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| 1 | RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation显示文摘PTEN 肿瘤 suppressor 是在调整 phosphatidylinositol-3-kinase (PI3K ) 有一个中央角色的类脂化合物磷酸酶信号 transduction 串联。不过, PTEN 活动被在房间调整的机制需要进一步的说明。尽管以前的研究证明了 PTEN 的 ubiquitination 能调制它的稳定性和 subcellular 本地化,在 PTEN 功能的最批评的方面的 ubiquitination 的角色,它的磷酸酶活动,充分没被探讨。这里,我们识别 PTEN 的新奇 E3 ubiquitin ligase,沤手指蛋白质(RFP ) ,那能支持 PTEN 的不正常的 polyubiquitinations。这些 ubiquitinations 不导致 PTEN 不稳定性或本地化,但是相当显著地禁止 PTEN 磷酸酶活动因此调制它的能力调整 PI3K 信号 transduction 串联。确实, RFP overexpression 在 AKT 激活上减轻调停 PTEN 的禁止的效果;相反,调停 RNAi 内长的 RFP 击倒提高 PTEN 的能力压制 AKT 激活。而且, PTEN 的调停 RFP 的 ubiquitination 禁止小道表示的 PTEN 依赖的激活并且也压制它的能力导致 apoptosis。我们的调查结果在控制 PTEN 表明调停 RFP 的 ubiquitination 的一个关键角色活动。 | James T Lee Jing Shan Jiayun Zhong Muyang Li Brenda Zhou Amanda Zhou Ramon Parsons Wei Gu | 2013 | Cell Research2013，23，4： | 5 |
| 2 | The Use of Negative-Pressure Wound Therapy (NPWT) in the Temporary Treatment of Soft-Tissue Injuries Associated With High-Energy Open Tibial Shaft Fractures显示文摘 | Barnaby T Dedmond Bill Kortesis Kathleen Punger Jordan Simpson Joseph Argenta Brenda Kulp Michael Morykwas Lawrence X Webb | 2007 | Journal of Orthopaedic Trauma2007，，1： | 2 |
| 3 | Effect of postharvest processing on texture profile analysis of cooked rice 显示文摘 | Elaine T C Brenda G L Bong K M | 1995 | Crereal Chemistry1995，75，2： | 1 |
| 4 | Cure studies of interpenetrating networks by microdielectrometry显示文摘 | Brenda S H Craig A T | 1988 | Journal of Applied Polymer Science1988，35，5： | 1 |
| 5 | Viral load of human papillomavirus and risk of CIN3 or cervical cancer显示文摘 | Attila T Lorincz Philip E Castle Mark E Sherman David R Scott Andrew G Glass Sholom Wacholder Brenda B Rush Patti E Gravitt John E Schussler Mark Schiffman | 2002 | The Lancet . 2002 (9328)2002，，9328： | 1 |
| 6 | Microbial indicators of faecal contamination in water: a current perspective 显示文摘 | PAM T BRENDA M CASSANDRA L | 2005 | Water Air SoilPollu2005，166，： | 1 |
| 7 | Isolation and identification of rhizoxin analogs from Pseudomonas fluorescens Pf- 5 by using a genomic mining strategy显示文摘 | Joyce E L Marcella D H Brenda T S | 2008 | Appl Environ Microbiol2008，74，10： | 1 |
| 8 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 9 | Effect of post harvest processing on texture profile analysis of cooked rice显示文摘 | Elaine T Champagne Brenda GLyon Bong Kee Min | 1998 | Cereal Chemistry1998，75，2： | 1 |
| 10 | 显示文摘 | Brenda K M Annabel T T Tmothy S B | 1999 | Biomaterials1999，20，： | 1 |
| 11 | Properties of Drosophila mela- nogaster prophenoloxidases expressed in Escherichia coli 显示文摘 | XUQUAN L BRENDA T B ERJUN L el al | 2012 | Developmen- tal & Comparative hrnnunology2012，4，36： | 1 |
| 12 | Retinal stem cells in the adult mammalian eye 显示文摘 | Brenda LKC Bernard JC Horsford DJ Andrew JE Roderick RM | 2000 | Science2000，287，17： | 1 |
| 13 | Endogenous mono- ADP-ribosylation mediates smooth muscle cell proliferation and migration via protein kinase N-dependent induction of e-los expression显示文摘 | Lorraine Y Brenda L Shawn T | 2003 | Biochem2003，270，： | 1 |
| 14 | An efficiency/effectiveness approach to logistics performance measuremet 显示文摘 | Mentzer John T Brenda P Konrad | 1992 | Journal of business logistics1992，12，1： | 1 |
| 15 | Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS) 显示文摘 | Wesley EE Brenda T Ayumi S | 2003 | JAMA2003，289，22： | 1 |
| 16 | Factors influencing Agrobacterium-mediated transformation of monocotyledonous species显示文摘 | Ming C Brenda A Lowe T | | 0，，： | 1 |
| 17 | Assessment of multi-modality evaluations of obscure gastrointestinal bleeding显示文摘AIM To determine the frequency of bleeding source detection in patients with obscure gastrointestinal bleeding(OGIB) who underwent double balloon enteroscopy(DBE) after pre-procedure imaging [multiphase computed tomography enterography(MPCTE), video capsule endoscopy(VCE), or both] and assess the impact of imaging on DBE diagnostic yield.METHODS Retrospective cohort study using a prospectively maintained database of all adult patients presenting with OGIB who underwent DBE from September 1^(st), 2002 to June 30^(th), 2013 at a single tertiary center.RESULTS Four hundred and ninety five patients(52% females; median age 68 years) underwent DBE for OGIB. AVCE and/or MPCTE performed within 1 year prior to DBE(in 441 patients) increased the diagnostic yield of DBE(67.1% with preceding imaging vs 59.5% without). Using DBE as the gold standard, VCE and MPCTE had a diagnostic yield of 72.7% and 32.5% respectively. There were no increased odds of finding a bleeding site at DBE compared to VCE(OR = 1.3, P = 0.150). There were increased odds of finding a bleeding site at DBE compared to MPCTE(OR = 5.9, P < 0.001). In inpatients with overt OGIB, diagnostic yield of DBE was not affected by preceding imaging.CONCLUSION DBE is a safe and well-tolerated procedure for the diagnosis and treatment of OGIB, with a diagnostic yield that may be increased after obtaining a preceding VCE or MPCTE. However, inpatients with active ongoing bleeding may benefit from proceeding directly to antegrade DBE. | Ryan Law Jithinraj E Varayil Louis M Wong Kee Song Jeff Fidler Joel G Fletcher John Barlow Jeffrey Alexander Elizabeth Rajan Stephanie Hansel Brenda Becker Joseph J Larson Felicity T Enders David H Bruining Nayantara Coelho-Prabhu | 2017 | World Journal of Gastroenterology2017，23，4： | 1 |
| 18 | Tornadoes,social science,and the false alarm effect显示文摘 | JOSEPH E T DANIELLE N BRENDA P | 2015 | Weather Climate and Society2015，7，4： | 1 |
| 19 | The SOCS box: a tale of destruction and degradation显示文摘 | Benjamin T Kile Brenda A Schulman Warren S Alexander Nicos A Nicola Helene M.E Martin Douglas J Hilton | 2002 | Trends in Biochemical Sciences2002，，5： | 1 |
| 20 | Retinal stem cells in the adult mammalian eye显示文摘 | Vincent T Brenda L K C Bernard J C | 2000 | Science2000，287，5460： | 1 |
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