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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response显示文摘Triptolide (TP ) ,氧化 diterpene,举办许多有益的 pharmacodynamic 活动但是它的临床的应用程序由于严重阴囊的损害被限制。这研究试图描出在 vitro 并且在 vivo 的导致 TP 的阴囊的损害的分子的机制。TP (5-50000 nmol/L ) dose-dependently 减少了有在 24 h 的 669.5-269.45 nmol/L 的 IC 50 价值的 TM4 Sertoli 房间的生存能力。TP (125, 250,和 500 nmol/L ) dose-dependently 在 TM4 房间增加了 ROS, JNK 的 phosphorylation, mitochondrial 机能障碍和内在的 apoptosis 小径的激活的累积。这些过程被合作处理与抗氧化剂 N 乙酰半胱氨酸稀释(NAC, 1 mmol/L ) 。而且, TP 处理从细胞质禁止了 Nrf2 的 translocation 进原子核以及下游的基因 NAD (P) H quinone 的表示 oxidoreductase1 (NQO1 ) ,过氧化氢酶(猫) 和 hemeoxygenase 1 (HO-1 ) ,因此对氧化应力废除调停 Nrf2 的防卫机制。而且, Nrf2 击倒的 siRNA 显著地加强了 TM4 房间的导致 TP 的 apoptosis。从在 vitro 实验的上述结果进一步在 TP 的口头的管理以后在雄的老鼠被验证(30, 60,和 120 mg 吗? | Yu WANG Su-han GUO Xue-jun SHANG Li-sha YU Jian-wei ZHU Ang ZHAO Yan-fen ZHOU Guo-hua AN Qi ZHANG BO MA | 2018 | Acta Pharmacologica Sinica2018，39，2： | 22 |
| 3 | Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism显示文摘Volatile anesthetics improve postischemic cardiac function and reduce infarction even when administered for only a brief-time at the onset of reperfusion.A recent study showed that sevoflurane postconditioning (SPC)attenuated myocardial reperfusion injury, but the underlying mechanisms remain unclear,in this study,we examined the effects of sevoflurane on nitric oxide (NO)release and autophagic flux during the myocardial ischemia/reperfusion (I/R)injury in rats in vivo and ex vivo.Male rats were subjected to 30 min ischemia and 2 h reperfusion in the presence or absence of sevoflurane (1.0 minimum alveolar concentration)during the first 15 min of reperfusion.We found that SPC significantly improved hemodynamic performance after reperfusion,alleviated postischemic myocardial infarction,reduced nicotinamide adenine dinucleotide content loss,and cytochrome c.release in heart tissues.Furthermore,SPC significantly increased the phosphorylation of endothelial nitric oxide synthase (NOS)and neuronal nitric oxide synthase,and elevated myocardial NOS activity and NO production.All these effects were abolished by treatment with an NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME,10 mg/kg,i.v.).We also observed myocardial I/R-induced accumulation of autophagosomes in heart tissues,as evidenced by increased ratios of microtubule:associated protein 1 light chain 3 Ⅱ/Ⅰ,upregulation of Beclin 1 and P62,and reduced lysosome-assciated membrane protein-2 expression.SPC significantly attenuated I/R- impaired autophagic flux,which were blocked by L-NAME.Moreover,pretreatment with the autophagic flUX blocker chloroquine (10 mg/kg,i.p.)increased autophagosome accumulation in SPC-treated heart following I/R and blocked SPC-induced cardioprotection.The same results were also observed in a rat model of myocardial I/R injury ex vivo,suggesting that SPC protects rat hearts against myocardial reperfusion injury by restoring I/R-impaired autophagic flux yia an NO-dependent mechanism. | Shi-gang Qiao Ying Sun Bo Sun An Wang Jia Qiu Lei Hong Jian-zhong An Chen Wang Hui-ling Zhang | 2019 | Acta Pharmacologica Sinica2019，40，1： | 21 |
| 4 | Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus显示文摘 | DU Jian-ling SUN Chang-kai LU Bo MEN Li-li YAO Jun-jie AN Li-jia SONG Gui-rong | 2008 | Chinese Medical Journal2008，，13： | 20 |
| 5 | Efficient Gene Targeting in Zebrafish Mediated by a Zebrafish-Codon-Optimized Cas9 and Evaluation of Off-Targeting Effect显示文摘Targeted genome modifications with the Cas9/gRNA system derived from the clustered regularly interspaced short palindromic repeat/CRISPR-associated(CRISPR/Cas)system have been successfully used in cultured human cells as well as in most model organisms,including zebrafish(Danio rerio),mouse,and fruit fly(Chang et al.,2013;Cong et al.,2013; | Da Liu Zhanxiang Wang An Xiao Yutian Zhang Wenyuan Li Yao Zu Shaohua Yao Shuo Lin Bo Zhang | 2014 | Journal of Genetics and Genomics2014，41，1： | 18 |
| 6 | Evolution of boundary layer ozone in Shijiazhuang,a suburban site on the North China Plain显示文摘The structure of the boundary layer affects the evolution of ozone(O3), and research into this structure will provide important insights for understanding photochemical pollution.In this study, we conducted a one-month observation(from June 15 to July 14, 2016) of the boundary layer meteorological factors as well as O3 and its precursors in Luancheng County,Shijiazhuang(37°53′N, 114°38′E). Our research showed that photochemical pollution in Shijiazhuang is serious, and the mean hourly maximum and mean 8-hr maximum O3 concentrations are 97.9 ± 26.1 and 84.4 ± 22.4 ppbV, respectively. Meteorological factors play a significant role in the formation of O3. High temperatures and southeasterly winds lead to elevated O3 values, and at moderate relative humidity(40%–50%) and medium boundary layer heights(1200–1500 m), O3 production sensitivity occurred in the transitional region between volatile organic compounds(VOC) and nitrogen oxides(NOx) limitations,and the O3 concentration was the highest. The vertical profiles of O3 were also measured by a tethered balloon. The results showed that a large amount of O3 was stored in the residual layer, and the concentration was positively correlated with the O3 concentration measured the previous day. During the daytime of the following day, the contribution of O3 stored in the residual layer to the boundary layer reached 27%± 7% on average. | Wei Zhao Guiqian Tang Huan Yu Yang Yang Yinghong Wang Lili Wang Junlin An Wenkang Gao Bo Hu Mengtian Cheng Xingqin An Xin Li Yuesi Wang | 2019 | Journal of Environmental Sciences2019，31，9： | 15 |
| 7 | Development of Land Surface Model BCC_AVIM2.0 and Its Preliminary Performance in LS3MIP/CMIP6显示文摘The improvements and validation of several parameterization schemes in the second version of the Beijing Climate Center Atmosphere–Vegetation Interaction Model(BCC_AVIM2.0) are introduced in this study. The main updates include a replacement of the water-only lake module by the common land model lake module(Co LM-lake) with a more realistic snow–ice–water–soil framework, a parameterization scheme for rice paddies added in the vegetation module, renewed parameterizations of snow cover fraction and snow surface albedo to accommodate the varied snow aging effect during different stages of a snow season, a revised parameterization to calculate the threshold temperature to initiate freeze(thaw) of soil water(ice) rather than being fixed at 0°C in BCC_AVIM1.0, a prognostic phenology scheme for vegetation growth instead of empirically prescribed dates for leaf onset/fall, and a renewed scheme to depict solar radiation transfer through the vegetation canopy. The above updates have been implemented in BCC_AVIM2.0 to serve as the land component of the BCC Climate System Model(BCC_CSM). Preliminary results of BCC_AVIM in the ongoing Land Surface, Snow, and Soil Moisture Model Intercomparison Project(LS3 MIP) of the Coupled Model Intercomparison Project Phase 6(CMIP6) show that the overall performance of BCC_AVIM2.0 is better than that of BCC_AVIM1.0 in the simulation of surface energy budgets at the seasonal timescale. Comparing the simulations of annual global land average before and after the updates in BCC_AVIM2.0 reveals that the bias of net surface radiation is reduced from-12.0 to-11.7 W m-2 and the root mean square error(RMSE) is reduced from 20.6 to 19.0 W m-2;the bias and RMSE of latent heat flux are reduced from 2.3 to-0.1 W m-2 and from 15.4 to14.3 W m-2, respectively;the bias of sensible heat flux is increased from 2.5 to 5.1 W m-2 but the RMSE is reduced from 18.4 to 17.0 W m-2. | Weiping LI Yanwu ZHANG Xueli SHI Wenyan ZHOU Anning HUANG Mingquan MU Bo QIU Jinjun JI | 2019 | Journal of Meteorological Research2019，33，5： | 14 |
| 8 | Influence of FasL gene expression on hepatic metastasis of colorectal carcinoma显示文摘BACKGROUND: FasL expression was reported to be asso- ciated with hepatic metastasis of colorectal cancer. The aim of this study was to study FasL gene expression in colorectal carcinoma and its influences on biological behavior and he- patic metastasis of colorectal carcinoma. METHODS: FasL gene expressions were examined with re- verse transcriptase-polymerase chain reaction (RT-PCR) in the primary focus of colorectal carcinoma, adjacent can- cerous mucosae, and metastasized liver focus from colorec- tal cancer. HR-8348 cells of human rectal cancer cell line were transfected with FasL cDNA. Cell growth suppression rate and response to 5-FU and carboplatin were observed and analyzed with the MTT method. RESULTS: FasL gene expression was detected in the prima- ry focus of colorectal cancer ( n = 58), adjacent cancerous mucosae ( n = 58), and metastasized hepatic tumor tissues (n =28). The positive rate of FasL expression was 24% (14/ 58), 8% (5/58), and 100% (58/58) in the primary focus, adjacent cancerous mucosae and metastasized hepatic tumor tissues respectively. FasL expression rate in the me- tastasized hepatic tumor tissues was higher than that in the primary focus (χ2 = 43.49, P<0. 01) and adjacent cance- rous mucosae (χ2=57.66, P<0.01). In a group of patients with hepatic metastasis, the FasL expression rate in primary focus was higher than that in patients without hepatic me- tastasis (χ2=3.96, P <0.05). In vitro study positive expres- sion of FasL was shown in transfected HR-8348 cells. When 5-FU or carboplatin was added, there was a significant difference in growth suppression rate between FasL positive and controlled cancer cells (t=9.02, t = 11.93, P<0.01). Under the same concentration of chemotherapeutic agents, the survival rate of FasL positive HR-8348 cells was higher than that of controlled cells. CONCLUSIONS: FasL positive cancer cells are powerfullyresistant to chemotherapeutic agents. The expression of the FasL gene in colorectal cancer cells is related to immune evasion to escape from being killed by immune cells, show- ing stronger drug-resistance, and it facilitates hepatic me- tastasis. | Shi-Yong Li, Bo Yu, Ping An, Jia-Chen Wei, Fu-Yi Zuo and Hui-Yun Cai Beijing, China Department of General Surgery, Beijing Military Commend General Hospital, Beijing 100700, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 14 |
| 9 | Isolation and characterization of Zika virus imported to China using C6/36 mosquito cells显示文摘Dear Editor,Zika virus(ZIKV)is a mosquito-borne flavivirus that usually causes asymptomatic infections or mild illness in humans.However,the unprecedented epidemics of ZIKV in Latin America since early 2015 have made this flavivirus an international health risk(Liu and Zhang,2016).In particular,the potential association of ZIKV infection with the remarkable increase in the number | Chenglin Deng Siqing Liu Qiuyan Zhang Mingyue Xu Honglei Zhang Dayong Gu Lei Shi Jian'an He Gengfu Xiao Bo Zhang | 2016 | Virologica Sinica2016，31，2： | 12 |
| 10 | Chemical Constituents from Pericarpium Citri Reticulatae显示文摘Objective To study the chemical constituents from Pericarpium Citri Reticulatae(Citrus reticulata). Methods The chemical constituents were isolated and purified by silica gel column, Sephadex LH-20, and ODS column chromatography. The structures were identified by spectral data. Results Nineteen compounds were isolated and identified as 4′,5,6,7-tetramethoxyflavone(1), 3,3′,4′,5,6,7,8-heptmethoxyflavone(2), sinensetin(3), 5-O-demethylnobiletin(4), tangeretin(5), nobiletin(6), apigenin(7), 5-Odesmethyltangeretin(8), 5,7-dihydroxy-3,3′,4′,6-tetramethoxyflavone(9), pachypodol(10), 4′,5,6,7-tetramethoxyflavanone(11), 3′,4′,5,7,8-pentamethoxyflavanone(12), agestricin C(13), scoparone(14), isoscopoletin(15), hesperidin(16), didymin(17), methylhesperidine(18), and naringin(19). Conclusion Compounds 9-15 are obtained from this plant for the first time. | Man-qin Fu Geng-sheng Xiao Ji-jun wu Yu-long Chen Bo Zou Ke-jing An Yu-juan Xu | 2017 | Chinese Herbal Medicines2017，9，1： | 12 |
| 11 | A cytotoxic compound from the leaves of Juglans mandshurica显示文摘From Juglans mandshurica leaves, a new quinone compound was isolated through bioassay-guided fractionation. The structure elucidation of the compound was established based on spectroscopic studies, notably of the 2D NMR spectra. The compound exhibited moderate cytotoxic activities against Hela, MCF-7, BGC823 and 3T3-L1cell lines with IC50 ranges from 7.5 to26.8 mmol/L. | Zhi Bo Li Yong Ming Bao Hong Bo Chen Jing Yun Wang Jie Han Hu Li Jia An | 2007 | Chinese Chemical Letters2007，18，7： | 11 |
| 12 | FOXP3 expression and clinical characteristics of hepatocellular carcinoma显示文摘AIM: To study the biological and clinical characteristics of transcription factor forkhead box protein 3 (FOXP3) in hepatocellular carcinoma (HCC). METHODS: We analyzed the expression and localization of FOXP3 in HCC tissues and cell lines to evaluate its biological features. The relationship between FOXP3 staining and clinical risk factors of HCC was assessedto identify the clinical characteristics of FOXP3 in HCC. RESULTS: The mRNA and protein expression of FOXP3 were found in some hepatoma cell lines. Immunohistochemical (IHC) analysis of HCC sections revealed that 48% of HCC displayed FOXP3 staining, but we did not find any FOXP3 staining in normal liver tissues and para-tumor tissues. IHC and Confocal analysis showed that the expressions of FOXP3 were mainly present in the nucleus and cytoplasm of tumor cells in tissues or cell lines. In HCC, the distribution of FOXP3 was similar to that of the cirrhosis, but not to the hepatitis B virus. Those findings implicate that FOXP3 staining seems to be associated with the high risk of HCC. CONCLUSION: The clinical characteristics of FOXP3 in HCC warrants further studies to explore its functions and roles in the cirrhosis and development of HCC. | Wei-Hua Wang, Jun-Zhi Wang, National Center for Safety Evaluation of Drugs, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China Wei-Hua Wang, Chang-Li Jiang, Cun Zhang, Bo Yan, Wei Zhang, Wei Han, Ying-Qi Zhang, Biotechnology Center, School of Pharmacy, the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Wei-Hua Wang, Chang-Li Jiang, Cun Zhang, Bo Yan, Wei Zhang, Wei Han, Ying-Qi Zhang, State Key Laboratory of Cancer Biology, Xi’an 710032, Shaanxi Province, China Wei Yan, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Yu-Hai Zhang, Department of Health Statistics, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Jiang-Tao Yang, Department of Pathology, Xi’an Gaoxin Hospital, Xi’an 710032, Shaanxi Province, China | 2010 | World Journal of Gastroenterology2010，16，43： | 10 |
| 13 | Stress evolution and support mechanism of a bolt anchored in a rock mass with a weak interlayer显示文摘By applying experimental method, the bolt stress and supporting mechanism is studied during the deformation process of a rock mass containing a weak interlayer. The force measuring bolt is installed manually and instrumented five pairs of symmetrical strain gauges. The experimental results show that the fully grouted bolt suffers tensile, compressive, bending and shear stress at the same time. The bolt stress evolution is closely related to the deformation stages of the rock mass which are very gradually varying stage, gradually varying stage at the pre-peak and suddenly varying stage at the post peak stage.The axial compressive stress in the bolt is mainly induced by the moment. Thus, in most cases the axial compressive stress is distributed on one side of the bolt. For axial stresses, induced by the axial force and the bending moment at the post-peak stage, three types of changing are observed, viz. increasingincreasing type, decreasing-increasing type and increasing-decreasing type. The stress characteristics of the bolt section in the weak interlayer are significantly different from those in the hard rock. The failure models of the anchored bolt are tensile failure and shear failure, respectively. The bolt not only provides constraints on the free surface of the rock mass, but also resists the axial and lateral loading by the bending moment. This study provides valuable guidelines for bolting support design and its safety assessment. | Ding Shuxue Jing Hongwen Chen Kunfu Xu Guo'an Meng Bo | 2017 | International Journal of Mining Science and Technology2017，27，3： | 9 |
| 14 | Cryogenic minimum quantity lubrication machining: from mechanism to application显示文摘Cutting fluid plays a cooling-lubrication role in the cutting of metal materials.However,the substantial usage of cutting fluid in traditional flood machining seriously pollutes the environment and threatens the health of workers.Environmental machining technologies,such as dry cutting,minimum quantity lubrication(MQL),and cryogenic cooling technology,have been used as substitute for flood machining.However,the insufficient cooling capacity of MQL with normal-temperature compressed gas and the lack of lubricating performance of cryogenic cooling technology limit their industrial application.The technical bottleneck of mechanical-thermal damage of difficult-to-cut materials in aerospace and other fields can be solved by combining cryogenic medium and MQL.The latest progress of cryogenic minimum quantity lubrication(CMQL)technology is reviewed in this paper,and the key scientific issues in the research achievements of CMQL are clarified.First,the application forms and process characteristics of CMQL devices in turning,milling,and grinding are systematically summarized from traditional settings to innovative design.Second,the cooling-lubrication mechanism of CMQL and its influence mechanism on material hardness,cutting force,tool wear,and workpiece surface quality in cutting are extensively revealed.The effects of CMQL are systematically analyzed based on its mechanism and application form.Results show that the application effect of CMQL is better than that of cryogenic technology or MQL alone.Finally,the prospect,which provides basis and support for engineering application and development of CMQL technology,is introduced considering the limitations of CMQL. | Mingzheng LIU Changhe LI Yanbin ZHANG Qinglong AN Min YANG Teng GAO Cong MAO Bo LIU Huajun CAO Xuefeng XU Zafar SAID Sujan DEBNATH Muhammad JAMIL Hafz Muhammad ALI Shubham SHARMA | 2021 | Frontiers of Mechanical Engineering2021，16，4： | 8 |
| 15 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 16 | Effects of bile acids on proliferation and ultrastructural alteration of pancreatic cancer cell lines显示文摘AIM: Pancreatic cancer in the head is frequently accompanied by jaundice and high bile acid level in serum. This study focused on the direct effects of bile acids on proliferation and ultrastructural alteration of pancreatic cancer.METHODS: Pancreatic cancer cell lines PANC-1, MIA PaCa2 and PGHAM-1 were explored in this study. The cell lines were cultured in media supplemented with certain bile acids,CA, DCA, LCA, TCDC, TDCA and GCA. Their influence on cell growth was measured with MTT assay after 72 h of incubation. Cell cycles of PANC-1 cells in 40 μM of bile acids media were analyzed by flow cytometry. Ultrastructural alteration of PANC-1 cells induced by DCA was observed using scanning and transmission electron microscope (SEM and TEM).RESULTS: At various concentrations of bile acids and incubation time, no enhanced effects of bile acids on cell proliferation were observed. Significant inhibitory effects were obtained in almost all media with bile acids. DCA and CA increased the percentage of G0+G1 phase cells, while GCA and TDCA elevated the S phase cell number. After 48 h of incubation in DCA medium, PANC-1 cells showed some structural damages such as loss of their microvilli and vacuolization of organelles in cytoplasm.CONCLUSION: Bile acids can reduce proliferation of pancreatic cancer cells due to their direct cytotoxicity. This result implies that elevation of bile acids in jaundiced serum may inhibit pancreatic cancer progression. | Zheng Wu Yi Lü Bo Wang Chang Liu Zuo-Ren Wang Department of Hepatobiliary Surgery,The First Hospital of Xi’an Jiaotong University,Xi’an 710061,Shaanxi Province,China | 2003 | World Journal of Gastroenterology2003，9，12： | 8 |
| 17 | Water Modeling of Twin-Roll Strip Casting显示文摘Twin-roll strip casting is regarded as a prospective technology of near net shape continuous casting. The fluid flow field and level fluctuation in the pool have a strong influence not only on composition and temperature homogeneity of pool, but also on the strip quality. A 1∶1 water model of a twin-roll strip caster was set up based on the criteria of Froude number and Reynold number similarity. The level fluctuation was measured. The influence of pool depth, casting speed and feeding system configuration on level fluctuation in the pool was studied. The experimental results provided a basis for the optimization of feeding system and process parameters. | WANG Bo ZHANG Jie-yu FAN Jun-fei ZHAO Shun-li FANG Yuan AN Sheng-li | 2006 | Journal of Iron and Steel Research(International)2006，13，1： | 8 |
| 18 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 19 | 关于李萨如图形讨论的小结显示文摘对《大学物理》和其它一些刊物上多年来关于李萨如图形的讨论作了归纳和分析. | Zhao Bo (Xi’an Institute of Post and Telecommunication, Xi’an, Shaanxi, 710061, China) | 1997 | 大学物理1997，16，11： | 8 |
| 20 | Numerical and physical simulation of a twin-roll strip caster显示文摘The 1:1 water model of a twin-roll strip caster was set up based on the Froude number and the Reynolds number similarity criteria. A new type metal delivery system was designed for the twin-roll strip caster. The level fluctuation and the fluid flow in the pool of the water model were measured using the level detector and the 3D-LDV (laser Doppler velocimetry) technology. It is shown that a wedged delivery system can produce the desirable level fluctuation and even fluid flow distribution in the pool. Numerical simulations for the water model were performed. Comparisons between the numerical and physical simulation results show good agreement near the side dams. | Bo Wang Jieyu Zhang Yin Zhang Youduo He Junfei Fan Yuan Fang Shengli An | 2006 | Journal of University of Science and Technology Beijing2006，13，5： | 7 |
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