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| 1 | The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families显示文摘We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes. | ZHAO Jinying WANG Heng XIONG Momiao HUANG Wei ZUO Jin CHEN Zhu QIANG Boqin SUN Qi LI Yuxiu LIU Qiuying DU Weinan CHEN Jialun DING Wei YUAN Wentao ZHAO Yang XU Hongyan JIN Li FANG Fude | 2000 | Chinese Science Bulletin2000，45，19： | 8 |
| 2 | Formation of wormlike mi-celles in anionic surfactant AES aqueous solutions显示文摘The growth and structure of anionic micelles of sodium dodecyl trioxyethylene sulfate (AES) in the presence of multivalent counterion Al3+ were investigated by means of dynamic rheological methods. It has been obtained by themeasurements of shear viscosity, complex viscosity anddynamic moduli, as well as the application of Cox-Merz rule and Cole-Cole plot that wormlike micelle and networkstructure could be formed in AES/AlCl3 aqueous solutions. The structure was of a character of nonlinear viscoelasticfluid and departure from the simple Maxwell model. Thetechnique of freeze-fracture transmission electronmicroscopy (FF-TEM) was also used to confirm theformation of this interesting structure. | MU Jianhai LI Ganzuo XIAO Hongdi LIAO Guangzhi LIU Yi HUANG Li LI Boqin | 2001 | Chinese Science Bulletin2001，46，16： | 2 |
| 3 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 4 | Research on question bank constructing and automatic marking design for network open examination system显示文摘 | Liu Boqin | 2012 | Advances in Information Sciences and Service Sciences2012，4，23： | 1 |
| 5 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 6 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 7 | MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer’s-associated pathogenesis in SAMP8 mice显示文摘 | Wei Liu Chang Liu Jingxi Zhu Pengcheng Shu Bin Yin Yanhua Gong Boqin Qiang Jiangang Yuan Xiaozhong Peng | 2012 | Neurobiology of Aging2012，，3： | 1 |
| 8 | The cloning and preliminarily functional analysis of the human neurotrimin gene显示文摘Proteins of the immunoglobulin superfamily (IgSF) are involved in a variety of spe- cific cell-cell interactions in the developing nervous system. To identify and characterize new members of this protein family in human nervous system, we screen the human fetal brain cDNA library and isolate a full-length cDNA clone which contains a 1032 bp open reading frame en- coding a protein of 344 amino acids. Sequence analysis reveals that it is a glycoprotein com- prised of three C2-1ike immunoglobulin domains and is anchored to the plasma membrane via a post-translationally attached glycosyl-phosphatidylinositol (GPI) moiety. The protein shows high sequence similarity to the rat Ntm (97%), so we term it human neurotrimin (NTM). Northern blot analysis reveals that (HUMAN)NTM has three different transcripts with the length of 3.2 kb, 4.0 kb and 9.0 kb respectively. It has a wider expression pattern than that of (RAT) Ntm. Notably, the expression of NTM in fetal brain is higher than that in mature brain and is stronger in nervous tumors than that in normal brain tissues. We insert an HA epitope tag between the third Ig-like domain of NTM and the site of GPI attachment, then construct it into the eukaryotic expression vector pcDNA3.1+/Zeocin. The pcDNA3.1-HA-NTM is transfected into the Chinese Hamster Ovary (CHO) cells. The results demonstrate that HA-NTM is expressed on the surface of CHO cells and could strengthen the aggregation of CHO-NTM cells. | LIU Jin, LI Guangtao, PENG Xiaozhong, LIU Bingyan, YIN Bin, TAN Xinyu, FAN Ming, FAN Wenhong, QIANG Boqin & YUAN Jiangang National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, National Human Genome North Center, Beijing 100005, China Department of Neuro- biology, Institute of Basic Medical Science, 27 Taiping Road, Beijing 100850, China | 2004 | Science China(Life Sciences)2004，47，2： | 1 |
| 9 | MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G显示文摘 | Yang Chen Wei Liu Tengfei Chao Yu Zhang Xingqi Yan Yanhua Gong Boqin Qiang Jiangang Yuan Maosheng Sun Xiaozhong Peng | 2008 | Cancer Letters2008，，： | 1 |
| 10 | Identification and analysis of intermediate-size noncoding RNAs in the rhesus macaque fetal brain显示文摘Although only about 2%of the human genome has proved to be protein-coding genes,recent advances in genome wide analysis have revealed that the majority of the genome is transcribed,mainly from noncoding segments that were once considered'junk sequences'or'dark matters'(Liu et al.,2011a;Zhang et al., | Liyuan Zhu Xiaochao Tan Wei Liu Fengbiao Mao Chao Wu Junjie Zhou Xiao Liu Shuaiyao Lu Kaili Ma Bin Yin Jianjun Luo Jiangang Yuan Boqin Qiang Runsheng Chen Xiaozhong Peng | 2017 | Journal of Genetics and Genomics2017，44，3： | 0 |
| 11 | The Tianlai Cylinder Pathfinder array: System functions and basic performance analysis显示文摘The Tianlai Cylinder Pathfinder is a radio interferometer array designed to test techniques for 21 cm intensity mapping in the post-reionization Universe,with the ultimate aim of mapping the large scale structure and measuring cosmological parameters such as the dark energy equation of state.Each of its three parallel cylinder reflectors is oriented in the north-south direction,and the array has a large field of view.As the Earth rotates,the northern sky is observed by drift scanning.The array is located in Hongliuxia,a radio-quiet site in Xinjiang,and saw its first light in September 2016.In this first data analysis paper for the Tianlai cylinder array,we discuss the sub-system qualification tests,and present basic system performance obtained from preliminary analysis of the commissioning observations during 2016-2018.We show typical interferometric visibility data,from which we derive the actual beam profile in the east-west direction and the frequency band-pass response.We describe also the calibration process to determine the complex gains for the array elements,either using bright astronomical point sources,or an artificial on site calibrator source,and discuss the instrument response stability,crucial for transit interferometry.Based on this analysis,we find a system temperature of about 90 K,and we also estimate the sensitivity of the array. | JiXia Li ShiFan Zuo FengQuan Wu YouGang Wang JuYong Zhang ShiJie Sun YiDong Xu ZiJie Yu Reza Ansari YiChao Li Albert Stebbins Peter Timbie YanPing Cong JingChao Geng Jie Hao QiZhi Huang JianBin Li Rui Li DongHao Liu YingFeng Liu Tao Liu John PMarriner ChenHui Niu Ue-Li Pen Jeffery BPeterson HuLi Shi Lin Shu YaFang Song HaiJun Tian GuiSong Wang QunXiong Wang RongLi Wang WeiXia Wang Xin Wang KaiFeng Yu Jiao Zhang BoQin Zhu JiaLu Zhu XueLei Chen | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，12： | 0 |
| 12 | Generating a reporter mouse line marking medium spiny neurons in the developing striatum driven by Arpp21 cis-regulatory elements显示文摘The striatum, as the primary input nucleus in the basal ganglion,plays an important role in neural circuits crucial for the control of critical motivation, motor planning and procedural learning(Kreitzer and Malenka, 2008). Most cells in the striatum are GABAergic, including a large population (90%-95%) of medium spiny neurons (MSNs) and a small population of interneurons. | Pan Chen Xiangbin Ruan Yongqiang Chen Shilong Chu Kunlun Mo Chao Wu Wei Liu Bin Yin Junjie Zhou Liang Li Lin Hou Jiangang Yuan Boqin Qiang Jiekai Chen Pengcheng Shu Xiaozhong Peng | 2018 | Journal of Genetics and Genomics2018，45，12： | 0 |
| 13 | Spray drift characteristics of pulse-width modulation sprays in wind tunnel显示文摘Pulse-width modulation(PWM)sprays can improve flow accuracy by adjusting duty cycle and frequency signal which accurately controls the relative proportion of opening time of solenoid valve.The objective of this research was to determine the impacts of PWM duty cycle and frequency on spray drift characteristic.Spray tests were conducted in a wind tunnel with a PWM variable-rate spraying system.The airborne drift and sediment drift were determined with tracer method,and the drift potential reduction(DPR)compared with reference condition of 100%duty cycle at vertical profile and horizontal planes were calculated,respectively.The results show that,at a given frequency,droplet size decreases with the increase of duty cycle,the main reason is that the liquid does not reach full pattern development at lower duty cycle.Duty cycle has a greater impact than the frequency on spray drift,the influence weights of duty cycle on airborne drift and sediment drift were 88.32%and 77.89%,respectively.At a lower PWM frequency,in addition to the droplet size,the spray drift may be affected by the pulsed spray pattern.From the perspective of reducing spray drift,it is recommended that the PWM duty cycle should be set in the range of 20%-70%to reduce the potential drift in PWM sprays.This research provides a pesticide drift reduction scheme for variable spraying technology,which can serve as a theoretical basis for PWM parameter selection. | Longlong Li Liping Chen Ruirui Zhang Qing Tang Tongchuan Yi Boqin Liu Wei Deng | 2022 | International Journal of Agricultural and Biological Engineering2022，15，4： | 0 |
| 14 | Text clustering based on fusion of ant colony and genetic algorithms显示文摘Focusing on the problem that the ant colony algorithm gets into stagnation easily and cannot fully search in solution space,a text clustering approach based on the fusion of the ant colony and genetic algorithms is proposed.The four parameters that influence the performance of the ant colony algorithm are encoded as chromosomes,thereby the fitness function,selection,crossover and mutation operator are designed to find the combination of optimal parameters through a number of iteration,and then it is applied to text clustering.The simulation results show that compared with the classical k-means clustering and the basic ant colony clustering algorithm,the proposed algorithm has better performance and the value of F-Measure is enhanced by 5.69%,48.60%and 69.60%,respectively,in 3 test datasets.Therefore,it is more suitable for processing a larger dataset. | Yun ZHANG Boqin FENG Shouqiang MA Lianmeng LIU | 2009 | Frontiers of Electrical and Electronic Engineering in China2009，4，1： | 0 |
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