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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility显示文摘Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is debated.The aim of this study was to compare successful resection rates(RR)with upfront ALPPS vs.PVE with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ALPPS.Methods:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day mortality.Results:A total of 189 patients were included.Successful RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on demand.The sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS. | Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 3 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 4 | Evaluation of the effects of different freezing and thawing methods on color, polyphenol and ascorbic acid retention in strawberries 显示文摘 | Holzwarth M Korhummel S Carle R | 2012 | Food Research International2012，48，： | 1 |
| 5 | Quantitative determination of carotene stereoisomers in carrot juices and vitamin supplemented (ATBC) drinks显示文摘 | Marx M Schieber A Carle R | 2000 | Food Chemistry2000，70，： | 1 |
| 6 | Evaluation of fruit authenticity and determination of the fruit content of fruit products using FT-NIR spectroscopy of cell wall components显示文摘 | KURZ C LEITENBERGER M CARLE R | 2010 | Food Chemistry2010，119，： | 1 |
| 7 | The Microwave Power Module:A Versatile RF Building Block for High-Power Transmitters 显示文摘 | Carl R Smith Carter M Armstrong Joseph Duthie | 1999 | Proceedings of the IEEE1999，87，5： | 1 |
| 8 | N',2 -diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists Ⅱ显示文摘 | ELLIOTT J M CARLING R W CHICCHI G G | 2006 | Bioorg Med Chem Lett2006，16，22： | 1 |
| 9 | An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties显示文摘 | CHAMBERS M S ATACK Jr CARLING R W | 2004 | J Med Chem2004，47，24： | 1 |
| 10 | Surface characterization of a silicon-chip-based DNA microarray显示文摘 | Lenigk R Carles M Ip N Y | 2001 | Langmuir2001，17，8： | 1 |
| 11 | Histologic analysis of renalleukocyte infiltration in antineutrophil cytoplasmic antibodyassociatedvasculitis: importance of monocyte and neutrophilinfiltration in tissue damage显示文摘 | Weidner S Carl M Riess R | 2004 | Arthritis Rheum2004，50，11： | 1 |
| 12 | Evaluation of methods for sampling, recovery and enumeration of bacteria applied to the phylloplane 显示文摘 | Donegan K Carl M Seidler R et d | 1991 | Applied and Environmental Microbiology1991，57，： | 1 |
| 13 | Esti- mation of geometrical parameters for fan beam tomo- graphy显示文摘 | Gullberg G T Benjamin M W Carl R | 1987 | Phys Med Biol1987，32，12： | 1 |
| 14 | Identification of antimicrobial resistance and class 1 integrons in Shiga toxin-producing Escherichia coli recovered from humans and food animals 显示文摘 | Singh R Carl M Schroeder | 2005 | Antimicrob Chemother2005，56，： | 1 |
| 15 | Evaluation of the effects of different freezing and thawing methods on color, polyphenol and ascorbic acid retention in strawberries显示文摘 | HOLZWARTH M KORHUMMEL S CARLE R | 2012 | Food Research International2012，48，1： | 1 |
| 16 | Gassmann fluid substitutions : a tutorial显示文摘 | Tad M Smith Carl H Sondergeld Chandra S R | 2003 | Geophysics2003，68，2： | 1 |
| 17 | Comparison of racemic albuterol and levalbuterol for treatment of acute asthma显示文摘 | Carl J C Myers T R Kirchner H L Kercsmar C M | 2003 | Pediatr2003，143，： | 1 |
| 18 | Digital mammography显示文摘 | John M L Carl J D Edward R H | 2004 | Radiol Clin North Am2004，42，6： | 1 |
| 19 | Rapid flash annealing of thermally reactive copolymers in a roll-to-roll process for polymer solar cells显示文摘 | Helgesen M Carle J E Andreasen B Hosel M NorrmanK Sondergaard R Krebs F C | 2012 | Polymer Chemistry2012，3，9： | 1 |
| 20 | Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans显示文摘 | Ubeda Carles Taur Ying Jenq Robert R Equinda Michele J Son Tammy Samstein Miriam Viale Agnes Socci Nicholas D van den Brink Marcel R M Kamboj Mini Pamer Eric G | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
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