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| 1 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 2 | Expert consensus on maintenance treatment for metastatic colorectal cancer in China显示文摘The impact of maintenance therapy on progression-free survival and overall survival as well as quality of life of Chinese patients with metastatic colorectal cancer has long been under discussion.Recently,some phase III clinical trials have revealed that maintenance therapy can significantly prolong the progression-free survival while maintain an acceptable safety profile.Based on this evidence and common treatment practice in China,we now generated one Expert Consensus on Maintenance Treatment for Metastatic Colorectal Cancer in China to further specify the necessity of maintenance therapy,suitable candidates for such treatment,and appropriate regimens. | Rui-Hua Xu Lin Shen Jin Li Jian-Ming Xu Feng Bi Yi Ba Li Bai Yong-Qian Shu Tian-Shu Liu Yu-Hong Li Chun-Mei Bai Xiang-Lin Yuan Jun Zhang Gong Chen Ai-Ping Zhou Ying Yuan Xi-Jing Wang Xiao-Ping Qian Yan-Hong Deng | 2016 | Chinese Journal of Cancer2016，35，1： | 8 |
| 3 | miR-10a inhibits cell proliferation and promotes cell apoptosis by targeting BCL6 in diffuse large B-cell lymphoma显示文摘BCL6 (B 房间淋巴瘤 6 ) 基因是经常在弥漫的大 B 房间淋巴瘤(DLBCL ) 被表示的 proto-oncogene。功能的 BCL6 损失能杀死 DLBCL 房间,证明 BCL6 为 DLBCL 房间的幸存是必要的并且能是一个治疗学的目标。在这研究,我们发现那 BCL6 蛋白质层次,建议那是一致地在 DLBCL 纸巾的 upregulated 而它的 mRNA 层次在纸巾随机变化了, post-transcriptional 机制涉及 BCL6 规定。我们使用了生物信息学分析寻找 miRNAs,它潜在地指向 BCL6,并且在 BCL6 的 3-untranslated 区域(3-UTR ) 为 miR-10a 识别了特定的指向的地点。我们进一步鉴别在 miR-10a 层次和 BCL6 蛋白质层次之间的反的关联,然而并非 mRNA 铺平,在 DLBCL 肿瘤织物样品。由 overexpressing 或在 DLBCL 房间将 miR-10a 击倒,我们试验性地直接验证了那 miR-10a 认出 BCL6 抄本和调整 BCL6 表示的 3-UTR。而且,我们证明否定地由 miR-10a 调整 BCL6 压制了增长并且支持了 DLBCL 房间的 apoptosis。 | Qian Fan Xiangrui Meng Hongwei Liang Huilai Zhang Xianming Liu Lanfang Li Wei Li Wu Sun Haiyang Zhang Ke Zen Chen-Yu Zhang Zhen Zhou Xi Chen Yi Ba | 2016 | Protein & Cell2016，7，12： | 5 |
| 4 | Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish显示文摘 | Qian BA Juan DUAN Jia-qiang TIAN Zi-liang WANG Tao CHEN Xiao-guang LI Pei-zhan CHEN Song-jie WU Li XlANG Jing-quan LI Rui-ai CHU Hui WANG | 2013 | Acta Pharmacologica Sinica2013，34，8： | 3 |
| 5 | A Platform to Improve Echinococcosis Control in Tibetan Populations-Sichuan Province,China,2015‒2020显示文摘Echinococcosis is a neglected parasitic zoonotic disease that is distributed worldwide.Previous data has shown that China holds the highest disease burden of echinococcosis in the world,resulting in 22.97×10^(5) disability adjusted life year(DALYs)lost annually(1).Echinococcosis is one of the epidemiological factors responsible for poverty in China.Since 2000,China’s central government(CG)has taken several actions to control echinococcosis in Western China.Since 2005. | Tian Tian Shuai Han Chuizhao Xue Xu Wang Shijie Yang Bo Zhong Qian Wang Wenjie Yu Sha Liao Dan Ba Ze Li Wei Li Fei Xie Qiang Wang Zelin Zhu Yuwan Hao Weiping Wu Ning Xiao Xiao-nong Zhou | 2021 | China CDC weekly2021，3，5： | 2 |
| 6 | 严重创伤后血清胆碱酯酶活性的动态变化(英文)显示文摘研究目的:探讨严重创伤患者早期血清胆碱酯酶(ChE)活性的动态变化规律与临床意义。创新要点:阐明了在严重创伤后早期血清Ch E动态的变化规律,为评估创伤的严重程度和预后判断提供新的参考辅助指标。研究方法:前瞻性观察研究:分析81例严重创伤患者伤后第1、3、7天血清Ch E活性的动态变化,通过亚组(不同预后、不同伤情严重程度)间变化比较及与损伤严重度评分(ISS)、急性生理和慢性健康评分III(APACHE III)和创伤严重程度评分(TRISS)进行比较,评估其反映病情严重程度和预后的价值;同时分析伤后血清Ch E活性与急性期蛋白(APP),如白蛋白(ALB)、前白蛋白(PAB)、转铁蛋白(T RF)和C反应蛋白(CRP)浓度变化的关系。重要结论:血清Ch E活性在严重创伤后显著降低,持续下降的幅度越大,则提示损伤越重,预后可能越差,而且血清Ch E或可视为负急性期蛋白的一种,血清Ch E作为严重创伤伤情和预后评估的简单辅助指标具有一定的可靠性。 | Li BA Ding-qian WU An-yu QIAN Mao ZHANG Bing XIONG | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，12： | 2 |
| 7 | Prevale nee and spatial distribution patterns of human echinococcosis at the township level in Sichuan Province, China显示文摘Background:Echinococcosis is a global zoonotic parasitic disease caused by Echinococcus larvae.This disease is highly endemic in Sichuan Province,China.This study investigates the prevalence and spatial distribution characteristics of human echinococcosis at the township level in Sichuan Province,geared towards providing a future reference for the development of precise prevention and control strategies. | Wei He Li-Ying Wang Wen-Jie Yu Guang-Jia Zhang Bo Zhong Sha Liao Qi Wang Rui-Rui Li Liu Yang Ren-Xin Yao Yang Liu Zeli Dan ba Sheng-Chao Qin Shi-An Wang Yan-Xia Wang Yan Huang Qian Wang | 2021 | Infectious Diseases of Poverty2021，10，3： | 2 |
| 8 | Prospective analysis of multifocality in renal cell carcinoma:influence of histological pattern,grade,number,size,volume and deoxyribonucleic acid ploidy显示文摘 | Kletscher BA Qian J Bostwick DG | 1995 | J Urol1995，153，32： | 1 |
| 9 | Effects of steam curing on strength and porous structure of concrete with low water/binder ratio显示文摘 | BA Ming-fang QIAN Chun-xiang GUO Xin-jun | 2011 | Construction and Building Materials2011，25，1： | 1 |
| 10 | Prospective analysis of mul-tifocality in renal cell carcinoma:influence of histological pattern,grade,number,size,volume and deoxyribonucleic acid ploidy显示文摘 | Kletscher BA Qian J Bostwick DG | 1995 | J Urol1995，153，32： | 1 |
| 11 | C6 produced by macrophages contributes to cardiac allograft rejection显示文摘 | Qian Z Wasowska BA Behrens E | 1999 | Am J Pathol1999，155，4： | 1 |
| 12 | Prospective analysis of multifocality in renal cell carcinoma:influence of histological pattern,grade,number,size,volume and deoxyribonucleic acid ploidy显示文摘 | Kletscher BA Qian J Bost wick DG | | 0，，： | 1 |
| 13 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S Li R Zhang Z Li L Gu X Fan W Lucas WJ Wang X Xie B Ni P Ren Y Zhu H Li J Lin K Jin W Fei Z Li G Staub J Kilian A van der Vossen E A G Wu Y Guo J He J Jia Z Ren Y Tian G Lu Y Ruan J Qian W Wang M Huang Q Li B Xuan Z Cao J Asan Wu Z Zhang J Cai Q Ba | | 0，，12： | 1 |
| 14 | Prospective analysis of multifocality in renal cell carcinoma:influence of histological pattern,grade,number,size,volume and deoxyribonucleic acid ploidy显示文摘 | Kletscher BA Qian J Bostwick DG | 1995 | J Urol1995，153，32： | 1 |
| 15 | Prospective analysis of multifocality in renal cell carcinoma: influence of histological pattern, grade, number, size, volume and deoxyribonucleic acid ploidy显示文摘 | Kletscher BA Qian J Bostwick DG | 1995 | J Urol1995，153，32： | 1 |
| 16 | Effects of Steam Curing on Strength and Porous Structure of Concrete with Low Water/Binder Ratio显示文摘 | Ba MF Qian CX Guo XJ | 2011 | Construction and Building Materials2011，25，1： | 1 |
| 17 | Effects of stem curing on strength and porpous struture of concrete with low water/binder ratio显示文摘 | Ba M F Qian C GuoX J | | Construction and Building Materials0，25，1： | 1 |
| 18 | Evolution of capillary porousstructure in steam curing concrete with mineral admix-tures 显示文摘 | Ba M F Qian C X | 2012 | Advanced Materials Research2012，，： | 1 |
| 19 | Effects of steam curing on strength and porous structure of concrete with low water/binder ratio 显示文摘 | BA M F QIAN C X GUO X J | 2011 | Construc- tion and Building Materials2011，，25： | 1 |
| 20 | Effects of steam curing on strength and porous structure of concrete with low water/binder ratio 显示文摘 | BA M F Qian C X Gup X J | 2011 | Construction and Building Materials2011，25，1： | 1 |
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