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| 1 | Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury显示文摘Apelin-13 is a novel endogenous ligand for an angiotensin-like orphan G-protein coupled receptor,and it may be neuroprotective against cerebral ischemia injury.However,the precise mechanisms of the effects of apelin-13 remain to be elucidated.To investigate the effects of apelin-13 on apoptosis and autophagy in models of cerebral ischemia/reperfusion injury,a rat model was established by middle cerebral artery occlusion.Apelin-13(50μg/kg)was injected into the right ventricle as a treatment.In addition,an SH-SY5Y cell model was established by oxygen-glucose deprivation/reperfusion,with cells first cultured in sugar-free medium with 95%N2 and 5%CO2 for 4 hours and then cultured in a normal environment with sugar-containing medium for 5 hours.This SH-SY5Y cell model was treated with 10-7 M apelin-13 for 5 hours.Results showed that apelin-13 protected against cerebral ischemia/reperfusion injury.Apelin-13 treatment alleviated neuronal apoptosis by increasing the ratio of Bcl-2/Bax and significantly decreasing cleaved caspase-3 expression.In addition,apelin-13 significantly inhibited excessive autophagy by regulating the expression of LC3B,p62,and Beclin1.Furthermore,the expression of Bcl-2 and the phosphatidylinositol-3-kinase(PI3K)/Akt/mammalian target of rapamycin(mTOR)pathway was markedly increased.Both LY294002(20μM)and rapamycin(500 nM),which are inhibitors of the PI3K/Akt/mTOR pathway,significantly attenuated the inhibition of autophagy and apoptosis caused by apelin-13.In conclusion,the findings of the present study suggest that Bcl-2 upregulation and mTOR signaling pathway activation lead to the inhibition of apoptosis and excessive autophagy.These effects are involved in apelin-13-induced neuroprotection against cerebral ischemia/reperfusion injury,both in vivo and in vitro.The study was approved by the Animal Ethical and Welfare Committee of Jining Medical University,China(approval No.2018-JS-001)in February 2018. | Zi-Qi Shao Shan-Shan Dou Jun-Ge Zhu Hui-Qing Wang Chun-Mei Wang Bao-Hua Cheng Bo Bai | 2021 | Neural Regeneration Research2021，16，6： | 35 |
| 2 | Clinical and Angiographic Predictors of Major Side Branch Occlusion after Main Vessel Stenting in Coronary Bifurcation Lesions显示文摘 | Dong Zhang Bo Xu Dong Yin Yi-Ping Li Yuan He Shi-Jie You Shu-Bin Qiao Yong-Jian Wu Hong-Bing Yan Yue-Jin Yang Run-Lin Gao Ke-Fei Dou | 2015 | Chinese Medical Journal2015，，11： | 8 |
| 3 | Two-year clinical outcome after successful implantation of drug-eluting and bare metal stents in diabetic patients: results from a real-world single center registry显示文摘背景 Drug-eluting stents (DES ) 由戏剧性地改善革命化了 interventional 心病学的地临床并且 angiographic 结果。有糖尿病 mellitus (DM ) 的病人在经皮的冠的干预(一种总线标准) 以后与不利临床的结果的增加的风险被联系。在糖尿病的病人的 DES 和赤裸的金属 stent (BMS ) 的功效和安全的可得到的信息从 2004 年 4 月仍然是 scarce.Methods 到 2006 年 10 月,有糖尿病的 1565 个病人,成功地在中国北京在 Fu Wai 医院经历了选任的 stenting,在这研究被注册。所有注册病人被分到一个药 eluting stent 组和一个赤裸的金属 stent 组。我们获得了后续数据:死亡,心肌的梗塞(MI ) ,血栓,目标损害 revascularization (TLR ) ,和在 30 天和 12 和 24 个月的目标容器 revascularization (TVR ) 由学术研究协会定义弧) 。我们计算了并且比较所有 unadjusted 在二个组的各种各样的不利事件的累积频率。考克斯与倾向分数调整的比例危险的模型被用来在 24 个月在 24 months.Results 估计所有结果措施的相对风险,在二的定义 stent 血栓组织的所有弧是类似的;在 30 天,更明确的血栓在 BES 组被发现(0.08% 对 0.81% , P=0.016 ) 。与 DES 对待的病人显示出 TLR 的重要更低的风险(3.88% 对 10.89% ;危险比率(HR ) 0.159 (95% CI:0.151-0.444 ) , P < 0.001 ) , TVR (5.48% 对 11.69% ;HR 0.383 (95% CI:0.232-0.633 ) , P < 0.001 ) ,并且任何 revascularization (12.47% 对 18.55% ;HR 0.555 (95% CI:0.370-0.831 ) , P=0.0004 ) 在 24 个月。没有重要差别以在当代的社会的大、糖尿病的人口的所有原因死亡, MI,和所有原因 mortality/MI.Conclusions 是明显的, DES 的使用在 TLR, TVR,和任何 revascularization 的风险与长期的重要减小被联系。在在在有在 24 月的后续的糖尿病的病人的 DES 和 BMS 之间的所有原因死亡, MI,和血栓没有重要差别。 | DOU Ke-fei XU Bo YANG Yue-jin CHEN Ji-lin QIAO Shu-bin LI Jian-jun QIN Xue-wen LIU Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun GAO Run-lin | 2009 | Chinese Medical Journal2009，，6： | 7 |
| 4 | A prospective multicenter parallel-controlled trial of TIVOLI biodegradable-polymer-based sirolimus-eluting stent compared to ENDEAVOR zotarolimus-eluting stent for the treatment of coronary artery disease: 8-month angiographic and 2-year clinical follow-up results显示文摘背景可得到的 drug-eluting stents (DES ) 在减少狭窄率获得了大成功。最近,调查者证明了持久的聚合物搬运人在愈合的 DES 相关的过分敏感的反应和延期容器起一个重要作用。TIVOLI stent 是新奇 sirolimus-eluting 有可被细菌破坏的涂层包含的冠的 stent sirolimus 和 polylactic-co-glycolic 酸(PLGA ) 聚合物。现在的学习寻求了在与冠的动脉 disease.Methods A 对待病人评估 TIVOLI biodegradable-polymer-based sirolimus-eluting stent 的有效性和安全未来, multicenter 有努力 zotarolimus-eluting stent 的临床的试用比较 TIVOLI 可被细菌破坏的涂的 sirolimus-eluting stent 在 324 个病人被进行(TIVOLI 组:168 个病人;努力 group:156 病人) 在中国在 12 点集中晚表明 in-stent 的非低劣有与在有二个 de novo 土著人的最大值的题目的努力 stent 相比的 TIVOLI stent 的损失冠的动脉损害(损害长度 40 公里,参考容器直径 2.25-4.00 公里) 。主要结束点晚是 angiographic in-stent 损失在 8 月。第二等的结束点是在 2 年的临床的结果,包括主要不利心脏的事件(心脏的死亡,心肌的梗塞,或目标损害 revascularization ) ,在在 TIVOLI 组的 8 个月的 stent thrombosis.Results Angiographic 迟了的腔损失比 ENDEAVOR 组优异(in-stent (0.25 眠獡爠摥 ' 讚??? | XU Bo DOU Ke-fei HAN Ya-ling LU Shu-zheng YANG Yue-jin HUO Yong WANG Le-feng CHEN Yun-dai WANG Hai-chang LI Wei-min CHEN Ji-yan WANG Lei WANG Yong GE Jun-bo LI Wei GAO Run-lin | 2011 | Chinese Medical Journal2011，，6： | 6 |
| 5 | miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor显示文摘Embryo implantation is a crucial step in mammalian reproduction.However,little is known regarding the physiological roles of microRNAs in the regulation of embryo implantation.Here we show that a minimum uterine expression of miR-181 is essential for the onset of embryo implantation.Both transient and prolonged transgenic expression of miR-181 led to impaired implantation,which can be rescued by exogenous administration of leukemia inhibitory factor(LIF).Mechanistically,miR-181 is able to directly target LIF and downregulate LIF expression,thereby inhibiting embryo implantation.We also show that miR-181 expression is regu-lated by the transcriptional factor Emx2,and the Emx2–miR-181 axis plays an importantrole in regulating embryo implantation.Taken together,these results reveal a novel function of miR-181 in embryo implantation through the regulation of LIF,and also indicate a potential link between miR-181 dysregulation and human embryo implantation defects. | Bo Chu Liangwen Zhong Shuang Dou Jun Wang Jianmin Li Mingwei Wang Qinghua Shi Yide Mei Mian Wu | 2015 | Journal of Molecular Cell Biology2015，7，1： | 5 |
| 6 | Clinical and angiographic characteristics of premenopausal women with coronary artery disease显示文摘当中年的 men.It 的疾病广泛地被接受,背景冠的动脉疾病( CAD )通常被考虑因为荷尔蒙 protection.Based ,为绝经前的女人的 CAD 的风险是低的,没有足够的 concern.Even nowthere ,更绝经前的女人受不了咽峡炎和心肌的梗塞,这仍然是有限的详细数据为了描述绝经前的 CAD patients.This 的 characteristicsmechanism 和预后,文章瞄准了到分析临床所有 P < 0.05 )我们在绝经前的 CAD 发现了单个容器的更多的经常的参与的 .Although (43.2%对 26.9%P=0 ),并且三倍的容器在绝经后( 56-60 岁) CAD 病人(33.8%对 20.4%P=0 )更严重的损害(90%)在留给主要(2.9%对1.1%, P=0.048 )并且近似左前面的下降动脉(男孩)(28.2%对 16.6%P=0 )在绝经前的 CAD ,组是有胸不快的绝经前的女人总是被发现把明显的 atherosclerosismore 使倾向了被定位的 found. | DOU Ke-fei XU Bo YANG Yue-jin Lü Rong QIU Hong YANG Wei-xian MU Zhao-wei GAO Run-lin GAO Zhan CHEN Ji-lin QIAO Shu-bin LI Jian-jun QIN Xue-wen LIU Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun | 2008 | Chinese Medical Journal2008，，23： | 5 |
| 7 | Characteristics of soil seed bank in plantation forest in the rocky mountain region of Beijing, China显示文摘We investigated characteristics (scales and composition) of soil seed banks at eight study sites in the rocky mountain region of Beijing by seed identification and germination monitoring. We also surveyed the vegetation communities at the eight study sites to explore the role of soil seed banks in vegetation restoration. The storage capacity of soil seed banks at the eight sites ranked from 766.26 to 2461.92 seeds·m -2 . A total of 23 plant species were found in soil seed banks, of which 63 80% of seeds were herbs in various soil layers and 60% of seeds were located in the soil layer at 0 5cm depth. Biodiversity indices indicated clear differences in species diversity of soil seed banks among different plant communities. The species composition of aboveground vegetation showed low similarity with that based on soil seed banks. In the above- ground plant community, the afforestation tree species showed high importance values. The plant species originating from soil seed banks represented natural regeneration, which also showed relatively high importance values. This study suggests that in the rocky mountain region of Beijing the soil seed banks played a key role in the transformation from pure plantation forest to near-natural forest, promoting natural ecological processes, and the role of the seed banks in vegetation restoration was important to the improvement of ecological restoration methods. | HU Zeng-hui YANG Yang LENG Ping-sheng DOU De-quan ZHANG Bo HOU Bing-fei | 2013 | Journal of Forestry Research2013，24，1： | 5 |
| 8 | Clinical characteristics of early and late drug-eluting stent in-stent restenosis and mid-term prognosis after repeated percutaneous coronary intervention显示文摘Background:The mechanism and characteristics of early and late drug-eluting stent in-stent restenosis(DES-ISR)have not been fully clarified.Whether there are different outcomes among those patients being irrespective of their repeated treatments remain a knowledge gap.Methods:A total of 250 patients who underwent initial stent implantation in our hospital,and then were readmitted to receive treatment for the reason of recurrent significant DES-ISR in 2016 were involved.The patients were categorized as early ISR(<12 months;E-ISR;n=32)and late ISR(≥12 months;L-ISR;n=218).Associations between patient characteristics and clinical performance,as well as clinical outcomes after a repeated percutaneous coronary intervention(PCI)were evaluated.Primary composite endpoint of major adverse cardiac events(MACEs)included cardiac death,non-fatal myocardial infarction(MI),or target lesion revascularization(TLR).Results:Most baseline characteristics are similar in both groups,except for the period of ISR,initial pre-procedure thrombolysis in myocardial infarction,and some serum biochemical indicators.The incidence of MACE(37.5%vs.5.5%;P<0.001)and TLR(37.5%vs.5.0%;P<0.001)is higher in the E-ISR group.After multivariate analysis,E-ISR(odds ratio[OR],13.267;[95%CI 4.984-35.311];P<0.001)and left ventricular systolic dysfunction(odds ratio[OR],6.317;[95%CI 1.145-34.843];P=0.034)are the independent predictors for MACE among DES-ISR patients in the mid-term follow-up of 12 months.Conclusions:Early ISR and left ventricular systolic dysfunction are associated with MACE during the mid-term follow-up period for DES-ISR patients.The results may benefit the risk stratification and secondary prevention for DES-ISR patients in clinical practice. | Jian-Feng Zheng Ting-Ting Guo Yuan Tian Yong Wang Xiao-Ying Hu Yue Chang Hong Qiu Ke-Fei Dou Yi-Da Tang Jin-Qing Yuan Yong-Jian Wu Hong-Bing Yan Shu-Bin Qiao Bo Xu Yue-Jin Yang Run-Lin Gao | 2020 | Chinese Medical Journal2020，，22： | 5 |
| 9 | Comparison of long-term clinical outcome after successful implantation of FIREBIRD and CYPHER sirolimus-eluting stents in daily clinical practice: analysis of a large single-center registry显示文摘背景最近的数据证明了 sirolimus-eluting stents (SES ) 减少了狭窄而且目标容器 revascularization (TVR ) 的发生不仅。密码和鲜艳的小鸟 stents 广泛地两个都被使用在 China.However 的 SES ,有关关于在中国人口的密码和鲜艳的小鸟 stents 的长期的安全和功效地的差别的比较数据仍然不是从2004年4月的 available.Methods 到经历了成功的 SES 的10月2006,3979日连续病人(鲜艳的小鸟 2274 ;密码 1705 )培植有希望地被注册进这研究。所有注册病人基于 stent 类型被划分成二个组。后续数据,包括的死亡,心肌的梗塞(MI ) ,血栓,目标损害 revascularization (TLR ) , TVR,和主要不利心脏的事件(向,死亡, MI,和 TVR 合成) 在 24 个月被获得。在倾向 match.Results Unadjusted 临床的结果表明了更高的 TVR (危险比率(HR ) 1.78,95%Cl 1.26-2.50 ) ,为病人的向(HR 1.40,95%C/1.08-1.82 ) 与鲜艳的小鸟 SES 对待前后,考克斯的比例危险的模型被用来估计在二个组之间的所有 outcomemeasures 的相对风险。在倾向火柴以后,然而,结果在所有分析参数向 CYPHER stent 的优势显示出一个不重要的趋势没有重要差别被作出对有利的裁决在在鲜艳的小鸟和密码组之间的 24 个月的所有事件,并且所有血栓由学术研究评价协会(弧)定义在在这张大、真实世界的人口的二 groups.Conclusions 之间是可比较的,在中国的国内鲜艳的小鸟 SES 的使用与被联系将近一样的安全和功效 versu 鲜艳的小鸟 SES 能在每日的实践为密码 SES 作为一种选择被拿。 | XU Bo DOU Ke-fei YANG Yue-jin CHEN Ji-lin QIAO Shu-bin WANG Yang LI Jian-jun QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YUAN Jin-qing YOU Shi-jie LI Wei GAO Run-lin | 2011 | Chinese Medical Journal2011，，7： | 5 |
| 10 | Two-year clinical outcomes following elective drug-eluting versus bare-metal stent implantation: results from a large single-center database显示文摘响应有 drug-eluting stent (DES ) 的安全的增加的 concem 的背景,试图评估 DES 的长期的安全和功效的现在的学习为一张中国耐心的人口使用了。方法经历了一个索引的所有病人有在到 2006 年 12 月的从 2004 年 4 月的一个单个机构的 DES 或赤裸金属的 stent (BMS ) 的培植的选任的经皮的冠的干预,在分析被包括。匹配技术的一个倾向分数被使用调整并且最小化使因素惊讶的影响。结果外套,有 1465 个病人(20.2%) ,经历了仅仅仅仅 DES 的 BMS,和 5769 个病人(79.8%) 的培植。匹配技术的倾向分数为分析建立了 1321 个病人。stent 血栓的率之间没有重要差别(明确、可能) 二个组(1.06% 对 1.21% , P=-0.8580 ) 。尽管死亡和心肌的梗塞( MI )的率没显著地在2年的后续时期期间不同, death/MI 的率(3.0%对4.5%, P=0.0263 ),目标损害 revascularization ( TLR ,3.2%对 8.5 , P=0.0001 ),目标容器 revascularization ( TVR ,5.8%对9.5%, P < 0.0001 )并且任何 revascularization (10.0%对13.3%, P=0.0066 )比为 BMS 组为 DES 组是显著地更低的。在设备为离开标签指示在被植入的病人之中,倾向分数匹配 stent 血栓,死亡, MI ,和 death/MI 的率不是显著地不同的,当时 TLR 的率, TVR 和任何 revascularization 在后续柱子 stenting 的 2 年期间比为 BMS group.Conclusions 为 DES 组是显著地更低的, DES 使用与 death/MI , TLR , TVR 和任何 revascularization 的更低的率被联系与 BMS 相比,在倾向分数匹配的脊骨在离开标签用法的背景, DES 使用也与类似的优点被联系。 | GAO Run-lin XU Bo CHEN Ji-lin YANG Yue-jin QIAO Shu-bin WANG Yang DOU Ke-fei QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun MA Wei-hua LI Wei | 2009 | Chinese Medical Journal2009，，19： | 4 |
| 11 | Comparison of long-term clinical outcome after successful implantation of Firebird sirolimus-and Taxus paclitaxel-eluting stents in Chinese population: analysis of a large single center registry显示文摘背景最近的研究证明了药 eluting stent (DES ) 培植与赤裸金属的 stent (BMS ) 相比有关功效改进了临床的结果培植,和 sirolimus-eluting stent (SES ) 在改进结果比 paclitaxel-eluting stent (足) 似乎优异。鲜艳的小鸟 SES 是在中国的最广泛地使用的 SES。在在中国 popuation 的鲜艳的小鸟 SES 和 Taxus 足之间的安全和功效的长期的比较仍然不是可得到的。这研究的目的是从 2004 年 4 月在中国 population.Methods 在鲜艳的小鸟 SES 和 TAXUS 足的成功的培植以后在 24 个月把安全和功效比作 2006 年 10 月,经历了成功的 DES 的 3110 个连续病人(鲜艳的小鸟 SES 2274;Taxus 足 836 ) 培植有希望地被注册进这研究。所有注册病人基于 stent 类型被划分成二个组。由门诊病人诊所访问和电话会见,我们包括死亡,心肌的梗塞( Ml ),血栓,目标损害 revascularization ( TLR ),目标容器 revascularization ( TVR ),和主要不利心脏的事件获得了24月的临床的结果(向,死亡合成, Ml ,并且 TVR )。我们使用了考克斯的比例危险的模型在倾向火柴前后估计所有结果措施的相对风险。结果 Unadjusted 临床的结果显示与鲜艳的小鸟 SES 对待的病人与 TLR 的更低的风险被联系(HR0.38, 95%CI 0.26-0.54 ) , TVR (HR 0.51,95%CI 0.38-0.68 ) 和向(HR 0.53, 95%CI 0.41-0.68 ) 。在倾向火柴以后的结果与一致在匹配前,降低 TLR 的风险( HR 0.33 , 95%CI 0.19-0.58 ), TVR ( HR 0.41 , 95%CI 0.26-0.64 ),向( HR 0.48 , 95%CI 0.33-0.68 )在鲜艳的小鸟 group.Conclusion 与 Taxus 相比足,国内鲜艳的小鸟 SES 的使用可以减少在每日的实践的 TLR , TVR 和向的风险。 | DOU Ke-fei XU Bo YANG Yue-jin CHEN Ji-lin QIAO Shu-bin WANG Yang LI Jian-jun QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YUAN Jin-qing YOU Shi-jie LI Wei GAO Run-lin | 2010 | Chinese Medical Journal2010，，7： | 4 |
| 12 | Macroporous magnetic poly(GMA-EGDMA-DVB) microspheres supported palladium complex as an efficient catalyst for Heck reaction显示文摘Macroporous magnetic poly(GMA-EGDMA-DVB) microspheres synthesized by suspension polymerization were used as supports for palladium catalyst.The results showed the novel magnetic catalyst can promote Heck reaction of aryl halides with acrylic acid efficiently without an inert atmosphere.In addition,the novel catalyst can be conveniently recovered by applying an external magnet and reused at least five times without significant loss of its activity. | Ding Zhong Yuan Qiu Yu Zhang Jin Bo Dou | 2010 | Chinese Chemical Letters2010，21，9： | 3 |
| 13 | Epidemiological and clinical characteristics of COVID-19 patients in Hengyang,Hunan Province,China显示文摘BACKGROUND In December 2019,an ongoing outbreak of coronavirus disease 2019(COVID-19)was first identified in Wuhan,China.The characteristics of COVID-19 patients treated in local hospitals in Wuhan are not fully representative of patients outside Wuhan.Therefore,it is highly essential to analyze the epidemiological and clinical characteristics of COVID-19 in areas outside Wuhan or Hubei Province.To date,a limited number of studies have concentrated on the epidemiological and clinical characteristics of COVID-19 patients with different genders,clinical classification,and with or without basic diseases.AIM To study the epidemiological and clinical characteristics of COVID-19 patients in Hengyang(China)and provide a reliable reference for the prevention and control of COVID-19.METHODS From January 16 to March 2,2020,a total of 48 confirmed cases of COVID-19 were reported in Hengyang,and those cases were included in this study.The diagnostic criteria,clinical classification,and discharge standard related to COVID-19 were in line with the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7)released by National Health Commission and National Administration of Traditional Chinese Medicine.The presence of SARS-CoV-2 in pharyngeal swab specimens was detected by quantitative reverse transcription polymerase chain reaction.All the data were imported into the excel worksheet and statistically analyzed by using SPSS 25.0 software.RESULTS A total of 48 cases of COVID-19 were collected,of which 1 was mild,38 were moderate,and 9 were severe.It was unveiled that there were 31(64.6%)male patients and 17(35.4%)female patients,with a female-to-male ratio of 1.82:1.The range of age of patients with COVID-19 was dominantly 30-49 years old[25(52.1%)of 48],followed by those aged over 60 years old[11(22.9%)].Besides,29.2%(14 of 48)of patients had basic diseases,and 57.2%(8 of 14)of patients with basic diseases were aged over 60 years old.The occupations of 48 COVID-19 patients were mainly farmers working in agricultural production[15(31.5%)of 48],rural migrant workers from Hengyang to Wuhan[15(31.5%)],and service workers operating in the service sector[8(16.7%)].The mean latent period was 6.86±3.57 d,and the median was 7[interquartile range(IQR):4-9]d.The mean time from onset of symptoms to the first physician visit was 3.38±2.98(95%CI:2.58-9.18)d,with a median of 2(IQR:1-5)d,and the mean time from hospital admission to confirmed diagnosis was 2.29±2.11(95%CI:1.18-6.42)d,with a median of 2(IQR:1-3)d.The main symptoms were fever[43(89.6%)of 48],cough and expectoration[41(85.4%)],fatigue[22(45.8%)],and chills[22(45.8%)].Other symptoms included poor appetite[13(27.1%)],sore throat[9(18.8%)],dyspnea[9(18.8%)],diarrhea[7(14.6%)],dizziness[5(10.4%)],headache[5(10.4%)],muscle pain[5(10.4%)],nausea and vomiting[4(8.3%)],hemoptysis[4(8.3%)],and runny nose[1(2.1%)].The numbers of peripheral blood leukocytes,lymphocytes,and eosinophils were significantly reduced in the majority of the patients.The levels of C-reactive protein,fibrinogen,blood glucose,lactate dehydrogenase,Ddimer,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl transferase(γ-GT),myoglobin(MB),and creatine kinase(CK)were increased in 64.6%,44.7%,43.2%,37.0%,29.5%,22.9%,20.8%,21.6%,13.6%,and 12.8%of patients,respectively.The incidence of ALT elevation in male patients was remarkably higher than that in females(P<0.01),while the incidences of AST,CK,and blood glucose elevations in severe patients were remarkably higher than those in moderate patients(P<0.05,respectively).Except for the mild patients,chest computed tomography showed characteristic pulmonary lesions.All the patients received antiviral drugs,38(79.2%)accepted traditional Chinese medicine,and 2(4.2%)received treatment of human umbilical-cord mesenchymal stem cells.On March 2,2020,48 patients with COVID-19 were all cured and discharged.CONCLUSION Based on our results,patients with COVID-19 often have multiple organ dysfunction or damage.The incidences of ALT elevation in males,and AST,CK,and blood glucose elevations in severe patients are remarkably higher. | Zhe-Feng Zhong Jia Huang Xia Yang Jin-Ling Peng Xiao-Yan Zhang Yang Hu Nian Fu Hai-Lian Lin Bo Jiang Ya-Ying Tian Hong-Yi Yao Li-Pu Deng Xiao-Qing Tang Jie-Can Zhou Jian Tang Xia Xie Qiong Liu Jing Liu Cheng-Yun Dou Rong-Juan Dai Bo Yan Xue-Feng Yang | 2020 | World Journal of Clinical Cases2020，8，12： | 3 |
| 14 | Liouville Type Theorems for a System of Integral Equations on Upper Half Space显示文摘In this paper,we consider the following system of integral equations on upper half space {u(x) = ∫Rn + (1/|x-y|n-α-1/|-y|n-α) λ1up1(y) + μ1vp2(y) + β1up3(y)vp4(y) dy;v(x) = ∫Rn + (1/|x-y|n-α-1/|-y|n-α)(λ2uq1(y) + μ2vq2(y) + β2uq3(y)vq4(y) dy,where Rn + = {x =(x1,x2,...,xn) ∈ Rn|xn> 0}, =(x1,x2,...,xn-1,-xn) is the reflection of the point x about the hyperplane xn= 0,0 < α < n,λi,μi,βi≥ 0(i = 1,2) are constants,pi≥ 0 and qi≥ 0(i = 1,2,3,4).We prove the nonexistence of positive solutions to the above system with critical and subcritical exponents via moving sphere method. | Su Fang TANG Jing Bo DOU | 2014 | Acta Mathematica Sinica,English Series2014，30，2： | 3 |
| 15 | Outcomes of peripheral blood stem cell transplantation in patients from human leukocyte antigen matched or mismatched unrelated donors显示文摘 | Cao Tingting Li Yanfen Wang Quanshun Li Honghua Bo Jian Zhao Yu Jing Yu Wang Shuhong Zhu Haiyan Dou Liping Jia Bojun Gao Chunji Yu Li Huang Wenrong | 2014 | Chinese Medical Journal2014，，14： | 2 |
| 16 | Unsupervised Learning of Gaussian Mixture Model with Application to Image Segmentation显示文摘 | LI Bo LIU Wenju DOU Lihua | 2010 | Chinese Journal of Electronics2010，19，3： | 2 |
| 17 | Effect of Carbonation and Drying-Wetting Cycles on Chloride Diffusion Behavior of Coral Aggregate Seawater Concrete显示文摘Based on seawater immersion,drying-wetting cycles,carbonation and drying-wetting cycles for coral aggregate sea-water concrete(CASC)with different strength grades,the effect of carbonation and drying-wetting cycles on chloride diffusion be-havior of CASC is studied.The results show that the free surface chloride concentration(Cs),free chloride diffusion coefficient(Df)and time-dependent index(m)of CASC in the drying-wetting cycles is obviously higher than that in seawater immersion.The Df and m of CASC of carbonation and drying-wetting cycles is higher than that in the drying-wetting cycles.Carbonation increases the Df and m of CASC,which is against CASC to resist chloride corrosion.The corrosion possibility of CASC structures in different ex-posed areas is as follows:splash zone(carbonation and drying-wetting cycles)>tidal zone(drying-wetting cycles)>underwater zone(seawater immersion).Besides,the chloride diffusion rate of C65-CASC is 17.8%-63.4%higher than that of C65-ordinary aggre-gate concrete(OAC)in seawater immersion(underwater zone).Therefore,anti-corrosion measures should be adopted to improve the service life of CASC structure in the oceanic environment. | DA Bo LI Yipeng YU Hongfa MA Haiyan CHEN Haoyu DOU Xuemei WU Zhangyu | 2022 | Journal of Ocean University of China2022，21，1： | 2 |
| 18 | Feasibility and safety of robotic PCI in China: first in man experience in Asia显示文摘Objectives To evaluate the feasibility and safety of a second generation robotic percutaneous coronary intervention(R-PCI)system in China.Background Robotic PCI has been shown to be an effective method for conducting coronary interventions.It has further benefits of more accurate lesion measurement,improved stent deployment,reduced incidence of geographic miss and reduction of operator radiation exposure.Methods This single center evaluation enrolled 10 consecutive patients who had been selected for PCI.Clinical success was defined as residual stenosis<30%and no in-hospital major adverse cardiovascular events.Learning curve effect was assessed by comparing efficiency metrics of early vs.later cases.Results Eleven lesions were treated all successfully without manual interruption or MACE events.Most lesions(63%)were ACC/AHA class B2 and C.Mean procedure time was 57.7±26.4 min,however two procedures were part of live demonstrations.Excluding the two live cases,the mean procedure time was 51.8±23.7 min.Procedural efficiency tended to improve from early cases to later cases based on PCI time(48.3±32.9 vs.25.5±13.0 min,P=0.27),fluoroscopy time(20.3±8.2 vs.12.5±4.6 min,P=0.16),contrast volume(145.0±28.9 vs.102.5±17.1 mL,P=0.05)and Air Kerma dose(1932±978 vs.1007±70 mGy,P=0.31).Conclusions Second generation robotic PCI was safe,effective and there were trends toward improvements in procedural efficiency during this early experience in China. | Ke-Fei DOU Chen-Xi SONG Chao-Wei MU Wei-Xian YANG Cheng-Gang ZHU Lei FENG Jue CHEN Lei SONG Yu NING Bo XU | 2019 | Journal of Geriatric Cardiology2019，16，5： | 2 |
| 19 | Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial显示文摘It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart disease.Here,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and placebo.After performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by DII.Furthermore,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol metabolism.We assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear regression.Our study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target drug.Modular methods facilitate the discovery of network pharmacologicalmechanisms and the advancement of precision medicine.(ClinicalTrials.gov identifier:NCTO1681316). | Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu Yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua Jing-Yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-Lin Mao Xiao-Fang Bin Yue Deng Yu-Dan Tian Qing-Hua Han Da-Jin Liu Li-Qin Duan Ming-Jun Zhao Cui-Ying Zhang Hai-Ying Dai Ze-Hua Li Ying Xiao You-Zhi Hu Xiao-Yu Huang Kun Xing Xin Jiang Chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying Yang Yao-Rong Dong Lei Zhang Guang Fu Ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li Yun Xia Jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan Yang Lin Ya-Bin Zhou Jian-Fei Yang Guo-Qing Ma Hui-Jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu Xiao-Jia Luo Xiao-Hong Bin Ya-Nan Yu Hai-Xia Dang Bing Li Fei Teng Wang-Min Qiao Xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan Wang Yun-Dai Chen Zhong Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 20 | Rheological Study on the Cure Kinetics of Two-component Addition Cured Silicone Rubber显示文摘The cure kinetics for two-component silicone rubber formed by addition reaction was studied by the rheological method. The influence of reaction temperature(T) on the cure kinetics was explored in detail. It was observed that the data of gel time(t_(gel), i.e. the time when the reaction reaches the gel point) or a specific reaction time(t_(nc))(defined as the reaction time before which time the influence of confinement of network on the diffusion of reaction components can be neglected) versus T obey certain functional relationship, which was well explained by the cure kinetics model of thermoset network. The cure kinetics for the two-component silicone rubber can be well fitted by the Kamal-Sourour(autocatalyst) reaction model rather than Kissinger model. When the reaction time was before or equal to t_(nc), the reaction order obtained by the Kamal-Sourour reaction model was 2, which was consistent with the reaction order inferred from the two components chemical reaction when the diffusion of reaction components was not influenced by the formed cross-linked polymer network. When the reaction time was larger than t_(nc), such as to the end of reaction(t_e), the influence of confinement of network on the diffusion of reaction components cannot be neglected, and the reaction order obtained by the Kamal-Sourour reaction model was larger than 2. It was concluded that the confinement effect of network had a greater influence on the cure kinetics of the silicone rubber. The reaction rate constants(k_r) under different temperatures were also determined by Kamal-Sourour reaction model.The activation energy(E) for the two-component silicone rubber was also calculated from the results of lnt_(gel), lnt_(nc), and lnk_r versus 1/T, respectively. The three values of E were close, which indicated that above analyses were self-consistent. | Dong-bo Guan Zhong-yi Cai Xin-chun Liu Bo Lou Yan-li Dou 许东华 姚卫国 | 2016 | Chinese Journal of Polymer Science2016，34，10： | 2 |
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