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| 1 | Clinical study of arterial anatomic variations for transradial coronary procedure in Chinese population显示文摘光线的动脉当前是的背景为冠的干预过程认为是一条有用途径。光线的动脉的足够的解剖信息应该在执行 transradial 是有用的冠的过程。关于中国人口的很少数据在这个领域里被获得了。因此,我们试着在 3000 个盒子,光线的动脉和 subclavical 的一件估计的样品评估发生和异常模式,和他们对干预 procedure.Methods 的影响的临床的意义动脉 angiography 在鞘和冠的 angiography (CA ) 的插入以后被执行。包括分支异例,光线的动脉的扭曲和程序的特征的可评估的数据被分析。过程成功被定义为 CA 或没有在这研究改变到另外的 routes.Results ,与起始的光线的动脉途径完成的经皮的冠的干预(一种总线标准), CA 的 1897 个盒子被承担,与一种总线标准相结合的 CA 的 1103 个盒子是 transradial 干预( TRI )的 performed.The 成功率是96.6%( 2899/3000 )。在 44 种情况中的途径被改变到 contralateral 光线的动脉和 57 个盒子与起始的光线的动脉途径由于失败被改变到臂的动脉或大腿骨的动脉。上面的手足动脉的 angiography 在所有情况中被执行。上面的手足动脉的解剖变化在 610 个病人(20.3%)被注意,它包括了光线的动脉(5.0%)的曲折配置,发育不全(2.2%),桡尺骨的循环(1.1%),光线的动脉(7.7%)的反常起源,光线的动脉(1.4%)的狭窄,臂的动脉(0.9%)的一种曲折配置,一锁骨下的动脉(1.9%)的曲折配置, lusoria 锁骨下的动脉(0.1%),和锁骨下的动脉吸藏(0.03%)。在正常人口的程序的成功率比在变化组高(97.6% 对 93.0% , P < 0.001 ) 。另外,除了光线的动脉吸藏的复杂并发症的另外的程序的结果和发生比光线的动脉的解剖变化是的变化 group.Conclusions 也显著地优异普通,在 trans 光线的途径完成重要限制。适当仪器和理解的一些技巧的选择是有用的克服障碍并且有效地减少学习曲线。 | NIE Bin ZHOU Yu-jie LI Guo-zhong SHI Dong-mei WANG Jian-long | 2009 | Chinese Medical Journal2009，，18： | 21 |
| 2 | Generation of a monkey with MECP2 mutations by TALEN-based gene targeting显示文摘Gene editing in model organisms has provided critical insights into brain development and diseases. Here, we report the generation of a cynomolgus monkey(Macaca fascicularis) carrying MECP2 mutations using transcription activator-like effector nucleases(TALENs)-mediated gene targeting. After injecting TALENs mRNA into monkey zygotes achieved by in vitro fertilization and embryo transplantation into surrogate monkeys, we obtained one male newborn monkey with an MECP2 deletion caused by frameshifting mutation in various tissues. The monkey carrying the MECP2 mutation failed to survive after birth, due to either the toxicity of TALENs or the critical requirement of MECP2 for neural development. The level of MeCP2 protein was essentially depleted in the monkey's brain. This study demonstrates the feasibility of introducing genetic mutations in non-human primates by site-specific gene-editing methods. | Zhen Liu Xue Zhou Ying Zhu Zhi-Fang Chen Bin Yu Yan Wang Chen-Chen Zhang Yan-Hong Nie Xiao Sang Yi-Jun Cai Yue-Fang Zhang Chen Zhang Wen-Hao Zhou Qiang Sun Zilong Qiu | 2014 | Neuroscience Bulletin2014，30，3： | 17 |
| 3 | The Practice of Forward Prospecting of Adverse Geology Applied to Hard Rock TBM Tunnel Construction: The Case of the Songhua River Water Conveyance Project in the Middle of Jilin Province显示文摘 | Shucai Li Lichao Nie Bin Liu | 2018 | Engineering2018，4，1： | 15 |
| 4 | Correlation between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models显示文摘瞄准:在老鼠在导致免疫者、导致 CCL4 的肝纤维变性模型评估在 TIMP-1 表示和肝纤维变性之间的浆液 TIMP-1 水平和关联。方法:导致免疫者、导致 CCL4 的肝纤维变性模型被地塞米松(0.01 mg ) 和 CCL4 分别地建立。浆液 TIMP-1 水平与 ELISA 被检测,当肝活体检视的组织病理学说的等级被评估时。枪兵等级关联测试被用来在二个纤维变性模型分析在 TIMP-1 表示和肝的纤维变性之间的关联的差别。而且,原位杂交被用来在二个模型决定 TIMP-1 mRNA 的表示差别。结果:积极关联在有免疫力的劝诱的组的浆液 TIMP-1 水平和相应老鼠的纤维变性肝的组织病理学说的阶段之间存在(枪兵等级关联测试, r = 0.812, P <
0.05 ) ,并且 TIMP-1 mRNA 的积极原位杂交信号是强壮的。在导致 CCL4 的肝纤维变性模型,在浆液 TIMP-1 水平和肝的纤维变性的严厉之间的关联不是统计上重要的(枪兵等级关联测试, r = 0.229, P >
0.05 ) 。并且与导致免疫者的模型,相比, TIMP-1 mRNA 的积极原位杂交信号是更弱的,当表达式变化在一样的严厉的肝的纤维变性是更高的时。结论:在在二个老鼠肝纤维变性模型的 TIMP-1 表示和肝纤维变性之间的关联是不同的。在导致免疫者的模型,,浆液 TIMP-1 水平能在导致 CCL4 的模型,反映肝纤维变性的严厉在浆液 TIMP-1 水平和肝的纤维变性的严厉之间的关联不是统计上重要的。 | Qing-He Nie Ya-Fei Zhang Yu-Mei Xie Xin-Dong Luo Bin Shao Jun Li Yong-Xing Zhou | 2006 | World Journal of Gastroenterology2006，12，19： | 12 |
| 5 | Plasma neutrophil-gelatinase-associated lipocalin and cystatin C could early diagnose contrast-induced acute kidney injury in patients with renal insufficiency undergoing an elective percutaneous coronary intervention显示文摘 | LIU Xiao-li WANG Zhi-jian YANG Qing YU Miao SHEN Hua NIE Bin HAN Hong-ya GAO Fei ZHOU Yu-jie | 2012 | Chinese Medical Journal2012，，6： | 12 |
| 6 | Detecting and monitoring of water inrush in tunnels and coal mines using direct current resistivity method:A review显示文摘Detecting, real-time monitoring and early warning of underground water-bearing structures are critically important issues in prevention and mitigation of water inrush hazards in underground engineering.Direct current(DC) resistivity method is a widely used method for routine detection, advanced detection and real-time monitoring of water-bearing structures, due to its high sensitivity to groundwater. In this study, the DC resistivity method applied to underground engineering is reviewed and discussed,including the observation mode, multiple inversions, and real-time monitoring. It is shown that a priori information constrained inversion is desirable to reduce the non-uniqueness of inversion, with which the accuracy of detection can be significantly improved. The focused resistivity method is prospective for advanced detection; with this method, the flanking interference can be reduced and the detection distance is increased subsequently. The time-lapse resistivity inversion method is suitable for the regions with continuous conductivity changes, and it can be used to monitor water inrush in those regions. Based on above-mentioned features of various methods in terms of benefits and limitations, we propose a three-dimensional(3D) induced polarization method characterized with multi-electrode array, and introduce it into tunnels and mines combining with real-time monitoring with time-lapse inversion and cross-hole resistivity method. At last, the prospective applications of DC resistivity method are discussed as follows:(1) available advanced detection technology and instrument in tunnel excavated by tunnel boring machine(TBM),(2) high-resolution detection method in holes,(3) four-dimensional(4D)monitoring technology for water inrush sources, and(4) estimation of water volume in water-bearing structures. | Shucai Li Bin Liu Lichao Nie Zhengyu Liu Mingzhen Tian Shirui Wang Maoxin Su Qian Guo | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，4： | 12 |
| 7 | Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes显示文摘 | Qiaozhen Liu Rui Yang Xiuzhen Huang Hui Zhang Lingjuan He Libo Zhang Xueying Tian Yu Nie Shengshou Hu Yan Yan Li Zhang Zengyong Qiao Qing-Dong Wang Kathy O Lui Bin Zhou | 2016 | Cell Research2016，26，1： | 12 |
| 8 | Predictors and in-hospital outcomes of preoperative acute kidney injury in patients with type A acute aortic dissection显示文摘BackgroundAcute 肾损害(AKI ) 在为尖锐大动脉的解剖(AAD ) 的外科以后是普通的并且增加在里面医院和长期的死亡。然而,很少数据与类型在病人在早外科手术前的 AKI 的临床、预示的关联上存在 AAD。我们试图在病人在在里面医院结果上决定外科手术前的 AKI 的发生和 AKI 的影响与打阿德梅索兹夫罗姆·梅 2009 到 2014 年 6 月,我们回顾地注册了为类型从症状发作和收到的开的外科在 48 h 以内进入我们的医院的 178 个病人 AAD。病人被划分成没有 AKI 和 AKI 组并且在 surgery.ResultsAKI 发生在 41 个病人(23.0%) 以前,根据 KDIGO 标准与 AKI 上演了严厉。在里面医院复杂并发症的发生在有与没有 AKI 相比的外科手术前的 AKI 的病人是显著地更高的(41.5% 对 9.5% , P <0.001 ) ,包括肾的梗塞(7.3% 对 0, P = 0.012 ) ,并且它与 AKI 严厉增加了(P 趋势 <0.001 ) 。尽管没有重要差别被发现,没有 AKI,有 AKI 的病人与病人相比有更高的在里面医院死亡(14.6% 对 5.1% , P = 0.079 ) 。Multivariate 分析显示那男性,承认上的心脏舒张的血压和双边的肾的动脉参与 AAD.ConclusionsEarly 是在有类型 A 的病人的外科手术前的 AKI 的独立预言者在外科前的 AKI 在有类型的病人是普通的 AAD,并且与增加的在里面医院复杂并发症被联系。男性,承认上的心脏舒张的血压和双边的肾的动脉参与是为外科手术前的 AKI 的主要预言者。 | Xiao WANG Hong-Mei PEN Chun-Yan HU Bin QUE Hui AI Chun-Mei WANG Li-Zhong SUN Shao-Ping NIE | 2016 | Journal of Geriatric Cardiology2016，13，8： | 12 |
| 9 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 10 | Deep learning applied to two-dimensional color Doppler flow imaging ultrasound images significantly improves diagnostic performance in the classification of breast masses:a multicenter study显示文摘Background:The current deep learning diagnosis of breast masses is mainly reflected by the diagnosis of benign and malignant lesions.In China,breast masses are divided into four categories according to the treatment method:inflammatory masses,adenosis,benign tumors,and malignant tumors.These categorizations are important for guiding clinical treatment.In this study,we aimed to develop a convolutional neural network(CNN)for classification of these four breast mass types using ultrasound(US)images.Methods:Taking breast biopsy or pathological examinations as the reference standard,CNNs were used to establish models for the four-way classification of 3623 breast cancer patients from 13 centers.The patients were randomly divided into training and test groups(n=1810 vs.n=1813).Separate models were created for two-dimensional(2D)images only,2D and color Doppler flow imaging(2D-CDFI),and 2D-CDFI and pulsed wave Doppler(2D-CDFI-PW)images.The performance of these three models was compared using sensitivity,specificity,area under receiver operating characteristic curve(AUC),positive(PPV)and negative predictive values(NPV),positive(LR+)and negative likelihood ratios(LR-),and the performance of the 2D model was further compared between masses of different sizes with above statistical indicators,between images from different hospitals with AUC,and with the performance of 37 radiologists.Results:The accuracies of the 2D,2D-CDFI,and 2D-CDFI-PW models on the test set were 87.9%,89.2%,and 88.7%,respectively.The AUCs for classification of benign tumors,malignant tumors,inflammatory masses,and adenosis were 0.90,0.91,0.90,and 0.89,respectively(95%confidence intervals[CIs],0.87-0.91,0.89-0.92,0.87-0.91,and 0.86-0.90).The 2D-CDFI model showed better accuracy(89.2%)on the test set than the 2D(87.9%)and 2D-CDFI-PW(88.7%)models.The 2D model showed accuracy of 81.7%on breast masses≤1 cm and 82.3%on breast masses>1 cm;there was a significant difference between the two groups(P<0.001).The accuracy of the CNN classifications for the test set(89.2%)was significantly higher than that of all the radiologists(30%).Conclusions:The CNN may have high accuracy for classification of US images of breast masses and perform significantly better than human radiologists.Trial registration:Chictr.org,ChiCTR1900021375;http://gffzz62a03ee25e6f4a77h0xbfw5qu0c0o66on.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=33139. | Teng-Fei Yu Wen He Cong-Gui Gan Ming-Chang Zhao Qiang Zhu Wei Zhang Hui Wang Yu-Kun Luo Fang Nie Li-Jun Yuan Yong Wang Yan-Li Guo Jian-Jun Yuan Li-Tao Ruan Yi-Cheng Wang Rui-Fang Zhang Hong-Xia Zhang Bin Ning Hai-Man Song Shuai Zheng Yi Li Yang Guang | 2021 | Chinese Medical Journal2021，，4： | 11 |
| 11 | Emergency material scheduling optimization model and algorithms:A review显示文摘In the emergency management of disruptions,efficient emergency material scheduling(EMS) is a key factor to save people’s lives and reduce loss.Based on the literature of EMS and related areas in recent years,the research was summarized from two aspects of EMS optimization model and algorithms.It is concluded that the EMS optimization models mainly aim at the shortest time,shortest distance,minimum cost,maximum satisfaction and fairness,etc.The constraints usually include the quantity of supply depots,relief supply and vehicles,the types of commodities,the road network conditions,the budgets and the demand forecast of emergency materials.Multi-objective model is more complex and it usually considers more than one objective.To find the optimized solution,the multiobjective model with complex constraints needs more efficient algorithms.The existing algorithms,including mathematic algorithm and heuristic algorithm,have been categorized.For NP-hard(non-deterministic polynomial hard) problems,heuristic algorithms should be designed,which mainly include genetic algorithm(GA),ant colony optimization(ACO),particle swarm optimization(PSO),etc.Based on the characteristics of the optimization model and various algorithms,appropriate algorithm or tools should be chosen and designed to obtain the optimized solution of EMS model.Finally,the development trends of EMS optimization model and algorithm in the future are proposed. | Hui Hu Jing He Xiongfei He Wanli Yang Jing Nie Bin Ran | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，5： | 11 |
| 12 | Safety and feasibility of repeated percutaneous transradial coronary intervention in the same route显示文摘背景光线的途径逐渐地被用作使用的更多的过程重复了的大腿骨的 access.And 的一种选择冠的干预( r-TRI )是的 transradial performed.However ,关于 r-TRI 的很少数据是 obtained.Therefore ,我们用一样的 route.Methods 调查了 r-TRI 的安全和可行性经历 r-TRI 的 423 个连续合格病人的一个总数与起始的 TRI ( i-TRI )在 r-TRI 组,和 846 个病人被注册在匹配的 2:1 被分到 i-TRI | Nie Bin Zhou Yu-jie Yang Qing Cheng Wan-jun Wang Zhi-jian Wang Jian-long | 2012 | Chinese Medical Journal2012，，2： | 10 |
| 13 | Risk factors of intra-abdominal bacterial infection after liver transplantation in patients with hepatocellular carcinoma显示文摘Objective: To explore the risk factors of intra-abdominal bacterial infection(IAI) after liver transplantation(LT) in patients with hepatocellular carcinoma(HCC). Methods: A series of 82 HCC patients who received LT surgeries in our department between March 2004 and April 2010 was recruited in this study. Then we collected and analyzed the clinical data retrospectively. Statistical analysis system(SPSS) software was adopted to perform statistical analysis. Chi-square test, t-test and Wilcoxon rank sum test were used to analyze the clinical data and compute the significance of the incidences of early-stage IAI after LT for HCC patients. Binary logistic regression was performed to screen out the risk factors, and multiple logistic regression analyses were performed to compute the independent risk factors. Results: A series of 13 patients(13/82, 15.9%) had postoperative IAI. The independent risk factors of postoperative intra-abdominal bacterial infections after LT for HCC patients were preoperative anemia [Hemoglobin(HGB) <90 g/L] and postoperative abdominal hemorrhage(72 hours >400 mL), with the odds ratios at 8.121(95% CI, 1.417 to 46.550, P=0.019) and 5.911(95% CI, 1.112 to 31.432, P=0.037). Conclusions: Postoperative IAI after LT in patients with HCC was a common complication. Preoperative moderate to severe anemia, as well as postoperative intra-abdominal hemorrhage more than 400 mL within the first 72 hours might independently indicate high risk of IAI for these patients. | Kai Nie Rongzheng Ran Weifeng Tan Bin Yi Xiangji Luo Yong Yu Xiaoqing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，3： | 10 |
| 14 | Transradial approach for coronary angioplasty in Chinese elderly patients显示文摘 | CAO Zheng ZHOU Yu-jie ZHAO Ying-xin LIU Yu-yang SHI Dong-mei GUO Yong-he CHENG Wan-jun NIE Bin WANG Jian-long | 2008 | Chinese Medical Journal2008，，12： | 9 |
| 15 | Reversal of idiopathic hypogonadotropic hypogonadism: a cohort study in Chinese patients显示文摘尽管自发的 hypogonadotropic 性腺机能减退(IHH ) 传统地被看作了释放 gonadotropin 荷尔蒙神经原的缺乏引起的终生的疾病,病人的部分可以逐渐地在神经质的代替治疗期间重获正常的繁殖的轴功能。为潜在的 IHH 颠倒的预兆的因素大部分是未知的。我们的学习的目的是调查发生和颠倒了繁殖的轴功能的 IHH 男病人的临床的特征。在这回顾的队研究,男 IHH 病人被分类进一个颠倒组(n = 18 ) 并且一个 nonreversal 组(n = 336 ) 。gonadotropins 和睾丸激素的集中,以及睾丸尺寸和精子数,被决定。354 个 IHH 病人,(5.1%) 18 在治疗期间获得了正常繁殖功能。为颠倒的中部的年龄是 24 岁(范围 21-34 年) 。与 nonreversal 组相比,可逆的组有更高基础的 luteinizing 荷尔蒙(LH )(1.0 ±0.7 IU l -1 对 0.4 ±0.4 IU l −1, P <0.05 ) 并且刺激 LH (28.3 ±22.6 IU l −1 对 1.9 ±1.1 IU l −1, P <0.01 ) 层次,以及更大的睾丸尺寸(5.1 ±2.6 ml 对 1.5 ±0.3 ml, P <0.01 ) ,在起始的访问。在摘要,更大的睾丸尺寸和更高刺激的 LH 集中是为颠倒的喜爱的参数。我们发现建议可逆病人可以在起始的诊断保留部分活跃的繁殖的轴功能。 | Jiang-Feng Mao Hong-Li Xu Jin Duan Rong-Rong Chen Li Li Bin Li Min Nie Le Min Hong-Bing Zhang Xue-Yan Wu | 2015 | Asian Journal of Andrology2015，17，3： | 9 |
| 16 | Changes in T lymphocyte subsets after severe traumatic brain injury显示文摘BACKGROUND: Besides local changes of cranial parenchymal cells, hemorrhage, etc., severe traumatic brain injuries also cause the changes of total body fluid and various functions, and the changes of lymphocytes and T lymphocyte subsets should be paid more attention to. OBJECTIVE: To reveal the changing laws of T lymphocyte subsets after severe traumatic brain injury, and compare with mild to moderate brain injury. DESIGN: A comparative observation. SETTINGS: Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City; Central Laboratory of Shenzhen Hospital of Prevention and Cure for Chronic Disease. PARTICIPANTS: All the subjects were selected from the Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City from August 2002 to August 2005. Thirty patients with severe brain injury, whose Glasgow coma score (GCS) was ≤ 8 points, were taken as the experimental group, including 21 males and 9 females, aging 16–62 years. Meanwhile, 30 patients with mild traumatic brain injury were taken as the control group (GCS ranged 14–15 points), including 18 males and 12 females, aging 15–58 years. All the subjects were in admission at 6 hours after injury, without disease of major organs before injury. Informed consents were obtained from all the patients or their relatives. METHODS: ① The T lymphocytes and the subsets in peripheral blood were detected with immunofluorescent tricolor flow cytometry at 1, 3, 7 and 14 days after injury in both groups. ② The conditions of pulmonary infections were observed at 4 days after injury. The differences of measurement data were compared with the t test. MAIN OUTCOME MEASURES: Changes of T lymphocytes subsets at 1–14 days after severe and mild or moderate traumatic injury. RESULTS: Finally, 28 and 25 patients with mild to moderate traumatic brain injury, whereas 25 and 21 patients with severe traumatic brain injury were analyzed at 7 and 14 days respectively, and the missed ones died due to the development of disease. ① Changes of T lymphocyte subsets: At 1 and 3 days after injury, CD3, CD4, CD8, CD4/CD8 began to decrease, whereas CD8 increased in the experimental group, which were very significantly different from those in the control group (t =2.77–3.26, P < 0.01), and began to recover at 7 days, which were significantly different from those in the control group (t = 2.06–2.24, P < 0.05), and generally recovered to the normal levels at 14 days (P > 0.05). ② Conditions of pulmonary infections: At 4 days after injury, the rate of pulmonary infection was significantly different between the experimental group and control group [73% (22/30), 0, χ2=37.29, P < 0.01]. CONCLUSION: Patients with severe traumatic brain injury suffer from damages of cellular immune function at early period (within 7 days), and they are easily to be accompanied by pulmonary infections. | Yulu Miao Mingxia Zhang Yulin Nie Wan Zhao Bin Huang Zhengming Jiang Shaoxiong Yu Zhibin Huang Hongjin Fu | 2007 | Neural Regeneration Research2007，2，2： | 7 |
| 17 | Relationship between acute kidney injury before thoracic endovascular aneurysm repair and in-hospital outcomes in patients with type B acute aortic dissection显示文摘ObjectiveAcute 肾损害(AKI ) 经常发生在基于导管的 interventional 过程和增加死亡以后。然而,类型 B 尖锐大动脉的解剖(AAD ) 的 AKI 以前胸的 endovascular 动脉瘤修理(TEVAR ) 的含意仍然保持不清楚。这研究与类型 B AAD.MethodsBetween 2009 在病人在 TEVAR 前评估了 AKI 的发生,预言者,和在里面医院结果并且 2013, 76 个病人回顾地被评估从症状发作在 36 h 以内为类型 B AAD 收到了 TEVAR。病人被分类进 no-AKI 对 AKI 组,并且 AKI 的严厉进一步根据肾疾病被上演:在外科手术前的 AKI 的 TEVAR.ResultsThe 发生前改进全球结果标准是 36.8% 。在里面医院复杂并发症与 no-AKI 相比在有外科手术前的 AKI 的病人是显著地更高的(50.0% 对 4.2% 分别地;P <0.001 ) ,包括尖锐肾的失败(21.4% 对 0 分别地;P <0.001 ) ,并且他们与 AKI 的严厉增加了(P <0.001 ) 。身体温度和白血房间计数的最大的层次是以前显著地与最大的浆液 creatinine 有关铺平 TEVAR。Multivariate 分析在承认上显示出那收缩血压(或:1.023;95% CI:1.003-1.044;P = 0.0238 ) 并且双边的肾的动脉参与(或:19.076;95% CI:1.914-190.164;P = 0.0120 ) 外科手术前的 AKI.ConclusionsPreoperative AKI 的强壮的预言者经常与类型 B AAD 在病人被发生,并且与更高的在里面医院复杂并发症相关并且提高了煽动性的反应。承认和双边的肾的动脉参与上的收缩血压是为在 TEVAR 前的 AKI 的主要风险因素。 | Hong-Mei REN Xiao WANG Chun-Yan HU Bin QUE Hui AI Chun-Mei WANG Li-Zhong SUN Shao-Ping NIE | 2015 | Journal of Geriatric Cardiology2015，12，3： | 7 |
| 18 | Basic transcription factor 3 is involved in gastric cancer development and progression显示文摘AIM: To further analyse cancer involvement of basic transcription factor 3 (BTF3) after detection of its upregulation in gastric tumor samples. METHODS: BTF3 transcription rates in human gastric tumor tissue samples (n = 20) and adjacent normal tissue (n = 18) specimens as well as in the gastric cancer cell lines AGS, SGC-7901, MKN-28, MKN-45 and MGC803 were analyzed via quantitative real-time polymerase chain reaction. The effect of stable BTF3 silencing via infection with a small interfering RNA (siRNA)-BTF3 expressing lentivirus on SGC-7901 cells was measured via Western blotting analysis, proliferation assays, cell cycle and apoptosis profiling by flow cytometry as well as colony forming assays with a Cellomic Assay System. RESULTS: A significant higher expression of BTF3 mRNA was detected in tumors compared to normal gastric tissues (P < 0.01), especially in section tissues from female patients compared to male patients, and all tested gastric cancer cell lines expressed high levels of BTF3. From days 1 to 5, the relative proliferation rates of stable BTF3-siRNA transfected SGC7901 cells were 82%, 70%, 57%, 49% and 44% compared to the control, while the percentage of cells arrested in the G 1 phase was significantly decreased (P = 0.000) and the percentages of cells in the S (P = 0.031) and G 2 /M (P = 0.027) phases were significantly increased. In addition, the colony forming tendency was significantly decreased (P = 0.014) and the apoptosis rate increased from 5.73% to 8.59% (P = 0.014) after BTF3 was silenced in SGC7901 cells. CONCLUSION: BTF3 expression is associated with enhanced cell proliferation, reduced cell cycle regulation and apoptosis and its silencing decreased colony forming and proliferation of gastric cancer cells. | Qi Liu Jian-Ping Zhou Bin Li Zhong-Cheng Huang Hong-Yu Dong Guang-Yi Li Ke Zhou Shao-Lin Nie | 2013 | World Journal of Gastroenterology2013，19，28： | 6 |
| 19 | Study on the α-cyclodextrin/poly(ethylene glycol) self-assembly supramolecular nanoparticles for drug delivery显示文摘This paper reports the synthesis and drug delivery properties of a novel supramolecular nanoparticle.α-Cyclodextrins(α-CD) were threaded on cinnamic acid modified poly(ethylene glycol) to form inclusion complex nanoparticles by supramolecular self-assemble.The anti-tumor drug doxorubicin was loaded in the nanoparticles and released in vitro to study the drug release behavior and the anti-tumor effects.The structure and morphology of the nanoparticles were characterized by nuclear magnetic resonance,X-ray diffraction,ultraviolet absorbance,dynamic laser scattering,scanning electronic microscopy,transmission electron microscopy and atom force microscopy.The distribution of the drug loaded nanoparticles in cells and the anti-tumor effects were studied by confocal laser microscopy.The results demonstrate that the supramolecular nanoparticle is biocompatible and it is a promising carrier for drug delivery systems. | LI Yuan,JI Li,WANG Gang,SONG LiQing,HE Bin,LI Li,NIE Yu,WU Yao & GU ZhongWei National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China | 2010 | Science China Chemistry2010，53，3： | 5 |
| 20 | Epidermal growth factor receptor mutation analysis in cytological specimens and responsiveness to gefitinib in advanced non-small cell lung cancer patients显示文摘Background: Epidermal growth factor receptor(EGFR) mutation is the key predictor of EGFR tyrosine kinase inhibitors(TKIs) efficacy in non-small cell lung cancer(NSCLC). We conducted this study to verify the feasibility of EGFR mutation analysis in cytological specimens and investigate the responsiveness to gefitinib treatment in patients carrying EGFR mutations.Methods: A total of 210 cytological specimens were collected for EGFR mutation detection by both direct sequencing and amplification refractory mutation system(ARMS). We analyzed EGFR mutation status by both methods and evaluated the responsiveness to gefitinib treatment in patients harboring EGFR mutations by overall response rate(ORR), disease control rate(DCR) and progression free survival(PFS).Results: Of all patients, EGFR mutation rate was 28.6%(60/210) by direct sequencing and 45.2%(95/210) by ARMS(P<0.001) respectively. Among the EGFR wild type patients tested by direct sequencing, 26.7% of them were positive by ARMS. For the 72 EGFR mutation positive patients treated with gefitinib, the ORR, DCR and median PFS were 69.4%, 90.2% and 9.3 months respectively. The patients whose EGFR mutation status was negative by direct sequencing but positive by ARMS had lower ORR(48.0% vs. 80.9%, P=0.004) and shorter median PFS(7.4 vs. 10.5 months, P=0.009) as compared with that of EGFR mutation positive patients by both detection methods. Conclusions: Our study verified the feasibility of EGFR analysis in cytological specimens in advanced NSCLC. ARMS is more sensitive than direct sequencing in EGFR mutation detection. EGFR Mutation status tested on cytological samples is applicable for predicting the response to gefitinib. Abundance of EGFR mutations might have an influence on TKIs efficacy. | Lin Li Zijin Zhang Zhixin Bie Zheng Wang Ping Zhang Xin Nie Yuanming Li Hui Wang Bin Ai Gang Cheng | 2015 | Chinese Journal of Cancer Research2015，27，3： | 5 |
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