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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | Evolution of regoliths and landscapes in deeply weathered terrain-implications for geochemical exploration显示文摘 | BUTT C R M LINTERN M J ANAND R R | 2000 | Ore Geology Reviews2000，16，34： | 1 |
| 3 | Micromechanical cantilever-based biosensor 显示文摘 | RAITERI R GRATTAROLA M BUTT H | 2001 | Sensors and Actuators2001，79，： | 1 |
| 4 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 5 | Pore geometry in woven fiber structures: 0 degrees/90 degrees plain- weave cloth layup preform 显示文摘 | LEE S B STOCK S R BUTTS M D | 1998 | Journal of Materials Research1998，13，5： | 1 |
| 6 | Prevalence and risks factors of age- related macular degeneration in Oklahoma Indians:the Vision Keepers Study显示文摘 | Butt AL Lee ET Klein R | 2011 | Ophthalmology2011，118，： | 1 |
| 7 | Strategies ofmaking TiO2 and ZnO visible light active显示文摘 | Rehman S Ullah R Butt A M | 2009 | J HazardMater2009，170，23： | 1 |
| 8 | A controlled challenge study on di(2-ethylhexyl)phthalate(DEHP)in house dust and the immune response in human nasal mucosa of allergic subjects显示文摘 | Deutschle T Reiter R Butte W | 2008 | Environ Health Perspect2008，116，11： | 1 |
| 9 | Particle size, particle size distribution and related measurements of supported metal catalyst显示文摘 | Matyi R J Schwartz L H Butt J B | 1987 | Catal Rev Sci Eng1987，29，1： | 1 |
| 10 | Risk factors for hypoxic ischemic encephalopathy in children显示文摘 | Butt TK Farooqui R Khan MA | 2008 | J Coll Phys Surg Pak2008，18，7： | 1 |
| 11 | The origin of the oxidative burst in plants显示文摘 | Bolwell G P Butt V S Davies D R | 1995 | Free Rad Res1995，23，： | 1 |
| 12 | Optimum design with finite elements:design of electrochemical machining显示文摘 | Butt R | 1993 | Journal of Computational and Applied Mathematics1993，47，2： | 1 |
| 13 | Increased quality of life among hepatocellular carcinoma patients treated with ra- dioembohzation,compared with chemoembolization显示文摘 | Salem R Gilbertsen M Butt Z | 2013 | Clin Gas- troenterol Hepato12013，11，10： | 1 |
| 14 | COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ显示文摘 | Boland GP Butt IS Prasad R | 2004 | Br J Cancer2004，90，2： | 1 |
| 15 | Evo- lution of regoliths and landscapes in deeply weathered ter- rain-Implications for geochemical exploration 显示文摘 | BUTT C R M LINTERN M J ANAND R R | 2000 | Ore Geology Reviews2000，16，34： | 1 |
| 16 | Boundary slip in Newtonian studies reports on progress in physics显示文摘 | NETO C EVANS D R BUTT H J | 2005 | 68:2859-28972005，68，： | 1 |
| 17 | Adjuvant therapy in non-srrmll cell lung cancer: current and future directions显示文摘 | Sangha R Price J Butts CA | 2010 | Oncologist2010，15，8： | 1 |
| 18 | Upper cervical and upper thoracic manipulation versus mobilization and exercise in patients with cervicogenic headache:a multi - center randomized clinical trial 显示文摘 | Dunning JR Butts R Mourad F | 2016 | BMC Musculoskelet Disord2016，17，1： | 1 |
| 19 | Inhibition of procollagen C2 proteinase reduces scar hypertrophy in a rabbit model of cutaneous scarring显示文摘 | Reid RR Mogford JE Butt R | 2006 | Wound Repair Regen2006，14，： | 1 |
| 20 | Synchronized phasor measurements of a power system event显示文摘 | Burnett R O Butts M M Cease T W | 1994 | IEEE Trans on Power Systems1994，9，3： | 1 |
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