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| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | Acquisition of deleterious mutations duringpotato polyploidization显示文摘Potatoes(Solanum tuberosum L.) represent an important tuber crop, worldwide. During its prolonged clonal propagation, numerous deleterious mutations have accumulated in the potato genome,leading to severe inbreeding depression; however,the shaping of this mutation burden during polyploidization and improvement is largely unknown.Here, we sequenced 20 diploid landraces of the Stenotomum group, eight tetraploid landraces, and 20 tetraploid modern cultivars, to analyze variations in their deleterious mutations. We show that deleterious mutations accumulated rapidly during the polyploidization of tetraploid potatoes. This study provides a foundation for future potato improvement. | Qun Lian Die Tang Zhiyan Bai Jianjian Qi Fei Lu Sanwen Huang Chunzhi Zhang | 2019 | Journal of Integrative Plant Biology2019，61，1： | 8 |
| 3 | Mesoproterozoic to Paleozoic Nd isotope stratigraphy of the South China continental nucleus and its geological significance显示文摘The Yangtze continental nucleus in South China is situated in the Huangling-Shennongjia area in western Hubei Province.It comprises the early Precambrian crystalline basement and generally successive Proterozoic to Phanerozoic sedimentary covers.This paper reports a comprehensive Nd isotope study of fine-grained sedimentary rocks from the regional Mesoproterozoic to early Paleozoic strata.The Nd model ages display a V-shaped variation from ~2.5-2.8 Ga during the late Mesoproterozoic through ~1.5-1.7 Ga during the Neoproterozoic Nanhua Period to ~1.8-2.1 Ga during the Paleozoic Ordovician,with corresponding Nd (t) ranges of 11 to 14,1.1 to 5.3,and 7.9 to 9.9,respectively.This evolutionary trend broadly resembles those documented in the sedimentary strata along the southeastern margin of the Yangtze Craton and within the Jiangnan orogenic belt,indicating that the whole South China block underwent a mantle-input related tectono-magmatic event at ~0.8 Ga or earlier.However,the Huangling-Shennongjia area is discriminated from the other two regions by highly variable model ages (~1.5-2.7 Ga) and Nd (t) values (1.38-12.0) of the early Mesoproterozoic strata.Combined with the Archean model ages of the late Mesoproterozoic strata,it is suggested that the Mesoproterozoic sedimentary provenance of the Yangtze continental nucleus was distinct from that of the southeastern Yangtze Craton,likely indicative of an intervening aulacogen (or rift zone) or oceanic basin.In addition,the high comparability in Neoproterozoic to Paleozoic Nd isotope stratigraphy between the Yangtze Craton and the Jiangnan orogenic belt infers that the whole South China block had shared the same sedimentary basin and provenance since the Yangtze-Cathaysia welding at ~0.9 Ga.Thus,it is proposed that the Yangtze Craton had comprised a collage of micro-continents during the pre-Neoproterozoic until the Rodinia assemblage when the primitive South China block was formed. | BAI Xiao LING WenLi DUAN RuiChun QIU XiaoFei LIU ChengXin KUANG Hua GAO YongJuan ZHOU Lian CHEN ZiWan LU Shah-Song | 2011 | Science China Earth Sciences2011，54，11： | 8 |
| 4 | Mechanism Study of Chlorine Release During Biomass Pyrolysis显示文摘以稻草为主要研究对象,以含氯生物质模化物为对照,通过管式炉、热重红外联用以及理论计算,对生物质中无机氯的热解析出机制进行探索。管式炉热解试验表明:低温下(200~600℃1稻草和模化物中的KCl可以与活性基团反应而析出HCl;灰成分对低温条件下氯析出的过程可能有催化促进作用;模化物中的氯在高温区(〉600℃1主要以气态碱金属氯化物形式析出。TG.FTIR试验表明:稻草热解脱挥发分过程与HCl的析出之间存在直接的关联;管式炉稻草热解过程在较低温度条件下析出的cl是HCl;在高温区,碱金属氯化物和灰成分Si02之间未发生显著的化学反应。理论计算表明:生物质中的Cl是以碱金属氯化物形式存在的;碱金属氯化物在高温下(〉700℃)主要以蒸汽态进入气相;碱金属氯化物与SiO2的反应在高温下(800-900℃)可以进行。 | WU Peng YU Chunjiang Bai Jisong Li lian ming Huang Fang | 2013 | 中国电机工程学报2013，33，11： | 8 |
| 5 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 6 | Determination of the ^(12)C(p, γ)^(13)N reaction rates fromthe ^(12)C(~7Li,~6He)^(13)N reaction显示文摘The angular distribution of the 12C(7Li,6He)13N reaction at E(7Li) = 44.0 MeV was measured at the HI-13 tandem accelerator of Beijing, China. The asymptotic normalization coefficient (ANC) of 13N → 12C + p was derived to be (1.64 ± 0.11) fm-1/2 through the distorted wave Born approximation (DWBA) analysis. The ANC was then used to deduce the astrophysical S (E) factors and reaction rates for the 12C(p,γ)13N direct capture reaction at energies of astrophysical relevance. | LI ZhiHong, SU Jun, GUO Bing, LI ZhiChang, BAI XiXiang, LIU JianCheng, LI YunJu, YAN ShengQuan, WANG BaoXiang, WANG YouBao, LIAN Gang, ZENG Sheng, LI ErTao, CHEN YongShou, SHU NengChuan, FAN QiWen & LIU WeiPing China Institute of Atomic Energy, Beijing 102413, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，4： | 6 |
| 7 | Effects of Selenium on Lipid Peroxidation and Oxidizing Ability of Rice Roots under Ferrous Stress显示文摘Water culture experiment was conducted to study the effects of selenium(Se) on glutathione peroxidase(GSH-Px) activity,reduced glutathione(GSH) concentration and the accumulation of malonaldehyde(MDA),the product of lipid peroxidation in rice seedling,as well as the effect of se on oxidizing ability of roots under ferrous stress.Results showed that appropriate amount of se significantly increased GSH-Px activity in rice leaves,F=5.5 *,enhanced the amount of GSH and oxidizing ability of roots and reduced the concentration of MDA,F=4.9 *.Compared with Se0+Fe treatment,Se treatments increased the dry matter weight of rice seedling from 10.06% to 10.43%,F=4.09 *. | PENG Xian long,LIU Yuan ying, LUO Sheng guo,JIANG Bai wen YU cai lian (Faculty of Natural Resources and Environmental Science, Northeast Agricultural University, Harbin 150030,PRC) | 2002 | Journal of Northeast Agricultural University(English Edition)2002，9，1： | 5 |
| 8 | A pure blue light emitting binaphthyl derivative:Synthesis and properties显示文摘有 3 和 3 个′位置上的分核的联萘衍生物被综合并且经由铃木描绘了偶合反应。在答案最大的排放被作为参考拿 9,10-diphenyl 蒽与 68% 的量子效率在 390 nm 定位,当它与从聚集状态导致固态膜的 104 nm 的 FWHM 被转移到 450 nm 时。玻璃化转变温度(Tg ) 和分解温度被测量分别地,由 DSC 和 TGA 是 184 和 447 ° C。不同于它的光致发光光谱,电镀物品发光光谱在大约 460 nm 和表演达到顶点相应于纯蓝排出物的 69 nm 的 FWHM。刺激电压,发光性和效率最大值是有并列的 CIE 颜色的 5 V, 2953 cd/m2 和 1.37 cd/A (0.16, 0.15 ) ,在 ITO/NPB (40 nm ) 的设备结构 /PY-BN-PY (15 nm )/BPhen (40 nm )/Mg :47 号元素银的化学符号。 | Qing Guo He Zeng Ze Chu Gang Tie Lei An Jun Qin Hong Zhen Lin Feng Lian Bai Jian Gong Cheng Yong Qiu | 2008 | Chinese Chemical Letters2008，19，4： | 4 |
| 9 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 10 | ST-Segment Elevation Myocardial Infarction Patients Complicated by Out-of-Hospital Cardiac Arrest May Not Benefit from Emergency Percutaneous Intervention显示文摘 | Kun Wang Yu Shen Pei-Wen Li Rong Go Jing-Mei Zhang Lian Wang Jian Bai Biao Xu | 2018 | Chinese Medical Journal2018，，6： | 3 |
| 11 | Preliminary Study on Drug Susceptibility Profile and Resistance Mechanisms to Macrolides of Clinical Isolates of Non-tuberculous Mycobacteria from China显示文摘Objective Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria(NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. Methods Four macrolides, including clarithromycin(CLAR), azithromycin(AZM), roxithromycin(ROX), and erythromycin(ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method. Two resistance mechanisms, 23 S r RNA and erm, were analyzed with nucleotide sequence analysis. Results Varied effectiveness of macrolides and species-specific resistance patterns were observed. Most Mycobacterium abscessus subsp. massiliense were susceptible and all M. fortuitum were highly resistant to macrolides. All the drugs, except for erythromycin, exhibited excellent activities against slow-growing mycobacteria, and drug resistance rates were below 22.2%. Only four highly resistant strains harbored 2,058/2,059 substitutions on rrl and none of other mutations were related to macrolide resistance. G2191 A and T2221 C on rrl were specific for the M. abscessus complex(MABC). Seven sites, G2140 A, G2210 C, C2217 G, T2238 C, T2322 C, T2404 C, and A2406 G, were specifically carried by M. avium and M. intracellulare. Three sites, A2192 G, T2358 G, and A2636 G, were observed only in M. fortuitum and one site G2152 A was specific for M. gordonae. The genes erm(39) and erm(41) were detected in M. fortuitum and M. abscessus and inducible resistance was observed in relevant sequevar. Conclusion The susceptibility profile of macrolides against NTM was demonstrated. The well-known macrolide resistance mechanisms, 23 S r RNA and erm, failed to account for all resistant NTM isolates, and further studies are warranted to investigate macrolide resistance mechanisms in various NTM species. | LI Fu LI Gui Lian PANG Hui LIU Hai Can XIAO Tong Yang LI Shuang Jun LUO Qiao JIANG Yi WANG Rui Bai WAN Kang Lin | 2018 | Biomedical and Environmental Sciences2018，31，4： | 3 |
| 12 | Astrophysical ^(13)N(p,γ)^(14)O Reaction Rate显示文摘13N(p,γ)14O is is one of the key reactions in the hot CNO cycle which occurs at stellar temperatures around T9≤0.1. At the energies of astrophysical interest, the 13N(p,γ) 14O reaction is dominated by | LI Zhi-hong,GUO Bing,YAN Sheng-quan,LIAN Gang,BAI Xi-xiang,WANG You-bao,ZENG Sheng,SU Jun,WANG Bao-xiang,LIU Wei-ping,SHU Neng-chuan,CHEN Yong-shou,CHANG Hong-wei,JIANG Li-yang | 2006 | Annual Report of China Institute of Atomic Energy2006，，1： | 3 |
| 13 | Study of the primordial lithium abundance显示文摘Lithium isotopes have attracted an intense interest because the abundance of both 6Li and 6Li from big bang nucleosynthesis (BBN) is one of the puzzles in nuclear astrophysics. Many investigations of both astrophysical observation and nucleosynthesis calculation have been carried out to solve the puzzle, but it is not solved yet. Several nuclear reactions involving lithium have been indirectly measured at China Institute of Atomic Energy, Beijing. The Standard BBN (SBBN) network calculations are then performed to investigate the primordial Lithium abundance. The result shows that these nuclear reactions have minimal effect on the SBBN abundances of 6Li and 7Li. | LI ZhiHong1, LI ErTao1, SU Jun1, LI YunJu1, BAI XiXiang1, GUO Bing1, WANG YouBao1, CHEN YongShou1, HOU SuQing1, ZENG Sheng1, LIAN Gang1, SHI JianRong2 & LIU WeiPing1 1 China Institute of Atomic Energy, Beijing 102413, China 2National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S1： | 3 |
| 14 | Antibacterial and biocompatible properties of vancomycin-loaded nano-hydroxyapatite/collagen/poly(lactic acid) bone substitute显示文摘Infected bone defects are normally regarded as contraindications for bone grafting.In the present study,an antibacterial bone graft substitute was synthesized by loading vancomycin(VCM) in our previously developed mineralized collagen based composite,nano-hydroxyapatite/collagen/poly(lactic acid)(nHAC/PLA),aiming to repair large size bone defects and inhibit related infections simultaneously.The VCM/nHAC/PLA showed typical porous structure with a porosity of(80.7± 6.7)%and compressive strength of 1.52 MPa.The delivery of VCM from VCM/nHAC/PLA was detected in vitro for up to 4weeks.And their antibacterial properties were determined using inhibition ratio assay and inhibition zone assay.Pretty high level of inhibition ratio(more than 99%) was obtained in VCM/nHAC/PLA group.Additionally,a distinct inhibition zone was clearly formed in Staphylococcus aureus bacterium incubation dish with VCM/nHAC/PLA disc for up to 18 days of incubation.Moreover,both of the nHAC/PLA composites with or without VCM exhibited favorable in vitro and in vivo biocompatibilities for rabbit marrow stromal cells(MSCs) adhesion,spreading,proliferation,and triggering no obvious inflammation responses in subcutaneous implantation.Our results suggested that the VCM/nHAC/PLA performed ideal antibacterial property and biocompatibility and has great promise for the treatment of bone defect-related infections in orthopedic surgeries. | Xiaojie Lian Huanye Liu Xiumei Wang Suju Xu Fuzhai Cui Xizhuang Bai | 2013 | Progress in Natural Science:Materials International2013，23，6： | 2 |
| 15 | Natural variations of ZmSRO1d modulate the trade-off between drought resistance and yield by affecting ZmRBOHC-mediated stomatal ROS production in maize显示文摘While crop yields have historically increased,drought resistance has become a major concern in the context of global climate change.The trade-off between crop yield and drought resistance is a common phenomenon;however,the underlying molecular modulators remain undetermined.Through genome-wide association study,we revealed that three non-synonymous variants in a drought-resistant allele of ZmSRO1d-R resulted in plasma membrane localization and enhanced mono-ADP-ribosyltransferase activity of ZmSRO1d toward ZmRBOHC,which increased reactive oxygen species(ROS)levels in guard cells and promoted stomatal closure.ZmSRO1d-R enhanced plant drought resilience and protected grain yields under drought conditions,but it led to yield drag under favorable conditions.In contrast,loss-of-function mutants of ZmRBOHC showed remarkably increased yields under well-watered conditions,whereas they showed compromised drought resistance.Interestingly,by analyzing 189 teosinte accessions,we found that the ZmSRO1d-R allele was present in teosinte but was selected against during maize domestication and modern breeding.Collectively,our work suggests that the allele frequency reduction of ZmSRO1d-R in breeding programs may have compromised maize drought resistance while increased yields.Therefore,introduction of the ZmSRO1d-R allele into modern maize cultivars would contribute to food security under drought stress caused by global climate change. | Huajian Gao Junjun Cui Shengxue Liu Shuhui Wang Yongyan Lian Yunting Bai Tengfei Zhu Haohao Wu Yijie Wang Shiping Yang Xuefeng Li Junhong Zhuang Limei Chen Zhizhong Gong Feng Qin | 2022 | Molecular Plant2022，15，10： | 2 |
| 16 | Two new ceramides from the stems of Piper betle L.显示文摘Two new ceramides,(2S,3S,4R)-2-N-[(2'R)-2'-hydroxypentacosanoylamino]-nonacosane-1,3,4-triol(1) and(2S,3S,4R,8E)-2- N-[(2'R)-2'-hydroxytetracosanoylamino]-8-eicosylene-1,3,4-triol(2) have been isolated from the stems of Piper betle L.collected from Baoshan city of Yunnan Province in China.Their structures were determined by spectroscopic and chemical methods. | Huang, Xiang Zhong Yin, Yan Dai, Jian Hui Liang, Hui Dai, Yun Bai, Lian | 2010 | Chinese Chemical Letters2010，21，4： | 2 |
| 17 | Langmuir-Blodgett Films from Schiff Base Aluminium (Ⅲ) Complex显示文摘The characteristics of the LB films of Schiff base aluminium( Ⅲ ), tris(2-hydroxy-5-nitro N-dodecyl-benzylideneaminato) aluminium ( Ⅲ ) [Al (TA 12) 3], were studied. The surface pres sure-area(r-A) isotherm of Al(TA12)3 in the pure water subphase was investigated. The molec ular area, 0.48 nm2, is one-third of the expected value that indicates the formation of an aggre gate. The Langmuir-Blodgett (LB) films of Al(TA12) 3 were transferred and characterized. The UV-Vis spectra and the AFM image both confirmed that the J-aggregates formed. The polarized UV-Vis spectra indicated that the complex plane had to be oriented with an angle of about 30° to the substrate surface. The IR spectra suggested that the complexation took place between aluminium ions and the oxygen atoms of the ligand rather than the nitrogen atom. | LIAN Wei~1, CAO Wei~2, WANG Gang~2, WEI Li~2, HONG Xia~2, SHEN Dong-fang~2 LIU Chun-yan~1, SHAO Hui-bo~(3**) and BAI Yu-bai~2(1. Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing 100101, P. R. China 2. Center for Intelligent Materials United Research(CIMUR), Department of Chemistry, Jilin University, Changchun 130023, P. R. China 3. Department of Chemistry, Capital Normal University, Beijing 100037, P. R. China) To whom correspondence should be addressed. | 2001 | Chemical Research in Chinese Universities2001，17，3： | 2 |
| 18 | Telbivudine plus adefovir therapy for chronic hepatitis B patients with virological breakthrough or genotypic resistance to telbivudine显示文摘 | Ye Zhang Jian-Qi Lian Yu Li Jie-Pin Wang Chang-Xing Huang Xue-Fan Bai Jiu-Ping Wang | 2013 | European Journal of Gastroenterology & Hepatology2013，，7： | 2 |
| 19 | Feasibility Analysis of ^(13)N+p Elastic Resonance Scattering显示文摘13N(p,γ)14O is one of the key reactions involved in the hot CNO cycle that takes place in the evolution of massive stars[1]. Its reaction rates are dominated by a 1-broad resonance state which lies at 5.17 MeV in 14O. However, there are several low-lying levels above the 13N+p threshold which might | WANG You-bao,WANG Bao-xiang,BAI Xi-xiang,GUO Bing,LI Zhi-hong,LIAN Gang,LIU Wei-ping,SU Jun,ZENG Sheng | 2006 | Annual Report of China Institute of Atomic Energy2006，，1： | 2 |
| 20 | 腹腔镜胃切除术治疗老年胃癌患者:与腹腔镜胃切除术治疗非老年患者以及与开腹手术治疗老年患者的对比分析显示文摘背景:腹腔镜胃切除术对于老年胃癌患者的获益尚不明确。本研究旨在探讨腹腔镜胃切除术应用于老年胃癌患者的可行性和安全性。方法:回顾性分析2009年6月至2015年7月间于第四军医大学西京医院行胃切除术的胃癌患者的临床资料。老年(年龄≥70岁)腹腔镜组114例,非老年(年龄<70岁)腹腔镜组740例,老年开腹组383例。比较老年腹腔镜组与其他两组患者术中情况、术后近期疗效及远期生存结局。结果:相较于非老年腹腔镜组,老年腹腔镜组除术后首次排气时间延长外,其他近期疗效指标差异无统计学意义。老年腹腔镜组5年总体生存率低于非老年腹腔镜组(57.0%vs 65.5%,P<0.001),而5年肿瘤特异生存率两组差异则无统计学意义(64.9%vs 66.2%,P=0.476)。相较于老年开腹组,老年腹腔镜手术时间延长[(236.4±77.3)vs(179±52.2)min,P<0.001],术中出血量减少[(174.0±88.4)vs(209.3±133.8)ml,P=0.008],术后住院时间缩短[(8.3±2.5)vs(9.2±4.5)d,P=0.048];两组术后并发症严重程度相当。多因素分析结果显示,腹腔镜手术不是发生术后并发症的危险因素。结论:腹腔镜胃切除术治疗老年胃癌患者安全可行,可获得较为满意的近期疗效和远期生存。 | Zheng-Yan Li Jie Chen Bin Bai Shuai Xu Dan Song Bo Lian Ji-Peng Li Gang Ji Qing-Chuan Zhao | 2021 | Gastroenterology Report2021，9，2： | 2 |
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