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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Helicobacter pylori secreted peptidyl prolyl cis , trans -isomerase drives Th17 inflammation in gastric adenocarcinoma显示文摘 | Amedeo Amedei Fabio Munari Chiara Della Bella Elena Niccolai Marisa Benagiano Lapo Bencini Fabio Cianchi Marco Farsi Giacomo Emmi Giuseppe Zanotti Marina Bernard Manikuntala Kundu Mario Milco D’Elios | 2014 | Internal and Emergency Medicine2014，，3： | 2 |
| 3 | Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions显示文摘 | Amedeo Amedei Elena Niccolai Marisa Benagiano Chiara Della Bella Fabio Cianchi Paolo Bechi Antonio Taddei Lapo Bencini Marco Farsi Paola Cappello Domenico Prisco Francesco Novelli Mario Milco D’Elios | 2013 | Cancer Immunology, Immunotherapy2013，，7： | 2 |
| 4 | Management of ventricular tachycardia in the setting of a dedicated unit for the treatment of complex ventricular arrhythmias:long-term outcome after ablation显示文摘 | Della Bella P Baratto F Tsiachris D | 2013 | Circulation2013，127，13： | 1 |
| 5 | Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity : a key mechanism in osteoporosis显示文摘 | D' Amelio P Grimaldi A Di Bella S | 2008 | Bone2008，43，1： | 1 |
| 6 | Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28显示文摘 | Di Bella D Lazzaro F Brusco A | 2010 | Nat Genet2010，42，4： | 1 |
| 7 | Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects 显示文摘 | Palmieri V Bella J N Arnett D K | 2001 | Circulation2001，103，1： | 1 |
| 8 | Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue coalition显示文摘 | Curt GA Breitbart W Bella D | 2000 | Oncologist2000，5，5： | 1 |
| 9 | Decolorization of textile azo dyes by aerobic bacterial consortium显示文摘 | Bella D T Dinesh G Sunil K | 2009 | International Biodeterioration & Biodegradation2009，，63： | 1 |
| 10 | Banding Structures in Induced Morphology Crystal Aggregates of CaCO3 显示文摘 | Bella S D Garcia-Ruizj J M | 1987 | Journal of Materials Science1987，22，9： | 1 |
| 11 | Aberrant nuclear factor-kB/Rel expression and the pathogenesis of breast cancer显示文摘 | SOVAK M A BELLAS R E KIM D W | 1997 | J Clln Invest1997，100，12： | 1 |
| 12 | Sulfide production in anaerobic microcosms显示文摘 | Ramn A E D A Bella | 1974 | Limnol Oceanogr1974，19，1： | 1 |
| 13 | Evaluation of biodiesel storage stability using reference methods 显示文摘 | BONDIOLI P GASPAROLI A BELLA L D | 2004 | Eur J Lipid Sci Technol2004，104，12： | 1 |
| 14 | 显示文摘 | BELLA S D FRAGALA I GUERRI A | 2004 | Inorg Chim Acta2004，357，4： | 1 |
| 15 | Synthesis, characterization, optical spectroscopic, electronic structure, and secondorder nonlinear optical (NLO) properties of a novel class of donor - acceptor bis (salicylaldiminato) nickel ( Ⅱ ) Schiff base NLO chromophores显示文摘 | Fragala I Ledoux L | 1997 | J Am Chem Soc1997，，119： | 1 |
| 16 | Obsessivecompulsive disorder,5 -HqSFLPR polymorphism and treatment response 显示文摘 | Bella D Euzegovesi S | 2002 | The pharmacogenomics Journal2002，2，： | 1 |
| 17 | Management of pelvic giant cell tumours involving the acetabular bone 显示文摘 | Donati D Wafa H Di Bella C | 2008 | Acta Orthop Belg2008，74，6： | 1 |
| 18 | 显示文摘 | BELLA S D | 2001 | Chem Soc Rev2001，30，6： | 1 |
| 19 | A boundary value problem for fourth-order elastic beam equations显示文摘 | Bonanno G Bella B D | 2008 | J Math Anal Appl2008，343，： | 1 |
| 20 | Unrelated umbilical cord blood transplantation in adult patients显示文摘 | Gwynn D Long Mary Laughlin Bella Madan Joanne Kurtzberg Cristina Gasparetto Ashley Morris David Rizzieri Clayton Smith James Vredenburgh Edward C Halperin Gloria Broadwater Donna Niedzwiecki Nelson J Chao | 2003 | Biology of Blood and Marrow Transplantation2003，，： | 1 |
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