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| 1 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 2 | Based on the D-S evidence theory of regional power grid power quality assessment显示文摘 | Chen Tiemin Fu Chaohao Lin Sihai Sun Peijun Pu Qin | 2012 | power and energy2012，06，： | 1 |
| 3 | Perovskite photodetector-based single pixel color camera for artificial vision显示文摘Narrowband red,green,blue self-filtering perovskite photodetectors and a broadband white photodetector are incorporated into a single pixel imaging camera to mimic the long-,medium-,and short-wavelength cone cells and rod cells in human visual system,leading to the demonstration of high-resolution color images in diffuse mode. | Chaohao Chen Ziyuan Lie Lan Fu | 2023 | Light(Science & Applications)2023，12，4： | 0 |
| 4 | Bypassing the limit in volumetric imaging of mesoscale specimens显示文摘The development of light-sheet microscopy(LSM)1,2 has revolutionized high-resolution imaging of biological organisms in three dimensions(3D)with minimal photodamage3 and high temporal resolution,4 therefore allowing long-term observation of biological processes.5,6 The key is to obtain information on subcellular events at both high spatial and temporal resolutions,but the spatial resolution of current LSM methods has been pixel-limited when each frame of the image is collected under a large field of view from an entire large-volume specimen. | Chaohao Chen Zhen Liu Dayong Jin | 2019 | Advanced Photonics2019，1，2： | 0 |
| 5 | Computational and dark-field ghost imaging with ultraviolet light显示文摘Ultraviolet(UV)imaging enables a diverse array of applications,such as material composition analysis,biological fluorescence imaging,and detecting defects in semiconductor manufacturing.However,scientific-grade UV cameras with high quantum efficiency are expensive and include complex thermoelectric cooling systems.Here,we demonstrate a UV computational ghost imaging(UV-CGI)method to provide a cost-effective UV imaging and detection strategy.By applying spatial–temporal illumination patterns and using a 325 nm laser source,a singlepixel detector is enough to reconstruct the images of objects.We use UV-CGI to distinguish four UV-sensitive sunscreen areas with different densities on a sample.Furthermore,we demonstrate dark-field UV-CGI in both transmission and reflection schemes.By only collecting the scattered light from objects,we can detect the edges of pure phase objects and small scratches on a compact disc.Our results showcase a feasible low-cost solution for nondestructive UV imaging and detection.By combining it with other imaging techniques,such as hyperspectral imaging or time-resolved imaging,a compact and versatile UV computational imaging platform may be realized for future applications. | JIAQI SONG BAOLEI LIU YAO WANG CHAOHAO CHEN XUCHEN SHAN XIAOLAN ZHONG LING-AN WU FAN WANG | 2024 | Photonics Research2024，12，2： | 0 |
| 6 | Optimization of Solid-state Fermentation Conditions of Sophora japonica cv.jinhuai by Response Surface Methodology显示文摘[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single factor experiment and response surface methodology with quercetin content as the dependent variable.[Results]According to the established model,the optimal fermentation process of Flos Sophorae Immaturus was obtained as follows:temperature 29.97℃,time 6.88 d,rotation speed 180.86 rpm,inoculation amount 3.93 mL,and the expected content of quercetin was 34.8053 mg/g.Based on this,the fermentation parameters were adjusted,and the actual content was 33.67 mg/g,which was close to the predicted value.[Conclusions]The optimization of fermentation process of Flos Sophorae Immaturus by response surface methodology provides a reference for the development and utilization of this medicinal material. | Miao YANG Chaohao GU Qiling LI Zhiqiang HUANG Hao LIU Yanxi LAI Zongyou CHEN Kaimei ZHU | 2023 | Medicinal Plant2023，14，5： | 0 |
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