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| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | Cutaneous leishmaniasis显示文摘 | Richard Reithinger Jean-Claude Dujardin Hechmi Louzir Claude Pirmez Bruce Alexander Simon Brooker | 2007 | The Lancet Infectious Diseases2007，，9： | 2 |
| 4 | Customer Loyalty Isn't Enough Grow Your Share of Wallet显示文摘 | Timothy L K Lerzan A Alexander Buoye Bruce Cooii | 2011 | Harvard Business Review2011，，10： | 1 |
| 5 | Assessment of the oxidative stability of lubricant oil using fiber-coupled fluorescence excitation–emission matrix spectroscopy显示文摘 | Hengameh Omrani Alexander E. Dudelzak Bruce P. Hollebone Hans-Peter Loock | 2013 | Analytica Chimica Acta2013，，： | 1 |
| 6 | Personality,Life Events,and Subjective Weil-Being:Toward a Dynamic Equilibrium Model显示文摘 | Bruce Headey Alexander Wearing | | 0，，04： | 1 |
| 7 | Blood meal identification and parasite detection in laboratory-fed and field-captured Lutzomyia longipalpis by PCR using FTA databasing paper显示文摘 | Mauricio R.V. Sant'Anna Nathaniel G. Jones Jonathan A. Hindley Antonio F. Mendes-Sousa Rod J. Dillon Reginaldo R. Cavalcante Bruce Alexander Paul A. Bates | 2008 | Acta Tropica2008，，3： | 1 |
| 8 | A comparative study of the tolerance of skeletal musle to ischemia显示文摘 | Richard Scott Alexander Sapega | 1986 | J Bone Joint Surg1986，68，： | 1 |
| 9 | The High Accuracy Atmospheric Correction for Hyperspectral Data (HATCH) Model显示文摘 | Zheng Qu Bruce C Kindel Alexander F H Goetz | 2003 | IEEE Transactions on Geoscience and Remote Sensing2003，41，6： | 1 |
| 10 | Assessing Resident Competency in Laboratory Medicine显示文摘 | C. Bruce Alexander | 2007 | Clinics in Laboratory Medicine2007，，2： | 1 |
| 11 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial显示文摘 | Alexander GG Turpie Michael R Lassen Bruce L Davidson Kenneth A Bauer Michael Gent Louis M Kwong Fred D Cushner Paul A Lotke Scott D Berkowitz Tiemo J Bandel Alice Benson Frank Misselwitz William D Fisher | 2009 | The Lancet2009，，9676： | 1 |
| 12 | P-Type semiconducting nickel oxide as an efficiency-enhancing anode interfacial layer in polymer bulk-heterojunction solar cells显示文摘 | Irwin Michael D Buchholz D Bruce Hains Alexander W | 2008 | Proceedings of the National AcademySciences of the United States of America2008，105，8： | 1 |
| 13 | Entropic lattice Boltzmann methods显示文摘 | Boghosian Bruce M Yepez Jeffrey Coveney Peter V Wager Alexander | 2001 | Proceedings of the Royal Society A: Mathematical Physical and Engineering Sciences2001，，2007： | 1 |
| 14 | Making a firm decision:multifaceted regulation of cell fate in the early mouse embryo显示文摘 | Magdalena Zernicka-Goetz Samantha A Morris Alexander W Bruce | 2009 | Nature Reviews Genetics2009，10，： | 1 |
| 15 | Asia-Pacific mussel watch: monitoring contamination of persistent organochlorine compounds in coastal waters of Asian countries显示文摘 | In Monirith Daisuke Ueno Shin Takahashi Haruhiko Nakata Agus Sudaryanto Annamalai Subramanian Subramanian Karuppiah Ahmad Ismail Muswerry Muchtar Jinshu Zheng Bruce J Richardson Maricar Prudente Ngyen Duc Hue Touch Seang Tana Alexander V Tkalin Shinsuke T | 2002 | Marine Pollution Bulletin2002，，3： | 1 |
| 16 | Design, rationale, and initiation of the Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial: A report from the Cardiothoracic Surgical Trials Network显示文摘 | Peter K. Smith Robert E. Michler Y. Joseph Woo John H. Alexander John D. Puskas Michael K. Parides Rebecca T. Hahn Judson B. Williams John M. Dent T. Bruce Ferguson Ellen Moquete Eric A. Rose Pierre Pagé Neal O. Jeffries Patrick T. O’Gara Deborah D. Asche | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，1： | 1 |
| 17 | Accretion in strong field gravity with eXTP显示文摘In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced 'spectral-timing-polarimetry' techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process. | Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 1 |
| 18 | Assessment of the oxidative stability of lubricant oil using fiber-coupled fluorescence excita- tion-emission matrix spectroscopy显示文摘 | Hengameh O Alexander E Bruce P | 2014 | Analytica Chimica Acta2014，81，： | 1 |
| 19 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial显示文摘 | Alexander GG Turpie Michael R Lassen Bruce L Davidson Kenneth A Bauer Michael Gent Louis M Kwong Fred D Cushner Paul A Lotke Scott D Berkowitz Tiemo J Bandel Alice Benson Frank Misselwitz William D Fisher | 2009 | The Lancet2009，，9676： | 1 |
| 20 | Cutaneous leishmaniasis显示文摘 | Richard Reithinger Jean-Claude Dujardin Hechmi Louzir Claude Pirmez Bruce Alexander Simon Brooker | 2007 | The Lancet Infectious Diseases2007，，9： | 1 |
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