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| 1 | Association between Helicobacter pylori status and metachronous gastric cancer after endoscopic resection显示文摘AIM To investigate the effect of Helicobacter pylori(H. pylori) status test and H. pylori eradication on the occurrence of metachronous gastric cancer(MGC) after endoscopic submucosal dissection(ESD) of early gastric cancer(EGC) and risk factors of MGC. METHODS The authors retrospectively reviewed the medical records of 433 patients(441 lesions) who underwent ESD for EGC from January 2005 to January 2015 in Yeungnam University Hospital. Patients were categorized into two groups; the H. pylori tested group(n = 257) and the H. pylori non-tested group(n = 176) based on performance of H. pylori status test after ESD of EGC. The H. pylori tested group was further categorized into three subgroups based on H. pylori status; the H. pylori-eradicated subgroup(n = 120), the H. pylori-persistent subgroup(n = 42), and the H. pylori-negative subgroup(n = 95). Incidences of MGC and risk factors of MGC were identified.RESULTS Median follow-up duration after ESD was 30.00 mo(range, 6-107 mo). Total 15 patients developed MGC during follow-up. MGC developed in 11 patients of the H. pylori tested group(7 in the H. pylori-negative subgroup, 3 in the H. pylori-eradicated subgroup, and 1 in the H. pylori-persistent subgroup) and 4 patients of the H. pylori non-tested group(P > 0.05). The risk factors of MGC were endoscopic mucosal atrophy in the H. pylori tested group and intestinal metaplasia in all patients. CONCLUSION H. pylori eradication and H. pylori status test seems to have no preventive effect on the development of MGC after ESD for EGC. The risk factors of MGC development were endoscopic mucosal atrophy in the H. pylori tested group alone and intestinal metaplasia in all patients. | Sung Bum Kim Si Hyung Lee Seung Il Bae Yo Han Jeong Se Hoon Sohn Kyeong Ok Kim Byung Ik Jang Tae Nyeun Kim | 2016 | World Journal of Gastroenterology2016，22，44： | 8 |
| 2 | Short-term overlap lamivudine treatment with adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B显示文摘AIM:To evaluate the efficacy of short-term overlap lamivudine therapy with adefovir in patients with lamivudine-resistant and nave chronic hepatitis B,we compared patients receiving overlap therapy with those receiving adefovir alone. METHODS:Eighty patients who had received lamivudine treatment for various periods and had a lamivudine- resistant liver function abnormality were enrolled.Forty of these patients received adefovir treatment combined with lamivudine treatment for≥2 mo,while the other 40 received adefovir alone.We assessed the levels of hepatitis B virus(HBV)DNA at 0,12 and 48 wk and serum alanine aminotransferase(ALT)levels after 0,12, 24 and 48 wk of adefovir treatment in each group. RESULTS:We found serum ALT became normalized in 72(87.5%)of the 80 patients,and HBV DNA decreased by≥2 log10 copies/mL in 60(75%)of the 80 patients at the end of a 48-wk treatment.HBV DNA levels were not significantly different between the groups.The improvements in serum ALT were also not significantly different between the two groups. CONCLUSION:These findings suggest short-term overlap lamivudine treatment results in no better virological and biological outcomes than non-overlap adefovir monotherapy. | Soon Woo Nam Si Hyun Bae Seung Woo Lee Yeon Soo Kim Sang Bum Kang Jong Young Choi Se Hyun Cho Seung Kew Yoon Joon-Yeol Han Jin Mo Yang Young Suk Lee | 2008 | World Journal of Gastroenterology2008，14，11： | 3 |
| 3 | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion显示文摘Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely understood.Here,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)fragments.Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses.Moreover,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model.The FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein expression.Moreover,targeting the MNK1/2 pathway diminished arthritic bone erosion.These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min | 2021 | Bone Research2021，9，4： | 2 |
| 4 | 来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的Ⅱ期、多中心、随机试验的包含神经病变相关量表的生活质量结果:韩国癌症研究组试验(KCSG BR13-11)显示文摘背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似。在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表–紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL)。方法使用韩国版的FACT-Taxane问卷评估QoL。在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL。使用线性混合模型评估EG组和PG组QoL的差异。结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复。EG组和PG组之间的基线QoL评分没有差异。在治疗期间,除了第11个疗程外,在第2–13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P<0.05)。神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P<0.001)。结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生。因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品。 | Ji‑Yeon Kim Seri Park Seock‑Ah Im Sung‑Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young‑Hyuck Im Tae‑Yong Kim Kyung‑Hun Lee Jin‑Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | 癌症2019，38，8： | 2 |
| 5 | Incremental Predictive Value of Red Cell Distribution Width for 12‐Month Clinical Outcome After Acute Myocardial Infarction显示文摘 | Jang Hoon Lee Dong Heon Yang Se Yong Jang Won Suk Choi Kyun Hee Kim Won Kee Lee Myung Hwan Bae Hun Sik Park Yongkeun Cho Shung Chull Chae | 2013 | Clin Cardiol2013，，6： | 2 |
| 6 | Protective effect of hexane extracts of Uncaria sinensis against photothrombotic ischemic injury in mice显示文摘 | Sun Haeng Park Ji Hyun Kim Se Jin Park Sun Sik Bae Young Whan Choi Jin Woo Hong Byung Tae Choi Hwa Kyoung Shin | 2011 | Journal of Ethnopharmacology2011，，3： | 1 |
| 7 | Lipodystrophia centri-fugalis abdominalis in Korea显示文摘 | Chang SE Bae GY Jeong YI | | 0，，： | 1 |
| 8 | Temperature-independent strain sensor sensor system using a tilted fiber Bragg grating demodulator显示文摘 | Sung Chul Kang Se Yoon Kim Sang Bae Lee | 1998 | IEEE Photonics Technology Letters1998，10，10： | 1 |
| 9 | Controlled release of bone morpho- genetic protein (BMP) -2 from nanocomplex incorporated on hydroxyapatite-formed titanium surface 显示文摘 | Bae SE Choi J Joung YK | 2012 | J Control Release2012，160，3： | 1 |
| 10 | Synthesis and characterization of heparinized polyurethanes using plasma glow discharge显示文摘 | Bae J S Se E J Kang I K | 1999 | Biomaterials1999，20，6： | 1 |
| 11 | Design of infection-resistant antibiotic-releasing polymers (Ⅰ):Fabrication and formulation显示文摘 | Bae J S Se E J Kang I K | 1999 | Journal of Controlled Release1999，62，3： | 1 |
| 12 | Lipodystrophia centrifugalis abdominalis in Korea显示文摘 | Chang SE Bae GY Jeong YI | 2004 | Pediatr Dermatol2004，21，5： | 1 |
| 13 | Immunohistochemical studyof the distribution of adrenergic and peptidergic innervation in the equine uterus and the cervix显示文摘 | Bae SE Corcoran BM Watson ED | 2001 | Reproduction2001，122，2： | 1 |
| 14 | Non-HDL-cholesterol/HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B/apolipoprotein A1显示文摘 | Se Won Kim Jae Hwan Jee Hye Jeong Kim Sang-Man Jin Sunghwan Suh Ji Cheol Bae Sun Wook Kim Jae Hoon Chung Yong-Ki Min Myung-Shik Lee Moon-Kyu Lee Kwang-Won Kim Jae Hyeon Kim | 2013 | International Journal of Cardiology2013，，： | 1 |
| 15 | Benefit of Negative Pressure Drain Within Surgical Wound After Cytoreductive Surgery for Ovarian Cancer显示文摘 | Se Ik Kim Myong Cheol Lim Hyo Sook Bae Se Ra Shin Sang-Soo Seo Sokbom Kang Sang-Yoon Park | 2015 | International Journal of Gynecological Cancer2015，，1： | 1 |
| 16 | Lipodystrohia centrifugalis abdom-inalis in Korea显示文摘 | Chang SE Bae GY Jeong YI | 2004 | Pediatr Dermatol2004，21，5： | 1 |
| 17 | Matrix metalloproteinase-2 and-9 secretion by the equine ovary during follicular growth and prior to ovulation显示文摘 | Riley SC Thomassen R Bae SE | 2004 | Anim Reprod Sci2004，81，： | 1 |
| 18 | Fabrication of covered porous PLGA microspheres using hydrogen peroxide for controlled drug delivery and regenerative medicine显示文摘 | Bae SE Son JS Park KD | | 0，，01： | 1 |
| 19 | Regulation of pituitary MT1 melatonin receptor expression by gonadotrophin-releasing hormone (GnRH) and early growth response factor-1 (Egr-1): in vivo and in vitro studies显示文摘 | Bae SE Wright IK Wyse C | 2014 | PLoS One2014，9，90： | 1 |
| 20 | Controlled release of bone morphogenetic protein (BMP)-2 from nanocomplex incorporated on hydroxyapatite-formed titanium surface显示文摘 | Bae SE Choi J Joung YK | 2012 | J Control Release2012，160，3： | 1 |
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