Seung Jun Kwack Kyu Bong Kim Byung Mu Lee | 2009 | Journal of Toxicology and Environmental Health, Part A . 2009 (21-2)2009，，21： | 1 |
| 13 | A Complementary Problem Formulation for Two-dimensional Frictional Contact Problems显示文摘 | Byung Man Kwak Seok Soon Lee | 1988 | Computers & Structure1988，28，4： | 1 |
| 14 | Sonographic characteristics of small hepatocellular carcinoma显示文摘 | Byung Ihn Choi M.D. Chu -Wan Kim Man Chung Han Chung Yong Kim Hyo Suk Lee Soo Tae Kim Yong Il Kim | 1989 | Gastrointestinal Radiology1989，，1： | 1 |
| 15 | Optimal stochastic design four-bar mechanismfor tolerance and clearance 显示文摘 | Je Ha Ruyu Byung Man Kwak | 1988 | Transac- tions of ASME1988，110，9： | 1 |
| 16 | Post-buckling analysis of nonfrictional contact problems using linear complementarity formulation 显示文摘 | Jeong Seo Koo Byung Man Kwak | 1995 | Computer & Strucaares1995，57，5： | 1 |
| 17 | Synthesis of dimethyl carbonate by vapor phase oxidative carbonylation of methanol over Cu- based catalysts显示文摘 | Man Seok Han Byung Gwon Lee Insuk Suh | 2001 | Journal of Molecular Catalysis A: Chemical2001，170，12： | 1 |
| 18 | Optimization of Finite Element Grids Using Shape Sensitivity Analysis in Terms of Nodal Positions 显示文摘 | Koo Tae Kang Byung Man Kwak | 1997 | Finite Elements in Analysis and Design1997，，26： | 1 |
| 19 | The analysis of dark signals in the CMOS APS imagers from the characterization of test structures 显示文摘 | Hyuck In Kwon In Man Kang Byung - Gook Park | 2004 | IEEE Transactions on Electron Devices2004，51，2： | 1 |
| 20 | Evaluation of Flowmeters for Heat Metering 显示文摘 | Hae Man Choi Byung Ro Yoon Chul Gyun Kim Yong Moon Choi | 2011 | Flow Measurement and Instrumentation2011，22，5： | 1 |
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