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| 1 | Long-term stabilization of the optical fiber phase control using dual PID显示文摘We propose an approach of long-term stabilization of optical fiber phase by controlling a piezo-based phase modulator and a Peltier component attached to the fiber via a phase-locked loop( PLL) circuit w ith dual proportional-integral- derivative( PID) adjustment. With this approach,we can suppress the fast disturbance and slow drifting of optical fiber to satisfy the requirements of optical phase long-term locking. In theory,a mathematical model of an optical fiber phase control system is established. The disturbance term induced by environment influence is considered into the PLL model. The monotonous and continuous changing environment disturbance w ill cause a steady-state error in this theory model. The experimental results accords w ell w ith the theory. The steady-state performance,adjusting time,and overshoot can be improved by using the dual PID control. As a result,the long-term,highly stable and low noise fiber phase locking is realized experimentally. | WU Yue CHEN Guozhu SHEN Yong ZOU Hongxin | 2015 | Instrumentation2015，2，4： | 11 |
| 2 | CD146 is essential for PDGFRβ-induced pericyte recruitment显示文摘 | Jianan Chen Yongting LUO Hongxin Huang Shuilong Wu Jing Feng Jingjing Zhang Xiyun Yan | 2018 | Protein & Cell2018，9，8： | 9 |
| 3 | A mini-review on recent progress of new sensitizers for luminescence of lanthanide doped nanomaterials显示文摘Trivalent lanthanide(Ln2+)doped luminescent nanocrystals are promising for applications ranging from biosensor,lasing,super-resolution nanoscopy,information security and so on.Although the utility prospect is of great attractions,the light absorption of these lanthanide doped nanocrystals is inherently weak due to the electric dipole-forbidden 4f→4f transitions.Even worse,the quantum yields of upconverison nanocrystals are very low,which will unavoidably hinder their further applications.In a typical lanthanide luminescent nanosystem,both sensitizers as light absorption centers and activators as light emitting centers are necessary and important for desired luminescence properties.Among various sensitization systems,only Yb3+and Nd+are considered as the most efficient sensitizers.Thus,the corresponding excitation wavelengths are strictly limited around 980 and 808 nm.To enrich excitation wavelengths and boost luminescence intensity,exploring more sensitization units that possess larger absorption cross section,higher efficiency of energy transfer process and independent excitation is imperative and beneficial for the demands of different applications,such as broadened absorption in near infrared(NIR)region for higher conversion efficiency of solar cells,prolonged excitation wavelength to second near infrared windows region(NIR Ⅱ,1,000-1,700 nm)for in vivo fluorescence imaging with deeper tissue depth and higher spatial resolution,more orthogonal excitations and emissions to improve optical multiplexing,and so on.Therefore,in the review,we primarily conclude several major energy transfer mechanisms from sensitizers to activators.Then we present three kinds of sensitizers,including lanthanide ions,organic dyes and quantum dots(QDs),and introduce the newly designed sensitization system that allows us to exploit superior excitation wavelength and amplity luminescence intensity.Finally,several future challenges and opportunities for the sensitizing strategies are discussed in hope of directing and broadening the applications of lanthanide nanosystem. | Hongxin Zhang Zi-Han Chen Xuan Liu Fan Zhang | 2020 | Nano Research2020，13，7： | 7 |
| 4 | African Swine Fever Virus Protein E199L Promotes Cell Autophagy through the Interaction of PYCR2显示文摘African swine fever virus(ASFV),as a member of the large DNA viruses,may regulate autophagy and apoptosis by inhibiting programmed cell death.However,the function of ASFV proteins has not been fully elucidated,especially the role of autophagy in ASFV infection.One of three Pyrroline-5-carboxylate reductases(PYCR),is primarily involved in conversion of glutamate to proline.Previous studies have shown that depletion of PYCR2 was related to the induction of autophagy.In the present study,we found for the first time that ASFV E199 L protein induced a complete autophagy process in Vero and HEK-293 T cells.Through co-immunoprecipitation coupled with mass spectrometry(Co IP-MS)analysis,we firstly identified that E199 L interact with PYCR2 in vitro.Importantly,our work provides evidence that E199 L down-regulated the expression of PYCR2,resulting in autophagy activation.Overall,our results demonstrate that ASFV E199 L protein induces complete autophagy through interaction with PYCR2 and down-regulate the expression level of PYCR2,which provide a valuable reference for the role of autophagy during ASFV infection and contribute to the functional clues of PYCR2. | Sheng Chen Xinheng Zhang Yu Nie Hongxin Li Weiguo Chen Wencheng Lin Feng Chen Qingmei Xie | 2021 | Virologica Sinica2021，36，2： | 7 |
| 5 | Comparing salinities of 0, 10 and 20 in biofloc genetically improved farmed tilapia (Oreochromis niloticus) production systems显示文摘A 150 days(150-d)experiment was carried out to investigate the production efficiency,inorganic nitrogen syndrome and bacteria community of indoor biofloc technology(BFT)systems used to rear genetically improved farmed tilapia(Oreochromis niloticus)under 0(S-0),10(S-10),and 20 salinities(S20).The start-up period for BFT was 50,60 and 80 d for S-0,S-10 and S-20 groups,respectively.At steady state,the total ammonium nitrogen(NH4þ-N)and nitrite nitrogen(NO2-N)were lower than 3.0 mg/L and 0.34 mg/L,respectively and no nitrate-nitrogen(NO3-N)accumulation was observed.The fish survival rate was above 95%for all the groups.The final fish biomass of the S-10 group(35.83±1.08 kg/m^(3))was not significantly different from the S-0(34.79±1.33 kg/m^(3))group but was significantly higher than S-20(32.6±1.04 kg/m3).The feed conversion ratio for the tilapia in S-20 was 1.46,which was higher than the ratio in S-0(1.40)and S-10(1.39)tilapia.There was no significant difference in the crude protein content of the back muscle from tilapia of the three experimental groups.No significant difference in blood parameters,except for aspartate aminotransferase and alkaline phosphatase was observed between the three groups.Evaluation of microorganisms in the three BFT systems revealed that Proteobacteria,Bacteroidetes,and Fusobacteria were the top three at the phylum level in all groups.However,a significant difference was observed at the genus level in the bacteria of the three BFTs at different salinity(P<0.05).©2017 Published by Elsevier B.V.on behalf of Shanghai Ocean University.This is an open access article。 | Guozhi Luo Wenqing Li Hongxin Tan Xiaoqing Chen | 2017 | Aquaculture and Fisheries2017，2，5： | 5 |
| 6 | Carbothermic reduction of vanadium titanomagnetite with the assistance of sodium carbonate显示文摘The carbothermic reduction of vanadium titanomagnetite concentrate(VTC)with the assistance of Na_(2)CO_(3)was conducted in an argon atmosphere between 1073 and 1473 K.X-ray diffraction and scanning electron microscopy were used to investigate the phase transformations during the reaction.By investigating the reaction between VTC and Na_(2)CO_(3),it was concluded that molten Na_(2)CO_(3)broke the structure of titanomagnetite by combining with the acidic oxides(Fe_(2)O_(3),TiO_(2),Al_(2)O_(3),and SiO_(2))to form a Na-rich melt and release FeO and MgO.Therefore,Na_(2)CO_(3)accelerated the reduction rate.In addition,adding Na_(2)CO_(3)also benefited the agglomeration of iron particles and the slag–metal separation by decreasing the viscosity of the slag.Thus,Na_(2)CO_(3)assisted carbothermic reduction is a promising method for treating VTC at low temperatures. | Luming Chen Yulan Zhen Guohua Zhang Desheng Chen Lina Wang Hongxin Zhao Fancheng Meng Tao Qi | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，2： | 5 |
| 7 | Dangerous Driving Behavior Recognition and Prevention Using an Autoregressive Time-Series Model显示文摘Time headway is an important index used in characterizing dangerous driving behaviors. This research focuses on the decreasing tendency of time headway and investigates its association with crash occurrence. An autoregressive(AR) time-series model is improved and adopted to describe the dynamic variations of average daily time headway. Based on the model, a simple approach for dangerous driving behavior recognition is proposed with the aim of significantly decreasing headway. The effectivity of the proposed approach is validated by means of empirical data collected from a medium-sized city in northern China. Finally, a practical early-warning strategy focused on both the remaining life and low headway is proposed to remind drivers to pay attention to their driving behaviors and the possible occurrence of crash-related risks. | Hongxin Chen Shuo Feng Xin Pei Zuo Zhang Danya Yao | 2017 | Tsinghua Science and Technology2017，22，6： | 3 |
| 8 | Overview of the Solar Polar Orbit Telescope Project for Space Weather Mission显示文摘The Solar Polar ORbit Telescope(SPORT) project for space weather mission has been under intensive scientific and engineering background studies since it was incorporated into the Chinese Space Science Strategic Pioneer Project in 2011.SPORT is designed to carry a suite of remote-sensing and in-situ instruments to observe Coronal Mass Ejections(CMEs),energetic particles,solar high-latitude magnetism,and the fast solar wind from a polar orbit around the Sun.The first extended view of the polar regions of the Sun and the ecliptic enabled by SPORT will provide a unique opportunity to study CME propagation through the inner heliosphere,and the solar high-latitude magnetism giving rise to eruptions and the fast solar wind.Coordinated observations between SPORT and other spaceborne/ground-based facilities within the International Living With a Star(ILWS) framework can significantly enhance scientific output.SPORT is now competing for official selection and implementation during China's 13 th Five-Year Plan period of 2016-2020. | XIONG Ming LIU Ying LIU Hao LI Baoquan ZHENG Jianhua ZHANG Cheng XIA Lidong ZHANG Hongxin RAO Wei CHEN Changya SUN Weiying WU Xia DENG Yuanyong HE Han JIANG Bo WANG Yuming WANG Chuanbing SHEN Chenglong ZHANG Haiying ZHANG Shenyi YANG Xuan SANG Peng WU Ji | 2016 | 空间科学学报2016，36，3： | 3 |
| 9 | Adriamycin Thermotherapy through the Hepatic Artery Using VX2 Carcinoma in Rabbit Liver as a Model显示文摘OBJECTIVE It has been reported that heating can enhance sensitivity of rabbit VX2 cells to adriamycin and increase the intracellular concentration of adriamycin. This study was designed to evaluate the anti-tumor effect of interventional hyperthermia and interventional thermochemotherapy on VX2 carcinoma in rabbit liver. METHODS VX2 carcinoma cells were surgically implanted into the right liver lobe of 60 male New Zealand white rabbits, which were randomly divided into 4 groups (15 per group). The 4 groups (designated as 1, 2, 3, 4 respectively) were injected with 10 ml of the following via the hepatic artery: physiological saline (37℃); adriamycin (37℃); physiological saline (60℃); adriamycin (60℃). One week later, the tumor volume, serum level of aspartate transaminase (AST) and the survival of the rabbits bearing VX2 were observed and compared among the different treated groups. RESULTS The tumor growth rate in group 4 (ADM 60℃) (0.53±0.21)% was significantly lower than that in group 1 (3.48±1.17)%, in group 2 (1.09±0.26)% and group 3 (3.32±1.28)% (P<0.05, P<0.05, P<0.01, respectively). The days of survival days for group 4 (87.0±2.0) were significantly more than that in group 1 (40.0±3.0). Group 4 showed a significantly higher increase in serum AST compared to group 1 (P<0.05), but without significant differences compared to the other groups (P>0.05). CONCLUSION Adriamycin treatment at 60℃ significantly deceased the tumor growth, prolonged the survival period and resulted in reversible liver damage. | Hongxin Zhang Wei Cao Zhimin Wang Weiping Guo Daihui Ni Wenxian Li Chen Lan Heng Wang | 2006 | Chinese Journal of Clinical Oncology2006，3，2： | 3 |
| 10 | Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP显示文摘Objective:Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma(DLBCL)are available.This study aimed to comprehensively describe BCL2 genetic alterations in DLBCL patients,and examine correlation of BCL2,TP53 and other genetic alterations with outcomes in patients treated with R-CHOP.Methods:Probe capture-based high-resolution sequencing was performed on 191 patients diagnosed with de novo DLBCL.MYC,BCL2,and BCL6 protein expressions were detected by immunohistochemistry.Results:The presence of BCL2 alterations significantly correlated with poor progression-free survival(PFS)(5-year PFS:13.7%vs.40.8%;P=0.003)and overall survival(OS)(5-year OS:34.0%vs.70.9%;P=0.036).Importantly,patients who harbored BCL2 gain/amplifications(BCL2GA/AMP)also had a remarkably inferior 5-year PFS(11.1%vs.38.3%;P<0.001)and OS(22.1%vs.69.6%;P=0.009).In contrast,neither BCL2 mutations nor BCL2 translocations were significantly prognostic for survival.Multivariable analyses showed that the presence of BCL2 alterations,especially BCL2GA/AMP,TP53 mutations,and International Prognostic Index(IPI)were significantly associated with inferior PFS and OS.Novel prognostic models for OS were constructed based on 3 risk factors,including BCL2 alterations(Model 1)or BCL2GA/AMP(Model 2),TP53 mutations,and IPI,to stratify patients into 4 risk groups with different survival outcomes.Conclusions:This study showed that DLBCL patients treated with R-CHOP,BCL2 alterations,especially BCL2GA/AMP and TP53 mutations were significantly associated with inferior outcomes,which were independent of the IPI.The novel prognostic models we proposed predicted outcomes for DLBCL patients treated with R-CHOP,but further validation of the prognostic models is still warranted. | Yan Qin Haizhu Chen Peng Liu Changgong Zhang Jianliang Yang Lin Gui Xiaohui He Liqiang Zhou Shengyu Zhou Shiyu Jiang Hongxin Jiang Yuankai Shi | 2022 | Cancer Biology & Medicine2022，19，6： | 2 |
| 11 | Impacts of outdated CSI for secure cooperative systems with opportunistic relay selection显示文摘Dear editor,Cooperative relaying has been proven to be capable of improving the reliability and throughput of wireless transmissions[1,2],and thus its application in physical layer security communication systems has recently been intensively investi- | Rui ZHAO Hongxin LIN Yu-Cheng HE Dong-Hua CHEN Yongming HUANG | 2017 | Science China(Information Sciences)2017，60，6： | 2 |
| 12 | Two Ultraviolet Radiation Datasets that Cover China显示文摘Ultraviolet(UV) radiation has significant effects on ecosystems, environments, and human health, as well as atmospheric processes and climate change. Two ultraviolet radiation datasets are described in this paper. One contains hourly observations of UV radiation measured at 40 Chinese Ecosystem Research Network stations from 2005 to 2015. CUV3 broadband radiometers were used to observe the UV radiation, with an accuracy of 5%, which meets the World Meteorology Organization's measurement standards. The extremum method was used to control the quality of the measured datasets. The other dataset contains daily cumulative UV radiation estimates that were calculated using an all-sky estimation model combined with a hybrid model. The reconstructed daily UV radiation data span from 1961 to 2014. The mean absolute bias error and root-mean-square error are smaller than 30% at most stations, and most of the mean bias error values are negative, which indicates underestimation of the UV radiation intensity. These datasets can improve our basic knowledge of the spatial and temporal variations in UV radiation. Additionally, these datasets can be used in studies of potential ozone formation and atmospheric oxidation, as well as simulations of ecological processes. | Hui LIU Bo HU Yuesi WANG Guangren LIU Liqin TANG Dongsheng JI Yongfei BAI Weikai BAO Xin CHEN Yunming CHEN Weixin DING Xiaozeng HAN Fei HE Hui HUANG Zhenying HUANG Xinrong LI Yan LI Wenzhao LIU Luxiang LIN Zhu OUYANG Boqiang QIN Weijun SHEN Yanjun SHEN Hongxin SU Changchun SONG Bo SUN Song SUN Anzhi WANG Genxu WANG Huimin WANG Silong WANG Youshao WANG Wenxue WEI Ping XIE Zongqiang XIE Xiaoyuan YAN Fanjiang ZENG Fawei ZHANG Yangjian ZHANG Yiping ZHANG Chengyi ZHAO Wenzhi ZHAO Xueyong ZHAO Guoyi ZHOU Bo ZHU | 2017 | Advances in Atmospheric Sciences2017，34，7： | 2 |
| 13 | A Controller of Bruthlcss DC Motor Used for Hybid Electric Vehicle显示文摘 | Hongxin Wu Shukang chen | 2005 | IEEE transactions on May2005，4，1： | 1 |
| 14 | A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel显示文摘 | MaLing Gou XingYi Li Mei Dai ChangYang Gong XianHuo Wang Yao Xie HongXin Deng LiJuan Chen Xia Zhao ZhiYong Qian YuQuan Wei | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 15 | Widely Tunable Single-Frequency Erbium-Doped Fiber Lasers显示文摘 | F Babin M Leblanc | 2003 | IEEE Photonics Technology Letters2003，15，2： | 1 |
| 16 | A pa- rameter estimation method for FH signal based on SPWVD 显示文摘 | ZHANG Hongxin CHEN Canfeng WANG Haiqing | 2011 | The Journal of China Universities of Posts and Telecom- munications2011，，18： | 1 |
| 17 | A Model for Drying of Porous Materials: From Generality to Specific Applications显示文摘 | Wei Wang Hongxin Ma Guohua Chen | 2011 | Drying Technology2011，，13： | 1 |
| 18 | Ionic liquids based simultaneous ultrasonic and microwave assisted extraction of phenolic compounds from burdock leaves显示文摘 | Zaixiang Lou Hongxin Wang Song Zhu Shangwei Chen Ming Zhang Zhouping Wang | 2011 | Analytica Chimica Acta2011，，： | 1 |
| 19 | SIHR- rumor spreading mod- el in social networks显示文摘 | Laijun Zhao Jiajia Wang Yucheng Chen Qin Wang Jingjing Cheng Hongxin Cui | 2012 | Physica A: Statistical Mechanics and its Applications2012，7，391： | 1 |
| 20 | Lithocarpinols A and B,a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508显示文摘Lithocarpinols A(1) and B(2), a pair of tenellone diastereoisomers with novel fused skeleton were isolated from the deep-sea derived fungus Phomopsis lithocarpus FS508. Their structures were elucidated by comprehensive spectroscopic analyses, X-ray diffraction and quantum molecular calculation. Their plausible biogenetic pathway featured an intriguing carbonyl-ene cyclization. Lithocarpinol A exhibited moderate inhibitory effect against HepG-2 and A549 tumor cell lines with IC_(50) values of 9.4 μmol/L and10.9 μmol/L,respectively. | Jianlin Xu Haibo Tan Yuchan Chen Saini Li Heng Guo Zilei Huang Haohua Li Xiaoxia Gao Hongxin Liu Weimin Zhang | 2019 | Chinese Chemical Letters2019，30，2： | 1 |
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