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| 1 | Assessment of vascular invasion in gastric cancer: A comparative study显示文摘AIM: To evaluate and compare detection of lymphatic and blood vessel invasion (LVI and BVI) by hematox-ylin-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correlate with lymph node status. METHODS: IHC using D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was performed to study LVI and BVI in surgical specimens froma consecutive series of 95 primary gastric cancer cases. The results of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphologic features of the tumors and the presence of LVI and BVI were related to the presence of lymph node metastasis. A χ2 test was performed to obtain associations between LVI and BVI and other prognostic factors for gastric cancer. RESULTS: The detection rate of LVI was considerably higher than that of BVI. The IHC study identified eight false-positive cases and 13 false-negative cases for LVI, and 24 false-positive cases and 10 false-negative cases for BVI. The average Kappa value determined was moderate for LVI (k=0.50) and low for BVI (k=0.20). Both LVI and BVI were statistically associated with the presence of lymph node metastasis (HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phologic features associated with LVI were location of the tumor in the distal third of the stomach (P=0.039), Borrmann's macroscopic type (P=0.001), organ inva-sion (P=0.03) and the depth of tumor invasion (P=0.001). The presence of BVI was related only to the depth of tumor invasion (P=0.003). CONCLUSION: The immunohistochemical identification of lymphatic and blood vessels is useful for increasing the accuracy of the diagnosis of vessel invasion and for predicting lymph node metastasis. | Letícia Trivellato Gresta Ismael Alves Rodrigues-Júnior Lúcia Porto Fonseca de Castro Geovanni Dantas Cassali Mnica Maria Demas lva-res Cabral | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 2 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 3 | Asymptomatic dogs are highly competent to transmit Leishmania ( Leishmania ) infantum chagasi to the natural vector显示文摘 | Márcia Dalastra Laurenti Claudio Nazaretian Rossi Vania Lúcia Ribeiro da Matta Thaise Yumie Tomokane Carlos Eduardo Pereira Corbett Nágila Francinete Costa Secundino Paulo Filemon Paulocci Pimenta Mary Marcondes | 2013 | Veterinary Parasitology2013，，： | 1 |
| 4 | Encephalitozoonand Enterocytozoon(microsporidia)spores in stool from pigeons and exotic birds microsporidia spores in birds显示文摘 | Maria A L Patrícia C Liliane M | 2012 | Vet Parasitol2012，190，： | 1 |
| 5 | Efficient Genetic Transformation System for the Ochratoxigenic Fungus Aspergillus carbonarius显示文摘 | Luiz Rodrigo I. Morioka Márcia C. Furlaneto Andréa C. Bogas Patrícia Pompermayer Rubens T. D. Duarte Maria Lúcia C. Vieira Maria Angélica Ehara Watanabe Maria Helena P. Fungaro | 2006 | Current Microbiology2006，，6： | 1 |
| 6 | Waist-to-height ratio distinguish obstructive sleep apnea from primary snoring in obese children显示文摘 | de Sousa Caixêta J A Saramago A M de Cácia Pradella-Hallinan M L | 2015 | Sleep Breath2015，19，1： | 1 |
| 7 | NF - kappaB activation and Fas ligand overexpres- sion in blood and plaques of patients with carotid atheroselerosis: potential implication in plaque instability 显示文摘 | MARTIN VENTURA J L BLANCO COLIO L M MUNOZ GAR- CIA B | 2004 | Stroke2004，35，2： | 1 |
| 8 | Central and eastern Bransfield basins (Antarctica) from high-resolution swath-ba- thymetry data显示文摘 | GRA CIA E CANALS M FARRAN M L | 1997 | Antarctic Science1997，9，02： | 1 |
| 9 | Stabilizing a class of time delay systems using the Hermite-Biehler theorem显示文摘 | Vilma A O Marcelo C M Lúcia C | 2003 | Linear Algebra and Its Applications2003，369，： | 1 |
| 10 | An- tioxidant responses to water deficit by drought-tolerant and - sensitive sugarcane varieties 显示文摘 | CIA M C GUIMARAES A C R MEDICI L O | 2012 | Annals of Ap- plied Biology2012，161，： | 1 |
| 11 | Beneficial Effects Of Lactobacillus Plantarum On Glycemia And Homocysteine Levels In Postmenopausal Women With Metabolic Syndrome: A Pilot Study显示文摘 | Fabíola Málaga Barreto Andréa Name Colado Sim?o Helena Kaminami Morimoto Marcell Alysson Batisti Lozovoy Isaias Dichi Lúcia Helena da Silva Miglioranza | 2013 | Nutrition2013，，： | 1 |
| 12 | Development and Validation of Passive Samplers for Atmo- spheric Monitoring of SO2, NO2, 03 and H:S in Tropical Areas 显示文摘 | VANIA P Campos L CIA P S Cruz RICARDO H M Godoi | 2010 | Microchemical Journal2010，96，： | 1 |
| 13 | Assessment of uterine involution in bitches using B-mode and Doppler ultrasonography显示文摘 | Claudia da Cunha Barbosa Mírley Barbosa de Souza Luana Azevedo de Freitas Ticiana Franco Pereira da Silva Sheyla Farhayldes Souza Domingues Lúcia Daniel Machado da Silva | 2013 | 2013 (1-4)2013，，1： | 1 |
| 14 | β-Glucans in promoting health: Prevention against mutation and cancer显示文摘 | Mário S. Mantovani Marilanda F. Bellini José Pedro F. Angeli Rodrigo J. Oliveira Ariane F. Silva Lúcia R. Ribeiro | 2008 | Mutation Research-Reviews in Mutation Research2008，，3： | 1 |
| 15 | Enzymatic oxidation in aqueous and micellar media based on horse- radish peroxidase-hydrogen peroxide system using a SIA manifold显示文摘 | Passos M L C Saraiva M Lu' cia M F S | 2008 | Talanta2008，77，2： | 1 |
| 16 | Biochemical and locomotorresponses of Carcinus maenas exposed to the serotonin reuptakeinhibitor fluoxetine显示文摘 | Raquel M S Lúcia G Laura G | 2011 | Chemosphere2011，85，6： | 1 |
| 17 | Determination of chloramphenicol residues in rainbow trouts by gas chromatography-mass spectometry and liquid chromatography-tandem mass spectometry显示文摘 | Lúcia Santos Jorge Barbosa Conceic(a)o Castilho M | 2005 | Analytica Chimica Acta2005，529，： | 1 |
| 18 | Corporate social responsibility and resource-based perspectives显示文摘 | Branco M Rodrigues Lúcia | 2006 | Journal of Business Ethics2006，69，2： | 1 |
| 19 | Utilization of cereal and fruit fibres in low fat dry fermented sausages显示文摘 | M L Gra cia | 2002 | Meat Science2002，，60： | 1 |
| 20 | C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn’s disease in Hungarian patients显示文摘 | Lilla Lakner Veronika Cs?ngei Patrícia Sarlós Luca Járomi Enik? Sáfrány Márta Varga Péter Orosz Lili Magyari Judit Bene Pál Miheller Zsolt Tulassay Béla Melegh | 2009 | International Journal of Colorectal Disease2009，，5： | 1 |
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