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| 1 | Achalasia: A review of clinical diagnosis, epidemiology,treatment and outcomes显示文摘Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function.Historically,annual achalasia incidence rates were believed to be low,approximately 0.5-1.2 per 100000.More recent reports suggest that annual incidence rates have risen to 1.6 per 100000 in some populations.The aetiology of achalasia is still unclear but is likely to be multi-factorial.Suggested causes include environmental or viral exposures resulting in inflammation of the oesophageal myenteric plexus,which elicits an autoimmune response.Risk of achalasia may be elevated in a sub-group of genetically susceptible people.Improvement in the diagnosis of achalasia,through the introduction of high resolution manometry with pressure topography plotting,has resulted in the development of a novel classification system for achalasia.This classification system can evaluate patient prognosis and predict responsiveness to treatment.There is currently much debate over whether pneumatic dilatation is a superior method compared to the Heller’s myotomy procedure in the treatment of achalasia.A recent com-parative study found equal efficacy,suggesting that patient preference and local expertise should guide the choice.Although achalasia is a relatively rare condition,it carries a risk of complications,including aspiration pneumonia and oesophageal cancer.The risk of both squamous cell carcinoma and adenocarcinoma of the oesophagus is believed to be significantly increased in patients with achalasia,however the absolute excess risk is small.Therefore,it is currently unknown whether a surveillance programme in achalasia patients would be effective or cost-effective. | Orla M O'Neill Brian T Johnston Helen G Coleman | 2013 | World Journal of Gastroenterology2013,19,35: | 26 |
| 2 | Hemoglobin Concentrations Influence Birth Outcomes in Pregnant Afican- American Adolesents显示文摘 | Chang S C O'Brian K O Nathanson M S | | 0,,07: | 1 |
| 3 | KatG is the primary detoxifier of hydrogen peroxide produced by aerobic metabolism in Bradyrhizobium japonicum 显示文摘 | Panek H R O'Brian M R | 2004 | Journal of Bacteriology2004,186,23: | 1 |
| 4 | Highly efficient phosphorescent emission from organic electroluminescent devices显示文摘 | Baldo M A O'Brian D F You Y | | 0,,01: | 1 |
| 5 | Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response显示文摘 | Margaret J Leckie Anneke ten Brinke Jamey Khan Zuzana Diamant Brian J O’Connor Christine M Walls Ashwini K Mathur Hugh C Cowley K Fan Chung Ratko Djukanovic Trevor T Hansel Stephen T Holgate Peter J Sterk Peter J Barnes | 2000 | The Lancet2000,,9248: | 1 |
| 6 | B-type natriuretic peptide predicts adverse cardiovascular events in pediatric outpatients with chronic left ven- trieular systolic dysfunction 显示文摘 | Price JF Thomas AK Grenier M Eidem BW O'Brian Smith E Denfield SW | 2006 | Circulation2006,114,10: | 1 |
| 7 | The Australian national workplace health project:design and baseline findings显示文摘 | Judy M Brian O Neville O | 2000 | Preventive Medicine2000,,31: | 1 |
| 8 | Activation of mitochondrial ATP-dependent potassium channels by nitric oxide显示文摘 | Norihito S Toshiaki S Andreas O Brian O Eduardo M Sasaaki N | 2000 | Circulation2000,101,: | 1 |
| 9 | Genetic features of resident biofilms determine attach ment of Listeria monocytogenes 显示文摘 | Habimana O Meyrand M Meylheuc T Kulakauskas S Brian det R | 2009 | Appl Environ Microhiol2009,75,: | 1 |
| 10 | Using Collabora- tive Filtering to Weave an Information Tapestry 显示文摘 | Goldberg D Nichols D Brian M O | 1992 | Com- munications of the ACM1992,35,12: | 1 |
| 11 | Using linear algebra for intelligent information retrieval显示文摘 | Berry M W Dumais S T O' brian G W | 1995 | SIAM Review1995,37,4: | 1 |
| 12 | Prevalence of anxi- ety disorders among adults seeking speech therapy for stut- tering显示文摘 | Iverach L Onslow M O'brian S | 2009 | Journal of Anxiety Disorders2009,23,7: | 1 |
| 13 | Theory of multimode laser operation 显示文摘 | O'brian III C L Sargent III M | 1973 | Physics Review1973,8,6: | 1 |
| 14 | Simultaneous single event charge sharing and parasitic bipolar conduction in a highly-scaled sram design 显示文摘 | BRIAN D O DENNIS R B KEVIN M W | 2005 | IEEE Trans on Nucl Sci2005,52,6: | 1 |
| 15 | Resveratrol:a candidate nutritional substance for prostate cancer prevention 显示文摘 | STEWART J R ARTIME M C O' BRIAN C | 2003 | J Nutr2003,133,: | 1 |
| 16 | Long - term follow - up of effi- cacy and safety of megavoltage radiotherapy in high - risk giant cell tumor of bone 显示文摘 | Shawn M Brian O Charles C | 1995 | Radiation Oncology Biol Phys1995,33,: | 1 |
| 17 | Operations on rigid for- mations of autonomous agents 显示文摘 | Tolga E Brian D O A Stephen M A | 2004 | Communications in Information and Systems2004,,: | 1 |
| 18 | Quantitative evaluation of the oil-leg potential in the Oliver gas field, Timor Sea, Australia显示文摘 | Lisk M Brian W O' Eadington P J | 2002 | AAPG Bulletin2002,86,9: | 1 |
| 19 | Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer显示文摘 | Brian DP O’Neill Gina Brown RJ Heald David Cunningham Diana M Tait | 2007 | Lancet Oncology2007,,: | 1 |
| 20 | High ambient temperature and the risk of preterm delivery显示文摘 | Rupa B Brian M Bart O | 2010 | Am J Epidemiol2010,172,10: | 1 |