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| 1 | 慢性肾脏病患者铁剂应用的争议:来自改善全球肾脏病预后组织(KDIGO)会议的结论显示文摘慢性肾脏病和终末期肾病患者常需补铁治疗。但近年来铁剂的使用逐年增加,带来了铁超载、氧化应激和超敏反应等新问题,并可能促进感染的发生,其使用的安全性受到关注。为此,改善全球肾脏病预后组织(KDIGO)召开专家组会议,全面评估铁剂使用的利和弊,并且提供合理使用方案以减轻急性反应及其他毒副作用。 | Iain C.Macdougall Andreas J.Bircher Kai-Uwe Eckardt Gregorio T.Obrador Carol A.Pollock Peter Stenvinkel Dorine W.Swinkels Christoph Wanner Gü nter Weiss Glenn M.Chertow 陈佩玲(翻译) 龚德华(审校) | 2016 | 肾脏病与透析肾移植杂志2016，，4： | 5 |
| 2 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 3 | Catalytic reduction of nitrate and nitrite on Pt- Cu/Al2O3 catalysts in aqueous solution:role of the interaction between copper and platinum in the reaction显示文摘 | Florence E Florence G Carole P | 2001 | Journal of Catalysis2001，198，： | 3 |
| 4 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 5 | The intracellular production and secetion of HIV-1 envelope protein in the methylotrophic yeast Pichia pastoris 显示文摘 | Carol A S Richard G B Jeffrey J C | 1993 | Gene1993，136，： | 2 |
| 6 | Plant FtsZ1 and FtsZ2 expressed in a eukaryotic host: GTPase activity and self-assembly显示文摘 | Aaron G S Carol B J Stanislav V et ol | 2010 | FEBS letters2010，584，1： | 1 |
| 7 | Learning domain ontologies for semantic Web service descriptions显示文摘 | MARTA S CHRIS W CAROLE G | 2005 | Web Semantics:Science Services and Agents on the World Wide Web2005，，3： | 1 |
| 8 | Local Recurrence of Breast Cancer after Breast Conservation Therapy in Patients Examin?ed by Means of Stereotactic Core-Needle Biopsy显示文摘 | Allen M Chen Bruce G Haffiy Carol H Leea | 2002 | Radiology2002，225，12： | 1 |
| 9 | Current Practices in Sedation and Analgesia for Mechanically Ventilated Critically Ill Patients: A Prospective Multicenter Patient-based Study显示文摘 | Jean-Francois Payen Gérald Chanques Jean Mantz Christiane Hercule Igor Auriant Jean-Luc Leguillou Michèle Binhas Céline Genty Carole Rolland Jean-Luc Bosson | 2007 | Anesthesiology2007，，4： | 1 |
| 10 | Canopy transpiration using time series analysis: A case study illustrating the effect of soil moisture deficit on Pinus taeda 显示文摘 | Ford C R Carol E G Robert J M | 2005 | Journal of Agricultural and Forest Meteorology2005，130，： | 1 |
| 11 | Cysteine protease gene expression and proteolytic activity during senescence of Alstroemeria petals显示文摘 | Carol W Michael K L Gareth G | 2002 | Journal of Experimental Botany2002，53，： | 1 |
| 12 | The callipyge locus:evidence for the trans interaction of reciprocally imprinted genes显示文摘 | Miche G Carole c Noelle C | 2003 | Trends in Genetics2003，19，5： | 1 |
| 13 | Diurnal and seasonal variability in the radial distribution of sap flow:Predicting total stem flow in Pinus taeda trees显示文摘 | Chelcy R F Carol E G Robert J M | 2004 | Tree Physiology2004，24，： | 1 |
| 14 | Circumscribed choroidal hemangioma显示文摘 | Carol L Shields Santosh G Honavar Jerry A Shields Jacqueline Cater Hakan Demirci | 2001 | Ophthalmology2001，，12： | 1 |
| 15 | Ceftiofur Sodium Monoclonal antibody development and cross - reactivity studies with structurally related cephalosporins显示文摘 | Beate G R Sandra A B Carol K H | 1996 | J Agric Food Chem1996，44，： | 1 |
| 16 | Annexin V counteracts apoptosis while inducing Ca2 + influx in human lymphocytic T cells显示文摘 | Carole G Egle S Andreas H | 1999 | Biochemi Biophy Res Communi1999，265，3： | 1 |
| 17 | Molecular cloning and functional characterization of a novel human CC chemokine receptor ( CCR5 ) for RANTES, MIP-1α and MIP-1β显示文摘 | Jennifa G Vicki L | 1996 | J Bio Chem1996，271，17： | 1 |
| 18 | Prevention of rickets and vitamin D deficiency in infants,children,and adolescents显示文摘 | Carol L W Frank R G the Section on Breastfeeding and Committee on Nutrition | 2008 | Pediatrics2008，122，5： | 1 |
| 19 | Clinical relevance of cytogenetic abnormalities at diagnosis of acquired aplastic anaemia in adults显示文摘 | Vikas G Carol B Jennifer A | 2006 | Br J Haematol2006，134，6： | 1 |
| 20 | Oleate desaturase enzymes of soybean : evidence of regulation through differential stabili- ty and phosphorylation 显示文摘 | Tang G Q Novitzky W P Carol G H | 2005 | The Plant Journal2005，44，3： | 1 |
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