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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 反流性食管炎中埃索美拉唑比奥美拉唑更能促进病变愈合和症状缓解显示文摘 | Kahrilas PJ Falk GW Johnson DA Schmitt C Collins DW Whipple J D’Amino D Hamelin B Joelsson B 钟捷 | 2002 | 中华消化杂志2002，22，11： | 19 |
| 3 | 血管紧张素Ⅱ诱导的高血压所引起的T淋巴细胞活化与血管炎症的中枢和外周机制显示文摘研究者先前就发现,T淋巴细胞对血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)诱导的高血压的发生发展是必需的,但是,高血压发生过程中的T细胞活化机制尚不明确。该文研究者探讨了中枢神经系统和血压升高在AngⅡ导致的T细胞活化与血管炎症中的作用。 | 张玲玉 叶鹏 Marvar PJ Thabet SR Guzik TJ Lob HE McCann LA Weyand C Gordon FJ Harrison DG | 2010 | 中华高血压杂志2010，18，12： | 15 |
| 4 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 5 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 6 | Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms显示文摘 | Coutelle C Ward PJ Fleury B Quattrocchi P Chambrin H Iron A | 1997 | Hum Genet1997，99，3： | 3 |
| 7 | Toward a quantitative assessment of diffusion anisotropy显示文摘 | Pierpaoli C Basser PJ | 1996 | Magn Reson Med1996，36，6： | 2 |
| 8 | In vivo fiber tractography using DT-MRI data显示文摘 | Basser PJ Pajevic S Pierpaoli C | 2000 | Magn Reson Med2000，44，4： | 2 |
| 9 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 10 | Argon plasma coagulation in flexible gastrointestinal endoscopy: pilot experiences 显示文摘 | Wahab PJ Mulder C J Den Hattog G | 1997 | Endoscopy1997，29，3： | 2 |
| 11 | Hepatobiliary transporters and drug-induced cholestasis 显示文摘 | Pauli-Magnus C Meier PJ | 2006 | Hepatology2006，44，： | 1 |
| 12 | Motor cortex organization after stroke is related to side of stroke and level of recovery显示文摘 | Zemke AC Heagerty PJ Lee C | 2003 | Stroke2003，34，： | 1 |
| 13 | An increased polymerlc IgA level is not a prognostic marker for progressive IgA nephropathy显示文摘 | Van der Boog PJ Van Kooten C Van Seggelen A | 2004 | Nephrol Dial Transplant2004，19，10： | 1 |
| 14 | Cell envelope protein PPE68 contributes Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6显示文摘 | Demangel C Brodin P Cockle PJ | 2004 | Infect Immun2004，72，4： | 1 |
| 15 | An analysis of multip lestaging management strategies for carcinoma of the esophagus:computed tomography,endoscopic ultrasound,positronem is 2 sion tomography,and thoraco scopy? laparo scopy显示文摘 | Wallace MB Nietert PJ Earle C | 2002 | Ann Thorac Surg2002，74，8： | 1 |
| 16 | Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function 显示文摘 | Day ND Branigan PJ Liu C et ol | 2006 | Virol J2006，3，1： | 1 |
| 17 | Dual chronic hepatitis B virus and hepatitis C virus infection 显示文摘 | Liu C J Chen PJ Chen DS | 2009 | Hepatol Int2009，3，4： | 1 |
| 18 | Enhanced expression of intra- cellular adheusion molecule - 1 and P - selection in the diabetic hu- man aretinaand choroid显示文摘 | Mcleod DS Lefer PJ Merges C | 1995 | Arm J Pathol1995，147，： | 1 |
| 19 | An improved mathematical approach for theassessment of the medial thickness of pulmonary arteries显示文摘 | Barth PJ Kimpel C Roy S | 1993 | Pathol Res Pract1993，189，5： | 1 |
| 20 | Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen 显示文摘 | Mitchell PJ Wang C Tijian R | 1987 | Cell1987，50，6： | 1 |
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