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| 1 | Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation显示文摘瞄准:检验 isoliquiritigenin (ISL ) 是否能稀释心肌的 ischemiareperfusion (MI/R ) 在由通过双面联胎激酶的激活导致 metallothionein (MT ) 的老鼠的损害 2 (JAK 2 )/signal 变换器和抄写 3 的使活跃之物(STAT 3 ) 小径。方法:在老鼠的 MI/R 的试验性的模型被局部缺血和灌注的 30 min 为 2 h 产生。MT, COX-2,和 i NOS 的 mRNA 表示被 RT-PCR 测量。MT, JAK/STAT,细胞外的调整信号的激酶(英皇家空军之阶级最低之兵) ,和 Akt 的蛋白质表情被在一个 JAK 激酶禁止者的缺席或存在的西方的弄污决定, tyrphostin AG490 (1.0 mg/kg, iv,在局部缺血前的 1 h ) 。结果:有 ISL 的预告的处理显著地减少了导致 reperfusion 的心律不齐和心肌的梗塞尺寸的严厉。在 ISL 20 mg/kg 组,当时, lactate 脱氢酶(LDH ) 和肌酸酐磷酸激酶(CPK ) 的活动被 38.4% 和 51.3% 减少与车辆组相比。增加的 JAK 2/STAT 3 磷酸化被 MT 然而并非 COX-2 或 i NOS 的增加的合成在对待 ISL 的组伴随。AG490 能显著地削弱导致 ISL 的 cardioprotection 并且阻止 MT 表示和 JAK 2/STAT 的增加 3 磷酸化。结论:ISL 通过 JAK 2/STAT 的激活保护了 MI/R 损害 3 信号转导变异小径,它可能涉及调停起来 MT 的规定表示。 | Wei AN Jing YANG Ying AO | 2006 | Acta Pharmacologica Sinica2006，27，11： | 23 |
| 2 | Farmland marginalization in the mountainous areas: Characteristics, influencing factors and policy implications显示文摘基于 SPOT-5 图象, 1:1 百万张地志的地图,到森林工程和重庆森林工程的回来的农田的地图,聚会和经济统计,等等,这份报纸识别影响农田 marginalization 的特征和因素。结果出现了:(1 ) 在 20022012 期间,农田 marginalization 的率是 16.18% ,它主要在北 Qiyao 山的高区域和南部的 Qiyao 山的中等高度的区域被发现。并且这农田 marginalization 将增加,与农村劳动者的 non-agriculturalization 和留下的劳动者的老化联系了。(2 ) 举起,来自村庄的距离半径和道路连接在农田 marginalization 上有大影响。农田 marginalization 率随举起的增加显示出一个增加的趋势,并且 60.88% 全部的农田 marginalization 区域在海水平上面在比 1000 m 大的高度被发现。marginalization 趋势也从分发网络与斜坡和距离增加。(3 ) 农田区域每劳动者和农场劳动者的平均年龄是驾驶农田 marginalization 的主要因素。农田转移和小农业机械集合关于管理和生产率效率影响农田 marginalization。(4 ) 有 comparative-disadvantage-dominated marginalization 的农田说明了 55.32% 全部的农田 marginalization 区域,由地点主导的 marginalization (33.80%) 列在后面。(5 ) 根据每种真实状况的细节,不同政策被建议减轻 marginalization。一条连续 marginalization 政策将在地面主导的 marginalization 鼓励农田的回来到森林。一条 anti-marginalization 政策被建议创造新农村住所并且改进农村道路系统抵抗地面主导的 marginalization。并且另一条 anti-marginalization 政策被计划改进管理并且为 comparative-disadvantage-dominated marginalization 微机械化。一个新想法被开发与调查信息集成高分辨率遥感和统计数据在多山的区域识别陆地 marginalization 和它的驱动力。 | SHAO Jing'an ZHANG Shichao LI Xiubin | 2015 | Journal of Geographical Sciences2015，25，6： | 22 |
| 3 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 4 | Forming limits under multi-index constraints in NC bending of aluminum alloy thin-walled tubes with large diameters显示文摘With increasing diameters of aluminum alloy thin-walled tubes (AATTs), the tube forming limits, i.e. the minimum bending factors, and their predictions under multi-index constraints including wrinkling, thinning and flattening have been being a key problem to be urgently solved for improving tube forming potential in numerical control (NC) bending processes of AATTs with large diameters. Thus in this paper, a search algorithm of the forming limits is put forward based on a 3D elastic-plastic finite element (FE) model and a wrinkling energy prediction model for the bending processes under axial compression loading (ACL) or not. This algorithm enables to be considered the effects of process parameter combinations including die, friction parameters on the multi-indices. Based on this algorithm, the forming limits of the different size tubes are obtained, and the roles of the process parameter combinations in enabling the limit bending processes are also revealed. The followings are found: the first, within the appropriate ranges of friction and clearances between the different dies and the tubes enabling the bending processes with smaller bending factors, the ACL enables the tube limit bending processes after a decrease of the mandrel ball thickness and diameters; then, without considering the effects of the tube geometry sizes on the tube constitutive equations, the forming limits will be decided by the limit thinning values for the tubes with diameters smaller than 80 mm, while the wrinkling for the tubes with diameters no less than 80 mm. The forming limits obtained from this algorithm are smaller than the analytical results, and reduced by 57.39%; the last, the roles of the process parameter combinations in enabling the limit bending processes are verified by experimental results. | YAN Jing, YANG He, ZHAN Mei & LI Heng College of Materials Science and Engineering, State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China | 2010 | Science China(Technological Sciences)2010，53，2： | 21 |
| 5 | The value of vegetation ecosystem services:a case of Qinling-Daba Mountains显示文摘According to differences in vegetation types and their coverage, combining the latest research, using theory and method on the value of vegetation ecosystem services, this paper not only calculated goods produced by different types of vegetation but also estimated the value of various vegetation ecosystem services and set up database, GIS and eco-account of vegetation ecosystem. The result was as follows: the value of vegetation’s primary productivity, soil and fertility conservation, water conservation, CO 2 fixation and O 2 release was 199.6 billion yuan/a, 22.64 billion yuan/a, 22.66 billion yuan/a, 352.24 billion yuan/a and 374.19 billion yuan/a, respectively. The total value of ecosystem services was 968.33 billion yuan/a. The temperate deciduous broad-leaved forest had the highest contribution rate, accounting for 16.42%. The result of value can reflect regional reality more exactly. | REN Zhiyuan,ZHANG Yanfang,LI Jing(College of Tourism and Environment, Shaanxi Normal University, Xi’an 710062, China) | 2003 | Journal of Geographical Sciences2003，13，2： | 20 |
| 6 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 7 | Asian summer monsoon precipitation recorded by stalagmite oxygen isotopic composition in the western Loess Plateau during AD1875―2003 and its linkage with ocean-atmosphere system显示文摘Based on 5 high-precision 230Th dates and 103 stable oxygen isotope ratios (δ18O) obtained from the top 16 mm of a stalagmite collected from Wanxiang Cave,Wudu,Gansu,variation of monsoonal precipita-tion in the modern Asian Monsoon (AM) marginal zone over the past 100 years was reconstructed. Comparison of the speleothem δ18O record with instrumental precipitation data at Wudu in the past 50 years indicates a high parallelism between the two curves,suggesting that the speleothem δ18O is a good proxy for the AM strength and associated precipitation,controlled by 'amount effect' of the pre-cipitation. Variation of the monsoonal precipitation during the past 100 years can be divided into three stages,increasing from AD 1875 to 1900,then decreasing from AD 1901 to 1946,and increasing again thereafter. This variation is quite similar to that of the Drought/Flooding index archived from Chinese historical documents. This speleothem-derived AM record shows a close association with the Pacific Decadal Oscillation (PDO) between AD 1875 and 1977,with higher monsoonal precipitation corre-sponding to cold PDO phase and vice versa at decadal timescale. The monsoonal precipitation varia-tion is out of phase with the PDO after AD 1977,probably resulting from the decadal climate jump in the north Pacific occurring at around AD 1976/77. These results demonstrate a strong linkage between the AM and associated precipitation and the Pacific Ocean via ocean/atmosphere interaction. This rela-tionship will aid to forecast future hydrological cycle for the AM monsoon region,and to improve forecasting potential of climatic model with observation data from cave. | LIU JingHua ZHANG PingZhong CHENG Hai CHEN FaHu YANG XunLin ZHANG DeZhong ZHOU Jing JIA JiHong AN ChunLei SANG WenCui Kathleen R. JOHNSON | 2008 | Chinese Science Bulletin2008，53，13： | 13 |
| 8 | Impact of built environment on physical activity and obesity among children and adolescents in China:A narrative systematic review显示文摘Background: Neighborhood built environment may profoundly influence children's physical activity(PA) and body weight. This study systematically reviewed scientific evidence regarding the impact of built environment on PA and obesity among children and adolescents in China.Methods: A keyword and reference search was conducted in Active Living Research, Cochrane Library, PubMed, and Web of Science. Studies that met all of the following criteria were included in the review:(1) study designs—experimental studies, observational studies, and qualitative studies;(2) study subjects—Chinese children and/or adolescents aged 17 years;(3) exposures—neighborhood built environment;(4)outcomes—PA and/or body weight status;(5) article type—peer-reviewed publications;(6) time window of search—from the inception of an electronic bibliographic database to May 31, 2018;(7) country—China; and(8) language—articles written in English.Results: A total of 20 studies, including 16 cross-sectional studies, 3 longitudinal studies, and 1 descriptive study, met the predetermined selection criteria and were included in the review. A total of 13 studies adopted subjective built environment measures reported by parents and/or children, 2 adopted objective measures(e.g., geographical information system, field observations), and 5 adopted both objective and subjective measures. PA behaviors included PA, physical inactivity, sedentary behavior, active/passive commuting from/to school, and park visits. Among the 16 studies that provided some quantitative estimates of the influence of built environment on PA and body weight status, all reported a statistically significant relationship in the expected direction. Availability and accessibility in proximity to greenspaces, parks, recreational facilities,and sidewalks were found to be associated with increased PA levels, reduced sedentary behaviors, and/or active commuting among Chinese children and adolescents. In contrast, the absence of bike lanes and living in higher density residential areas were associated with increased likelihood of childhood overweight and obesity.Conclusion: Neighborhood built environment plays an important role in Chinese children's PA engagement and weight outcomes. Building new exercise facilities and enhancing the accessibility of existing facilities hold the potential to enhance PA engagement among Chinese children and adolescents. In addition, urban designs that incorporate sidewalks, bike lanes, walking paths, less motorized traffic, and lower residential density are likely to promote PA and prevent childhood obesity in China. | Ruopeng An Jing Shen Qiuying Yang Yan Yang | 2019 | Journal of Sport and Health Science2019，8，2： | 13 |
| 9 | Comparison of symptom and risk assessment methods among patients with chronic obstructive pulmonary disease显示文摘 | Zhang Rongbao Tan Xingyu He Quanying Chen Qing Gai Jun Wei Jing'an Wang Yan | 2014 | Chinese Medical Journal2014，，14： | 12 |
| 10 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 11 | Angiostatin up-regulation in gastric cancer cell SGC7901 inhibits tumorigenesis in nude mice显示文摘AIM: To explore the influence of angiostatin up-regulationon the biologic behavior of gastric cancer cells in vitro andin vivo, and the potential of angiostatin gene therapy in thetreatment of human gastric cancer.METHODS: Mouse angiostatin cDNA was subcloned intothe eukaryotic expression vector pcDNA3.1(+) and identifiedby restriction endonucleases digestion and sequencing. Therecombinant vector pcDNA3. 1(+)-angio was transfected intohuman gastric cancer cells SGC7901 with liposome andparalleled with the vector control and the mock control.Angiostatin transcription and protein expression wereexamined by RT-PCR and Western blot in the stable celllines selected by G418. Cell proliferation and growth in vitroof the three groups were observed respectively undermicroscope, cell number counting and FACS. The cellsoverexpressing angiostatin, vector transfected and untreatedwere respectively implanted subcutaneously into nude mice.After 30days the size of tumors formed was measured, andmicrovessel density count (MVD) in the tumor tissues wasassessed by immunohistochemistry with the primary anti-vWF antibody.RESULTS: The recombinant vector pcDNA3.1(+)-angio wasconfirmed with the correct sequence of mouse angiostatinunder the promoter CMV. After 30 d of transfection andselection with G418, macroscopic resistant cell clones wereformed in the experimental group transfected with pcDNA3.1(+)-angio and the vector control. But no untreated cellssurvived in the mock control. Angiostatin mRNAtranscription and protein expression were detected in theexperimental group. No significant differences wereobserved among the three groups in cell morphology, cellgrowth curves and cell cycle phase distributions in vitro.However, in nude mice model, markedly inhibitedtumorigenesis and slowed tumor expansion were observedin the experimental group as compared with the controls,which was paralleled with decreased microvessel density inand around tumor tissues (P<0. 05).CONCLUSION: Angiostatin does not directly inhibit humangastric cancer cell proliferation and growth in vitro, but exertsits anti-tumor functions through antiangiogenesis in aparacrine way in vivo. | Jing Wu Yong-Quan Shi Kai-Chun Wu De-Xin Zhang Jing-Hua Yang Dai-Ming Fan Institute of Gastrointestinal Diseases Research,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shannxi Province,China | 2003 | World Journal of Gastroenterology2003，9，1： | 11 |
| 12 | A cytotoxic compound from the leaves of Juglans mandshurica显示文摘From Juglans mandshurica leaves, a new quinone compound was isolated through bioassay-guided fractionation. The structure elucidation of the compound was established based on spectroscopic studies, notably of the 2D NMR spectra. The compound exhibited moderate cytotoxic activities against Hela, MCF-7, BGC823 and 3T3-L1cell lines with IC50 ranges from 7.5 to26.8 mmol/L. | Zhi Bo Li Yong Ming Bao Hong Bo Chen Jing Yun Wang Jie Han Hu Li Jia An | 2007 | Chinese Chemical Letters2007，18，7： | 11 |
| 13 | An overview of design for CSNS/RCS and beam transport显示文摘The China Spallation Neutron Source (CSNS) is the first accelerator-based pulsed neutron source in China. Its accelerators are made up of an 80 MeV H- linac, a Rapid Cycling Synchrotron (RCS) and two beam transport lines. RCS accumulates and accelerates protons to the design energy of 1.6 GeV, and extracts high energy beam to strike the target. The overview of RCS is presented, and the key problems of the physics design are discussed. The two beam transport lines, from linac to RCS and from RCS to the target, are also introduced. | WANG Sheng AN YuWen FANG ShouXian HUANG Nan LIU WeiBin LIU YuDong QIN Qing QIU Jing WANG Na XU Gang XU ShouYan YU ChengHui | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 11 |
| 14 | The characteristics of temperature variability with terrain, latitude and longitude in Sichuan- Chongqing Region显示文摘用从四川重庆区域和它的包围区域的 95 个气象学的车站的每日的温度数据,这份报纸采用了这些方法(例如,线性回归,趋势系数,地理统计,灰色的关系分析和空间分析 GIS 工作)与地形学分析温度可变性的关系,纬度和经度。而且,在温度可变性和举起,经度,纬度,地志的位置和表面粗糙之间的灰色的关联的等级也被测量。这些结果显示了:(1 ) 举起最显然影响了温度可变性,由纬度,和经度列在后面。在温度变化率和举起,纬度和经度之间的线性回归的斜坡分别地是 0.4142, 0.0293 和 0.3270。(2 ) 在温度变化率和地理因素之间的灰色的关联的等级是举起 > 纬度 > 表面粗糙 > 地志的位置 > 经度。在温度变化率和举起之间的灰色的关联度是 0.865,与 0.796 由纬度列在后面,并且有 0.671 的经度。(3 ) 温度变化的率随举起的增加提高了。特别,温暖的趋势在西方的四川,和西南的四川的山脉和山谷区域的高原和山区是重要的(与 0.74 | SHAO Jing'an LI Yangbing NI Jiupai | 2012 | Journal of Geographical Sciences2012，22，2： | 10 |
| 15 | Apogossypolone, a novel inhibitor of anfiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro显示文摘有限治疗选择为好攻击的前列腺癌症是可得到的。Gossypol 被报导了在癌症的许多类型举办一项有势力 anticancer 活动。它能增加癌症房间的敏感到 alkylating 代理人,减少 multidrug 抵抗和减少转移。它是否能在癌症房间导致 autophagy,还没是坚定的。这里,我们在 vitro 在人的前列腺癌症房间线 PC3 和 LNCaP 上调查了 apogossypolone (ApoG2 ) 和(?)-gossypol 的 antiproliferative 活动。到 ApoG2 的 PC-3 和 LNCaP 房间的暴露导致了 autophagy 的几个特定的特征特征,包括在酸的小囊的细胞器的细胞质和形成的膜的液泡的外观。联系 autophagy 的 LC3-II 和 beclin-1 的表示在治疗以后在两根房间线增加了。有 3-methyladenine 的 autophagy 的抑制支持了两种房间类型的 apoptosis。一起拿,这些数据证明 autophagy 的那正式就职能在人的前列腺癌症房间对 apoptosis 代表防卫机制。 | Xian-Qing Zhang Xiao-Feng Huang Xing-Bin Hu Yong-Hua Zhan Qun-Xing An Shi-Ming Yang Ai-Jun Xia Jing Yi Rui Chen Shi-Jie Mu Dao-Cheng Wu | 2010 | Asian Journal of Andrology2010，12，5： | 10 |
| 16 | Evidences for vagus nerve in-maintenance of immune balance and transmission of immune information from gut to brain in STM-infected rats显示文摘AIM:To determine whether salmonella Typhimurium(STM) in gastrointestinal tract can induce the functional activation of brain,whether the vagus nerve involves in signaling immune infomation from gastrointestinal tract to brain and how it influences the immune function under natural infection condition.METHODS:Animal model of gastrointestinal tract infection in the rat was established by an intuation of Salmonella Typhimurium(STM) into stomach to minic the condition of natural bacteria infection,Subdiagphragmatic vagotomy was performed in some of the animals 28 days before infection The changes of Fos expression visualized with immunohistochemistry technique in hypothalamic paraventricular nucleus(pVN) and superaoptic nuclesu (SON)were conted.Meanwhilie,the percentage and the Mean Intensities of Flurescent (MIFs)of CD4+ and CD8+ T cells in peripheral blood were measured by using flow cytometry(FCM),and the pathological changes in ileum and mesenteric lymph node were observed in HE stained sections.RESULTS:In bacteria-stimulated groups,inflammatory pathological changes were seen in ileum and mesenteric lymph node,The percentages of CD4+ T cells in peripheral blood were decreased from 43%±4.5%to 34%±4.9%(P<0.5)and MIFs of CD8+ T cells were also decreased from 2.9±0.39to 2.1±0.36(P<0.05)with STM stimulation.All of them proved that our STM-infection model was reliable Fos immunoreactive(Fos-ir) cells in PVN and SON incerased significantly with STM stimulation,from 189±41 to467±62(P<0.05)and from 64±21 to 282±47(P<0.05)individually,which suggested that STM in gastointestinal tract induced the functional activation of brain Subdiagphragmatic vagotomy attenuated FOs expression in PVN and SON induced by STM,from 467±62to 226±45(P<0.05)and from 282±47to 71±19(P<0.05)individually,and restored the decreased percentages of CD4+ T cells induced by STM from 34%±4.9% to original level 44%±6.0%(P<0.05).In addition,subdiagphragmatic vagotomy itself also decreased the percentages of CD8+ T cells (from 28%±3.0%to 21%±5.9%),P<0.05 and MIFs of CD4+(from 6.6±0.6to4.9±1.0P<0.05)and CD8+ T cells (from 2.9±0.39to 1.4±0.34,P<0.05).Both of them manifested the important role of vagus nerve in transmitting immune information from gut to brain and maintaining the immune balance of the organism.CONCLUSION:Vagus nerve dose involve in transmitting adbominal immune informaton into the brain in STM infection condition and play an important role in maintenance of the immune balance of the oranism. | Xi Wang Bai-Ren Wang Zhen Xu Yu-Qiang Ding Gong Ju,Institute of Neuroscience,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Xi-Jing Zhang,Department of Anesthesiology,Xi Jing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 10 |
| 17 | Classification and Gradation of Cultivated Land Quality in Bishan County of Chongqing, China显示文摘The conflicts among food security, economic development and ecological protection are the “sticking point” of undeveloped southwestern mountainous areas of China. The objectives of this study are to identify appropriate inte- grated indicators influencing the classification and gradation of cultivated land quality in the southwestern mountainous area of China based on semi-structure interview, and to promote the monitoring of cultivated land quality in this region. Taking Bishan County of Chongqing as a study case, the integrated indicators involve the productivity, protection, ac- ceptability, and stability of cultivated land. The integrated indicators accord with the characteristics of land resources and human preference in southwestern mountainous area of China. In different agricultural zones, we emphasize different indicators, such as emphasizing productivity, stabilization and acceptability in low hilly and plain agricultural integrative zone (LHP-AIZ), protection, productivity and stability in low mountain and hill agro-forestry ecological zone (LMH-AEZ), and acceptability in plain outskirts integrative agricultural zone (PO-IAZ), respectively. The pronounced difference of classification and gradation of cultivated land, regardless of inter-region or intra-region, is observed, with the reducible rank from PO-IAZ, LHP-AIZ to LMH-AEZ. Research results accord with the characteristics of assets management and intensive utilization of cultivated land resources in the southwestern mountainous area of China. Semi-structure interview adequately presents the principal agent of farmers in agricultural land use and rural land market. This method is very effective and feasible to obtain data of the quality of cultivated land in the southwestern mountainous area of China. | SHAO Jing'an GE Xiaofeng WEI Chaofu XIE Deti | 2007 | Chinese Geographical Science2007，17，1： | 10 |
| 18 | High quality reference genome of drumstick tree(Moringa oleifera Lam.), a potential perennial crop显示文摘The drumstick tree(Moringa oleifera Lam.) is a perennial crop that has gained popularity in certain developing countries for its high-nutrition content and adaptability to arid and semi-arid environments. Here we report a high-quality draft genome sequence of M. oleifera. This assembly represents 91.78% of the estimated genome size and contains 19,465 protein-coding genes. Comparative genomic analysis between M. oleifera and related woody plant genomes helps clarify the general evolution of this species, while the identification of several species-specific gene families and positively selected genes in M. oleifera may help identify genes related to M. oleifera's high protein content, fast-growth, heat and stress tolerance. This reference genome greatly extends the basic research on M. oleifera, and may further promote applying genomics to enhanced breeding and improvement of M. oleifera. | TIAN Yang ZENG Yan ZHANG Jing YANG Cheng Guang YAN Liang WANG XuanJun SHI ChongYing XIE Jing DAI TianYi PENG Lei ZENG HUAN Yu XU An Ni HUANG YeWei ZHANG JiaJin MA Xiao DONG Yang HAO ShuMei SHENG Jun | 2015 | Science China(Life Sciences)2015，58，7： | 10 |
| 19 | Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus(HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established. In this study, we evaluated the expression of HCMV pp65 antigen in brain sections from 26 patients with RE and 20 non-RE patients by immunohistochemistry and in situ hybridization, and assessed the associations between HCMV infection and clinical parameters.Elevated expression of HCMV pp65 protein and DNA was observed in 88.5%(23/26) and 69.2%(18/26) of RE cases, respectively. In the non-RE group, HCMV pp65 antigen was detected only in two cases(10%), both of which were negative for DNA staining. Additionally, the intensity of HCMV pp65 staining was correlated with a shorter duration of the prodromal stage, younger age of seizure onset, and more severe unilateral cortical atrophy. Elevated expression of HCMV pp65 was observed in RE brain tissue and was correlated with the clinical features of RE disease. In summary, our results suggested that HCMV infection may be involved in the occurrence and progression of RE disease. Thus, further studies are needed to determine whether early treatment with anti-HCMV antibodies could modulate the course of RE. | Yao Zhang Yisong Wang Sichang Chen Shuai Chen Yuguang Guan Changqing Liu Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，2： | 9 |
| 20 | Stress evolution and support mechanism of a bolt anchored in a rock mass with a weak interlayer显示文摘By applying experimental method, the bolt stress and supporting mechanism is studied during the deformation process of a rock mass containing a weak interlayer. The force measuring bolt is installed manually and instrumented five pairs of symmetrical strain gauges. The experimental results show that the fully grouted bolt suffers tensile, compressive, bending and shear stress at the same time. The bolt stress evolution is closely related to the deformation stages of the rock mass which are very gradually varying stage, gradually varying stage at the pre-peak and suddenly varying stage at the post peak stage.The axial compressive stress in the bolt is mainly induced by the moment. Thus, in most cases the axial compressive stress is distributed on one side of the bolt. For axial stresses, induced by the axial force and the bending moment at the post-peak stage, three types of changing are observed, viz. increasingincreasing type, decreasing-increasing type and increasing-decreasing type. The stress characteristics of the bolt section in the weak interlayer are significantly different from those in the hard rock. The failure models of the anchored bolt are tensile failure and shear failure, respectively. The bolt not only provides constraints on the free surface of the rock mass, but also resists the axial and lateral loading by the bending moment. This study provides valuable guidelines for bolting support design and its safety assessment. | Ding Shuxue Jing Hongwen Chen Kunfu Xu Guo'an Meng Bo | 2017 | International Journal of Mining Science and Technology2017，27，3： | 9 |
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