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| 1 | Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma显示文摘AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P < 0.0001,respectively). In contrast,the serum levels of VEGF-D were signif icantly higher in control subjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay. | Mansour S Al-Moundhri A Al-Shukaili M Al-Nabhani B Al-Bahrani IA Burney A Rizivi SS Ganguly | 2008 | World Journal of Gastroenterology2008，14，24： | 32 |
| 2 | NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations显示文摘AIM: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic signifi cance of NAT2.METHODS: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses.RESULTS: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic signifi cance.CONCLUSION: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic signif icance. | Mansour S Al-Moundhri Mohamed Al-Kindi Maryam Al-Nabhani Bassim Al-Bahrani Ikram A Burney Ali Al-Madhani Shyam S Ganguly Misbah Tanira | 2007 | World Journal of Gastroenterology2007，13，19： | 5 |
| 3 | Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk显示文摘AIM:To investigate the associations between CDH1 gene polymorphisms and gastric cancer(GC) risk predisposition.METHODS:We analyzed four CDH1 polymorphisms(+54 T>C,-160 C>A,-616 G>C,-3159 T>C) in an Omani population,by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.RESULTS:CDH1-160-AA genotype was associated with an increased risk of GC(OR = 3.6,95% CI:1.1-11.8)(P = 0.03).There was no significant association between the other polymorphisms and GC risk.The haplotype analysis of +54 T>C,-160 C>A,-616 G>C,-3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5(95% CI:0.7-3.5) and 1.5(95% CI:0.2-3.0),but did not reach statistical significance.CONCLUSION:The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman. | Mansour S Al-Moundhri Manal Al-Khanbashi Mohammed Al-Kindi Maryam Al-Nabhani Ikram A Burney Abdulaziz Al-Farsi Bassim Al-Bahrani | 2010 | World Journal of Gastroenterology2010，16，27： | 4 |
| 4 | Assessment of Scales of Disability and Handicap for Stroke Patients显示文摘 | C. D.A. Wolfe N. A. Taub E. J. Woodrow P. G.J. Burney | 1991 | Stroke1991，，10： | 2 |
| 5 | Excretion of collagen derived peptides is incorased in women with stress urinary incontinence 显示文摘 | Kushner L Mathrubutham M Burney T | 2004 | Neurourol Urody2004，23，3： | 1 |
| 6 | Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia显示文摘 | Burney BO Hayes TG Smiechowska J | 2012 | J Clin Endocrinol Metab2012，97，5： | 1 |
| 7 | The development of parenting efficacy among new mothers and fathers显示文摘 | Leerkes EM Burney RV | 2007 | Infancy2007，12，1： | 1 |
| 8 | Pathogenesis and pathophysiology of endometriosis显示文摘 | Burney RO Giudice LC | 2012 | Fertil Steril2012，98，3： | 1 |
| 9 | Case-flnding options for COPD:results from the Burden of Obstructive Lung Disease study显示文摘 | Iithoo A Enright PL Burney P | 2013 | Eur Respir J2013，41，3： | 1 |
| 10 | Validity and repeatability of theIUATLD( 1984 ) bronchial symptoms questionnaire-an international comparison显示文摘 | Burney P Laitinen LA Perdrizet S | 1989 | Eur Respir J1989，2，： | 1 |
| 11 | Excretion of collagen derived peptides is increased in women with stress urinary incontinence显示文摘 | KUSHNER L MATHRUBUTHAM M BURNEY T | 2004 | Neurourol Urodyn2004，23，3： | 1 |
| 12 | Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis显示文摘 | Burney RO Talbi S Hamilton AE | 2007 | Endocrinology2007，148，8： | 1 |
| 13 | Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis 显示文摘 | Burney RO Talbi S Hamilton AE | 2007 | Endocrinology2007，148，： | 1 |
| 14 | Pathogenesis and pathophysiology of endometriosis显示文摘 | Richard O. Burney Linda C. Giudice | 2012 | Fertility and Sterility2012，，3： | 1 |
| 15 | Detection of Toxoplasma gondii parasitemia in experimentally inoculated cats 显示文摘 | BURNEY D P LAPPIN M R SPILKER M | 1999 | J Parasitol1999，85，5： | 1 |
| 16 | Enhanced capillary blood flow in rapidly expanded random pattern flaps 显示文摘 | Marks MW Burney RE Mackenzie JR | 1986 | J Trauma1986，26，10： | 1 |
| 17 | A refined fuzzy time se- ries model for stock market forecasting 显示文摘 | Jilani TA Burney SMA | 2008 | Physica A2008，，387： | 1 |
| 18 | Interpretation of metal concentrations in estuarine sediments of Florida using aluminum as a reference element显示文摘 | Steven J. Schropp F. Graham Lewis Herbert L. Windom Joe D. Ryan Fred D. Calder Louis C. Burney | 1990 | Estuaries1990，，3： | 1 |
| 19 | Outcome of vaportrode transurethralvaporization of the prostate using pressure-flow urodynamiccriteria显示文摘 | Desautel MG Burney TL Diaz DA | 1998 | Urology1998，51，6： | 1 |
| 20 | DNA damage in deoxynucleosides and oligonucleotides treated with peroxynitrite 显示文摘 | Burney S Niles J C Dedon P C | 1999 | Chem Res Toxicol1999，12，6： | 1 |
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