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| 1 | Bone marrow derived stem cells for the treatment of end-stage liver disease显示文摘End-stage disease due to liver cirrhosis is an important cause of death worldwide. Cirrhosis results from progressive, extensive fibrosis and impaired hepatocyte regeneration. The only curative treatment is liver transplantation, but due to the several limitations of this procedure, the interest in alternative therapeutic strategies is increasing. In particular, the potential of bone marrow stem cell(BMSC) therapy in cirrhosis has been explored in different trials. In this article, we evaluate the results of 18 prospective clinical trials, and we provide a descriptive overview of recent advances in the research on hepatic regenerative medicine. The main message from the currently available data in the literature is that BMSC therapy is extremely promising in the context of liver cirrhosis. However, its application should be further explored in randomized, controlled trials with large cohorts and long follow-ups. | Cristina Margini Ranka Vukotic Lucia Brodosi Mauro Bernardi Pietro Andreone | 2014 | World Journal of Gastroenterology2014，20，27： | 18 |
| 2 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis显示文摘 | Richard Moreau Rajiv Jalan Pere Gines Marco Pavesi Paolo Angeli Juan Cordoba Francois Durand Thierry Gustot Faouzi Saliba Marco Domenicali Alexander Gerbes Julia Wendon Carlo Alessandria Wim Laleman Stefan Zeuzem Jonel Trebicka Mauro Bernardi Vicente Arro | 2013 | Gastroenterology2013，，7： | 12 |
| 3 | Stem cells for end stage liver disease: How far have we got?显示文摘End stage liver disease (ESLD) is a health problem worldwide. Liver transplantation is currently the only effective therapy, but its many drawbacks include a shortage of donors, operative damage, risk of rejection and in some cases recidivism of the pre-transplant disease. These factors account for the recent growing interest in regenerative medicine. Experiments have sought to identify an optimal source of stem cells, sufficient to generate large amounts of hepatocytes to be used in bioartificial livers or injected in vivo to repair the diseased organ. This update aims to give non-stem cell specialists an overview of the results obtained to date in this fascinating field of biomedical research. | Stefania Lorenzini Stefano Gitto Elena Grandini Pietro Andreone Mauro Bernardi | 2008 | World Journal of Gastroenterology2008，14，29： | 8 |
| 4 | Diet in neurogenic bowel management:A viewpoint on spinal cord injury显示文摘The aim of this review is to offer dietary advice for individuals with spinal cord injury(SCI)and neurogenic bowel dysfunction.With this in mind,we consider health conditions that are dependent on the level of lesion including skeletal muscle atrophy,autonomic dysreflexia and neurogenic bladder.In addition,SCI is often associated with a sedentary lifestyle,which increases risk for osteoporosis and diseases associated with chronic low-grade inflammation,including cardiovascular and chronic kidney diseases.The Mediterranean diet,along with exercise and dietary supplements,has been suggested as an anti-inflammatory intervention in individuals with SCI.However,individuals with chronic SCI have a daily intake of whole fruit,vegetables and whole grains lower than the recommended dietary allowance for the general population.Some studies have reported an increase in neurogenic bowel dysfunction symptoms after high fiber intake;therefore,this finding could explain the low consumption of plant foods.Low consumption of fibre induces dysbiosis,which is associated with bothendotoxemia and inflammation.Dysbiosis can be reduced by exercise and diet in individuals with SCI.Therefore,to summarize our viewpoint,we developed a Mediterranean diet-based diet and exercise pyramid to integrate nutritional recommendations and exercise guidelines.Nutritional guidelines come from previously suggested recommendations for military veterans with disabilities and individuals with SCI,chronic kidney diseases,chronic pain and irritable bowel syndrome.We also considered the recent exercise guidelines and position stands for adults with SCI to improve muscle strength,flexibility and cardiorespiratory fitness and to obtain cardiometabolic benefits.Finally,dietary advice for Paralympic athletes is suggested. | Marco Bernardi Anna Lucia Fedullo Elisabetta Bernardi Diego Munzi Ilaria Peluso Jonathan Myers Florigio Romano Lista Tommaso Sciarra | 2020 | World Journal of Gastroenterology2020，26，20： | 7 |
| 5 | 成人急诊氧疗新指南显示文摘 | Marco Ricca Emenuele Bernardi Bruno Tartaglino 魏捷 燕小薇 | 2009 | 临床急诊杂志2009，10，6： | 6 |
| 6 | The management of ascites in cirrhosis: Report on the consensus conference of the International Ascites Club显示文摘 | Kevin P. Moore Florence Wong Pere Gines Mauro Bernardi Andreas Ochs Francesco Salerno Paolo Angeli Michael Porayko Richard Moreau Guadelupe Garcia-Tsao Wladimiro Jimenez Ramon Planas Vicente Arroyo | 2003 | Hepatology2003，，1： | 4 |
| 7 | Hepatitis C virus reinfection after liver transplantation: Is there a role for direct antiviral agents?显示文摘Recurrence of hepatitis C virus(HCV)infection following liver transplantation(LT)is almost universal and can accelerate graft cirrhosis in up to 30%of patients.The development of effective strategies to treat or prevent HCV recurrence after LT remains a major challenge,considering the shortage of donor organs and the accelerated progression of HCV in LT recipients.Standard antiviral therapy with pegylated-interferon plus ribavirin is the current treatment of choice for HCV LT recipients,even though the combination is not as effective as it is in immunocompetent patients.A sustained virological response in the setting of LT improves patient and graft survival,but this is only achieved in 30%-45%of patients and the treatment is poorly tolerated.To improve the efficacy of pre-and post-transplant antiviral therapy,a new class of potent direct-acting antiviral agents (DAAs)has been developed.The aim of this review is to summarize the use of DAAs in LT HCV patients.PubMed,Cochrane Library,MEDLINE,EMBASE,Web of Science and clinical trial databases were searched for this purpose.To date,only three clinical studies on the topic have been published and most of the available data are in abstract form.Although a moderately successful early virological response has been reported,DAA treatment regimens were associated with severe toxicity mitigating their potential usefulness.Moreover,the ongoing nature of data,the lack of randomized studies,the small number of enrolled patients and the heterogeneity of these studies make the results largely anecdotal and questionable.In conclusion,large welldesigned clinical studies on DAAs in HCV LT patients are required before these drugs can be recommended after transplantation. | Marco Dall’Agata Annagiulia Gramenzi Maurizio Biselli Mauro Bernardi | 2014 | World Journal of Gastroenterology2014，20，28： | 4 |
| 8 | Mechanisms involved in the inhibition of myoblast proliferation and differentiation by myostatin显示文摘 | Dominique Joulia Henri Bernardi Véronique Garandel Fanjaniriana Rabenoelina Barbara Vernus Gérard Cabello | 2003 | Experimental Cell Research2003，，2： | 3 |
| 9 | Incidence and treatment of mediastinal leakage after esophagectomy:Insights from the multicenter study on mediastinal leaks显示文摘BACKGROUND Mediastinal leakage(ML) is one of the most feared complications of esophagectomy. A standard strategy for its diagnosis and treatment has beendifficult to establish because of the great variability in their incidence and mortality rates reported in the existing series.AIM To assess the incidence, predictive factors, treatment, and associated mortality rate of mediastinal leakage using the standardized definition of mediastinal leaks recently proposed by the Esophagectomy Complications Consensus Group(ECCG).METHODS Seven Italian surgical centers(five high-volume, two low-volume) affiliated with the Italian Society for the Study of Esophageal Diseases designed and implemented a retrospective study including all esophagectomies(n = 501) with intrathoracic esophagogastric anastomosis performed from 2014 to 2017.Anastomotic MLs were defined according to the classification recently proposed by the ECCG.RESULTS Fifty-nine cases of ML were recorded, yielding an overall incidence of 11.8%(95%CI: 9.1%-14.9%). The surgical approach significantly influenced the occurrence of ML: the proportion of leakage was 10.5% and 9% after open and hybrid esophagectomy(HE), respectively, and doubled(20%) after totally minimally invasive esophagectomy(TMIE)(P = 0.016). No other predictive factors were found. The 30-and 90-d overall mortality rates were 1.4% and 3.2%,respectively; the 30-and 90-d leak-related mortality rates were 5.1% and 10.2%,respectively; the 90-d mortality rates for TMIE and HE were 5.9% and 1.8%,respectively. Endoscopy was the first-line treatment in 49% of ML cases, with the need for retreatment in 17.2% of cases. Surgery was needed in 44.1% of ML cases.Endoscopic treatment had the lowest mortality rate(6.9%). Removal of the gastric tube with stoma formation was necessary in 8(13.6%) cases.CONCLUSION The incidence of ML after esophagectomy was high mainly in the TMIE group.However, the general and specific(leak-related) mortality rates were low. Early treatment(surgical or endoscopic) of severe leaks is mandatory to limit related mortality. | Uberto Fumagalli Gian Luca Baiocchi ANDrea Celotti Paolo Parise ANDrea Cossu Luigi Bonavina Daniele Bernardi Giovanni de Manzoni Jacopo Weindelmayer Giuseppe Verlato Stefano Santi Giovanni Pallabazzer Nazario Portolani Maurizio Degiuli Rossella Reddavid Stefano de Pascale | 2019 | World Journal of Gastroenterology2019，25，3： | 3 |
| 10 | Love wave tomography in Italy from seismic ambient noise显示文摘We estimate Love wave empirical Green's functions from cross-correlations of ambient seismic noise to study the crust and uppermost mantle structure in Italy.Transverse-component ambient noise data from October 2005 through March 2007 recorded at 114 seismic stations from the Istituto Nazionale di Geofisica e Vulcanologia (INGV) national broadband network,the Mediterranean Very Broadband Seismographic Network (MedNet) and the Austrian Central Institute for Meteorology and Geodynamics (ZAMG) yield more than 2 000 Love wave group velocity measurements using the multiple-filter analysis technique.In the short period band (5-20 s),the cross-correlations show clearly one-sided asymmetric feature due to non-uniform noise distribution and high local activities,and in the long period band (>20 s) this feature becomes weak owing to more diffusive noise distribution.Based on these measurements,Love wave group velocity dispersion maps in the 8-34 s period band are constructed,then the SH wave velocity structures from the Love wave dispersions are inverted.The final results obtained from Love wave data are overall in good agreement with those from Rayleigh waves.Both Love and Rayleigh wave inversions all reveal that the Po plain basin is resolved with low velocity at shallow depth,and the Tyrrhenian sea is characterized with higher velocity below 8 km due to its thin oceanic crust. | Hongyi Li Fabrizio Bernardi Alberto Michelini | 2010 | Earthquake Science2010，23，5： | 3 |
| 11 | Serum α-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status显示文摘 | Franco Trevisani Paola Emanuela D’Intino Antonio Maria Morselli-Labate Giuseppe Mazzella Esterita Accogli Paolo Caraceni Marco Domenicali Stefania De Notariis Enrico Roda Mauro Bernardi | 2001 | Journal of Hepatology2001，，4： | 3 |
| 12 | Liver transplantation from hepatitis B surface antigen positive donors: A safe way to expand the donor pool显示文摘 | Elisabetta Loggi Lorenzo Micco Giorgio Ercolani Alessandro Cucchetti Florian K. Bihl Gian Luca Grazi Stefano Gitto Andrea Bontadini Mauro Bernardi Paolo Grossi Alessandro Nanni Costa Antonio Daniele Pinna Christian Brander Pietro Andreone | 2011 | Journal of Hepatology2011，，3： | 2 |
| 13 | Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation显示文摘AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic regression.RESULTS: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, 'too sick to be treated' and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the 'non-responders'(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence. | Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone | 2015 | World Journal of Gastroenterology2015，21，13： | 2 |
| 14 | Coronavirus disease 2019 (COVID-19) and prosthetic heart valve: An additional coagulative challenge显示文摘Dear editor,A new infectious disease outbreak,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is now spreading all around the world.[1]One of the most critical understandings of the current pandemic of the coronavirus disease 2019(COVID-19)focuses on an imbalanced coagulation status.Based on the current evidence,we can divide the COVID-19-related hypercoagulable state into two categories[2]:patients without other pre-existing indications for anticoagulant therapy who develop a state of hypercoagulability linked to SARS-CoV-2 infection especially during the cytokine storm phase,and patients already on anticoagulation in whom we have to reevaluate their drug choices,dosages,and pharmacokinetics.At the same time,recent literature recommends the use of heparin in severe SARS-CoV-2 infection,both as thromboembolic prophylaxis and as an anticoagulant therapy,in light of possible anti-infl ammatory and antiviral mechanisms and less pharmacological interferences.[3]This indication should be adopted in all patients except for those with prosthetic heart valves,in whom vitamin K antagonists continue to remain the drug of choice.[4]In this subgroup of patients,strict monitoring of PT-INR is required to maintain the therapeutic range.The purpose of this article is to underline the need for good quality evidence regarding the management of this high-risk category of the patient population. | Attilio Allione Jacopo Davide Giamello Sara Bernardi Giulia Paglietta Giulia Lucia Massimina Cavalot Luca Alessio Dutto Daniela Caruso Andrea Tortore Giuseppe Lauria | 2020 | World Journal of Emergency Medicine2020，11，4： | 2 |
| 15 | MR differential diagnosis of acute deep grey matter pathology in paediatric patients显示文摘 | Carlo Cosimo Quattrocchi Daniela Longo Luciana Nogueira Delfino Yuri Errante Costanza Aiello Giuseppe Fariello Bruno Bernardi | 2013 | Pediatric Radiology2013，，： | 2 |
| 16 | Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study显示文摘 | Fabiana C. B. Bernardi Francine Felisberto Francieli Vuolo Fabricia Petronilho Daniela R. Souza Thais F. Luciano Cl??udio T. de Souza Cristiane Ritter Felipe Dal-Pizzol Neelam Khaper | 2012 | Oxidative Medicine and Cellular Longevity2012，，： | 2 |
| 17 | A mathematical model of the solid-polymer-electrolyte fuel cell 显示文摘 | Bernardi D M Verbrugge M | 1992 | Eleetrochem Soc1992，139，9： | 1 |
| 18 | Hypoglycemia, hypoxia, and ischemia in a corticostriatal slice preparation: electrophysiologic changes and ascorbyl radical formation显示文摘 | Pedersen JZ Bernardi G Centonze D | 1998 | J Cereb Blood Flow Metab1998，18，8： | 1 |
| 19 | Exited-state potential surface crossings in acrolein; A method for understanding the photochemistry and photophysics of a,b-enones显示文摘 | Mar Reguero Massimo Olivucci Fernando Bernardi | 1994 | J Am Chem Soc1994，116，： | 1 |
| 20 | The role of ecto-5'-nucleotidase/CD73 in glioma cell line显示文摘 | Bavaresco L Bernardi A Battastini Q | 2008 | Mol Cell Biochem2008，319，： | 1 |
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