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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Soil Erosion Changes over the Past Five Decades in the Red Soil Region of Southern China显示文摘This paper reports the dynamic changes of soil and water loss in the red soil region of Southern China since the 1950s. The red soil region covers eight provinces: Jiangxi, Zhejiang, Fujian, Anhui, Hubei, Hunan, Guangdong and Hainan. From the 1950s to 1986, the annual rate of soil erosion increased by 3.4%. From 1986 to 1996 and from 1996 to 2000, the annual rates of soil erosion decreased by 2.0% and 0.32%, respectively. Field surveys showed that from 2000 to 2005, the area of soil and water loss decreased annually by 1.2%. This decrease was a result of large-scale erosion control activities across China. Although the eroded soil has been restored, the restoration process is very slow and full restoration will take a long time. Our report suggests that controlling soil and water loss is a challenging task, and additional measures must be taken to effectively control the soil erosion in the red soil region. | LIANG Yin LI Decheng LU Xixi YANG Xuan PAN Xianzhang MU Huan SHI Deming ZHANG Bin | 2010 | Journal of Mountain Science2010，7，1： | 18 |
| 3 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 4 | A study on building data warehouse of hospital information system显示文摘有简单统计函数的背景存在医院信息系统不能满足当前的管理需要。医院资源与在医院之中的私有财产权利是分布式的,是众所周知的,例如在医疗服务的地区性的协作的情况中。在这研究,有效地集成并且充分利用医药数据,我们建议为医院信息系统为方法建模的一个数据仓库。方法能也为一个分布式医院的医疗服务系统被采用。保证医院信息支持护理的多样的需要的方法,医院信息系统的框架有三层:datacenter 层,系统功能层,和用户接口层。这份报纸在从数据主题的建立处理医院信息到一个数据模型的设计到一个数据仓库的建立讨论一个数据仓库管理系统的角色。联机分析处理工具从很多个不同角度帮助用户友好的多维的分析提取要求的数据和信息。数据仓库的结果使用改进联机分析处理并且在决定支持系统减轻缺乏。医院信息系统有效地基于一个数据仓库采用统计分析和数据采矿技术处理历史的数据的巨大的数量,并且总结从临床并且为决策的医院信息。这份报纸建议一个数据的使用的结论为一个医院信息系统储藏,明确地为医院信息到的主题的一个数据仓库决定纬度,等等当模特儿。处理耐心的信息作为在医院信息管理的情况中表明这个方法的实用性的一个例子被给。数据仓库技术是一种演变技术,并且越来越多的决定支持信息由数据采矿提取,与决策,技术为进一步的研究被要求。 | LI Ping WU Tao CHEN Mu ZHOU Bin XU Wei-guo | 2011 | Chinese Medical Journal2011，，15： | 10 |
| 5 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 6 | Preliminary results of TiO_2 mapping using Imaging Interferometer data from Chang'E-1显示文摘The distribution of titanium abundance on the lunar surface is important knowledge for lunar geologic studies and future resource utilization.In this paper,we develop a preliminary model based on'ground truths'from Apollo and Luna sample-return sites to produce a titanium abundance map from Chang’E-1 Imaging Interferometer(IIM) images.The derived TiO2 abundances are validated with Clementine UVVIS results in several regions,including lunar highlands neighboring the Apollo 16 landing site,and high-Ti and low-Ti maria near the standard site of Mare Serenitatis(MS2) .The validation results show that TiO2 abundances modeled with Chang’E-1 IIM data are overestimated for highlands(~0.7 wt.%) and low-Ti maria(~1.5 wt.%) and underestimated for high-Ti maria(~0.8 wt.%). | LING ZongCheng ZHANG Jiang LIU JianZhong ZHANG WenXi ZHANG GuangLiang LIU Bin REN Xin MU LingLi LIU JianJun LI ChunLai | 2011 | Chinese Science Bulletin2011，56，20： | 10 |
| 7 | Green Production Technology of the Monomer of Nylon-6: Caprolactam显示文摘 | Baoning Zong Bin Sun Shibiao Cheng Xuhong Mu Keyong Yang Junqi Zhao Xiaoxin Zhang Wei Wu | 2017 | Engineering2017，3，3： | 9 |
| 8 | Recent Progress on Visible Light Responsive Heterojunctions for Photocatalytic Applications显示文摘Photocatalysis has attracted much attention in recent years due to its potential in solving energy and environmental issues.Even though numerous achievements have been made,the photocatalytic systems developed to date are still far from practical applications due to the low efficiency and poor durability.Efficient light absorption and charge separation are two of the key factors for the exploration of high performance photocatalytic systems,which is generally difficult to be obtained in a single photocatalyst.The combination of various materials to form heterojunctions provides an effective way to better harvest solar energy and to facilitate charge separation and transfer,thus enhancing the photocatalytic activity and stability.This review concisely summarizes the recent development of visible light responsive heterojunctions,including the preparation and performances of semiconductor/semiconductor junctions,semiconductor/cocatalyst junctions,semiconductor/metal junctions,semiconductor/nonmetal junctions,and surface heterojunctions,and their mechanism for enhanced light harvesting and charge separation/transfer. | Songcan Wang Jung-Ho Yun Bin Luo Teera Butburee Piangjai Peerakiatkhajohn Supphasin Thaweesak Mu Xiao Lianzhou Wang | 2017 | Journal of Materials Science & Technology2017，33，1： | 9 |
| 9 | Solar energy conversion on g-C3N4 photocatalyst:Light harvesting,charge separation,and surface kinetics显示文摘Photocatalysis, which utilizes solar energy to trigger chemical reactions, is one of the most desirable solar-energy-conversion approaches. Graphitic carbon nitride(g-C_3N_4), as an attractive metal-free photocatalyst, has drawn worldwide research interest in the area of solar energy conversion due to its easy synthesis, earth-abundant nature, physicochemical stability and visible-light-responsive properties. Over the past ten years, g-C_3N_4 based photocatalysts have experienced intensive exploration, and great progress has been achieved. However, the solar conversion efficiency is still far from industrial applications due to the wide bandgap, severe charge recombination, and lack of surface active sites. Many strategies have been proposed to enhance the light absorption, reduce the recombination of charge carriers and accelerate the surface kinetics. This work makes a crucial review about the main contributions of various strategies to the light harvesting, charge separation and surface kinetics of g-C_3N_4 photocatalyst. Furthermore, the evaluation measurements for the enhanced light harvesting, reduced charge recombination and accelerated surface kinetics will be discussed. In addition, this review proposes future trends to enhance the photocatalytic performance of g-C_3N_4 photocatalyst for the solar energy conversion. | Mu Xiao Bin Luo Songcan Wang Lianzhou Wang | 2018 | Journal of Energy Chemistry2018，27，4： | 9 |
| 10 | Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study显示文摘 | Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong | 2016 | Chinese Medical Journal2016，，22： | 8 |
| 11 | Utilization of Ogura CMS germplasm with the clubroot resistance gene by fertility restoration and cytoplasm replacement in Brassica oleracea L显示文摘Clubroot disease,a major plant root disease caused by Plasmodiophora brassicae,has become one of the most destructive diseases among cultivated cruciferous vegetables.However,clubroot-resistant Brassica oleracea materials are rare.A few clubroot-resistant cabbage varieties are available on the market,but all are Ogura cytoplasmic male sterile(CMS)types.Therefore,in this study,to reutilize the clubroot-resistant Ogura CMS germplasm of cabbage,a new fertility-restored Ogura CMS material,16Q2-11,was used as a bridge to transfer the clubroot resistance(CR)gene from the Ogura CMS cytoplasm to the normal cytoplasm by a two-step method(a fertility restoration and cytoplasm replacement method).In the first cross for fertility restoration of Ogura CMS clubroot-resistant cabbage(FRCRC),16Q2-11 was used as a restorer to cross with Ogura CMS materials containing the CR gene CRb2.Eleven Rfo-positive progenies were generated,of which four contained CRb2:F8-514,F8-620,F8-732 and F8-839.After inoculation with race 4 of P.brassicae,these four CRb2-positive individuals showed resistance.Furthermore,F8-514 and F8-839 were then used as male parents in the second cross of FRCRC to cross with cabbage inbred lines,resulting in the successful introgression of the CRb2 gene into the inbred lines.All offspring produced from this step of cross,which had a normal cytoplasm,showed a high resistance to race 4 of P.brassicae and could be utilized for the breeding of clubrootresistant cabbage varieties in the future.This is the first time that the Ogura CMS restorer has been used to restore the fertility of Ogura CMS clubroot-resistant cabbages,which could improve germplasm diversity in cabbage and provide a reference method for using CMS germplasm in Brassica crops. | Wenjing Ren Zhiyuan Li Fengqing Han Bin Zhang Xing Li Zhiyuan Fang Limei Yang Mu Zhuang Honghao Lv Yumei Liu Yong Wang Hailong Yu Yangyong Zhang | 2020 | Horticulture Research2020，7，1： | 7 |
| 12 | Highly sensitive wearable sensor based on a flexible multi-layer graphene film antenna显示文摘The use of advanced carbon nanomaterials for flexible antenna sensors has attracted great attention due to their outstanding electromechanical properties. However, carbon nanomaterial based composites have yet to overcome drawbacks, such as low conductivity and toughness. In this work, a flexible multi-layer graphene film(FGF) with a high conductivity of 10~6 S/m for antenna based wearable sensors is investigated. A 1.63 GHz FGF antenna sensor exhibits significantly high strain sensitivity of 9.8 for compressive bending and 9.36 for tensile bending, which is super than the copper antenna sensor(5.39 for compressive bending and 4.05 for tensile bending). Moreover, the FGF antenna sensor shows very good mechanical flexibility, reversible deformability and structure stability, and thus is well suited for applications like wearable devices and wireless strain sensing. | Danli Tang Qianlong Wang Zhe Wang Quantao Liu Bin Zhang Daping He Zhi Wu Shichun Mu | 2018 | Science Bulletin2018，63，9： | 7 |
| 13 | Intensive phototherapy vs.exchange transfusion for the treatment of neonatal hyperbilirubinemia:a multicenter retrospective cohort study显示文摘Background:Intensive phototherapy(IPT)and exchange transfusion(ET)are the main treatments for extreme hyperbilirubinemia.However,there is no reliable evidence on determining the thresholds for these treatments.This multicenter study compared the effectiveness and complications of IPT and ET in the treatment of extreme hyperbilirubinemia.Methods:This retrospective cohort study was conducted in seven centers from January 2015 to January 2018.Patients with extreme hyperbilirubinemia that met the criteria of ET were included.Patients were divided into three subgroups(low-,medium-,and high-risk)according to gestational week and risk factors.Propensity score matching(PSM)was performed to balance the data before treatment.Study outcomes included the development of bilirubin encephalopathy,duration of hospitalization,expenses,and complications.Mortality,auditory complications,seizures,enamel dysplasia,ocular motility disorders,athetosis,motor,and language development were evaluated during follow-up at age of 3 years.Results:A total of 1164 patients were included in this study.After PSM,296 patients in the IPT only group and 296 patients in the IPT plus ET group were further divided into the low-,medium-,and high-risk subgroups with 188,364,and 40 matched patients,respectively.No significant differences were found between the IPT only and IPT plus ET groups in terms of morbidity,complications,and sequelae.Hospitalization duration and expenses were lower in the low-and medium-risk subgroups in the IPT only group.Conclusions:In this study,our results suggest that IPT is a safe and effective treatment for extreme hyperbilirubinemia.The indication of ET for patients with hyperbilirubinemia could be stricter.However,it is necessary to have a contingency plan for emergency ET as soon as IPT is commenced especially for infants with risk factors.If IPT can be guaranteed and proved to be therapeutic,ET should be avoided as much as possible. | Meng Zhang Yang He Jun Tang Wenbin Dong Yong Zhang Benjin Zhang Hong Wan Quanmin Deng Lirong Guan Bin Xia Zhong Chen Min Ge Jing Zhao Wenxing Li Jingjun Pei Yi Qu Dezhi Mu | 2022 | Chinese Medical Journal2022，，5： | 7 |
| 14 | Tantalum (Oxy)Nitride: Narrow Bandgap Photocatalysts for Solar Hydrogen Generation显示文摘 | Mu Xiao Songcan Wang Supphasin Thaweesak Bin Luo Lianzhou Wang | 2017 | Engineering2017，3，3： | 7 |
| 15 | A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury显示文摘Collagen scaffolds possess a three-dimensional porous structure that provides sufficient space for cell growth and proliferation,the passage of nutrients and oxygen,and the discharge of metabolites.In this study,a porous collagen scaffold with axially-aligned luminal conduits was prepared.In vitro biocompatibility analysis of the collagen scaffold revealed that it enhances the activity of neural stem cells and promotes cell extension,without affecting cell differentiation.The collagen scaffold loaded with neural stem cells improved the hindlimb motor function in the rat model of T8 complete transection and promoted nerve regeneration.The collagen scaffold was completely degraded in vivo within 5 weeks of implantation,exhibiting good biodegradability.Rectal temperature,C-reactive protein expression and CD68 staining demonstrated that rats with spinal cord injury that underwent implantation of the collagen scaffold had no notable inflammatory reaction.These findings suggest that this novel collagen scaffold is a good carrier for neural stem cell transplantation,thereby enhancing spinal cord repair following injury.This study was approved by the Animal Ethics Committee of Nanjing Drum Tower Hospital(the Affiliated Hospital of Nanjing University Medical School),China(approval No.2019AE02005)on June 15,2019. | Shuo Liu Yuan-Yuan Xie Liu-Di Wang Chen-Xu Tai Dong Chen Dan Mu Yan-Yan Cui Bin Wang | 2021 | Neural Regeneration Research2021，16，11： | 6 |
| 16 | Natural products as LSD1 inhibitors for cancer therapy显示文摘Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, natural product-based drug discovery is now reaching a new era. Natural products have also shown promise in epigenetic drug discovery, some of them have advanced into clinical trials or are presently being used in clinic. The histone lysine specific demethylase1(LSD1), an important class of histone demethylases, has fundamental roles in the development of various pathological conditions. Targeting LSD1 has been recognized as a promising therapeutic option for cancer treatment. Notably, some natural products with different chemotypes including protoberberine alkaloids, flavones, polyphenols, and cyclic peptides have shown effectiveness against LSD1. These natural products provide novel scaffolds for developing new LSD1 inhibitors. In this review, we mainly discuss the identification of natural LSD1 inhibitors, analysis of the co-crystal structures of LSD1/natural product complex, antitumor activity and their modes of action. We also briefly discuss the challenges faced in this field. We believe this review will provide a landscape of natural LSD1 inhibitors. | Yuan Fang Chao Yang Zhiqiang Yu Xiaochuan Li Qingchun Mu Guochao Liao Bin Yu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 6 |
| 17 | Expression pattern of neural synaptic plasticity marker-Arc in different brain regions induced by conditioned drug withdrawal from acute morphine-dependent rats显示文摘 | Mu LI Yuan-yuan HOU Bin LU Jie CHEN Zhi-qiang CHI Jing-gen LIU | 2009 | Acta Pharmacologica Sinica2009，30，3： | 5 |
| 18 | Effects of 2'-O-methyl nucleotide on ligation capability of T4 DNA ligase显示文摘为了推进,理解结扎机制, T4 DNA 结扎效率上的 2-O-methyl 核苷酸(2 预兆) 的效果被调查。荧光回声精力转移试金被用来由 T4 DNA ligase 监视加入刻痕的进程。结果证明在刻痕的 5 结束和 3 结束的替换减少了在 48.7% | Bin Zhao Zhaoxue Tong Guojie Zhao Runqing Mu Hong Shang Yifu Guan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 5 |
| 19 | From waste hot-pot oil as carbon precursor to development of recyclable attapulgite/carbon composites for wastewater treatment显示文摘The utilization of waste products as valuable materials was a technical imperative for waste management. In this study, the cost-effective attapulgite/carbon(APT/C) composite was developed for wastewater treatment using waste hot-pot oil as a carbon precursor through a facile one-step calcination process. The APT/C composite prepared at 300°C exhibited the excellent adsorption capacity and rapid equilibrium rate over a broad p H range for the removal of various pollutants. More importantly, the removal ratios of the composites toward Methyl Violet and tetracycline still remained 77.6% and 60.2% of the initial adsorption capacity after ten adsorption–regeneration cycles via a facile thermal regeneration strategy, respectively.Beyond all doubt, this research provided a feasible and economical way for the sustainable utilization of waste hot-pot oil in wastewater treatment, achieving the concept of disposal waste with waste and recycling. | Jie Tang Bin Mu Li Zong Aiqin Wang | 2019 | Journal of Environmental Sciences2019，31，1： | 5 |
| 20 | Differentiation of a Miniature Inverted Transposable Element (MITE) System in Asian Rice Cultivars and Its Inference for a Diphyletic Origin of Two Subspecies of Asian Cultivated Rice显示文摘在现在的学习,我们在在亚洲栽培米饭(Oryza sativa L.) 的 102 个变化作为 mPing 知道的一个缩小的转换 TransposableElement (螨) 系统上报导调查。我们发现 mPing 人口能被概括进二个家庭, mPing-1 和 mPing-2,根据他们的顺序结构。进一步的分析证明 mPing 的这二个家庭在米饭的二亚种在他们的分发模式有重要偏爱,也就是 O。sativa ssp.japonica 和 indica。O。sativa 装饰用的梨树作为一个一般特点有 mPing-1 的一个更高的比例,而 O。sativa indica 有 mPing-2 的一个更高的比例。我们也在一个加倍的单倍体(DH ) 检验了 mPing 系统 jingxi 的跨 breeding 人口 17 (装饰用的梨树) 并且 zhaiyeqing 8 (indica ) 变化并且观察到 mPing 系统紧没被连接到主要 subspecies-determininggenes。而且,我们在亚洲普通野米饭 O.rufipogon 的 28 就职检查了 mPing 系统并且在 O 发现了 mPing 系统。rufipogon。在 O 的 mPing 系统的分发模式。rufipogon 显示亚洲人的来自二个祖先的起源栽培了米饭 O。sativa 种类。我们没在另一 20 Oryza 种类发现 mPing 系统。这些结果证实了一个以前的假设那 O。rufipogon 和 O。nivara 种类是 O 的近亲。sativa 并且 O 的二现存亚种。sativa 从 O.rufipogon 的相应生态型独立地被发展…… | Hao Hu Jie Mu Hong-Ji Zhang Yue-Zhi Tao Bin Han | 2006 | Journal of Integrative Plant Biology2006，48，3： | 4 |
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