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| 1 | Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases:An update显示文摘Long-chain acyl-Co A synthetase(ACSL) family members include five different ACSL isoforms, each encoded by a separate gene and have multiple spliced variants. ACSLs on endoplasmic reticulum and mitochondrial outer membrance catalyze fatty acids with chain lengths from 12 to 20 carbon atoms to form acyl-Co As, which are lipid metabolic intermediates and involved in fatty acid metabolism, membrane modifications and various physiological processes. Gain- or lossof-function studies have shown that the expression of individual ACSL isoforms can alter the distribution and amount of intracellular fatty acids. Changes in the types and amounts of fatty acids, in turn, can alter the expression of intracellular ACSLs. ACSL family members affect not only the proliferation of normal cells, but the proliferation of malignant tumor cells. They also regulate cell apoptosis through different signaling pathways and molecular mechanisms. ACSL members have individual functions in fatty acid metabolism in different types of cells depending on substrate preferences, subcellular location and tissue specificity, thus contributing to liver diseases and metabolic diseases, such as fatty liver disease, obesity, atherosclerosis and diabetes. They are also linked to neurological disorders and other diseases. However, the mechanisms are unclear. This review addresses new findings in the classification and properties of ACSLs and the fatty acid metabolismassociated effects of ACSLs in diseases. | Sheng Yan Xue-Feng Yang Hao-Lei Liu Nian Fu Yan Ouyang Kai Qing | 2015 | World Journal of Gastroenterology2015，21，12： | 18 |
| 2 | Two stomach-originated lactobacillus strains improve Helicobacter pylori infected murine gastritis显示文摘AIM:To investigate the potential anti-Helicobacter pylori(H.pylori ) and anti-inflammation in vivo effects of two lactobacillus strains from human stomach.METHODS:Forty H.pylori infected Balb/c mice were randomly divided into 4 groups:proton pump inhibitor and antibiotics triple treated group,Lactobacillus fermenti(L.fermenti ) treated group,Lactobacillus acidophilus treated group and normal saline control group.Ten uninfected mice were also included as blank control group.The infection of H.pylori was detected by rapid urease tests,Giemsa staining and bacterial culture.The colonization of H.pylori was assessed in bacterial density score and gastric inflammation was assessed in histological score.The colonization of L.fermenti was performed by fluorescent probe.RESULTS:Histopathologic evaluation showed significant release of mucosal inflammation in gastric antrum and gastric body in lactobacillus treated groups and triple treated group.H.pylori eradication rate in both lactobacillus treated groups and triple treated group were higher than normal saline control group.Lactobacillus treated groups and triple treated group showed significant decrease of H.pylori bacterial density.CONCLUSION:Both lactobacillus strains have a significant anti-H.pylori activity;L.fermenti displays more efficient antagonistic activity in vivo against H.pylori infection. | Cui, Yi Wang, Chun-Lian Liu, Xiao-Wei Wang, Xue-Hong Chen, Lin-Lin Zhao, Xin Fu, Nian Lu, Fang-Gen | 2010 | World Journal of Gastroenterology2010，16，4： | 7 |
| 3 | Dependence of creep age formability on initial temper of an Al-Zn-Mg-Cu alloy显示文摘The initial temper of the material may directly affect the whole creep age forming(CAF)process. In terms of creep deformation and stress relaxation, using the constant-stress creep aging and constant-strain stress relaxation aging tests, the relationship between initial temper and CAF formability is investigated for an Al-Zn-Mg-Cu alloy at 165 °C for 18 h. Three tempers are selected as the initial tempers in CAF, viz., solution, retrogression and re-solution. The CAF formability of this alloy with initial temper of retrogression is the best, and the creep strain of the retrogression tempered specimen after creep aging of 18 h is about 1.21 and 1.34 times than that of the solution and the re-solution tempered specimens, respectively. The calculated stress exponents of this alloy with three initial tempers range from 7.3 to 9.5, indicating that the CAF of this alloy is mainly controlled by the dislocation creep. The various formability for three initial tempers are attributed to different inhibitions of the transgranular precipitates on the dislocation movement. For the retrogression temper, the initial fine and uniformly distributed precipitates are seriously coarsened after6 h of CAF, which minimally inhibit the dislocation movement. While, for the re-solution temper,the fine precipitates are re-precipitated in the matrix of the alloy, which observably hinder the dislocation movement and lead to the worst formability. | Lei Chao Yang He Li Heng Shi Nian Fu Jin Zhan Lihua | 2016 | Chinese Journal of Aeronautics2016，29，5： | 5 |
| 4 | Epidemiological and clinical characteristics of COVID-19 patients in Hengyang,Hunan Province,China显示文摘BACKGROUND In December 2019,an ongoing outbreak of coronavirus disease 2019(COVID-19)was first identified in Wuhan,China.The characteristics of COVID-19 patients treated in local hospitals in Wuhan are not fully representative of patients outside Wuhan.Therefore,it is highly essential to analyze the epidemiological and clinical characteristics of COVID-19 in areas outside Wuhan or Hubei Province.To date,a limited number of studies have concentrated on the epidemiological and clinical characteristics of COVID-19 patients with different genders,clinical classification,and with or without basic diseases.AIM To study the epidemiological and clinical characteristics of COVID-19 patients in Hengyang(China)and provide a reliable reference for the prevention and control of COVID-19.METHODS From January 16 to March 2,2020,a total of 48 confirmed cases of COVID-19 were reported in Hengyang,and those cases were included in this study.The diagnostic criteria,clinical classification,and discharge standard related to COVID-19 were in line with the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7)released by National Health Commission and National Administration of Traditional Chinese Medicine.The presence of SARS-CoV-2 in pharyngeal swab specimens was detected by quantitative reverse transcription polymerase chain reaction.All the data were imported into the excel worksheet and statistically analyzed by using SPSS 25.0 software.RESULTS A total of 48 cases of COVID-19 were collected,of which 1 was mild,38 were moderate,and 9 were severe.It was unveiled that there were 31(64.6%)male patients and 17(35.4%)female patients,with a female-to-male ratio of 1.82:1.The range of age of patients with COVID-19 was dominantly 30-49 years old[25(52.1%)of 48],followed by those aged over 60 years old[11(22.9%)].Besides,29.2%(14 of 48)of patients had basic diseases,and 57.2%(8 of 14)of patients with basic diseases were aged over 60 years old.The occupations of 48 COVID-19 patients were mainly farmers working in agricultural production[15(31.5%)of 48],rural migrant workers from Hengyang to Wuhan[15(31.5%)],and service workers operating in the service sector[8(16.7%)].The mean latent period was 6.86±3.57 d,and the median was 7[interquartile range(IQR):4-9]d.The mean time from onset of symptoms to the first physician visit was 3.38±2.98(95%CI:2.58-9.18)d,with a median of 2(IQR:1-5)d,and the mean time from hospital admission to confirmed diagnosis was 2.29±2.11(95%CI:1.18-6.42)d,with a median of 2(IQR:1-3)d.The main symptoms were fever[43(89.6%)of 48],cough and expectoration[41(85.4%)],fatigue[22(45.8%)],and chills[22(45.8%)].Other symptoms included poor appetite[13(27.1%)],sore throat[9(18.8%)],dyspnea[9(18.8%)],diarrhea[7(14.6%)],dizziness[5(10.4%)],headache[5(10.4%)],muscle pain[5(10.4%)],nausea and vomiting[4(8.3%)],hemoptysis[4(8.3%)],and runny nose[1(2.1%)].The numbers of peripheral blood leukocytes,lymphocytes,and eosinophils were significantly reduced in the majority of the patients.The levels of C-reactive protein,fibrinogen,blood glucose,lactate dehydrogenase,Ddimer,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl transferase(γ-GT),myoglobin(MB),and creatine kinase(CK)were increased in 64.6%,44.7%,43.2%,37.0%,29.5%,22.9%,20.8%,21.6%,13.6%,and 12.8%of patients,respectively.The incidence of ALT elevation in male patients was remarkably higher than that in females(P<0.01),while the incidences of AST,CK,and blood glucose elevations in severe patients were remarkably higher than those in moderate patients(P<0.05,respectively).Except for the mild patients,chest computed tomography showed characteristic pulmonary lesions.All the patients received antiviral drugs,38(79.2%)accepted traditional Chinese medicine,and 2(4.2%)received treatment of human umbilical-cord mesenchymal stem cells.On March 2,2020,48 patients with COVID-19 were all cured and discharged.CONCLUSION Based on our results,patients with COVID-19 often have multiple organ dysfunction or damage.The incidences of ALT elevation in males,and AST,CK,and blood glucose elevations in severe patients are remarkably higher. | Zhe-Feng Zhong Jia Huang Xia Yang Jin-Ling Peng Xiao-Yan Zhang Yang Hu Nian Fu Hai-Lian Lin Bo Jiang Ya-Ying Tian Hong-Yi Yao Li-Pu Deng Xiao-Qing Tang Jie-Can Zhou Jian Tang Xia Xie Qiong Liu Jing Liu Cheng-Yun Dou Rong-Juan Dai Bo Yan Xue-Feng Yang | 2020 | World Journal of Clinical Cases2020，8，12： | 3 |
| 5 | Human parvovirus B19-associated early postoperative acquired pure red cell aplasia in simultaneous pancreas-kidney transplantation:A case report显示文摘BACKGROUND Acquired pure red cell aplasia(aPRCA)related to human parvovirus B19(HPV B19)is rarely reported in simultaneous pancreas-kidney transplantation(SPKT)recipients;there has yet to be a case report of early postoperative infection.In this current study,we report the case of a Chinese patient who experienced the disease in the early postoperative period.CASE SUMMARY A 63-year-old man,with type 2 diabetes and end-stage renal disease,received a brain dead donor-derived SPKT.Immunosuppression treatment consisted of tacrolimus,prednisone,enteric-coated mycophenolate sodium(EC-MPS),and thymoglobulin combined with methylprednisolone as induction.The hemoglobin(Hb)level declined due to melena at postoperative day(POD)3,erythropoietinresistant anemia persisted,and reticulocytopenia was diagnosed at POD 20.The bone marrow aspirate showed decreased erythropoiesis and the presence of giant pronormoblasts at POD 43.Metagenomic next-generation sequencing(mNGS)of a blood sample identified HPV B19 infection at POD 66.EC-MPS was withdrawn;three cycles of intravenous immunoglobulin(IVIG)infusion therapy were administered;and tacrolimus was switched to cyclosporine.The HPV B19-associated aPRCA resolved completely and did not relapse within the 1-year follow-up period.The diminution in mNGS reads was correlated with Hb and reticulocyte count improvements.CONCLUSION HPV B19-associated aPRCA can occur at an early period after SPKT.An effective therapy regimen includes IVIG infusion and adjustment of the immunosuppressive regimen.Moreover,mNGS can be used for the diagnosis and to reflect disease progression. | Hui Wang Ying-Xin Fu Wen-Li Song Zhen Wang Gang Feng Jie Zhao Ye-Qi Nian Yu Cao | 2021 | World Journal of Clinical Cases2021，9，8： | 2 |
| 6 | Real time bipolar time-of-flight mass spectrometer for analyzing single aerosol particles显示文摘 | Lei Li Zhengxu Huang Junguo Dong Mei Li Wei Gao Huiqing Nian Zhong Fu Guohua Zhang Xinhui Bi Ping Cheng Zhen Zhou | 2011 | International Journal of Mass Spectrometry2011，，2： | 2 |
| 7 | A new alkylene dihydrofuran glycoside with antioxidation activity from the root bark of Morus alba L.显示文摘新 alkylene dihydrofuran glycoside (1 ) 从根被孤立桑属 alba L. 吠叫,与 moracin M-3 鈥 ?O- 尾 - 一起 d-glucopyranoside (2 ) ,和 moracin M-6, 3 鈥 ?di-O- 尾 - d-glucopyranoside (3 ) 。化合物 1 作为 2-methylene-3-methoxy-2 被识别, 5-dihydrofuran-4-O- 尾 - d-glucopyranoside 根据包括 1D 和 2D NMR 的化学、分光镜的数据光谱分析。另外, 1 的抗氧化剂活动用 1,1-diphenyl-2-picrylhydrazyl (DPPH ) 和 2,2 鈥 ? azinobis-3-ethylbenzothiazoline-6-sulphonic 被评估酸(ABTS ) 试金。IC50 价值分别地是 2.49 和 0.45 mg/mL。 | Wei Fu Yong Fang Lei Ya Ling Cai Dao Nian Zhou Jin Lan Ruan | 2010 | Chinese Chemical Letters2010，21，7： | 2 |
| 8 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 9 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 10 | MCU deficiency blocks cell proliferation by disrupting cytoplasmic Ca^2+transients due to altered Drp1 hospitalization显示文摘Mitochondrial calcium uniporter(MCU)is a highly selective Ca+channel protein of the mitochondria inner membrane [1],which allows divalent cations(Ca^2+≈Sr^2+》Mn^2+≈Ba^2+)to permeate[2].The MCU is a 40-kDa protein thar contains a proteolytically cleaved mitochondrial import sequence,two coiled-coil domains,two transmembrane domains,and a short motif of amino acids between the two transmembrane domains critical for Ca^2+ transport[3],MCU is widely expressed in the mitochondrial inner mem-brane of various cells[4].In addition,MCU is also a highly con-served protein among different species(Fig.1A),sugesting that MCU may play an ssential role in the process of physiology and puthology. | Li Wang Kai Zhang Nian Fu Lanfang Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 1 |
| 11 | Clinical Application of Gaofang(Medicated Paste)in Cardiovascular Disease显示文摘Gaofang(medicated paste),also known as gaoji in Chinese,is one of the eight dosage forms of traditional Chinese medicine.Originated in the Han and Tang dynasties,it is widely used in Shanghai,Jiangsu,Zhejiang,and Guangdong of China at present.It is generally believed that Gaofang can help reinforce deficiency,delay aging,and regulate the overall health status.Currently,Gaofang has been extensively used in the treatment of cardiovascular disease.Based on the relevant literature and clinical experience,this article reviews the general situation and the clinical application of Gaofang as well as the common Chinese medicines in Gaofang for cardiovascular diseases. | Hua Nian Qun-Qun Zhang Ming-Hua Ma Yi-Jun Zhang Tie-Jun Wu Jing Liu De-Yu Fu Ling-Ling Xu Ke Wang | 2022 | Chinese Medicine and Culture2022，5，3： | 1 |
| 12 | Comparison of effectiveness of different ashing auxiliaries for determination of phosphorus in natural waters, aquatic organisms and sediments by ignition method显示文摘 | Yi Zhou Fu sui Zhang Hong sheng Yang Shumei Zhang Xi nian Ma | 2003 | Water Research2003，，16： | 1 |
| 13 | Roles of Long-chain Acyl Coenzyme A Synthetase in Absorption and Transport of Fatty Acid显示文摘Long-chain acyl coenzyme A synthetase(ACSL) is a member of the synthetase family encoded by a multigene family;it plays an important role in the absorption and transport of fatty acid.Here we review the roles of ACSL in the regulating absorption and transport of fatty acid,as well as the connection between ACSL and some metabolic diseases. | Fan Gao Xue-feng Yang Nian Fu Yang Hu Yan Ouyang Kai Qing 无 | 2016 | Chinese Medical Sciences Journal2016，31，1： | 1 |
| 14 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 15 | Real time bipolar time-of-flight mass spectrometer for analyzing single aerosol particles显示文摘 | Lei Li Zhengxu Huang Junguo Dong Mei Li Wei Gao Huiqing Nian Zhong Fu Guohua Zhang Xinhui Bi Ping Cheng Zhen Zhou | 2011 | International Journal of Mass Spectrometry2011，，2： | 1 |
| 16 | Availabilith analysis of repairable standby human-machine system显示文摘 | Nian fu Yang Dhillon BS | 1995 | Microelectron Reliability1995，35，11： | 1 |
| 17 | Generalization of A Retarded Gronwall-Like Inequality and Its Applications显示文摘 | AGARWAL R P DENG Sheng fu ZHANG Wei nian | 2005 | ApplMathComput2005，165，： | 1 |
| 18 | Relative phase noise induced impairment in M - ary phase - shift - keying eoherent optical communication system using distributed fiber Raman amplifier 显示文摘 | Jing chi Cheng Ming Tang Song nian Fu | 2013 | OPTICS LETFERS2013，38，7： | 1 |
| 19 | ORGANOMETALLIC FERROELECTRIC LIQUID CRYSTALS Ⅰ. LIQUID CRYSTAL PROPERTIES OF ORTHO—PALLADATED BINUCLEAR COMPLEXES OF AZINE, IMINE AND AZO DERIVATIVES显示文摘The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridging groups of the complexes have profoand effects on the mesomorphic behavior, When the bridging groups are opticallhy active. the compleve show chiral | Liang Fu ZHANG~*, De Jian HUANG, Nu Yun XIONG and Guang Nian LI Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu 610015 | 1992 | Chinese Chemical Letters1992，3，10： | 1 |
| 20 | Comparison of effectiveness of different ashing auxiliaries for determination of phosphorus in natural waters, aquatic organisms and sediments by ignition method显示文摘 | Yi Zhou Fu sui Zhang Hong sheng Yang Shumei Zhang Xi nian Ma | 2003 | Water Research2003，，16： | 1 |
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