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| 1 | Characterization of Distinct T Cell Receptor Repertoires in Tumor and Distant Non-tumor Tissues from Lung Cancer Patients显示文摘T cells and T cell receptors(TCRs)play pivotal roles in adaptive immune responses against tumors.The development of next-generation sequencing technologies has enabled the analysis of the TCRb repertoire usage.Given the scarce investigations on the TCR repertoire in lung cancer tissues,in this study,we analyzed TCRb repertoires in lung cancer tissues and the matched distant non-tumor lung tissues(normal lung tissues)from 15 lung cancer patients.Based on our results,the general distribution of T cell clones was similar between cancer tissues and normal lung tissues;however,the proportion of highly expanded clones was significantly higher in normal lung tissues than in cancer tissues(0.021%±0.002%vs.0.016%±0.001%,P=0.0054,Wilcoxon signed rank test).In addition,a significantly higher TCR diversity was observed in cancer tissues than in normal lung tissues(431.37±305.96 vs.166.20±101.58,P=0.0075,Mann-Whitney U test).Moreover,younger patients had a significantly higher TCR diversity than older patients(640.7±295.3 vs.291.8±233.6,P=0.036,Mann-Whitney U test),and the higher TCR diversity in tumors was significantly associated with worse cancer outcomes.Thus,we provided a comprehensive comparison of the TCR repertoires between cancer tissues and matched normal lung tissues and demonstrated the presence of distinct T cell immune microenvironments in lung cancer patients. | Xiang Wang Botao Zhang Yikun Yang Jiawei Zhu Shujun Cheng Yousheng Mao Lin Feng Ting Xiao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 5 |
| 2 | Porothermoelastic response of an oil sand formation subjected to injection and micro-fracturing in horizontal wells显示文摘Stimulation of unconsolidated formations via horizontal wells has seen its vast implementation in the recent development of heavy oil reservoir to save the time and cost of preheating the reservoir before the steam-assisted gravity drainage(SAGD)process.A mathematical approach was proposed in this research that fully couples the hydraulic,mechanical and thermal responses of unconsolidated sandstone formations and also applies failure criteria for describing either shear dilation or tensile parting mechanism that generates microcracks.The approach was implemented to predict the porothermoelastic response of a pair of SAGD wells subject to injection and subsequent micro-fracturing using hot water.It was found that the predicted bottom hole pressures(BHPs)match closely with the field observed data.An elliptical dilation zone developed around the dual wells with relatively high pore pressure,porosity,permeability and temperature,implying good interwell hydraulic communication between both wells.The activation of microcracks dramatically accelerated the dissipation of pore pressure across the entire formation depth and also facilitated heat convection in between the dual wells,though to a lesser extent.In summary,the approach provides a convenient means to assist field engineers in the optimization of injection efficiency and evaluation of interference among multiple horizontal wells. | Botao Lin Han Meng Jingjun Pan Sen Chen | 2020 | Petroleum Science2020，17，3： | 2 |
| 3 | The potato amylase inhibitor gene Sb AI regulates cold‐induced sweetening in potato tubers by modulating amylase activity显示文摘 | Huiling Zhang Jun Liu Juan Hou Ying Yao Yuan Lin Yongbin Ou Botao Song Conghua Xie | 2014 | Plant Biotechnol J2014，，7： | 2 |
| 4 | StInvInh2 as an inhibitor of Stvac INV 1 regulates the cold‐induced sweetening of potato tubers by specifically capping vacuolar invertase activity显示文摘 | Xun Liu Yuan Lin Jun Liu Botao Song Yongbin Ou Huiling Zhang Meng Li Conghua Xie | 2013 | Plant Biotechnol J2013，，5： | 2 |
| 5 | MiR-200a is involved in rat epididymal development by targeting β-catenin mRNA显示文摘在到成年人的从出生后的开发的老鼠的 epididymis 的 350 microRNAs (miRNAs ) 的表达式(从出生后的天 770 ) 与自制 miRNA microarray 被介绍。在他们之中, 48 miRNAs 显著地变化了,在哪个 miR-200a 的表示与时间显然增加了,在与从北污点分析获得了那的一个好协议。即时量聚合酶的链反应结果显示老鼠 -catenin 的那时间的表情确切在老鼠 epididymal 开发期间是到 miR-200a 的 inversed,暗示 miR-200a 可能也指向在由 Saydam 等报导了的老鼠 epididymis 的 -catenin mRNA。在人。生物信息的分析显示老鼠 -catenin mRNA 的 3 untranslated 区域确实为 miR-200a 包含了一个通常认为的有约束力的地点。同时,这个有约束力的地点的顺序与有二邻近的核苷酸(U 和 C ) 的删除的人的 -catenin mRNA 的不同,这被发现。但是在老鼠 NRK 房间在 HEK 293T 房间和 miR-200a 的 overexpression 指向试金的酶的结果证明 miR-200a 确实指向了老鼠 -catenin mRNA 并且引起它的表示的抑制。所有这些结果证明 miR-200a 应该被指向老鼠的 -catenin mRNA 并且压制它的表达式涉及老鼠 epididymal 开发。 | Xiaojiang Wu Botao Zhao Wei Li Yue Chen Ruqiang Liang Lin Li Youxin Jin Kangcheng Ruan | 2012 | Acta Biochimica et Biophysica Sinica2012，44，3： | 2 |
| 6 | NEW PERTURBATION TECHNIQUE FOR TRANSIENT ANALYSIS AND ITS APPLICATIONS IN DC-DC PWM SWITCHING POWER CONVERTERS显示文摘An improved perturbation technique proposed in a recent paper (Int. J. Electronics, vol. 63, pp.403-414) has been successfully applied to steady-state analysis of PWM switching converters. This paper extends the algorithm to transient analysis of a broader class of non-linear systems. As an example, the transient response of a Boost PWM switching converter is analyzed to demonstrate its simplicity and accuracy. | Lin Botao Qiu Shuisheng(Department of Electronic Engineering, South China University of Technology, Guang Zhou 510641) | 1997 | Journal of Electronics(China)1997，14，4： | 1 |
| 7 | Enhanced stability of Pt/Al_(2)O_(3) modified by Zn promoter for catalytic dehydrogenation of ethane显示文摘Catalytic ethane dehydrogenation(EDH) to ethylene over Pt-based catalysts has received increasing interests in recent years as it is a potential alternative route to conventional steam cracking. However, the catalysts used in this reaction often suffer from rapid deactivation due to serious coke deposition and metal sintering. Herein, we reported the effects of Zn modification on the stability of Pt/Al2 O3 for EDH.The Zn-modified sample(PtZn2/Al2 O3) exhibits stable ethane conversion(20%) with over 95% ethylene selectivity. More importantly, it exhibits a significantly low deactivation rate of only 0.003 h-1 at 600 °C for70 h, which surpasses most of previously reported catalysts. Detailed characterizations including in situ FT-IR, ethylene adsorption microcalorimetry, and HAADF-STEM etc. reveal that Zn modifier reduces the number of Lewis acid sites on the catalyst surface. Moreover, it could modify Pt sites and preferentially cover the step sites, which decrease surface energy and retard the sintering of Pt particle, then prohibiting the further dehydrogenation of ethylene to ethylidyne. Consequently, the good stability is realized due to anti-sintering and the decrease of coke formation on the Pt Zn2/Al2 O3 catalyst. | Xiaoyu Li Yanliang Zhou Botao Qiao Xiaoli Pan Chaojie Wang Liru Cao Lin Li Jian Lin Xiaodong Wang | 2020 | Journal of Energy Chemistry2020，29，12： | 1 |
| 8 | Prediction of expansive soil swelling based on four micro-scale properties显示文摘 | Botao Lin Amy B. Cerato | 2012 | Bulletin of Engineering Geology and the Environment2012，，1： | 1 |
| 9 | Determination of folic acid by chemiluminescence based on peroxomonosulfate-cobalt(Ⅱ) system显示文摘 | ZHANG Botao ZHAO Lixia LIN Jinming | 2008 | Talanta2008，74，5： | 1 |
| 10 | Expression and characterization of rice putative PAUSED gene显示文摘在 Arabidopsis,暂停了(PSD ) 编码 los1p/exportin-t 的 ortholog,它调停在酵母和哺乳动物的转移 RNA (tRNA ) 的原子出口。在象米饭那样的 monocot 植物,然而,相应 ortholog 的知识被限制,并且它在生长开发和生产率的效果仍然保持未知。在这研究,我们验证了一根米饭 transfer-DNAinsertional 异种 psd 线并且分析了它的显型;异种与野类型的米饭相比包括延迟的开发和低富饶显示了严重词法缺点。与在野类型、变异的叶织物之间的北污点分析在细胞质、原子的部分检验 intronless tRNA-Tyr 和包含 intron pre-tRNA-Ala 表示层次建议米饭 PSD 可能从原子核涉及 tRNA 出口到细胞质。另外,反向的抄写聚合酶链反应分析表明那个 PSD 抄本在整个正常米饭植物开发被表示,并且 subcellular 本地化试金证明那米饭 PSD 蛋白质在原子核和细胞质是在场的。在摘要,我们的数据暗示通常认为的 PSD 基因可能为正常米饭开发是不可缺少的,它的函数可能与 Arabidopsis PSD 的一样。 | Chengguo Yao Liangfa Ge Wei Li Botao Zhao Chaoqun Li Kangcheng Ruan Hongxuan Lin Youxin Jin | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 1 |
| 11 | A unified approach to modeling, synthesizing and analyzing quasi-resonant converters 显示文摘 | LIN Botao LEE Y S | 1997 | IEEE Transactions on Power Electronics1997，12，6： | 1 |
| 12 | Room temperature synthesis and optical properties of SrMoO4 crystallites by W/O microemul sion 显示文摘 | LIU JUN MA JUNFENG LIN BOTAO | 2008 | Ceramics International2008，，34： | 1 |
| 13 | Applications of SEM and ESEM in Microstructural Investigation of Shale-Weathered Expansive Soils along Swelling-hrinkage Cycles显示文摘 | Botao Lin Amy B Ccrato | 2014 | Engineering Geology2014，177，： | 1 |
| 14 | Low-temperature synthesis of SrWO4 nano-partieles by a molten salt method显示文摘 | Xiaohui Jiang Junfeng Ma Yan Yao Yong Sun Zhensen Liu Yang Ren Jun Liu Botao Lin | 2009 | Journal of Ceramics International2009，35，8： | 1 |
| 15 | Resistance to chemical attack of bittern-resisting cement in high-bittern environment显示文摘A new kind of bittern-resisting cement (BRC) was introduced. This material is based on the ternary cementitious system of clinker containing C4A3 S phase, high-activity ground granulated blast-furnace slag (GGBFS) and fly ash (FA). The hydration proc- ess and the hydrated products of BRC were studied by means of XRD, TG-DTA and SEM, and the resistance to chemical attack of BRC in high-bittern environment was also examined. The corrosion experiment in seven kinds of brines proved that BRC exhibits an excellent resistance to chemical attack of bittern. The corrosion resistance factors were calculated and all of them were greater than 0.96. It showed that BRC totally controls the cement-based material corrosion in brines from four aspects: (1) making full use of the dominant complementation effect of mineral materials; (2) diminishing the hydrated products easy to be attacked; (3) improving the microstructure of hardened cement mortar; (4) degrading the chemical attack of bittern. | Yunbing Hou Bingwen Wang Yu Chen Botao Zhang Lin Yu | 2005 | Journal of University of Science and Technology Beijing2005，12，5： | 1 |
| 16 | Pd single-atom catalysts derived from strong metal-support interaction for selective hydrogenation of acetylene显示文摘Selective hydrogenation of acetylene in excess ethylene is an important reaction in both fundamental study and practical application.Pd-based catalysts with high intrinsic activity are commonly employed,but usually suffer from low selectivity.Pd single-atom catalysts(SACs)usually exhibit outstanding ethylene selectivity due to the weakπ-bonding ethylene adsorption.However,the preparation of high-loading and stable Pd SACs is still confronted with a great challenge.In this work,we report a simple strategy to fabricate Pd SACs by means of reducing conventional supported Pd catalysts at suitable temperatures to selectively encapsulate the co-existed Pd nanoparticles(NPs)/clusters.This is based on our new finding that single atoms only manifest strong metal-support interaction(SMSI)at higher reduction temperature than that of NPs/clusters.The derived Pd SACs(Pd1/CeO2 and Pd1/a-Fe2O3)were applied to acetylene selective hydrogenation,exhibiting much improved ethylene selectivity and high stability.This work offers a promising way to develop stable Pd SACs easily. | Yalin Guo Yangyang Li Xiaorui Du Lin Li Qike Jiang Botao Qiao | 2022 | Nano Research2022，15，12： | 0 |
| 17 | A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression显示文摘Although the role of copper (Cu) in promoting KRas- or BRaf-mutation driven cancers via activating MEK1/2 kinases is known, the mechanism by which the copper transporter SLC31A1 (CTR1) is upregulated in pancreatic cancer (PDAC, KRas mutation) is not defined. In this study, we provide evidence that MEK signal maintains a high level of SLC31A1 through silencing the expression of miR-124-3P (miR-124) via a novel MEK-DNMT1-miR-124 feedback loop in PDAC cells. Further, we reveal that miR-124 directly targets suppression of SLC31A1, and miR-124 introduction together with tetrathiomolybdate (TM) treatment hampered pancreatic cancer growth in vitro and in vivo. Our results demonstrate that a SLC31A1-MEK-DNMT1-miR-124 feedback loop is an important pathway to maintain copper absorption and promote pancreatic cancer progression, and we hope to provide a Cu-chelation as an adjuvant treatment strategy, to block the progression in Kras mutant PDAC patients. | Jing Jin Mingjun Ma Bingru Yan Botao Qiu Shounan Lu Lin Yang Yuzhe Nie Sheng Tai Ze Yu Chun-Bo Teng | 2023 | Genes & Diseases2023，10，3： | 0 |
| 18 | Intelligent production optimization method for a low pressure and low productivity shale gas well显示文摘Shale gas wells frequently suffer from liquid loading and insufficient formation pressure in the late stage of production.To address this issue,an intelligent production optimization method for low pressure and low productivity shale gas well is proposed.Based on the artificial intelligence algorithms,this method realizes automatic production and monitoring of gas well.The method can forecast the production performance of a single well by using the long short-term memory neural network and then guide gas well production accordingly,to fulfill liquid loading warning and automatic intermittent production.Combined with adjustable nozzle,the method can keep production and pressure of gas wells stable automatically,extend normal production time of shale gas wells,enhance automatic level of well sites,and reach the goal of refined production management by making production regime for each well.Field tests show that wells with production regime optimized by this method increased 15%in estimated ultimate reserve(EUR).Compared with the development mode of drainage after depletion recovery,this method is more economical and can increase and stabilize production effectively,so it has a bright application prospect. | ZHU Qikang LIN Botao YANG Guang WANG Lijia CHEN Man | 2022 | Petroleum Exploration and Development2022，49，4： | 0 |
| 19 | A time-resolved proteotranscriptomics atlas of the human placenta reveals pan-cancer immunomodulators显示文摘Dear Editor,The placenta separates fetus and mother,with the trophoblast playing a most important role in defense against potential harm from the maternal immune system.Although the placenta is normal tissue,it shares several common features with malignant cells.1 Based on similar strategies,these cells are able to successfully coexist in an immunologically hostile environment.2 A detailed analysis and comparison of different placental model systems will not only contribute to our in-depth understanding of the exciting field of placental development research but also may offer valuable insights on the broad field of cancer studies. | Na Ding Botao Zhang Wantao Ying Jie Song Lin Feng Kaitai Zhang Hongxia Li Juan Xu Ting Xiao Shujun Cheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 20 | Bacterial community diversity of meltwater runoff and soil in Midre Lovénbreen glacier in Ny-Alesund,Arctic显示文摘Glacial meltwater runoff is a dynamic ecosystem.On the one hand,nutrient concentration changes as it flows from upstream to downstream,and on the other hand,bacterial community structure changes due to its contact with nearby soil during the flow process.We studied meltwater and soil in the Midre Lovénbreen glacier region,to explore changes in bacterial diversity as meltwater flows,and the relationship between meltwater and soil bacterial diversity.As glacial meltwater flows from upstream to downstream,the relative abundance of dominant bacterial groups changes.In addition,we found that during the flowing process,nutrient exchange and bacterial contact had occurred between the meltwater runoff and the soil.As a result,the distribution patterns of some bacteria in the meltwater are very similar to those in the soil.Finally,we combined distance-based redundancy analysis and weighted correlation network analysis to show that NO_(3)^(-)-N and NO_(2)^(-)-N are the most two significant factors affecting glacial meltwater and soil,respectively.Our results suggest that in such a close-knit ecosystem,the interaction of glacial meltwater with soil,as well as environmental factors,together determine bacterial community composition. | LIN Lidong WANG Nengfei HAN Wenbing ZHANG Botao ZANGJiaye LI Qinxin QIN Yiling WANG Long ZHANG Fang LIU Jie | 2022 | Advances in Polar Science2022，33，2： | 0 |
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