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| 1 | Hydrochemical regime and its mechanism in Yamzhog Yumco Basin, South Tibet显示文摘The hydrochemistry of alpine lakes reflects water characteristic and its response to climatic change. Over 300 water samples had been collected from 52 sites of 5 lakes and 7 inflowing rivers in the Yamzhog Yumco Basin, South Tibet, during 2009–2014, basing which the hydrochemical regime and its mechanism were analyzed along with the adoption of hydrological investigations in 1979 and 1984 as well. Results revealed that the waters were hard with weak alkalinity for the Yamzhog Yumco Basin. Most of them were fresh, and the rest were slightly saline. The hydrochemical types of 5 lakes(i.e., Lake Yamzhog Yum Co, Puma Yum Co, Bajiu Co, Kongmu Co, and Chen Co) were SO_4^(2–)–HCO_3~––Mg^(2+)–Na^+, HCO_3~–– SO2–2+4–Mg^(2+)–Ca, SO_4^(2–)–Mg^(2+)–Na^+, SO_4^(2–)–HCO_3~––Ca^(2+), and SO_4^(2–)–Na^+–Mg^(2+)–Ca^(2+), respectively. As for rivers, HCO_3~– and SO_4^(2–) were the major anions, and Ca^(2+) was the dominant cation. Lake Yamzhog Yum Co, the largest lake in the basin, exhibited remarkable spatial variations in hydrochemistry at its surface but irregular changes with depth. The weathering of evaporates and carbonates, together with evaporation and crystallization, were the major mechanisms controlling the hydrochemistry of waters in the Yamzhog Yumco Basin. Global warming also had significant impacts on hydrochemical variations. | ZHE Meng ZHANG Xueqin WANG Buwei SUN Rui ZHENG Du | 2017 | Journal of Geographical Sciences2017，27，9： | 7 |
| 2 | Doctor-patient communication starts from medical students显示文摘Currently,with the increasing tensionin doctor-patient relationship and medical disputes,it is of great practical importance to train medical students’communication skills in order to establisha harmonious doctor-patient relationship to improve the quality of clinical teaching.This paper emphasizes the importance of cultivation of communication skills in medical education and suggests ways to improve communication skills among medical students. | WANG Buwei | 2013 | Journal of Medical Colleges of PLA(China)2013，28，4： | 3 |
| 3 | SUMOylation-modified Pelota-Hbs1 RNA surveillance complex restricts the infection of potyvirids in plants显示文摘RNA quality control nonsense-mediated decay is involved in viral restriction in both plants and animals.However,it is not known whether two other RNA quality control pathways,nonstop decay and no-go decay,are capable of restricting viruses in plants.Here,we show that the evolutionarily conserved Pelota–Hbs1 complex negatively regulates infection of plant viruses in the family Potyviridae(termed potyvirids),the largest group of plant RNA viruses that accounts for more than half of the viral crop damage worldwide.Pelota enables the recognition of the functional G1-2A6-7 motif in the P3 cistron,which is conserved in almost all potyvirids.This allows Pelota to target the virus and act as a viral restriction factor.Furthermore,Pelota interacts with the SUMO E2-conjugating enzyme SCE1 and is SUMOylated in planta.Blocking Pelota SUMOylation disrupts the ability to recruit Hbs1 and inhibits viral RNA degradation.These findings reveal the functional importance of Pelota SUMOylation during the infection of potyvirids in plants. | Linhao Ge Buwei Cao Rui Qiao Hongguang Cui Shaofang Li Hongying Shan Pan Gong Mingzhen Zhang Hao Li Aiming Wang Xueping Zhou Fangfang Li | 2023 | Molecular Plant2023，16，3： | 2 |
| 4 | Polymerization of methyl methacrylate catalyzed by mono-/bis-salicylaldiminato nickel(Ⅱ) complexes and methylaluminoxane显示文摘Two types of salicylaldiminato-based nickel complexes,mono-ligated Ni(II)complexes([O-C_(6)H_(4)-o-C(H)=N-Ar]Ni(PPh_(3))(Ph)(5),[O-(3,5-Br_(2))C_(6)H_(2)-o-C(H)=N-Ar]Ni(PPh_(3))(Ph)(6),[O-(3-t-Bu)C_(6)H_(3)-o-C(H)=N-Ar]Ni(PPh_(3))(Ph)(7))and bis-ligated Ni(II)complexes([O-(3,5-Br_(2))C_(6)H_(2)-o-C(H)=N-Ar]_(2)Ni(8),[O-(3,5-Br_(2))C_(6)H_(2)-o-C(H)=N-2-C_(6)H_(4)(PhO)]_(2)Ni(9),Ar=2,6-C_(6)H_(3)(i-Pr)_(2))were synthesized and characterized by Fourier transform infrared spectroscopy(FT-IR),nuclear magnetic resonance(NMR),mass spectrography(MS)and elemental analysis(EA).In the presence of methylaluminoxane(MAO)as cocatalyst,all the nickel complexes exhibited high activities for the polymerization of methyl methacrylate(MMA)and syndiotactic-rich poly(methyl methacrylate)(PMMA)was obtained.The complexes with less bulky substituents on salicylaldiminato framework possessed higher activities,while with the same salicylaldiminato,the mono-ligated nickel complexes showed higher catalytic activity than bis-ligated ones. | Jihong LU Danfeng ZHANG Qian CHEN Buwei YU | 2011 | Frontiers of Chemical Science and Engineering2011，5，1： | 2 |
| 5 | Accuracy of Regional Cerebral Oxygen Saturation in Predicting Postoperative Cognitive Dysfunction After Total Hip Arthroplasty显示文摘 | Rong Lin Fujun Zhang Qingsheng Xue Buwei Yu | 2012 | The Journal of Arthroplasty2012，，： | 1 |
| 6 | Sevoflurane induced amnesia inhibits hippocampal Arc expression partially through 5-hydroxytryptamine-7 receptors in the bilateral basolateral amygdala in rats显示文摘 | Fujun Zhang Xiaomei Feng Qingwen Zeng Bo Wang Kevin Wilhelmsen Qiang Li Xiaohua Cao Buwei Yu | 2014 | Neuroscience Letters2014，，： | 1 |
| 7 | Geminivirus satellite-encoded βC1 activates UPR,induces bZIP60 nuclear export,and manipulates the expression of bZIP60 downstream genes to benefit virus infection显示文摘UPR is a conserved response in eukaryotes and can alleviate endoplasmic reticulum(ER)stresses induced by abiotic and biotic stresses.The interactions between UPR and plant RNA viruses have been documented,while the interplays between UPR and plant DNA viruses remain unknown.Using tomato yellow leaf curl China virus(TYLCCNV)and its associated betasatellite(TYLCCNB)as a model,we indicate that TYLCCNBβC1 is a major inducer of UPR and can upregulate the expression of b ZIP60,a transcription factor in Nicotiana benthamiana plants.Treatment using ER stress inducers or overexpression of Nbb ZIP60 increasesβC1 accumulation and benefits TYLCCNV/TYLCCNB infection in N.benthamiana plants,and vice versa.In the TYLCCNV/TYLCCNB-infected or theβC1-expressing cells,Nbb ZIP60 is exported from the nucleus to the nuclear periphery via the XPO1 pathway,and blocking the XPO1 pathway inhibited TYLCCNV/TYLCCNB infection.We have found that the Nbb ZIP60-regulated pro-survival genes could promote virus infection,and the pro-death gene plays a contrasting role in virus infection.This study reveals that geminivirus infection activates UPR and utilizes the up-regulated molecular chaperons to promote viral infection,and then induces the nuclear export of Nbb ZIP60 to evade plant defense response,which is a distinct virulence strategy exploited by plant pathogens. | Mingzhen Zhang Buwei Cao Hui Zhang Zaifeng Fan Xueping Zhou Fangfang Li | 2023 | Science China(Life Sciences)2023，66，6： | 1 |
| 8 | Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice显示文摘Alzheimer’s disease(AD)is the most common form of dementia.At the present time,however,AD still lacks effective treatments.Our recent studies showed that chronic treatment with anesthetic propofol attenuated brain caspase-3 activation and improved cognitive function in aged mice.Accumulation ofβ-amyloid protein(Aβ)is a major component of the neuropathogenesis of AD dementia and cognitive impairment.We therefore set out to determine the effects of chronic treatment with propofol on Aβlevels in brain tissues of aged mice.Propofol(50 mg/kg)was administrated to aged(18 month-old)wild-type mice once a week for 8 weeks.The brain tissues of mice were harvested one day after the final propofol treatment.The harvested brain tissues were then subjected to enzyme-linked immunosorbent assay(ELISA)and Western blot analysis.Here we report that the propofol treatment reduced Aβ(Aβ40 and Aβ42)levels in the brain tissues of the aged mice.Moreover,the propofol treatment decreased the levels ofβ-site amyloid precursor protein cleaving enzyme(the enzyme for Aβgeneration),and increased the levels of neprilysin(the enzyme for Aβdegradation)in the brain tissues of the aged mice.These results suggested that the chronic treatment with propofol might reduce brain Aβlevels potentially via decreasing brain levels ofβ-site amyloid precursor protein cleaving enzyme,thus decreasing Aβgeneration;and via increasing brain neprilysin levels,thus increasing Aβdegradation.These preliminary findings from our pilot studies have established a system and postulated a new hypothesis for future research. | Yiying Zhang Haijun Shao Yuanlin Dong Celeste A Swain Buwei Yu Weiming Xia Zhongcong Xie | 2014 | Translational Neurodegeneration2014，3，1： | 1 |
| 9 | 显示文摘 | WANGQian(王倩) BUWei(卜玮) CHENXuan(陈璇) BAIXiao-Hong(白小红) | | 高等学校化学学报0，，： | 1 |
| 10 | Dock4 is required for the maintenance of cochlear hair cells and hearing function显示文摘Auditory hair cells(HCs)are the mechanosensory receptors of the cochlea,and HC loss or malfunction can result from genetic defects.Dock4,a member of the Dock180-related protein superfamily,is a guanine nucleotide exchange factor for Rac1,and previous reports have shown that Dock4 mutations are associated with autism spectrum disorder,myelodysplastic syndromes,and tumorigenesis.Here,we found that Dock4 is highly expressed in the cochlear HCs of mice.However,the role of Dock4 in the inner ear has not yet been investigated.Taking advantage of the piggyBac transposon system,Dock4 knockdown(KD)mice were established to explore the role of Dock4 in the cochlea.Compared to wild-type controls,Dock4 KD mice showed significant hearing impairment from postnatal day 60.Dock4 KD mice showed hair bundle deficits and increased oxidative stress,which eventually led to HC apoptosis,late-onset HC loss,and progressive hearing loss.Furthermore,molecular mechanism studies showed that Rac1/β-catenin signaling was significantly downregulated in Dock4 KD cochleae and that this was the cause for the disorganized stereocilia and increased oxidative stress in HCs.Overall,our work demonstrates that the Dock4/Rac1/β-catenin signaling pathway plays a critical role in the maintenance of auditory HCs and hearing function. | Guodong Hong Xiaolong Fu Jieyu Qi Buwei Shao Xuan Han Yuan Fang Shuang Liu Cheng Cheng Chengwen Zhu Junyan Gao Xia Gao Jie Chen Ming Xia Wei Xiong Renjie Chai | 2023 | Fundamental Research2023，3，4： | 0 |
| 11 | Geminiviral C2 proteins inhibit active autophagy to facilitate virus infection by impairing the interaction of ATG7 and ATG8显示文摘Autophagy is a conserved intracellular degradation process that plays an active role in plant response to virus infections.Here we report that geminiviruses counteract activated autophagymediated antiviral defense in plant cells through the C2 proteins they encode.We found that,in Nicotiana benthamiana plants,tomato leaf curl Yunnan virus(TLCYnV)infection upregulated the transcription levels of autophagy-related genes(ATGs).Overexpression of NbATG5,NbATG7,or NbATG8a in N.benthamiana plants decreased TLCYnV accumulation and attenuated viral symptoms.Interestingly,transgenic overexpression of NbATG7 promoted the growth of N.benthamiana plants and enhanced plant resistance to TLCYnV.We further revealed that the C2 protein encoded by TLCYnV directly interacted with the ubiquitinactivating domain of ATG7.This interaction competitively disrupted the ATG7–ATG8 binding in N.benthamiana and Solanum lycopersicum plants,thereby inhibiting autophagy activity.Furthermore,we uncovered that the C2-mediated autophagy inhibition mechanism was conserved in three other geminiviruses.In summary,we discovered a novel counter-defensive strategy employed by geminiviruses that enlists their C2 proteins as disrupters of ATG7–ATG8 interactions to defeat antiviral autophagy. | Buwei Cao Linhao Ge Mingzhen Zhang Fangfang Li Xueping Zhou | 2023 | Journal of Integrative Plant Biology2023，65，5： | 0 |
| 12 | A Demonstration of Automatically Switched Optical Network显示文摘We build an automatically switched optical network (ASON) testbed with four optical cross-connect nodes. Many fundamental ASON features are demonstrated, which is implemented by control protocols based on generalized multi-protocol label switching (GMPLS) framework. | Weisheng Hu, Yaohui Jin, Chun Jiang, Yue Wang, Xiaodong Wang, Chunlei Zhang, Yang Lu,Buwei Xu, Peigang Hu, Qingji ZengState Key Lab of Advanced Optical Communication Systems and Networks, Shanghai Jiao Tong University, P. R.China, Tel: 86-21-62932029, E-mail: wshu@sjtu.edu.cn | 2003 | 光学学报2003，23，S1： | 0 |
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