| 6 | Helicobacter pylori in ancient human remains显示文摘The bacterium Helicobacter pylori(H.pylori)infects the stomachs of approximately 50%of all humans.With its universal occurrence,high infectivity and virulence properties it is considered as one of the most severe global burdens of modern humankind.It has accompanied humans for many thousands of years,and due to its high genetic variability and vertical transmission,its population genetics reflects the history of human migrations.However,especially complex demographic events such as the colonisation of Europe cannot be resolved with population genetic analysis of modern H.pylori strains alone.This is best exemplified with the reconstruction of the 5300-year-old H.pylori genome of the Iceman,a European Copper Age mummy.Our analysis provided precious insights into the ancestry and evolution of the pathogen and underlined the high complexity of ancient European population history.In this review we will provide an overview on the molecular analysis of H.pylori in mummified human remains that were done so far and we will outline methodological advancements in the field of ancient DNA research that support the reconstruction and authentication of ancient H.pylori genome sequences. | Frank Maixner Kaisa Thorell Lena Granehall Bodo Linz Yoshan Moodley Thomas Rattei Lars Engstrand Albert Zink | 2019 | World Journal of Gastroenterology2019，25，42： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员