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| 1 | Effect of dietary interventions on the intestinal microbiota of Mongolian hosts显示文摘The gut microbiota of Mongolian hosts has distinctive characteristics due to their meat- and dairyoriented daily diets and unique genotype.The aim of the present study was to investigate the effect of switching from the typical high protein and fat Mongolian diets to carbohydrate-rich meals composed principally of wheat,rice and naked oats on the host gut microbiota within 3 weeks.Our study took the advantage of the long sequence reads produced by the Pac Bio single molecule real-time sequencing technology to enable the profiling of subjects' gut microbiota communities along the diet intervention to the species precision.We found that the bacterial richness and diversity decreased apparently along the diet intervention.During the diet intervention,the gut microbiota composition displayed no significant difference at phylum level(with major phyla of Firmicutes,Bacteroidetes,Tenericutes and Proteobacteria).The relative abundances of some genera such as Bacteroidetes,Faecalibacterium,Roseburia,Alistipes,Streptococcus,and Oscillospira were significantly altered after the diet switching started.Notably,significant changes were also observed in the proportions of the species Bacteroides dorei,Bacteroides fragilis,Bacteroides thetaiotaomicron,Ruminococcus albus,Ruminococcus faecis,Roseburia faecis and Eubacterium ventriosum.These results have demonstrated that diet and host gut microbiota is closely linked. | Jing Li Haiyan Xu Zhihong Sun Qiangchuan Hou Lai-Yu Kwok Wuri Laga Yanjie Wang Huimin Ma Zhongjie Yu Bilige Menghe Heping Zhang | 2016 | Science Bulletin2016，61，20： | 14 |
| 2 | Isolation and identification of lactic acid bacteria from Tarag in Eastern Inner Mongolia of China by 16S rRNA sequences and DGGE analysis显示文摘 | Wenjun Liu Qiuhua Bao Jirimutu Manjun Qing Siriguleng Xia Chen Ting Sun Meihua Li Jiachao Zhang Jie Yu Menghe Bilige Tiansong Sun Heping Zhang | 2011 | Microbiological Research2011，，2： | 2 |
| 3 | Koumiss Consumption Alleviates Symptoms of Patients with Chronic Atrophic Gastritis:A Possible Link to Modulation of Gut Microbiota显示文摘Intestinal dysbiosis is closely related to a variety of medical conditions,especially gastrointestinal diseases.The present study aimed to investigate the effects of koumiss on chronic atrophic gastritis(CAG)in an outpatient clinical trial(n=10;all female subjects aged 41-55;body mass index ranging from 19.5 to 25.8).Each patient consumed three servings of koumiss per day(i.e.250 ml daily before each of 3 meals)for a 60-day period.The improvement of patients'symptoms was monitored by comparing the total scores of symptoms before and after the treatment.Meanwhile,the changes in the patients’fecal microbiota composition and specific blood parameters were determined.After the 60-day koumiss administration,significant symptom improvements were observed,as evidenced by the reduction of the total symptoms score,and changes in blood platelet and cholesterol levels.The changes in patients’fecal microbiota composition were found.The patients’fecal microbiota fell into two distinct enterotypes,Bacteroides dorei/Bacteroides uniformis(BB-enterotype)and Prevotella copri(P-enterotype).Significant less Bacteroides uniformis was found in the BB-enterotype patient group,while significant more butyrate-producing bacteria(e.g.Eubacterium rectale and Faecalibacterium prausnitzii)were found in the P-enterotype patient group,following koumiss administration.After stopping koumiss consumption,the relative abundance of some biomarker taxa returned to the original level,suggesting that the gut microbiota modulatory effect was not permanent and that continuous koumiss administration was required to maintain the therapeutic effect.In conclusion,koumiss consumption could alleviate the symptoms of CAG patients.Our results may help understand the mechanism of koumiss in alleviating CAG disease symptoms,facilitating the development of such products with desired therapeutic functions. | Chang Kun Li Qiang Chuan Hou Duolana Wuri Laga Hong Xin Liu Siqinbateer Bao Ying Sun Aoqi Lai-Yu Kwok He Ping Zhang Bilige Menghe | 2017 | Journal of Nutritional Oncology2017，2，1： | 2 |
| 4 | Computational field models in fire research and engineering显示文摘 | | 1994 | Fire Safety Sci1994，，19： | 1 |
| 5 | Fractal Solitons, Arbitrary Function Solutions, Exact Periodic Wave and Breathers for a Nonlinear Partial Differential Equation by Using Bilinear Neural Network Method显示文摘This paper extends a method, called bilinear neural network method(BNNM), to solve exact solutions to nonlinear partial differential equation. New, test functions are constructed by using this method. These test functions are composed of specific activation functions of single-layer model,specific activation functions of '2-2' model and arbitrary functions of '2-2-3' model. By means of the BNNM, nineteen sets of exact analytical solutions and twenty-four arbitrary function solutions of the dimensionally reduced p-gB KP equation are obtained via symbolic computation with the help of Maple. The fractal solitons waves are obtained by choosing appropriate values and the self-similar characteristics of these waves are observed by reducing the observation range and amplifying the partial picture. By giving a specific activation function in the single layer neural network model, exact periodic waves and breathers are obtained. Via various three-dimensional plots, contour plots and density plots,the evolution characteristic of these waves are exhibited. | ZHANG Runfa BILIGE Sudao CHAOLU Temuer | 2021 | Journal of Systems Science & Complexity2021，34，1： | 1 |
| 6 | Immunological evaluation of Lactobacillus casei Zhang: a newly isolated strain from koumiss in Inner Mongolia, China显示文摘 | YA Tuo ZHANG Qi-jin BILIGE M | 2008 | BMC Immunol2008，9，： | 1 |
| 7 | An extended simplest equation method and its application to several forms of the fifth-order KdV equation显示文摘 | Sudao Bilige Temuer Chaolu | 2010 | Applied Mathematics and Computation2010，216，： | 1 |
| 8 | Isolation and pre- liminary probiotic selection of lactobacilli from koumiss in Inner Mongolia 显示文摘 | WURINA WANG Liping MRNGHE Bilige | 2009 | J Basic Microbiol2009，49，6： | 1 |
| 9 | Isolation and preliminary probiotic selection of lactobacilli from kou- miss in Inner Mongolia显示文摘 | Wu Rina WANG Liping Mrnghe Bilige | 2009 | J Basic Microbiol2009，49，6： | 1 |
| 10 | Two Generalizations of the(G/G)- Expansion Method and Their Applications 显示文摘 | Sudao Bilige Temuer Chaolu | 2010 | Journal of Inner Mongolia University :Natural Science Edition2010，41，2： | 1 |
| 11 | An extended simplest equation method and its application to several forms of the fifth-order KdV equation显示文摘 | Sudao Bilige Temuer Chaolu | 2010 | Appl Math Comput2010，216，： | 1 |
| 12 | Application of the extended simplest equation method to the coupled Schrdinger-Boussinesq equation显示文摘 | Sudao Bilige Temuer Chaolu Wang X M | 2013 | Appl Math Comput2013，224，： | 1 |
| 13 | An extended simplest equationmethod and its application to several forms of the fifth-order KdV equa-tion显示文摘 | BILIGE SUDAO CHAOLU TEMUER | 2010 | Appl Math Comput2010，216，： | 1 |
| 14 | An extended simplest equation method and its application to several forms of the fifth-order KdV equation显示文摘 | Sudao Bilige Temuer Chaolu | 2010 | Appl Math Comput2010，216，11： | 1 |
| 15 | Application of the extended simplest equation method to the coupled Schr?dinger–Boussinesq equation显示文摘 | Sudao Bilige Temuer Chaolu Xiaomin Wang | 2013 | Applied Mathematics and Computation2013，，： | 1 |
| 16 | A Generalized G'/G-Expansion Method and Its Application显示文摘 | Sudao Bilige Temuer Chaolu | | 0，，01： | 1 |
| 17 | Two generalizations of the (G'/G)-expansion method and their applicatiom显示文摘 | Sudao Bilige Temuer Chaolu | 2010 | Journal of Inner Mongolia University2010，41，2： | 1 |
| 18 | Complete genome sequence of probiotic Lactobacillus plantarum P-8 with an- tibacterial activity显示文摘 | Zhang W Sun Z Bilige M | 2015 | Journal of Biotechuology2015，193，： | 1 |
| 19 | Study of the anti-inflammatory effect of the Traditional Mongolian Medicine Hohgardi-9 in acute lung injury显示文摘Background:Hohgardi-9 is a well-known traditional Mongolian drug that relieves cough and removes phlegm.Although it is widely used to treat lung diseases clinically,Hohgardi-9’s bioactive constituents and mechanism of action are unknown.In this study,we explored the bioactive compounds in Hohgardi-9 and the mechanism underlying its therapeutic effect against acute lung injury(ALI).Methods:We obtained the main components of Hohgardi-9 and analyzed the targets related to ALI by searching the traditional Chinese medicine systems pharmacology database and existing literature.Then,we constructed the compound-target network using Cytoscape 3.8.0 software to obtain the bioactive compounds in Hohgardi-9 against ALI.We used a string database to investigate the interaction between the possible protein targets of Hohgardi-9.We also performed Gene Ontology function annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis to predict its anti-ALI mechanism.Further,to verify the therapeutical effects of Hohgardi-9,we used an ALI rat model and analyzed the components of Hohgardi-9 found in the rat plasma using ultra-high-performance liquid chromatography coupled with Q-Exactive mass spectrometry.Results:The network pharmacology and plasma component analysis showed that Hohgardi-9 contained 31 potentially bioactive components,including quercetin,herbacetin,izoteolin,and columbinetin acetate,which affected the NF-κB,TLR,and TNF signaling pathways via key targets,such as RELA(p65)and TLR4.The in vivo experiments using hematoxylin and eosin staining revealed that Hohgardi-9 significantly improved lung tissue injury and pulmonary edema in ALI rats.Simultaneously,Hohgardi-9 significantly reduced the expression levels of genes encoding inflammatory factors,such as TRL4,TNF-α,IL-1β,and ICAM1,in the lungs of ALI rats.Conclusion:Hohgardi-9 alleviated ALI by inhibiting inflammation-related gene expression through its active ingredients,such as quercetin and herbacetin. | Aodeng Qimuge Tegexi Baiyin Bilige Bilige Temuqile Temuqile Sha-Na Chen Ying-Chun Bai Wuhan Qimuge Siqin Siqin Hugejile Hang Chang-Shan Wang Huricha Baigued De-Zhi Yang | 2023 | Traditional Medicine Research2023，8，11： | 0 |
| 20 | Metabonomics study of liver and kidney subacute toxicity induced by garidi-5 in rats显示文摘Objective:Metabonomics was used to analyze and explore the biomarkers and possible mechanisms of liver and kidney subacute toxicity induced by garidi-5 in rats.Methods:Taking garidi-5 as the target drug and SD rats as the research objects,each administration group except the normal group was intragastric administration of the corresponding drug solution for28 d.The serum,liver and kidney samples of rats were detected by metabolomics and characterized by principal component analysis(PCA)and partial least squares discriminant analysis(PLS-DA)to identify the sensitive markers and metabolic pathways of liver and kidney subacute toxicity.Results:Metabolomics analysis showed that compared with the normal group(Z),the 52,64 and 54 different metabolites were identified in the serum,liver and kidney samples of garidi-5 high dose group(GG),which were mainly enriched in ABC transporters,arginine and proline metabolism,nicotinate and nicotinamide metabolism,central carbon metabolism in cancer pathways.Conclusion:The preliminarily suggested that garidi-5 can damage the liver and kidney by affecting the ABC transporters,arginine and proline metabolism,nicotinate and nicotinamide metabolism pathways,etc.Trimethylamine N-oxide,L-pyroglutamic acid,glycine-betaine,xanthine,glutathione,L-leucine,cytidine,L-arginine,spermidine,urea,5-aminovaleric acid,creatine,L-glutamic acid,1-methylnicotinamide and S-adenosyl-L-methionine can be used as potential biomarkers of liver and kidney toxicity sensitivity. | Wurihan Aodungerle Bilige Lili Sirguleng Aduqinfu Meirong Bai | 2022 | Chinese Herbal Medicines2022，14，3： | 0 |
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