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| 1 | Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG显示文摘Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a 'factory' to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG. | Chun-Yuan Chen Shan-Shan Rao Yi-Juan Tan Ming-Jie Luo Xiong-Ke Hu Hao Yin Jie Huang Yin Hu Zhong-Wei Luo Zheng-Zhao Liu Zhen-Xing Wang Jia Cao Yi-Wei Liu Hong-Ming Li Yang Chen Wei Du Jiang-Hua Liu Yan Zhang Tuan-Hui Chen Hao-Ming Liu Ben Wu Tao Yue Yi-Yi Wang Kun Xia Peng-Fei Lei Si-Yuan Tang Hui Xie | 2019 | Bone Research2019，7，3： | 14 |
| 2 | Fine mapping of the awn gene on chromosome 4 in rice by association and linkage analyses显示文摘Awnness is a key trait in rice domestication, yet no studies have been conducted on fine mapping or association mapping of the rice awn gene. In this study, we investigated the awnness and genotype of a core collection of 303 cultivated rice varieties and a BC5F2 segregating population of 200 individuals. Combining association and linkage analyses, we mapped the awnness related genes to chromosome 4. Primary association analysis using 24 SSR markers revealed five loci significantly associated with awnness on chromosome 4. The associated markers cover previously identified regions. Fine association mapping was conducted using another 29 markers within a 4-Mb region, covering the associated marker in34, which is close to the awn gene Awn4.1. Seven associated markers were revealed, distributed over an 870-kb region. Combining the fine association mapping and linkage analysis of awnness in the 200 BC5F2 segregating population, we finally identified a 330-kb region as the candidate region for Awn4.1. The results indicate that combining association mapping and linkage mapping provides an efficient and precise approach to both genome-wide mapping and fine mapping of rice genes. | HU GuangLong ZHANG DongLing PAN HuiQiao LI Ben WU JianTao ZHOU XueYa ZHANG QunYuan ZHOU Lei YAO GuoXin LI JunZhou LI JinJie ZHANG HongLiang LI ZiChao | 2011 | Chinese Science Bulletin2011，56，9： | 4 |
| 3 | A novel target detection approach based on adaptive radar waveform design显示文摘To resolve problems of complicated clutter, fast-varying scenes, and low signal-clutterratio (SCR) in application of target detection on sea for space-based radar (SBR), a target detection approach based on adaptive waveform design is proposed in this paper. Firstly, complicated sea clutter is modeled as compound Gaussian process, and a target is modeled as some scatterers with Gaussian reflectivity. Secondly, every dwell duration of radar is divided into several sub-dwells. Regular linear frequency modulated pulses are transmitted at Sub-dwell 1, and the received signal at this sub-dwell is used to estimate clutter covariance matrices and pre-detection. Estimated matrices are updated at every following sub-dwell by multiple particle filtering to cope with fast-varying clutter scenes of SBR. Furthermore, waveform of every following sub-dwell is designed adaptively according to mean square optimization technique. Finally, principal component analysis and generalized likelihood ratio test is used for mitigation of colored interference and property of constant false alarm rate, respectively. Simulation results show that, considering configuration of SBR and condition of complicated clutter, 9 dB is reduced for SCR which reliable detection requires by this target detection approach. Therefore, the work in this paper can markedly improve radar detection performance for weak targets. | Wang Haitao Shi Lei Wang Youlin Ben De | 2013 | Chinese Journal of Aeronautics2013，26，1： | 4 |
| 4 | Exposure to PM2.5 Enhances the PI3K/AKT Signaling and Malignancy of ERα Expression-dependent Non-small Cell Lung Carcinoma显示文摘Atmospheric particulate matter(PM)2.5 is a major carcinogen and is associated with an increased risk of developing various cancers and pulmonary fibrous diseases[1-2].Non-small cell lung cancer(NSCLC)is the major type of lung cancer with high morbidity and mortality rates.Epidemiological studies report that the incidence of NSCLC,particularly adenocarcinoma,significantly differs with the gender[3].Female patients with NSCLC have unique epidemiologic characteristics,imaging profiles,clinical manifestations,and pathological characteristics[4]. | TIAN Lei LI Ying LIU Huan Liang LAI Wen Qing SHI Yue LIU Xiao Hua XI Zhu Ge LIN Ben Cheng | 2021 | Biomedical and Environmental Sciences2021，34，4： | 3 |
| 5 | Cognitive Frequency Hopping Sequences显示文摘Since the immutable conventional Frequency hopping(FH) sequence cannot keep high FH communication reliability in complex electromagnetic environment, we propose an algorithm that can generate high-performance Cognitive frequency hopping sequence(CFHS) for Cognitive frequency hopping(CFH) system.By employing the pseudo-random perturbation mapping,the CFHS is generated by remapping the block cipher FH sequence with the adaptive frequency slot number and frequency gap. The CFHS inherits the great integrated performance and its parameters could change with the electromagnetic environment. The statistics properties of Markov and uniformity are analyzed based on the Markov process theory and probability theory. Simulation results show that CFHS outperforms the widely-used FH sequences on the performance of uniformity, randomness, Hamming correlation, complexity and sensitivity. The proposed CFHS could be extensively applied in high reliable CFH system. | GUAN Lei LI Zan HAO Benjian SI Jiangbo NING Ben | 2016 | Chinese Journal of Electronics2016，25，1： | 3 |
| 6 | Development of catalytic combustion and CO_(2)capture and conversion technology显示文摘Changes are needed to improve the efficiency and lower the CO_(2)emissions of traditional coal-fired power generation,which is the main source of global CO_(2)emissions.The integrated gasification fuel cell(IGFC)process,which combines coal gasification and high-temperature fuel cells,was proposed in 2017 to improve the efficiency of coal-based power generation and reduce CO_(2)emissions.Supported by the National Key R&D Program of China,the IGFC for nearzero CO_(2)emissions program was enacted with the goal of achieving near-zero CO_(2)emissions based on(1)catalytic combustion of the flue gas from solid oxide fuel cell(SOFC)stacks and(2)CO_(2)conversion using solid oxide electrolysis cells(SOECs).In this work,we investigated a kW-level catalytic combustion burner and SOEC stack,evaluated the electrochemical performance of the SOEC stack in H2O electrolysis and H2O/CO_(2)co-electrolysis,and established a multiscale and multi-physical coupling simulation model of SOFCs and SOECs.The process developed in this work paves the way for the demonstration and deployment of IGFC technology in the future. | Zhibin Yang Ze Lei Ben Ge Xingyu Xiong Yiqian Jin Kui Jiao Fanglin Chen Suping Peng | 2021 | International Journal of Coal Science & Technology2021，8，3： | 3 |
| 7 | Improving the Extreme Rainfall Forecast of Typhoon Morakot(2009) by Assimilating Radar Data from Taiwan Island and China's Mainland显示文摘This study examined the impact of an improved initial field through assimilating ground-based radar data from China's Mainland and Taiwan Island to simulate the long-lasting and extreme rainfall caused by Morakot(2009). The vortex location and the subsequent track analyzed through the radial velocity data assimilation(VDA) are generally consistent with the best track. The initial humidity within the radar detecting region and Morakot's northward translation speed can be significantly improved by the radar reflectivity data assimilation(ZDA). As a result, the heavy rainfall on both sides of Taiwan Strait can be reproduced with the joint application of VDA and ZDA. Based on sensitivity experiments, it was found that, without ZDA, the simulated storm underwent an unrealistic inward contraction after 12-h integration, due to underestimation of humidity in the global reanalysis, leading to underestimation of rainfall amount and coverage. Without the vortex relocation via VDA, the moister(drier) initial field with(without) ZDA will produce a more southward(northward) track, so that the rainfall location on both sides of Taiwan Strait will be affected. It was further found that the improvement in the humidity field of Morakot is mainly due to assimilation of high-value reflectivity(strong convection) observed by the radars in Taiwan Island, especially at Kenting station. By analysis of parcel trajectories and calculation of water vapor flux divergence, it was also found that the improved typhoon circulation through assimilating radar data can draw more water vapor from the environment during the subsequent simulation, eventually contributing to the extreme rainfall on both sides of Taiwan Strait. | Xuwei BAO Dan WU Xiaotu LEI Leiming MA Dongliang WANG Kun ZHAO Ben Jong-Dao JOU | 2017 | Journal of Meteorological Research2017，31，4： | 3 |
| 8 | 3D uniform nitrogen-doped carbon skeleton for ultra-stable sodium metal anode显示文摘Sodium metal batteries are arousing extensive interest owing to their high energy density,low cost and wide resource.However,the practical development of sodium metal batteries is inherently plagued by the severe volume expansion and the dendrite growth of sodium metal anode during long cycles under high current density.Herein,a simple electrospinning method is applied to construct the uniformly nitrogen-doped porous carbon fiber skeleton and used as three-dimensional(3D)current collector for sodium metal anode,which has high specific surface area(1,098 m^2/g)and strong binding to sodium metal.As a result,nitrogen-doped carbon fiber current collector shows a low sodium deposition overpotential and a highly stable cyclability for 3,500 h with a high coulombic effciency of 99.9%at 2 mA/cm^2 and 2 mAh/cm^2.Moreover,the full cells using carbon coated sodium vanadium phosphate as cathode and sodium pre-plated nitrogen-doped carbon fiber skeleton as hybrid anode can stably cycle for 300 times.These results illustrate an effective strategy to construct a 3D uniformly nitrogen-doped carbon skeleton based sodium metal hybrid anode without the formation of dendrites,which provide a prospect for further development and research of high performance sodium metal batteries. | Ben Liu Danni Lei Jin Wang Qingfei Zhang Yinggan Zhang Wei He Hongfei Zheng Baisheng Sa Qingshui Xie Dong-Liang Peng Baihua Qu | 2020 | Nano Research2020，13，8： | 3 |
| 9 | Influence of de electric current on the hardness of thermally aged Cu-Cr-Zr alloy 显示文摘 | Wang Z J Zhong Y B Cao G H Wang C Wang J Ren W L Lei Z S Ben Z M | 2009 | Journal of Alloys and Compounds2009，479，： | 1 |
| 10 | Accurate Solution to Overdetermined Linear Equations with Errors Using L1 Norm Minimization显示文摘 | J. Ben Rosen Haesun Park John Glick Lei Zhang | 2000 | Computational Optimization and Applications (-)2000，，2： | 1 |
| 11 | Single Wall Carbon Nanotube Induced Inflammation in Cruor-Fibrinolysis System显示文摘Objective To study single wall carbon nanotubes (SWCNT) and its role in inducing inflammatory cytokines in the cruor-fibrinolysis system of rat. Methods Twenty one Wistar rats were divided into four groups: 1) control; 2) low-dose SWCNT (0.15 mg/kg BW); 3) medium-dose SWCNT (0.75 mg/kg BW); 4) high-dose SWCNT (1.5 mg/kg BW). Intratracheal instillation of SWCNT suspensions was administered to rats once per day for 21 days. In order to assess the exposure effect of SWCNT to the rats, activity of Inflammatory cytokine was measured and markers of cruor-fibrinolysis system were studied via ELSIA. Also, change in clotting time was recorded and histopathology was studied. Results IL-6 and IL-8 concentrations of rats exposed to SWCNT were significantly higher than those in controls (P<0.05). The activity of inflammatory cytokines and histopathological change indicated that oxidative damage occurred. Change in clotting time in rats exposed to SWCNT decreased compared with controls. Meanwhile, t-PA (tissue-tupe plassminogen activator) and AT-Ⅲ (antithrombin-Ⅲ) levels in rats exposed to particulates increased or decreased significantly compared with controls (P<0.05). A similar trend was observed for D-dimer (D2D) levels, indicating that SWCNT can impact the cruor-fibrinolysis system ofrat. Conclusion The results from our study suggest that an increased procoagulant activity and reduced fibrinolytic activity in rats exposed to SWCNT can cause pulmonary oxidative stress and inflammation, due to the release of pro-thrombotic and inflammatory cytokines into the blood circulation of rat. | TIAN Lei LIN Zhi Qing LIN Ben Cheng LIU Huan Liang YAN Jun XI Zhu Ge | 2013 | Biomedical and Environmental Sciences2013，26，5： | 1 |
| 12 | Fucoidan antagonizes diet-induced obesity and inflammation in mice显示文摘Obesity is an escalating global pandemic posing a serious threat to human health.The intervention therapy using weight-reducing drugs,accompanied by lifestyle modification,is a strategy for the treatment of obesity.In the present study,we explored the role of fucoidan,a seaweed compound,on high-fat diet(HFD)-induced obesity in mice.We found that fucoidan treatment significantly reduced the body fat and caused redistribution of visceral and subcutaneous fat in HFD-fed mice.Meanwhile,fucoidan treatment inhibited adipocyte hypertrophy and inflammation in adipose tissue.Collectively,these results suggest that fucoidan may be a promising treatment for obesity and obesity-induced complications. | Lei Wang Kun Zhang Xin Ding Yan Wang Hui Bai Qing Yang Jingjing Ben Hanwen Zhang Xiaoyu Li Qi Chen Xudong Zhu | 2021 | The Journal of Biomedical Research2021，35，3： | 1 |
| 13 | The effect of energy, settling time and shaking time on the swirling flask dispersant apparatus显示文摘 | Merv F. Fingas Eleanor Huang Ben Fieldhouse Lei Wang Joseph V. Mullin | 1997 | Spill Science and Technology Bulletin1997，，4： | 1 |
| 14 | Rational Design of a Palladium‐Catalyzed C<sub>sp</sub>–C<sub>sp</sub> Cross‐Coupling Reaction Inspired by Kinetic Studies显示文摘 | Yue Weng Ben Cheng Chuan He Aiwen Lei | 2012 | Angew Chem Int Ed2012，，38： | 1 |
| 15 | Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population显示文摘BACKGROUND Alcohol consumption is a known modifiable risk factor for atrial fibrillation.The association,however,might differ according to gender.We investigated gender-specific associations between alcohol consumption and incident atrial fibrillation in an elderly Chinese population.METHODS Our study participants were elderly residents(≥65 years)recruited from five community health centers in the urban area of Shanghai(n=6,618).Alcohol intake was classified as never drinkers and current light-to-moderate(<40 g/day)and heavy drinkers(≥40 g/day).Atrial fibrillation was detected by a 30-s single-lead electrocardiography(ECG,AliveCor®Heart Monitor)and further evaluated with a regular 12-lead ECG.RESULTS During a median of 2.1 years(interquartile range:2.0−2.2)follow-up,the incidence rate of atrial fibrillation was 1.10%in all study participants.It was slightly but non-significantly higher in men(n=2849)than women(n=3769,1.30%vs.0.96%,P=0.19)and in current drinkers(n=793)than never drinkers(n=5825,1.64%vs.1.03%,P=0.12).In both unadjusted and adjusted analyses,there was interaction between sex and current alcohol intake in relation to the incidence of atrial fibrillation(P<0.0001).After adjustment for confounding factors,current drinkers had a significantly higher incidence rate of atrial fibrillation than never drinkers in women(12.96%[7/54]vs.0.78%[29/3715],adjusted odds ratio[OR]=10.25,95%confidence interval[CI]:3.54−29.67,P<0.0001),but not in men(0.81%[6/739]vs.1.47%[31/2110],OR=0.62,95%CI:0.25−1.51,P=0.29).CONCLUSIONS Our study showed a significant association between alcohol intake and the incidence of atrial fibrillation in elderly Chinese women,but not men. | Xiao-Fei YE Wei ZHANG Yi CHEN Chao-Ying MIAO Qi-Fang HUANG Chang-Sheng SHENG Shuai SHAO Dian WANG Shao-Kun XU Lei LEI Di ZHANG Yi-Lin CHEN Lei-Xiao HU Jia-Hui XIA Yi-Bang CHENG Ying WANG Qian-Hui GUO Yan LI Nicole Lowres Ben Freedman Ji-Guang WANG | 2022 | Journal of Geriatric Cardiology2022，19，1： | 1 |
| 16 | Manipulation of clusteroluminescence in carbonyl-based aliphatic polymers显示文摘Clusteroluminogens(CLgens),nonconjugated structures with visible luminescence at the clustering state,have recently received remarkable attention due to their great theoretical significance and practical values.In carbonyl-based aliphatic polymers,(n,π*)transition of carbonyl groups and the through-space interactions have been demonstrated to play an important role in their clusteroluminescence(CL)properties,but it is still a big challenge to manipulate their CL at the molecular level.In this work,six nonconjugated carbonyl-based polymers with different heteroatoms and steric hindrances were synthesized,and their photophysical properties were systematically studied.These polymers all showed CL but with different emission efficiency and wavelength.Experimental and theoretical studies indicated that the CL properties could be manipulated by changing the electronic structures of carbonyl groups and the rigidity of polymer chains.This work not only gains further insights into the CL mechanism but also provides reliable strategies to design and manipulate non-conjugated luminescent materials. | Ziteng Zhang Zuping Xiong Bo Chu Zhiming Zhang Yuan Xie Lei Wang Jing Zhi Sun Haoke Zhang Xing-Hong Zhang Ben Zhong Tang | 2022 | Aggregate2022，3，6： | 1 |
| 17 | Effect of mitofusin 2 overexpression on the proliferation and apoptosis of high - glucose - induced rat glomerular mesangial cells 显示文摘 | Wan2 Xin T Tian - Lei C Ben W | 2012 | J Nephrol2012，25，6： | 1 |
| 18 | Distribution of Microbiota in Fine Particulate Matter Particles in Guangzhou, China显示文摘Objective High PM2.5 concentration is the main feature of increasing haze in developing states,but information on its microbial composition remains very limited.This study aimed to determine the composition of microbiota in PM2.5 in Guangzhou,a city located in the tropics in China.Methods In Guangzhou,from March 5th to 10th,2016,PM2.5 was collected in middle volume air samplers for 23 h daily.The 16 S rDNA V4 region of the PM2.5 sample extracted DNA was investigated using high-throughput sequence.Results Among the Guangzhou samples,Proteobacteria,Bacteroidetes,Firmicutes,Cyanobacteria,and Actinobacteria were the dominant microbiota accounting for more than 90%of the total microbiota,and Stenotrophomonas was the dominant gram-negative bacteria,accounting for 21.30%–23.57%.We examined the difference in bacterial distribution of PM2.5 between Beijing and Guangzhou at the genus level;Stenotrophomonas was found in both studies,but Escherichia was only detected in Guangzhou.Conclusion In conclusion,the diversity and specificity of microbial components in Guangzhou PM2.5 were studied,which may provide a basis for future pathogenicity research in the tropics. | DONG Shi Rui HAN Ya Jing WU Jing ZENG Cheng Li ZHU Ke Hui CHEN Xiao Jing LIU Yu Mei ZOU Xiao Qian ZHENG Shao Ling WEN Zi Hao LIU Dan Dan WANG Yao HUANG Xiu Xia DU Xiu Ben HAO Jian Lei WANG Huan Yu GUO Shu JING Chun Xia YANG Guang | 2020 | Biomedical and Environmental Sciences2020，33，5： | 1 |
| 19 | Comparative elemental,mineral and microscopic investigation of sandstone matrix acidizing at HPHT conditions显示文摘Matrix acidizing is usually conducted on sandstone reservoirs to increase hydrocarbon production.Mineralogy plays an important role in designing acidizing treatments to enhance the production of oil and gas from sandstone reservoirs.The most common acid in practice to acidize sandstone formation is mud acid after the pre-flush acid stage.The main aim of the pre-flush acid stage is to dissolve positive ions like calcium,potassium,sodium,etc,which can cause precipitation reactions during the mud acid stage.This research is aimed to investigate the reaction mechanism of a new pre-flush acid combination(hydrochloric acid and acetic acid)with sandstone formation.Core flooding experiments were performed to react acid with the core samples(6 in×1.5 in)under high pressure and temperature(HPHT)condi-tions(80℃and 1000 psia).Analytical techniques such as Tescan Integrated Mineral Analysis(TIMA)have been used to illustrate the effect of these acids on sandstone formation.TIMA analysis showed that the new acid combination was effective in dissolving various minerals(ankerite,magnetite)and cations(calcium,magnesium,sodium,and iron).15%HCl proved to be more effective in the dissolution of different particles from sandstone core samples.It dissolved 32.8%of the initial number of particles present inside the sample while the dissolving power of 5%CH_(3)COOH:10%HCl is 26.7%.Subsequently,the number of pores increased by the application of 15%HCl is 22%while that by 5%CH_(3)COOH:10%HCl is 21.8%.Density analysis showed that both acid combinations removed heavy particles effectively,whereas 5%CH_(3)COOH:10%HCl proved more efficient in dissolving calcium ions which is very important for pre-flush acidizing. | Mian Umer Shafiq Hisham Khaled Ben Mahmud Lei Wang Khizar Abid Sophia Nawaz Gishkori | 2022 | Petroleum Research2022，7，4： | 0 |
| 20 | Study on Volume Variation and Stability of Riverbed in the Yangtze Estuary显示文摘In recent years,regional floods and typhoons have occurred in the Yangtze Estuary.Changing dynamic conditions and dramatic reduction of sediment discharge in the basin are affecting the dynamic equilibrium pattern of the Yangtze Estuary.Based on the field measurement data and theoretical derivation,this paper analyzed the changing process of runoff-sediment discharge into the sea after the operation of the Three Gorges Project(TGP),and the tidal dynamics and sediment variation characteristics of the Yangtze Estuary.The erosion of South Branch mainly occurs in the channel below-10 m contour,and the riverbed volume below contours 0 m and-10 m has a good correlation with the sediment discharge of Datong Station in the previous year.On this basis,the ratio of the horizontal distance from the starting point to the section centroid below the average water level(B_c)and the water depth at the section centroid(H_c)was proposed to describe the change of the section shape.The relationships between the water-diverting ratio,the sediment-diverting ratio and the water-diverting angle,the conditions of runoff and sediment discharge from the upper reach and the characteristics of the riverway section were established,and the theoretical calculation equations of the water-diverting ratio,the sediment-diverting ratio and the diverting angle of each bifurcation were also established. | DING Lei JIAO Jian TONG Chao-feng WANG Yi-fei CHEN Ben SUN Jie-ying DOU Xi-ping | 2023 | China Ocean Engineering2023，37，3： | 0 |
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