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| 1 | Th e role of ferroptosis in ionizing radiation-induced cell death and tumor suppression显示文摘Ferroptosis,a form of regulated cell death caused by lipid peroxidation,was recently identified as a natural tumor suppression mechanism.Here,we show that ionizing radiation(IR)induces ferroptosis in cancer cells.Mechanistically,IR induces not only reactive oxygen species(ROS)but also the expression of ACSL4,a lipid metabolism enzyme required for ferroptosis,resulting in elevated lipid peroxidation and ferroptosis.ACSL4 ablation largely abolishes IR-induced ferroptosis and promotes radioresistance.IR also induces the expression of ferroptosis inhibitors,including SLC7A11 and GPX4;as an adaptive response.IR-or KEAP1 deficiencyinduced SLC7A11 expression promotes radioresistance through inhibiting ferroptosis.Inactivating SLC7A11 or GPX4 with ferroptosis inducers(FINs)sensitizes radioresistant cancer cells and xenograft tumors to IR.Furthermore,radiotherapy induces ferroptosis in cancer patients,and increased ferroptosis correlates with better response and longer survival to radiotherapy in cancer patients.Our study reveals a previously unrecognized link between IR and ferroptosis and indicates that further exploration of the combination of radiotherapy and FINs in cancer treatment is warranted. | Guang Lei Yilei Zhang Pranavi Koppula Xiaoguang Liu Jie Zhang Steven HLin Jaffer AAjani Qin Xiao Zhongxing Liao Hui Wang Boyi Gan | 2020 | Cell Research2020，30，2： | 88 |
| 2 | Cystine transporter SLC7A11/xCT in cancer:ferroptosis,nutrient dependency,and cancer therapy显示文摘The cystine/glutamate antiporter SLC7A11(also commonly known as xCT)functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.Recent studies revealed that SLC7A11 overexpression promotes tumor growth partly through suppressing ferroptosis,a form of regulated cell death induced by excessive lipid peroxidation.However,cancer cells with high expression of SLC7A11(SLC7A11^(high))also have to endure the significant cost associated with SLC7A11-mediated metabolic reprogramming,leading to glucose-and glutamine-dependency in SLC7A11^(high) cancer cells,which presents potential metabolic vulnerabilities for therapeutic targeting in SLC7A11^(high) cancer.In this review,we summarize diverse regulatory mechanisms of SLC7A11 in cancer,discuss ferroptosis-dependent and-independent functions of SLC7A11 in promoting tumor development,explore the mechanistic basis of SLC7A11-induced nutrient dependency in cancer cells,and conceptualize therapeutic strategies to target SLC7A11 in cancer treatment.This review will provide the foundation for further understanding SLC7A11 in ferroptosis,nutrient dependency,and tumor biology and for developing novel effective cancer therapies. | Pranavi Koppula Li Zhuang Boyi Gan | 2021 | Protein & Cell2021，12，8： | 97 |
| 3 | Amino acid transporter SLC7A11/ xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer显示文摘Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs,and to maintain redox homeostasis.One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11(SLC7A11;also known as xCT).SLC7A11 promotes cystine uptake and glutathione biosynthesis,resulting in protection from oxidative stress and ferroptotic cell death.Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells.This review discusses the roles of SLC7A11 in regulating the anti-oxidant response and nutrient dependency of cancer cells,explores our current understanding of SLC7A11 regulation in cancer metabolism,and highlights key open questions for future studies in this emerging research area.A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment. | Pranavi Koppula Yilei Zhang Li Zhuang Boyi Gan | 2018 | Cancer Communications2018，38，1： | 77 |
| 4 | Mesoporous silica nanoparticles for drug and gene delivery显示文摘Mesoporous silica nanoparticles(MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume,selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly,the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted. | Yixian Zhou Guilan Quan Qiaoli Wu Xiaoxu Zhang Boyi Niua Biyuan Wu Ying Huang Xin Pan Chuanbin Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 31 |
| 5 | Ferroptosis,radiotherapy,and combination therapeutic strategies显示文摘Ferroptosis,an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsatu-rated-fatty-acid-containing phospholipids in cellular membranes,has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression,and to mediate the synergy between radiotherapy and immunotherapy.In this review,we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and fer-roptosis,discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy,and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy.This review will provide important frameworks for future investigations of ferroptosis in cancer therapy. | Guang Lei Chao Mao Yuelong Yan Li Zhuang Boyi Gan | 2021 | Protein & Cell2021，12，11： | 29 |
| 6 | Experimental study on hydrodynamic behaviors of high-speed gas jets in still water显示文摘现在的纸在流动模式和水动力学效果上描述试验性的调查在水下从超声、声音的嘴的煤气的喷气操作了在正确 -- 并且有瑕疵的扩大条件。流动可视化证明 jetting 是为以在在考虑下面的参数范围的高速度的沉没煤气的注射的流动政体。获得的结果显示静止的水里的高速度的煤气的喷气在过去膨胀、下面膨胀的喷气导致嘴出口和吃惊房间结构的存在在上游的大压力跳动在导致喷气的水动力学压力的紧张导致增加。 | Zhenqing Dai Boyi Wang Longxi Qi Honghui Shi | 2006 | Acta Mechanica Sinica2006，22，5： | 28 |
| 7 | Influence of physical properties of carrier on the performance of dry powder inhalers显示文摘Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI performance.The purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs. | Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 8 |
| 8 | A hybrid quantum-based PIO algorithm for global numerical optimization显示文摘A novel hybrid quantum-based pigeon-inspired optimization(PIO) algorithm for global numerical optimization is proposed to perceive deceptiveness and preserve diversity. In the proposed algorithm,the current best solution is regarded as a linear superposition of two probabilistic states, namely positive and deceptive. Through a quantum rotation gate, the positive probability is either enhanced or reset to balance exploration and exploitation. Simulation results reveal that the hybrid quantum-based PIO algorithm demonstrates an outstanding performance in global optimization owing to preserving diversity in the early evolution. As a result, the stability of the algorithm is enhanced so that the precision of optimization is improved statistically. The proposed algorithm is demonstrated to be effective for solving multimodal and non-convex problems in higher dimension with a smaller population size. | Boyi CHEN Hao LEI Haidong SHEN Yanbin LIU Yuping LU | 2019 | Science China(Information Sciences)2019，62，7： | 7 |
| 9 | NADPH debt drives redox bankruptcy:SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation显示文摘Cystine/glutamate antiporter solute carrier family 7 member 11(SLC7A11;also known as xCT)plays a key role in antioxidant defense by mediating cystine uptake,promoting glutathione synthesis,and maintaining cell survival under oxidative stress conditions.Recent studies showed that,to prevent toxic buildup of highly insoluble cystine inside cells,cancer cells with high expression of SLC7A11(SLC7A11high)are forced to quickly reduce cystine to more soluble cysteine,which requires substantial NADPH supply from the glucose-pentose phosphate pathway(PPP)route,thereby inducing glucose-and PPP-dependency in SLC7A11high cancer cells.Limiting glucose supply to SLC7A11high cancer cells results in significant NADPH“debt”,redox“bankruptcy”,and subsequent cell death.This review summarizes our current understanding of NADPH-generating and-consuming pathways,discusses the opposing role of SLC7A11 in protecting cells from oxidative stresseinduced cell death such as ferroptosis but promoting glucose starvationeinduced cell death,and proposes the concept that SLC7A11-mediated cystine uptake acts as a double-edged sword in cellular redox regulation.A detailed understanding of SLC7A11 in redox biology may identify metabolic vulnerabilities in SLC7A11high cancer for therapeutic targeting. | Xiaoguang Liu Yilei Zhang Li Zhuang Kellen Olszewski Boyi Gan | 2021 | Genes & Diseases2021，8，6： | 7 |
| 10 | The function and regulation of TET2 in innate immunity and inflammation显示文摘TET2,a member of ten-eleven translocation(TET)family as a-ketoglutarate-and Fe2+-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine(5mC),has been widely recognized to be an important regulator for normal hematopoiesis especially myelopoiesis.Mutation and dysregulation of TET2 contribute to the development of multiple hematological malignancies.Recent studies reveal that TET2 also plays an important role in innate immune homeostasis by promoting DNA demethylation or independent of its enzymatic activity.Here,we focus on the functions of TET2 in the initiation and resolution of inflammation through epigenetic regulation and signaling network.In addition,we highlight regulation of TET2 at various molecular levels as well as the correlated inflammatory diseases,which will provide the insight to intervene in the pathological process caused by TET2 dysregulation. | Boyi Cong Qian Zhang Xuetao Cao | 2021 | Protein & Cell2021，12，3： | 6 |
| 11 | Revisiting ovarian cancer microenvironment: a friend or a foe?显示文摘 | Boyi Zhang Fei Chen Qixia Xu Liu Han Jiaqian Xu Libin Gao Xiaochen Sun Yiwen Li Yan Li Min Qian Yu Sun | 2018 | Protein & Cell2018，9，8： | 6 |
| 12 | Developing single nucleotide polymorphism(SNP)markers from transcriptome sequences for identification of longan(Dimocarpus longan)germplasm显示文摘Longan(Dimocarpus longan Lour.)is an important tropical fruit tree crop.Accurate varietal identification is essential for germplasm management and breeding.Using longan transcriptome sequences from public databases,we developed single nucleotide polymorphism(SNP)markers;validated 60 SNPs in 50 longan germplasm accessions,including cultivated varieties and wild germplasm;and designated 25 SNP markers that unambiguously identified all tested longan varieties with high statistical rigor(P<0.0001).Multiple trees from the same clone were verified and off-type trees were identified.Diversity analysis revealed genetic relationships among analyzed accessions.Cultivated varieties differed significantly from wild populations(Fst=0.300;P<0.001),demonstrating untapped genetic diversity for germplasm conservation and utilization.Within cultivated varieties,apparent differences between varieties from China and those from Thailand and Hawaii indicated geographic patterns of genetic differentiation.These SNP markers provide a powerful tool to manage longan genetic resources and breeding,with accurate and efficient genotype identification. | Boyi Wang Hua-Wei Tan Wanping Fang Lyndel W Meinhardt Sue Mischke Tracie Matsumoto Dapeng Zhang | 2015 | Horticulture Research2015，2，1： | 6 |
| 13 | Healthcare data analytics:using a metadata annotation approach for integrating electronic hospital records显示文摘The data in electronic medical records(EMR)are complex in structure.They are independent,yet related to each other.In order to improve information access through the use of EMR,annotating work on these data is necessary.The annotation on metadata,the resource data which contain a meta-model of the database,is the basis of the annotating work if a semi-automated or an automated annotating approach which aims at making the database more accessible is expected.In this study,a method has been proposed to transform the terms which cannot be matched directly by changing them literally but maintaining their semantics,and then annotating them indirectly.After the transforming work,a refinement method which is reducible to phrase sense disambiguation(PSD)is employed to ensure accuracy.A pilot study on a hospital database has been conducted to test the accuracy and effectiveness of the proposed method. | Boyi Xu Ke Xu LiuLiu Fu Ling Li Weiwei Xin Hongming Cai | 2016 | Journal of Management Analytics2016，3，2： | 6 |
| 14 | Performance limitations in trajectory tracking control for air-breathing hypersonic vehicles显示文摘An integrated approach that considers the performance limitations of tracking control systems for air-breathing hypersonic vehicles is proposed. First, a set of ascent trajectories is obtained as candidates for tracking control through a trajectory design method that considers the available acceleration. Second, the basic theory of performance limitations, which is adopted to calculate the limits on control performance through the trajectory, is integrated. The openloop dynamics of air-breathing hypersonic vehicles is responsible for these limits on the control system. Comprehensive specifications on stability, tracking accuracy, and robustness are derived, and the flight envelope with constraints and control specifications is identified. Simulation results suggest that trajectory design should consider restrictions on control performance to obtain reliable solutions. | Boyi CHEN Yanbin LIU Haidong SHEN Hao LEI Yuping LU | 2019 | Chinese Journal of Aeronautics2019，32，1： | 4 |
| 15 | Planted forest is catching up with natural forest in China in terms of carbon density and carbon storage显示文摘Over the last several decades,China has taken multiple measures for afforestation and natural forest protection,including setting the goal of carbon neutrality by the middle of 21th century.In order to support the practice of relevant policies from the scientific perspective,it is essential to precisely estimate the carbon storage of arbor forest,as it plays an important role in the carbon cycle of ecosystems.In this study,we first used the latest four phases of national forest inventory data to investigate the variation of carbon storage for both natural and planted arbor forest in China during the covered period(1999-2018).Then we used machine leaning methods to simulate the carbon density based on various kinds of environmental factors and analyzed the contribution of each influencing factor.Our results demonstrate that the total carbon storage for arbor forest in China kept increasing over the last two decades,but this increment was mainly brought about by the continuous expansion of forest land.The gap of carbon sequestration between natural forest and planted forest showed a significant trend of reduction.Additionally,tree age was identified as the dominant factor for influencing the spatiotemporal variation of carbon density among all the independent variables while the impact of climatic factor was limited.Therefore,the future improvement of carbon sequestration of arbor forest in should mainly rely on additional projects of afforestation,reforestation,green space conservation and reduction of emissions in China.Conclusions of this study have important implications for policy makers and other stakeholders to evaluate the previous achievement of environmental projects and can also help to set future plans and finally realize the goals of carbon neutrality. | Boyi Liang Jia Wang Zheyuan Zhang Jia Zhang Junping Zhang Elizabeth L.Cressey Zong Wang | 2022 | Fundamental Research2022，2，5： | 3 |
| 16 | “Pincer movement”:Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles显示文摘The therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers.Intracellular glutathione(GSH)detoxification of cisplatin under the catalysis of glutathione S-transferases(GST)plays important roles in the development of cisplatin resistance.Herein,a strategy of“pincer movement”based on simultaneous GSH depletion and GST inhibition is proposed to enhance cisplatin-based chemotherapy.Specifically,a redox-responsive nanomedicine based on disulfide-bridged degradable organosilica hybrid nanoparticles is developed and loaded with cisplatin and ethacrynic acid(EA),a GST inhibitor.Responding to high level of intracellular GSH,the hybrid nanoparticles can be gradually degraded due to the break of disulfide bonds,which further promotes drug release.Meanwhile,the disulfide-mediated GSH depletion and EA-induced GST inhibition cooperatively prevent cellular detoxification of cisplatin and reverse drug resistance.Moreover,the nanomedicine is integrated into microneedles for intralesional drug delivery against cisplatin-resistant melanoma.The in vivo results show that the nanomedicine-loaded microneedles can achieve significant GSH depletion,GST inhibition,and consequent tumor growth suppression.Overall,this research provides a promising strategy for the construction of new-type nanomedicines to overcome cisplatin resistance,which extends the biomedical application of organosilica hybrid nanomaterials and enables more efficient chemotherapy against drug-resistant cancers. | Boyi Niu Yixian Zhou Kaixin Liao Ting Wen Sixian Lao Guilan Quan Xin Pan Chuanbin Wu | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 17 | Biomechanical characteristics of an anterior cruciate ligament injury in javelin throwing显示文摘目的:理解标枪运动中前十字韧带的损伤机制以及与前十字韧带损伤相关的标枪技术。方法:受试者是一名高水平女子标枪运动员,她在健康状态下完成前3次实验。在最近一次的田径大会期间进行了第4次实验,这次试验中她的左膝存在非外力引起的前十字韧带损伤。我们采集到损伤和非损伤实验中的三维运动学数据并从标枪生物力学数据库中获得52名男子和54名女子高水平标枪运动员的相关数据。结果:损伤和非损伤相比,在前25%的投掷阶段后,受试者质心向前的速度更大,垂直方向的速度更小:投掷阶段前21%的过程中,受试者左膝屈曲角度和角速度都更小,但左膝外翻和内旋角度没有明显差异。在损伤实验投掷阶段30%时,摄影图像中显示出明显的胫骨前移;受试者左脚触地时,左膝屈曲角度和角速度以及在投掷阶段中左膝最大屈曲角度与数据库中52名男子和54名女子优秀标枪运动员的数据没有相关性。结论:研究中的前十字韧带损伤发生在投掷阶段的前30%,更可能是前25%。左腿膝关节屈曲角度小,导致硬着陆是损伤的主要原因。标枪运动员应弯曲膝关节进行软着陆,这样能帮助他们预防前十字韧带损伤而不影响运动表现。 | Boyi Dai Min Mao William E. Garrett Bing Yu | 2015 | Journal of Sport and Health Science2015，4，4： | 3 |
| 18 | Planform characteristics and development of inter- channel wetlands in a gravel-bed anastomosing river, Maqu Reach of the Upper Yellow River显示文摘Both interchannel wetlands and multi-channels are crucial geomorphologic units in an anastomosing river system. Planform characteristics and development of interchannel wetlands and multi-channels control the characteristics of anastomosing rivers. To understand the role that interchannel wetlands play in the development of anastomosing rivers, a study was conducted on the Maqu Reach of the Upper Yellow River(MRUYR), a gravel-bed anastomosing river characterized by highly developed interchannel wetlands and anabranches. Geomorphologic units in the studied reach were extracted from high resolution satellite imagery in Google Earth. The size distributions of interchannel wetlands and interchannel wetland clusters(IWCs), a special combination of interchannel wetlands and anabranches, were investigated. Geomorphologic parameters, including the ratio of interchannel wetland area to IWC area(P), shoreline density(D_l), and node density(D_n) were used to analyze planform characteristics of IWCs and the development of multi-channels in the studied reach. The results suggest that small or middle sized interchannel wetlands and large or mega sized IWCs are more common at the study site. The area of IWC(S_u) is highly correlated with other geomorphologic parameters. P increases with increasing S_u, and the upper limit is about 80%, which indicates that the development of interchannel wetlands and anabranches in the IWC is in the equilibrium stage. In contrast, D_l and D_n show a tendency to decrease with increasing S u due to diverse evolution processes in IWCs with different sizes. There are three main reasons leading to the formation of IWCs: varying stream power due to the meandering principal channel; development of the river corridor due to the weakening of geologic structure control; and high stability of interchannel wetlands due to conservation by shoreline vegetation. | LIU Boyi WANG Suiji | 2017 | Journal of Geographical Sciences2017，27，11： | 3 |
| 19 | An Improved Method for the Fitting and Prediction of the Number of COVID-19 Confirmed Cases Based on LSTM显示文摘New coronavirus disease(COVID-19)has constituted a global pandemic and has spread to most countries and regions in the world.Through understanding the development trend of confirmed cases in a region,the government can control the pandemic by using the corresponding policies.However,the common traditional mathematical differential equations and population prediction models have limitations for time series population prediction,and even have large estimation errors.To address this issue,we propose an improved method for predicting confirmed cases based on LSTM(Long-Short Term Memory)neural network.This work compares the deviation between the experimental results of the improved LSTM prediction model and the digital prediction models(such as Logistic and Hill equations)with the real data as reference.Furthermore,this work uses the goodness of fitting to evaluate the fitting effect of the improvement.Experiments show that the proposed approach has a smaller prediction deviation and a better fitting effect.Compared with the previous forecasting methods,the contributions of our proposed improvement methods are mainly in the following aspects:1)we have fully considered the spatiotemporal characteristics of the data,rather than single standardized data.2)the improved parameter settings and evaluation indicators are more accurate for fitting and forecasting.3)we consider the impact of the epidemic stage and conduct reasonable data processing for different stage. | Bingjie Yan Jun Wang Zhen Zhang Xiangyan Tang Yize Zhou Guopeng Zheng Qi Zou Yao Lu Boyi Liu Wenxuan Tu Neal Xiong | 2020 | Computers, Materials & Continua2020，，9： | 2 |
| 20 | 足球运动中前十字韧带损伤:负载机制、风险因素及预防方案(英文)显示文摘足球运动中前十字韧带(ACL)损伤非常常见。了解ACL的负载机制以及造成ACL损伤的危险因素有助于设计有效的预防方案。本综述目的在于为足球运动员总结关于ACL负载机制、ACL损伤因素,以及当前关于ACL损伤预防方案的研究。文献表明,近端胫骨的剪切力引起的胫骨前移是最主要的ACL负载机制,并无证据表明膝外翻是ACL的主要负载机制。之前有关ACL损伤危险因素的研究大都忽视ACL负载机制,已确定的风险因素几乎都与ACL负载机制无关。关于球员ACL损伤预防方案的研究结果互不一致。现有的足球运动员ACL损伤预防方案依从性低、临床效果不佳。未来的研究迫切需要确定与球员ACL负载机制相关的、与ACL损伤有因果关系的危险因素,开发新的预防方案以提高临床依从性。 | Boyi Dai Dewei Mao William E.Garrett Bing Yu | 2014 | Journal of Sport and Health Science2014，3，4： | 2 |
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