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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | 阅读训练对儿童早期字词意识发展的作用显示文摘该研究探讨了幼儿园中、大班及小学一、二年级儿童在完成字 /词意识任务上的年龄差异以及阅读训练对字 /词意识发展的影响。实验结果表明 :(1) 5岁儿童的字词意识尚处于不断的发展之中。 6岁及 7岁儿童的字意识发展已经达到了成熟水平 ;但他们的词意识正处于不断的发展之中。 (2 )初级的阅读训练促进了5岁儿童字意识的发展 ,但对词意识的发展没有影响。 (3)小学语文教学对 6岁儿童的口头任务没有影响 ,但显著地促进了圈词任务成绩的提高。 | 徐芬 Bruce Homer Kang Lee | 2002 | 心理科学2002，25，6： | 5 |
| 3 | Pseudocirrhosis in a pancreatic cancer patient with liver metastases: A case report of complete resolution of pseudocirrhosis with an early recognition and management显示文摘We report a case of pseudocirrhosis arising in the setting of regression of liver metastases from pancreatic cancer. A 55-year-old asymptomatic woman presented to our clinic with newly diagnosed metastatic pancreatic cancer with extensive liver metastases. She underwent systemic chemotherapy with gemcitabine and oxaliplatin (GEMOX). After 8 cycles of therapy, she had a remarkable response to the therapy evidenced by decline of carcinoembryonic antigen (CEA) and CA19 by > 50% and nearly complete resolution of hepatic metastases in computed tomography (CT) scan. Shortly after, she developed increasing bilateral ankle edema and ascites, associated with dyspnea, progressive weight gain, and declining performance status. Gemcitabine and oxaliplatin were discontinued as other causes of her symptoms such as congestive heart disease or venous thrombosis were ruled out. CT scan 6 mo after the initiation of GEMOX revealed worsening ascites with a stable pancreatic mass. However, it also revealed a lobular hepatic contour, segmental atrophy, and capsular retraction mimicking the appearance of cirrhosis. She was managed with aggressive diuresis and albumin infusions which eventually resulted in a resolution of the above- mentioned symptoms as well as complete resolution of pseudocirrhotic appearance of the liver and ascites in CT scan. This case demonstrates that pancreatic cancer patients can develop pseudocirrhosis. Clinicians and radiologist should be well aware of this entity asearly recognition and management can lead to a near complete recovery of liver function and much improved quality of life as illustrated in this case. | Soonmo Peter Kang Tamar Taddei Bruce McLennan Jill Lacy | 2008 | World Journal of Gastroenterology2008，14，10： | 4 |
| 4 | Precision Phenotyping Reveals Novel Loci for Quantitative Resistance to Septoria Tritici Blotch显示文摘Accurate,high-throughput phenotyping for quantitative traits is a limiting factor for progress in plant breeding.We developed an automated image analysis to measure quantitative resistance to septoria tritici blotch(STB),a globally important wheat disease,enabling identification of small chromosome intervals containing plausible candidate genes for STB resistance.335 winter wheat cultivars were included in a replicated field experiment that experienced natural epidemic development by a highly diverse but fungicide-resistant pathogen population.More than 5.4 million automatically generated phenotypes were associated with 13,648 SNP markers to perform the GWAS.We identified 26 chromosome intervals explaining 1.9-10.6%of the variance associated with four independent resistance traits.Sixteen of the intervals overlapped with known STB resistance intervals,suggesting that our phenotyping approach can identify simultaneously(i.e.,in a single experiment)many previously defined STB resistance intervals.Seventeen of the intervals were less than 5 Mbp in size and encoded only 173 genes,including many genes associated with disease resistance.Five intervals contained four or fewer genes,providing high priority targets for functional validation.Ten chromosome intervals were not previously associated with STB resistance,perhaps representing resistance to pathogen strains that had not been tested in earlier experiments.The SNP markers associated with these chromosome intervals can be used to recombine different forms of quantitative STB resistance that are likely to be more durable than pyramids of major resistance genes.Our experiment illustrates how high-throughput automated phenotyping can accelerate breeding for quantitative disease resistance. | Steven Yates Alexey Mikaberidze Simon GKrattinger Michael Abrouk Andreas Hund Kang Yu Bruno Studer Simone Fouche Lukas Meile Danilo Pereira Petteri Karisto Bruce A.McDonald | 2019 | Plant Phenomics2019，1，1： | 2 |
| 5 | Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression显示文摘 | Motoyuki Otsuka Qing Jing Philippe Georgel Liguo New Jianming Chen Johann Mols Young Jun Kang Zhengfan Jiang Xin Du Ryan Cook Subash C. Das Asit K. Pattnaik Bruce Beutler Jiahuai Han | 2007 | Immunity2007，，1： | 2 |
| 6 | The effect of hold-time on fatigue crack growth behaviors of Waspaloy alloy at elevated temperature显示文摘 | Xingbo Liu Bruce Kang Keh-minn Chang | 2003 | Materials Science and Engineering A2003，340，： | 1 |
| 7 | VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors显示文摘 | Xin Lu Euphemia Mu Yong Wei Sabine Riethdorf Qifeng Yang Min Yuan Jun Yan Yuling Hua Benjamin J. Tiede Xuemin Lu Bruce G. Haffty Klaus Pantel Joan Massagué Yibin Kang | 2011 | Cancer Cell2011，，6： | 1 |
| 8 | Astrocyte elevated gene-1 : Recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration显示文摘 | Luni Emdad Devanand Sarkar Zao-Zhong Su Seok-Geun Lee Dong-Chul Kang Jeffrey N. Bruce David J. Volsky Paul B. Fisher | 2007 | Pharmacology and Therapeutics2007，，2： | 1 |
| 9 | MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer显示文摘 | Guohong Hu Robert A. Chong Qifeng Yang Yong Wei Mario A. Blanco Feng Li Michael Reiss Jessie L.-S. Au Bruce G. Haffty Yibin Kang | 2009 | Cancer Cell2009，，1： | 1 |
| 10 | Astrocyte elevated gene-1 : Recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration显示文摘 | Luni Emdad Devanand Sarkar Zao-Zhong Su Seok-Geun Lee Dong-Chul Kang Jeffrey N. Bruce David J. Volsky Paul B. Fisher | 2007 | Pharmacology and Therapeutics2007，，2： | 1 |
| 11 | Phase 1 and pharmacodynamic trial of everolimus in combination with cetuximab in patients with advanced cancer显示文摘 | Christine A. Ciunci Rodolfo F. Perini Anjali N. Avadhani Hyunseon C. Kang Weijing Sun Maryann Redlinger Kathleen Harlacker Keith T. Flaherty Bruce J. Giantonio Mark A. Rosen Chaitanya R. Divgi Hee Kwon Song Sarah Englander Andrea Troxel Mitchell Schnall P | 2014 | Cancer2014，，1： | 1 |
| 12 | Water immersion optical lithography for the 45nm node显示文摘 | Kang Hoyoung Bourov Anatoly | 2003 | SPIE2003，5040，： | 1 |
| 13 | Audit quality and properties of analyst earnings forecasts显示文摘 | Behn Bruce K Jong-Hag Choi and Tony Kang | 2008 | The Accounting Review2008，83，2： | 1 |
| 14 | Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression显示文摘 | Motoyuki Otsuka Qing Jing Philippe Georgel Liguo New Jianming Chen Johann Mols Young Jun Kang Zhengfan Jiang Xin Du Ryan Cook Subash C. Das Asit K. Pattnaik Bruce Beutler Jiahuai Han | 2007 | Immunity2007，，1： | 1 |
| 15 | The effect of hold-time on fatigue crack growth behaviors of WASPALOY alloy at elevated temperature显示文摘 | LIU Xingbo KANG Bruce CHANG Keh-Minn | 2003 | Materials science and Engineering2003，304，： | 1 |
| 16 | 发射市场的客户为何离不开SpaceX显示文摘海伦·休比(Helene Huby)想在欧洲太空历史上留下一笔。作为可重复使用太空舱开发商Exploration Co.的首席执行官,她帮助自己的初创公司在2022年赢得了阿丽亚娜6号(Ariane6)上的一个便宜位置。阿丽亚娜6号是欧洲打算匹敌马斯克旗下SpaceX公司系列火箭的产品。 | Bruce Einhorn Shinhye Kang Heejin Kim Nicholas Takahashi 融汐(译) | 2024 | 商业周刊(中文版)2024，，1： | 0 |
| 17 | 急性卒中影像学研究路径图Ⅱ显示文摘卒中影像学研究组(StrokeImagingResearchGroup,STIR)、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议,最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议(Stroke Treatment Academy Industry Roundtable,STAIR)期间举行。 | Max Wintermark Gregory W. Albers Joseph P. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler James C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen William A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin Patrick Lyden Grant Mair Bijoy IC Menon Patrik Michel Robert Mikulik Raul G. Nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer Peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip M. White Greg Zaharchuk Osama O. Zaidat Stephen M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs Gotz Thomalla Steven J. Warach 严晓铭 刘牧 张晶晶 柯开富 | 2014 | 国际脑血管病杂志2014，22，2： | 0 |
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