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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13显示文摘Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to immunopathology.Activation of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling molecules.However,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely understood.Here,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.Stimulation of DCs with the TLR11/12 ligand T.gondii profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and TLR9.Mechanistically,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of T.gondii infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic T.encephalitis,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection.In contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced immunopathology.Collectively,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases. | Floriana Mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi Anna Brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter | 2021 | Cellular & Molecular Immunology2021，18，6： | 4 |
| 3 | 现代欧洲冰场中天然制冷剂的应用和室内环境的探索显示文摘本文简要介绍了天然制冷剂NH3和CO2以及各种载冷剂在欧洲冰场中的应用历史和经验,以及微气候控制技术在现代欧洲冰场的应用。大量溜冰场馆建设经验分析的结果表明:NH3是速滑大道制冷应用中久经验证非常优秀的制冷剂,而室内速滑大道的发展趋势是采用主制冷剂为天然工质NH3或CO2的制冷系统,现代溜冰场馆发展方向是更加环保和节能。实践证明溜冰场室内微气候控制措施有助于进一步提高速滑速度并降低建筑能源消耗。 | Ernst BERENDS 何静梅 | 2020 | 制冷技术2020，40，2： | 3 |
| 4 | Molecular Simulation of CO2/H2 Mixture Separation in Metal-organic Frameworks: Effect of Catenation and Electrostatic Interactions显示文摘In this work grand canonical Monte Carlo simulations were performed to study gas separation in three pairs of isoreticular metal-organic frameworks (IRMOFs) with and without catenation at room temperature.Mixture composed of CO2 and H2 was selected as the model system to separate.The results show that CO2 selectivity in catenated MOFs with multi-porous frameworks is much higher than their non-catenated counterparts.The simulations also show that the electrostatic interactions are very important for the selectivity,and the contributions of different electrostatic interactions are different,depending on pore size,pressure and mixture composition.In fact,changing the electrostatic interactions can even qualitatively change the adsorption behavior.A general conclusion is that the electrostatic interactions between adsorbate molecules and the framework atoms play a dominant role at low pressures,and these interactions in catenated MOFs have much more pronounced effects than those in their non-catenated counterparts,while the electrostatic interactions between adsorbate molecules become evident with increasing pressure,and eventually dominant. | 阳庆元 许青 刘蓓 仲崇立 Smit Berend | 2009 | Chinese Journal of Chemical Engineering2009，17，5： | 3 |
| 5 | The 5-HT2c receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation显示文摘有终生的早泄(LPE ) 的人的坚持的短 intravaginal 射精潜伏时间(IELT ) 与 5-hydroxytryptamine (HT ) 有关是 2C 受体工作,这被要求了。这研究的目的是与 LPE 在人调查 Cys23Ser 5-HT 2C 受体基因多型性和 IELT 的持续时间的关系。因此,未来的研究与 LPE 在 64 个荷兰的白种人人被进行。基线 IELT 被秒表在一个 1 月的时期上在性交期间估计。所有人是为 Cys23Ser 5-HT 2C 受体基因多型性的 genotyped。Cys 的等位基因频率和 5-HT 2C 受体基因多型性的重量的单位变体是坚定的。在 Cys/Cys 和重量的单位 / 重量的单位遗传型和在有 LPE 的人的 IELT 的自然对数之间的协会被调查。作为结果,几何吝啬、中部、自然的吝啬的 IELT 是 25.2, 27.0, 33.9 s 分别地。所有人, 20.0% , 10.8% , 23.1% 和 41.5% 在 10 以内射精,在阴道穿入以后的 10-20, 20-30 和 30-60 s。64 个人,为 5-HT 2C 受体基因的 Cys23Ser 多型性的 Cys/Cys 和重量的单位 / 重量的单位遗传型频率分别地是 81% 和 19% 。wildtypes (Cys/Cys ) 的几何吝啬的 IELT 显著地更低(22.6 s;95% CI 18.3-27.8 s ) 比在男同型结合的异种(重量的单位 / 重量的单位)(40.4 s;95% CI 20.3-80.4 s )(P = 0.03 ) 。Cys23Ser 5-HT 2C 受体基因多型性与 LPE 在人与 IELT 被联系,这被结束。有 Cys/Cys 遗传型的人与重量的单位 / 重量的单位遗传型比人有更短的 IELT。 | Paddy KC Janssen Ron van Schaik Berend Olivier Marcel D Waldinger | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 6 | Treatment strategies for proximal femur fractures in osteoporotic patients显示文摘 | Felix Bonnaire Henry Zenker Christoph Lill Andreas T. Weber Berend Linke | 2005 | Osteoporosis International2005，，2： | 2 |
| 7 | Identification of uniparental disomy foiling prenatal detection of robertsonian translocations and isochromosomes显示文摘 | Berend SA Horwitz J McCaskill C | 2000 | Am J Hum Genet2000，6，： | 1 |
| 8 | Congenital heart disease in 5609 births: incidence and natural history显示文摘 | Mitchell S C Korones S B Berendes H W | 1971 | Circulation1971，43，3： | 1 |
| 9 | Rapid recovery protocol for pefi - operative care of total hip and total hip knee arthroplasty patients 显示文摘 | BEREND K R LOMBARDI A V Jr MALLOPY T H | 2004 | Surg technol Int2004，13，： | 1 |
| 10 | Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid haemorrhage显示文摘 | BERENDES E WALTER M | 1997 | Lancet1997，349，9047： | 1 |
| 11 | A versatile technique for the Investigation of Gunshot Residue Patterns on Fabrics and Other Surfaces:m-XRF J Forensic Sci显示文摘 | Berendes A Neimke D Schumacher R | | 0，，05： | 1 |
| 12 | Full-scale application of the BABE technology显示文摘 | Salem S Berends D van der Roest H | | 0，，07： | 1 |
| 13 | Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid haemorrhage显示文摘 | Berendes E Walter M Cullen P | 1997 | Lancet1997，349，9047： | 1 |
| 14 | Total knee arthroplasty in patients with greater than 20 degrees flexion contraeture显示文摘 | Berend KR Lombardi AV Jr Adams JB | 2006 | Clin Orthop Relat Res2006，452，11： | 1 |
| 15 | Differential secretion of atrial and brain natriuretic peptide in critically ill patients显示文摘 | Berendes E Van Aken H Raufhake C | 2001 | Anesth Analg2001，93，3： | 1 |
| 16 | An outlline of a risk assessment-based system of meat safety assurance and its future prospects 显示文摘 | Berends B R Van Knapen F | 1999 | Vet Q1999，21，4： | 1 |
| 17 | Body composition by dual energy X-ray absorptiometry in women with previous pre-eclampsia or small for gesta- tional age offspring 显示文摘 | BERENDS A L ZILLIKENS M C DE GROOT C J | 2009 | An International Journal of Ob- stetrics and Gynaecology2009，116，3： | 1 |
| 18 | Morbidly obese,diabetic,younger,and unilateral joint arthroplasty patientshave elevated total joint arthroplasty infection rates显示文摘 | Malinzak RA Ritter MA Berend ME | 2009 | J Ar-throplasty2009，24，6： | 1 |
| 19 | Simultaneous bilateral versus unilateral total hip arthroplasty an outcomes analysis显示文摘 | Berend ME Ritter MA Harty LD | 2005 | J Arthroplasty2005，，4： | 1 |
| 20 | Predicting patellar failure after total knee arthroplasty 显示文摘 | Meding J Fish M Berend M | 2008 | Clinical Orthopaedics and Related Research2008，466，11： | 1 |
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