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| 1 | Chronic HCV infection and inflammation:Clinical impact on hepatic and extra-hepatic manifestations显示文摘The liver has a central role in regulating inflammation by its capacity to secrete a number of proteins that control both local and systemic inflammatory responses. Chronic inflammation or an exaggerated inflammatory response can produce detrimental effects on target organs. Chronic hepatitis C virus(HCV) infection causes liver inflammation by complex and not yet well-understood molecular pathways, including direct viral effects and indirect mechanisms involving cytokine pathways,oxidative stress and steatosis induction. An increasing body of evidence recognizes the inflammatory response in chronic hepatitis C as pathogenically linked to the development of both liver-limited injury(fibrosis, cirrhosis and hepatocellular carcinoma) and extrahepatic HCV-related diseases(lymphoproliferative disease,atherosclerosis, cardiovascular and brain disease). Defining the complex mechanisms of HCV-induced inflammation could be crucial to determine the global impact of infection, to estimate progression of the disease, and to explore novel therapeutic approaches to avert HCVrelated diseases. This review focuses on HCV-related clinical conditions as a result of chronic liver and systemic inflammatory states. | Rosa Zampino Aldo Marrone Luciano Restivo Barbara Guerrera Ausilia Sellitto Luca Rinaldi Ciro Romano Luigi E Adinolfi | 2013 | World Journal of Hepatology2013，5，10： | 13 |
| 2 | Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms显示文摘Hepatitis C virus(HCV)infection represents a major health issue worldwide due to its burden of chronic liver disease and extrahepatic manifestations including cardiovascular diseases,which are associated with excess mortality.Analysis of published studies supports the view that HCV infection should be considered a risk factor for the development of carotid atherosclerosis,heart failure and stroke.In contrast,findings from studies addressing coronary artery disease and HCV have yielded conflicting results.Therefore,meta-analytic reviews and prospective studies are warranted.The pathogenic mechanisms connecting HCV infection,chronic liver disease,and atherogenesis are not completely understood.However,it has been hypothesized that HCV may promote atherogenesis and its complications through several direct and indirect biological mechanisms involving HCV colonization and replication within arterial walls,liver steatosis and fibrosis,enhanced and imbalanced secretion of inflammatory cytokines,oxidative stress,endotoxemia,mixed cryoglobulinemia,perturbed cellular and humoral immunity,hyperhomocysteinemia,hypo-adiponectinaemia,insulin resistance,type 2 diabetes and other components of the metabolic syndrome.Understanding these complex mechanisms is of fundamental importance for the development of novel therapeutic approaches to prevent and to treat vascular complications in patients with chronic HCV infection.Currently,it seems that HCV clearance by interferon and ribavirin treatment significantly reduces non-liver-related mortality;moreover,interferon-based treatment appears to decrease the risk of ischemic stroke. | Luigi E Adinolfi Rosa Zampino Luciano Restivo Amedeo Lonardo Barbara Guerrera Aldo Marrone Fabio Nascimbeni Anna Florio Paola Loria | 2014 | World Journal of Gastroenterology2014，20，13： | 6 |
| 3 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 4 | Calcium signaling in cholangiocytes显示文摘Cytosolic Ca2+ 是在房间的几乎每种类型的一个重要的秒送信人。而且, Ca2+ 通常在单个房间以内调整多重活动。这篇文章考察为在 cholangiocytes 发信号的 Ca2+ 负责的细胞的机械。另外,在 cholangiocytes 的二个调停 Ca2+ 的事件被讨论:酸式碳酸盐分泌物和 apoptosis。最后,新兴的证据被考察发信号的 Ca2+ 涉及影响表明小径的胆汁的树和那 Ca2+ 的疾病的致病,这能在胆汁郁积的混乱的治疗被操作到治疗学的优点。 | Noritaka Minagawa Barbara E Ehrlich Michael H Nathanson | 2006 | World Journal of Gastroenterology2006，12，22： | 4 |
| 5 | Examining the role of static and dynamic risk factors in the prediction of inpatient of violence显示文摘 | Barbara E McDermott John F Edens Cameron D | 2008 | Law Hum Behav2008，9，32： | 1 |
| 6 | The ecology of medical care revisited显示文摘 | Larry A Green George E Fryer Jr Barbara P Yawn David lanier Susan M Dovey | 2001 | The New England Journal of Medicine2001，334，26： | 1 |
| 7 | Detection of microcystins using electrospray ionization high-field asymmetric waveform ion mobility mass spectrometry/mass spectrometry显示文摘 | Kenneth Froese Steve E Hrudey | 2000 | Rapid Commun Mass Spectrom2000，14，： | 1 |
| 8 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 9 | The hnpact of the Alliance on the Partners: a Look at Cause- Brand Alliances 显示文摘 | Lafferty Barbara A Gold Smith Ronald E Huh G Tomas M | 2004 | Psychology & Marketing2004，21，7： | 1 |
| 10 | Quantitative TaqMan RTPCR for the detection and differantiation of European and North American strains of porcine reproductive and respiratory syndrome virus 显示文摘 | Christoph E Barbara T Luzia L | 2001 | Virol Meth2001，98，： | 1 |
| 11 | The American customer satisfaction index: Nature, purpose and findings 显示文摘 | Fornell C Johnson M D Aderson E W Cho J Barbara E Bryant | 1996 | Journal of Marketing1996，60，： | 1 |
| 12 | Enriched environment exposure regulates excitability, synaptic transmission,and LTP in the dentate gyrus of freely moving rats显示文摘 | Gemma II Barbara L Michael E | 2005 | Hippoeampus2005，15，2： | 1 |
| 13 | Insulin--like growth factor-- 1 is a potent neuronal rescue agent after hypoxic -- ischemic injury in fetallambs显示文摘 | Barbara M Johnston E Carina M | 1996 | Clin Invest1996，97，2： | 1 |
| 14 | Tackling Copyright in the Digital Age:An Initiative of the University of Connecticut Libraries显示文摘 | Barbara O Betsy P Rudnick T E | 2008 | Journal of Access Services2008，，： | 1 |
| 15 | Critical thinking and clinical competence:A study of their relationship in BSN seniors显示文摘 | Barbara A May Vivian E dell Sue Butell | 1999 | Journal of Nursing Education1999，38，3： | 1 |
| 16 | The utilization of bryophytes in bioclimatic modeling: predicted north- ward migration of peatlands in the Mackenzie River basin, Canan- da, as a result of global warming显示文摘 | Gignac L Dennis Barbara J Nicholson Suzanne E Bayley | 1998 | The Bryologist1998，101，： | 1 |
| 17 | Calcium sensing receptor- dependent and receptor-independent activation of osteoblast replica- tion and survival by strontium ranelate显示文摘 | Fromigu6 O Hay E Barbara A | 2009 | J Cell Mol Med2009，13，8： | 1 |
| 18 | Antioxidant and anti- stress compounds improve regrowth of cryopreserved Rubus shoot tips显示文摘 | Esther E U Magfrat M S Barbara M R | 2010 | In Vitro Cellular Developmental Biology-Plant2010，46，4： | 1 |
| 19 | Rapid diagnosis of bacterial meningitis by real-time PCR and fluorescence in situ hybridization显示文摘 | SVEN P ANDREAS E BARBARA S | 2005 | J Clin Microbiol2005，43，7： | 1 |
| 20 | Supporting global operations through logistics and purchasing显示文摘 | Stanley E Fawcett Laura Birou Barbara Cofield Taylor | 1993 | International Jour- nal of Physical Distribution & Logistics Management1993，23，4： | 1 |
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