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| 1 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 2 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 3 | A generalized supervised classification scheme to produce provincial wetland inventory maps:an application of Google Earth Engine for big geo data processing显示文摘Wetlands are important natural resources due to their numerous ecological services.Consequently,identifying their locations and extents is imperative.The stability,repeatability,cost-effectiveness,multi-scale coverage,and proper spatial resolution imagery of satellites provide a valuable opportunity for their use in various large-scale applications,such as provincial wetland mapping.To do so,it is required to(1)process and classify big geo data(i.e.a large amount of satellite datasets)in a time-and computationally-efficient approach and(2)collect a large amount of field samples.In this study,Google Earth Engine(GEE)and machine learning algorithms were utilized to process thousands of remote sensing images and produce provincial wetland inventory maps of the three Canadian provinces of Manitoba,Quebec,and Newfoundland and Labrador(NL).Additionally,using GEE,a generalized supervised classification method is proposed to produce a regional wetland map from a large area(e.g.,a province)when lacking field samples.In fact,using the field data from only Manitoba and assuming that all wetlands in Canada have similar characteristics,the wetland maps were generated for the other two provinces.The overall classification accuracies for Manitoba,Quebec,and NL were 84%,78%,and 82%,respectively,indicating the high potential of the proposed method for aiding provincial wetland inventory systems. | Meisam Amani Brian Brisco Majid Afshar S.Mohammad Mirmazloumi Sahel Mahdavi Sayyed Mohammad Javad Mirzadeh Weimin Huang Jean Granger | 2019 | Big Earth Data2019，3，4： | 4 |
| 4 | Diagnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement显示文摘 | Gregorios Paspatis Jean-Marc Dumonceau Marc Barthet S?ren Meisner Alessandro Repici Brian Saunders Antonios Vezakis Jean Gonzalez Stine Turino Zacharias Tsiamoulos Paul Fockens Cesare Hassan | 2014 | Endoscopy2014，，： | 4 |
| 5 | Long‐term infliximab maintenance therapy for ulcerative colitis: The ACT‐1 and ‐2 extension studies显示文摘 | WalterReinisch William J.Sandborn PaulRutgeerts Brian G.Feagan DanielRachmilewitz Stephen B.Hanauer Gary R.Lichtenstein Willem J.S.de Villiers MarionBlank YinghuaLang JewelJohanns Jean FrédéricColombel DanielPresent Bruce E.Sands | 2012 | Inflamm Bowel Dis2012，，2： | 3 |
| 6 | Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis显示文摘 | Jean Frédéric Colombel Paul Rutgeerts Walter Reinisch Dirk Esser Yanxin Wang Yinghua Lang Colleen W. Marano Richard Strauss Bj?rn J. Oddens Brian G. Feagan Stephen B. Hanauer Gary R. Lichtenstein Daniel Present Bruce E. Sands William J. Sandborn | 2011 | Gastroenterology2011，，4： | 3 |
| 7 | Malignant Gastrointestinal Stromal Tumors of the Small Intestine: A Review of 50 Cases From a Prospective Database显示文摘 | Jacqueline A. Crosby MD Charles N. Catton MD Aileen Davis PhD Jean Couture MD Brian O'Sullivan MD Rita Kandel MD Carol J. Swallow MD PhD | 2001 | Annals of Surgical Oncology2001，，1： | 2 |
| 8 | Yttrium-90 microspheres for the treatment of hepatocellular carcinoma显示文摘 | Jean Francois H. Geschwind Riad Salem Brian I. Carr Michael C. Soulen Kenneth G. Thurston Kathleen A. Goin Mark van Buskirk Carol A. Roberts James E. Goin | 2004 | Gastroenterology2004，，： | 2 |
| 9 | Modeling impacts of climate change on the potential distribution of six endemic baobab species in Madagascar显示文摘Madagascar,a globally renowned biodiversity hotspot characterized by high rates of endemism,is one of the few remaining refugia for many plants and animal species.However,global climate change has greatly affected the natural ecosystem and endemic species living in Madagascar,and will likely continue to influence species distribution in the future.Madagascar is home to six endemic baobab(Adansonia spp.,Bombacoideae[Malvaceae])species(Adansonia grandidieri,A.suarezensis,A.madagascariensis,A.perrieri,A.rubrostipa,A.za),which are remarkable and endangered plants.This study aimed to model the current distribution of suitable habitat for each baobab species endemic to Madagascar and determine the effect that climate change will have on suitable baobab habitat by the years 2050 and 2070.The distribution was modeled using MaxEnt based on locality information of 245 occurrence sites of six species from both online database and our own field work.A total of seven climatic variables were used for the modeling process.The present distribution of all six Madagascar's baobabs was largely influenced by temperature-related factors.Although both expansion and contraction of suitable habitat are predicted for all species,loss of original suitable habitat is predicted to be extensive.For the most widespread Madagascar baobab,A.za,more than 40%of its original habitat is predicted to be lost because of climate change.Based on these findings,we recommend that areas predicted to contract in response to climate change should be designated key protection regions for baobab conservation. | Jun-Nan Wan Ndungu J.Mbari Sheng-Wei Wang Bing Liu Brian N.Mwangi Jean R.E.Rasoarahona Hai-Ping Xin Ya-Dong Zhou Qing-Feng Wang | 2021 | Plant Diversity2021，43，2： | 2 |
| 10 | Class-1 hemoglobins, nitrate and NO levels in anoxic maize cell-suspension cultures显示文摘 | Christos Dordas Brian B. Hasinoff Jean Rivoal Robert D. Hill | 2004 | Planta2004，，1： | 1 |
| 11 | Abatacept for Crohn’s Disease and Ulcerative Colitis显示文摘 | William J. Sandborn Jean–Frederic Colombel Bruce E. Sands Paul Rutgeerts Stephan R. Targan Remo Panaccione Brian Bressler Karl Geboes Stefan Schreiber Richard Aranda Sheila Gujrathi Allison Luo Yun Peng Luisa Salter–Cid Stephen B. Hanauer | 2012 | Gastroenterology2012，，1： | 1 |
| 12 | Constraints on the acquisition of remanent magnetization in fine-grained sediments imposed by redeposition experiments显示文摘 | BRIAN C S JEAN P V MAXIME L G | 2006 | Earth and Planetary Science Letters2006，245，： | 1 |
| 13 | Mapping ideas from cyberspace to realspace: visualizing the spatial context of keywords from web page search results显示文摘We introduce a new method for visualizing and analyzing information landscapes of ideas and events posted on public web pages through customized web-search engines and keywords.This research integrates GIScience and web-search engines to track and analyze public web pages and their web contents with associated spatial relationships.Web pages searched by clusters of keywords were mapped with real-world coordinates(by geolocating their Internet Protocol addresses).The resulting maps represent web information landscapes consisting of hundreds of populated web pages searched by selected keywords.By creating a Spatial Web Automatic Reasoning and Mapping System prototype,researchers can visualize the spread of web pages associated with specific keywords,concepts,ideas,or news over time and space.These maps may reveal important spatial relationships and spatial context associated with selected keywords.This approach may provide a new research direction for geographers to study the diffusion of human thought and ideas.A better understanding of the spatial and temporal dynamics of the‘collective thinking of human beings’over the Internet may help us understand various innovation diffusion processes,human behaviors,and social movements around the world. | Ming-Hsiang Tsou Ick-Hoi Kim Sarah Wandersee Daniel Lusher Li An Brian Spitzberg Dipak Gupta Jean Mark Gawron Jennifer Smith Jiue-An Yang Su Yeon Han | 2014 | International Journal of Digital Earth2014，7，4： | 1 |
| 14 | Dietary β-Carotene is taken up by blood plasma and leukocytes in dogs显示文摘 | Boon P.Chew Jean Soon Park Brian C.Weng | | 0，，： | 1 |
| 15 | Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis显示文摘 | Jean Frédéric Colombel Paul Rutgeerts Walter Reinisch Dirk Esser Yanxin Wang Yinghua Lang Colleen W. Marano Richard Strauss Bj?rn J. Oddens Brian G. Feagan Stephen B. Hanauer Gary R. Lichtenstein Daniel Present Bruce E. Sands William J. Sandborn | 2011 | Gastroenterology2011，，4： | 1 |
| 16 | Quick sex determination of mouse fetuses 显示文摘 | JEAN - FRANCOIS L BRIAN O B GERALD A C | 2000 | Journal of Neuroseience Methods2000，95，： | 1 |
| 17 | Country Report: Medical Education in France 显示文摘 | Christophe Segoain Jean Jouquan Brian Hodges | 2007 | Medical Education2007，41，： | 1 |
| 18 | Simple constitutive equations for steel at high temperature显示文摘 | Patrick F. Kozlowski Brian G. Thomas Jean A. Azzi Hao Wang | 1992 | Metallurgical Transactions A1992，，3： | 1 |
| 19 | Antibody- based nanoprobe for measurement of a fluorescent analyte in a single cell显示文摘 | Tuan Vo - Dinh Jean - Pierre Alarie Brian M Cullum | 2000 | Nature Biotechnologe2000，18，： | 1 |
| 20 | Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis显示文摘 | Jean Frédéric Colombel Paul Rutgeerts Walter Reinisch Dirk Esser Yanxin Wang Yinghua Lang Colleen W. Marano Richard Strauss Bj?rn J. Oddens Brian G. Feagan Stephen B. Hanauer Gary R. Lichtenstein Daniel Present Bruce E. Sands William J. Sandborn | 2011 | Gastroenterology2011，，4： | 1 |
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