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| 1 | MiR-375 suppresses invasion and metastasis by direct targeting of SHOX2 in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 是在中国的最普通的组织学的类型。MicroRNAs 内长地在哺乳动物被表示并且由指向潜在的下游的基因在肿瘤侵略和转移起一个重要作用。在现在的学习, microarray 分析证明那 miR-375 表情是显然在 ESCC 的 downregulated 与那相比在正常食道的上皮纸巾。然后,酶记者试金证明 SHOX2 是 miR-375 的直接下游的目标,这个相互作用被营救实验证实。量的聚合酶链反应结果也证明那 SHOX2 表情是在 ESCC 房间和纸巾的 upregulated。进一步的分析证明 SHOX2 在 vivo 并且在 vitro 导致了 ESCC 的增长,侵略,和转移。而且,在 miR-375 和 SHOX2 之间的相互作用影响了 epithelial-to-mesenchymal 转变。我们断定 miR-375 可以由直接指向 SHOX2 压制 ESCC 的侵略和转移。miR-375/SHOX2 轴可以是为 ESCC 的一个新奇治疗学的目标。 | Jun Yi Li Jin Jing Chen BingFeng Zhenyue He Longbang Chen Haizhu Song | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 11 |
| 2 | MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 在最好攻击的恶意之中并且在中国有高发生。MicroRNAs (miRNAs ) 是调整多重 tumorigenic 过程的小内长的 RNA,包括增长,侵略,转移和预后。用 miRNA 表示 proling 分析,我们发现 miR-630 在配对的正常食道的纸巾与那相比在三件 ESCC 织物样品是显著地下面调整的。微分 miR-630 表示随后用量的即时 PCR 被证实。决定 miR-630 下面规定是否能被看作诊断指示物和不利预示的因素,我们与 ESCC 在病人调查了在 miR-630 和 clinicopathological 特征之间的协会。减少的 miR-630 表示总的来说与穷人被联系,这被发现在这些病人的幸存。另外,我们也由指向蛞蝓探索了 miR-630 的生物功能并且调查了在 miR-630 表示和上皮间充质的转变(EMT ) 之间的关联在 vivo 并且在 vitro 的前进。,宫外的 miR-630 表示能禁止增长,侵略和转移 miR-630 击倒的导致的增长,侵略,转移和 EMT 特点。总的来说,我们的学习在 ESCC 作为一个批评新奇调节的人为 miR-630 支持一个角色。 | Li Jin Jun Yi Yanping Gao Siqi Han Zhenyue He Longbang Chen Haizhu Song | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 11 |
| 3 | Base editing-mediated splicing correction therapy for spinal muscular atrophy显示文摘Dear Editor,Spinal muscular atrophy(SMA)is a devastating autosomal recessive motor neuron disease.1,2 Infants with more severe forms of type I SMA die before the age of 2 if no intervention is provided.1,2 Spinraza and zolgensma have been approved by the FDA as SMA therapeutics for pediatric patients.1,2 However,as an antisense oligonucleotide(ASO)based therapy,spinraza requires four loading doses,followed by three annual maintenance doses.The patients would be subjected to repeated intrathecal injections in the procedure.Zolgensma is a single-dose gene-replacement therapy for SMA,but unfortunately is unreliable in maintaining a high,stable level of gene expression.These issues have limited the therapeutic effects of the two approved drugs for SMA. | Xiang Lin Haizhu Chen Ying-Qian Lu Shunyan Hong Xinde Hu Yanxia Gao Lu-Lu Lai Jin-Jing Li Zishuai Wang Wenqin Ying Lixiang Ma Ning Wang Erwei Zuo Hui Yang Wan-Jin Chen | 2020 | Cell Research2020，30，6： | 5 |
| 4 | Fraction Arithmetic Operations Performed by P Systems显示文摘 | GUO Ping ZHANG Hong CHEN Haizhu CHEN Jingxin | 2013 | Chinese Journal of Electronics2013，22，4： | 4 |
| 5 | Arithmetic Expression Evaluations with Membranes显示文摘Arithmetic operations and expression evaluations are fundamental in computing models. This paper firstly designs arithmetic membranes without priority rules for basic arithmetic operations, and then proposes an algorithm to construct expression P systems based on several of such membranes after designing synchronous and asynchronous transmission strategies among the membranes.For any arithmetic expression, an expression P system can be built to evaluate it effectively. Finally, we discuss different parallelism strategies through which different expression P systems can be built for an arithmetic expression. | GUO Ping CHEN Haizhu ZHENG Hui | 2014 | Chinese Journal of Electronics2014，23，1： | 3 |
| 6 | Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP显示文摘Objective:Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma(DLBCL)are available.This study aimed to comprehensively describe BCL2 genetic alterations in DLBCL patients,and examine correlation of BCL2,TP53 and other genetic alterations with outcomes in patients treated with R-CHOP.Methods:Probe capture-based high-resolution sequencing was performed on 191 patients diagnosed with de novo DLBCL.MYC,BCL2,and BCL6 protein expressions were detected by immunohistochemistry.Results:The presence of BCL2 alterations significantly correlated with poor progression-free survival(PFS)(5-year PFS:13.7%vs.40.8%;P=0.003)and overall survival(OS)(5-year OS:34.0%vs.70.9%;P=0.036).Importantly,patients who harbored BCL2 gain/amplifications(BCL2GA/AMP)also had a remarkably inferior 5-year PFS(11.1%vs.38.3%;P<0.001)and OS(22.1%vs.69.6%;P=0.009).In contrast,neither BCL2 mutations nor BCL2 translocations were significantly prognostic for survival.Multivariable analyses showed that the presence of BCL2 alterations,especially BCL2GA/AMP,TP53 mutations,and International Prognostic Index(IPI)were significantly associated with inferior PFS and OS.Novel prognostic models for OS were constructed based on 3 risk factors,including BCL2 alterations(Model 1)or BCL2GA/AMP(Model 2),TP53 mutations,and IPI,to stratify patients into 4 risk groups with different survival outcomes.Conclusions:This study showed that DLBCL patients treated with R-CHOP,BCL2 alterations,especially BCL2GA/AMP and TP53 mutations were significantly associated with inferior outcomes,which were independent of the IPI.The novel prognostic models we proposed predicted outcomes for DLBCL patients treated with R-CHOP,but further validation of the prognostic models is still warranted. | Yan Qin Haizhu Chen Peng Liu Changgong Zhang Jianliang Yang Lin Gui Xiaohui He Liqiang Zhou Shengyu Zhou Shiyu Jiang Hongxin Jiang Yuankai Shi | 2022 | Cancer Biology & Medicine2022，19，6： | 2 |
| 7 | Evaluating Logical Expressions by Membrane Systems显示文摘Boolean and relational operations, which are defined for solving mathematically logical problems,are always required in computing models. Membrane computing is a kind of distributed parallel computing model.In this paper, we design different membranes for implementing primary Boolean and relational operations respectively. And based on these membranes, a membrane system can be constructed by a present algorithm for evaluating a logical expression. Some examples are given to illustrate how to perform the Boolean, relational operations and evaluate the logical expression correctly in these membrane systems. | GUO Ping JI Jinfang CHEN Haizhu LIU Ran | 2014 | Chinese Journal of Electronics2014，23，2： | 1 |
| 8 | A Linear-Time Solution for All-SAT Problem Based on P System显示文摘P system is a new kind of distributed parallel computing model, and its many variants are used to solve NP problems. All-SAT problem is a well-known NPhard problem and it has been widely applied in the fields of pro ject selection problem, capital budgeting problem and so on. In this paper, we present a family of P systems to solve All-SAT problem in a linear time based on membrane division and give an instance to illustrate the feasibility and effectiveness of our designed P systems. | GUO Ping ZHU Jian CHEN Haizhu YANG Ruilong | 2018 | Chinese Journal of Electronics2018，27，2： | 1 |
| 9 | Solving All-SAT Problems by P Systems显示文摘The satisfiability problem(SAT) is a well known NP-complete problem. Obtaining All of the truth assignments of SAT is called All-SAT and it has numerous applications in artificial intelligence and computer theories. Many algorithms about SAT have been built, but how to solve All-SAT is still difficult. P system is a new distributed and parallel computation model. We use membrane division, which is frequently investigated to obtain an exponential working space in a linear time, to design a family of P systems to solve All-SAT in polynomial time.Our work provides a new and effective solution to All-SAT in a distributed and parallel manner. | GUO Ping JI Jinfang CHEN Haizhu LIU Ran | 2015 | Chinese Journal of Electronics2015，24，4： | 1 |
| 10 | Determination of acrylamide in foods by solid phase microextraction-gas chromatography显示文摘 | CHEN Lianbi LIU Haizhu YU Ping | 2009 | Food Science and Biotechnology2009，18，4： | 1 |
| 11 | 局部热疗联合腔内化疗对恶性胸腔积液的疗效观察(英文)显示文摘Objective: The aim of our study was to assess the efficacy of regional hyperthermia combined with intrapleural chemotherapy and to evaluate the effect on the immunologic cells and vascular endothelial growth factor (VEGF) in patients with malignant pleural effusion. Methods: The 102 patients with malignant pleural effusion were included in this study: 52 patients undergoing regional hyperthermia with intrapleural chemotherapy (HICT), and 50 patients treated with intrapleural chemotherapy (ICT). Chemotherapy was administered into the thoracic cavity weekly through a tube with CDDP (dose = 40 mg/m2), and hyperthermia was performed twice a week for 60 minutes following the ICT. We evaluated the response rates and side-effects after 4 weeks. Before and after the treatment, T cell subsets and NK cells were detected by flow cytometry and VEGF was measured with ELISA kits. Results: Compared HICT to ICT, the overall response rates of the whole group, breast cancers and lung cancers were 80.8% vs 54% (P < 0.01), 86.7% vs 56.3% (P > 0.05) and 78.4% vs 52.9% (P < 0.05) respectively. The ratios of CD4+, CD4+/CD8+ and NK cells increased and the concentration of VEGF decreased more significantly after HICT. Conclusion: We concluded that combined regional hyperthermia with intrapleural chemotherapy could control the malignant pleural effusion effectively with mild toxicity. The levels of the T cell subset, NK cells and VEGF in both blood and effusion changed obviously. | Haizhu Song Longbang Chen Jinghua Wang Qu Zhang Xiaoyuan Chu Huaicheng Geng Xiaoxiang Guan | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，6： | 0 |
| 12 | Detection and classification of breast lesions using multiple information on contrast-enhanced mammography by a multiprocess deep-learning system: A multicenter study显示文摘Objective: Accurate detection and classification of breast lesions in early stage is crucial to timely formulate effective treatments for patients. We aim to develop a fully automatic system to detect and classify breast lesions using multiple contrast-enhanced mammography(CEM) images.Methods: In this study, a total of 1,903 females who underwent CEM examination from three hospitals were enrolled as the training set, internal testing set, pooled external testing set and prospective testing set. Here we developed a CEM-based multiprocess detection and classification system(MDCS) to perform the task of detection and classification of breast lesions. In this system, we introduced an innovative auxiliary feature fusion(AFF)algorithm that could intelligently incorporates multiple types of information from CEM images. The average freeresponse receiver operating characteristic score(AFROC-Score) was presented to validate system’s detection performance, and the performance of classification was evaluated by area under the receiver operating characteristic curve(AUC). Furthermore, we assessed the diagnostic value of MDCS through visual analysis of disputed cases,comparing its performance and efficiency with that of radiologists and exploring whether it could augment radiologists’ performance.Results: On the pooled external and prospective testing sets, MDCS always maintained a high standalone performance, with AFROC-Scores of 0.953 and 0.963 for detection task, and AUCs for classification were 0.909[95% confidence interval(95% CI): 0.822-0.996] and 0.912(95% CI: 0.840-0.985), respectively. It also achieved higher sensitivity than all senior radiologists and higher specificity than all junior radiologists on pooled external and prospective testing sets. Moreover, MDCS performed superior diagnostic efficiency with an average reading time of 5 seconds, compared to the radiologists’ average reading time of 3.2 min. The average performance of all radiologists was also improved to varying degrees with MDCS assistance.Conclusions: MDCS demonstrated excellent performance in the detection and classification of breast lesions,and greatly enhanced the overall performance of radiologists. | Yuqian Chen Zhen Hua Fan Lin Tiantian Zheng Heng Zhou Shijie Zhang Jing Gao Zhongyi Wang Huafei Shao Wenjuan Li Fengjie Liu Simin Wang Yan Zhang Feng Zhao Hao Liu Haizhu Xie Heng Ma Haicheng Zhang Ning Mao | 2023 | Chinese Journal of Cancer Research2023，35，4： | 0 |
| 13 | Aqueous-processed insulating polymer/nanocrystal solar cells with effective suppression of the leakage current and carrier recombination显示文摘As one of the most environmentally friendly photovoltaic(PV)conversion equipments,aqueousprocessed CdTe nanocrystal solar cells(NC SCs)have attracted great interest in recent years because of their excellent properties such as high charge-carrier mobility and broad absorption.However,two issues including interfacial recombination and leakage current seriously restrict their performance.In this paper,insulating polymer poly(vinyl pyrrolidone)(PVP)is introduced into CdTe NC SCs to solve the problems.The experimental results of transmission electron microscopy(TEM),atomic force micro scopy(AFM)and dark current measurements,etc.,demonstrate the leakage current is effectively suppressed by introducing PVP.Through further designing device structure,the reduction of interfacial recombination after introducing PVP is confirmed.By strategically taking the advantages of PVP properties(e.g.,water solubility and thermostability),the power conversion efficiency of the devices with PVP is enhanced by almost 37%compared to pure CdTe devices.This work demonstrates an effective and low-cost method to fabricate NC SCs via aqueous route.Moreover,it also proves that appropriate content of insulating polymer is of beneficial in promoting the PV performance. | Henan Sun Nannan Chen Yaohua Wang Gan Jin Wei Yuan Haizhu Sun Bai Yang | 2020 | Chinese Chemical Letters2020，31，6： | 0 |
| 14 | 吉非替尼一线治疗细支气管肺泡癌致出血性膀胱炎(英文)显示文摘A 45-year-old man with bronchioloalveolar carcinoma was treated with gefitinib. The most severe side effect was hemorrhagic cystitis but he had a dramatic response. | Haizhu Song Longbang Chen | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，6： | 0 |
| 15 | Clinical characteristics and treatment outcomes of Chinese diffuse large B-cell lymphoma patients in the era of rituximab(2005–2018)显示文摘Background Rituximab combined with cyclophosphamide,doxorubicin hydrochloride,vincristine,and prednisone(R-CHOP)regimen has improved the survival of diffuse large B-cell lymphoma(DLBCL)patients worldwide,compared with CHOP alone.Several limitations were seen in previous studies of Chinese DLBCL patients treated with R-CHOP or R-CHOP-like regimens.This study aimed to investigate the clinical characteristics and treatment outcomes of Chinese DLBCL patients treated with the standard first-line treatment.Methods Clinical data were collected from DLBCL patients who received frontline R-CHOP or R-CHOP-like regimens at the Cancer Hospital Chinese Academy of Medical Sciences&Peking Union Medical College(CHCAMS)between January 1,2005,and December 31,2018.The treatment outcomes were compared with those of patients diagnosed with DLBCL between 2004 and 2017 and who received immunochemotherapy from the United States Surveillance,Epidemiology,and End Results(SEER)database.Survival rates were estimated using the Kaplan-Meier method and compared using the log-rank test.Multivariate analysis of progression-free survival(PFS)and overall survival(OS)was performed using Cox proportional hazard regression.Results Overall,1084 patients from the CHCAMS and 4013 patients from the SEER database were included in the study.As of April 30,2022,the median follow-up period for the CHCAMS group was 87.3(range:0.5-195.4)months.For the CHCAMS group,the 5-year PFS and OS rates were 61.7%(95%confidence interval[CI]:58.8-64.7%)and 70.6%(95%CI:67.8-73.4%),respectively.For the SEER group,the 5-year OS rate was 66.5%(95%CI:65.0-68.0%),which was inferior to that of the CHCAMS group(P<0.001).After adjusting for clinical factors and treatment,no significant difference was observed in the OS between the CHCAMS and SEER groups(P=0.867).In the CHCAMS group,multivariate analysis showed that an Eastern Cooperative Oncology Group performance status score≥2,presence of B symptoms,Ann Arbor stage III-IV,elevated serumβ2-microglobulin levels,and bulky mass were independent adverse prognostic factors affecting PFS and OS(P<0.05).Additionally,patients aged over 60 years,elevated lactate dehydrogenase levels,and more than two extranodal sites were independent adverse prognostic factors for OS(P<0.05).Local radiotherapy was significantly associated with better PFS(P<0.001)and OS(P=0.001).Conclusion After adjusting for clinical and treatment-related factors,no significant difference was observed in the 5-year OS rate between Chinese DLBCL patients treated with standard first-line treatment and those from the SEER database. | Yuankai Shi Haizhu Chen Yan Qin Jianliang Yang Peng Liu Xiaohui He Shengyu Zhou Liqiang Zhou Changgong Zhang Yongwen Song Yueping Liu Lin Gui Shulian Wang Jing Jin Hui Fang Shunan Qi Ning Li Yu Tang Xin Wang Sheng Yang | 2023 | Cancer Pathogenesis and Therapy2023，1，1： | 0 |
| 16 | A Practical Quantum Network Coding Protocol Based on Non-Maximally Entangled State显示文摘In many earlier works,perfect quantum state transmission over the butterfly network can be achieved via quantum network coding protocols with the assist of maximally entangled states.However,in actual quantum networks,a maximally entangled state as auxiliary resource is hard to be obtained or easily turned into a non-maximally entangled state subject to all kinds of environmental noises.Therefore,we propose a more practical quantum network coding scheme with the assist of non-maximally entangled states.In this paper,a practical quantum network coding protocol over grail network is proposed,in which the non-maximally entangled resource is assisted and even the desired quantum state can be perfectly transmitted.The achievable rate region,security and practicability of the proposed protocol are discussed and analyzed.This practical quantum network coding protocol proposed over the grail network can be regarded as a useful attempt to help move the theory of quantum network coding towards practicability. | Zhen-Zhen Li Zi-Chen Li Xiu-Bo Chen Zhiguo Qu Xiaojun Wang Haizhu Pan | 2021 | Computers, Materials & Continua2021，，8： | 0 |
| 17 | A lysosomal polarity-specific two-photon fluorescent probe for visualization of autophagy显示文摘Autophagy plays a vital role in maintaining the balance of normal physiological state of living cells.In this paper,a polarity-specific two-phot on fluorescent probe Lyso-NA based on naphthalimide was synthesized for the purpose of monitoring autophagy during biological research.The results of photophysical properties and theoretical calculation con firmed that different polarities of solvents mainly effected fluorescent intensities of probe.Fluoresce nt intensity,quantum yield and fluorescence lifetime of probe kept a good linear relationship with polarity respectively.In addition,due to its low toxicity and selective accumulation in lysosomes,Lyso-NA is suitable for detecting changes in lysosomal polarity of living cells.Compare with the imaging results of plasmid transfection,a better performed realtime long-term fluoresce nt visualization of autophagy in living cells was achieved.Probe Lyso-NA can work as an efficient and cost effective imaging tool for visualizing autophagy in living cells. | Zixiang Yuan Jun Chen Qin Zhou Ao Liu Zeming Qiang Min Fang Man Chen Yan Feng Haizhu Yu Xiuli Yang Xiangming Meng | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
| 18 | Nicotinamide adenine dinucleotide(NAD^(+))reduction enabled by an atomically precise Au-Ag alloy nanocluster显示文摘The redox property of the ultrasmall coinage nanoclusters(with several to tens of Au/Ag atoms)has elucidated the electrontransfer capacity of nanoclusters,has been successfully utilized in a variety of redox conversions(such as from CO_(2)to CO).Nevertheless,their biological applications are mainly restricted by the scarcity of atomically precise,water-soluble metal nanoclusters,the limited application(mainly on the decomposition of H_(2)O_(2)in these days).Herein,mercaptosuccinic acid(MSA)protected ultrasmall alloy AuAg nanoclusters were prepared,the main product was determined[Au_(3)Ag_(5)(MSA)_(3)]−by electrospray ionization mass spectrometry(ESI-MS).The clusters can not only mediate the decomposition of H_(2)O_(2)to generate hydroxyl radicals,but is also able to mediate the reduction of nicotinamide adenine dinucleotide(NAD)to its reduced form of NADH.This is the first time that the atomically precise metal nanoclusters were used to mediate the coenzyme reduction.The preliminary mechanistic insights imply the reaction to be driven by the hydrogen bonding between the carboxylic groups(on the surface of MSA)and the amino N–H bonds(on NAD).In this context,the presence of the carboxylic groups,the sub-nanometer size regime(~1 nm),the synergistic effect of the Au-Ag clusters are pre-requisite to the NAD reduction. | Ling Chen Yonglei Du Ying Lv Daoqing Fan Junfei Wu Lingbao Wu Mengting Cui Haizhu Yu Manzhou Zhu | 2023 | Nano Research2023，16，5： | 0 |
| 19 | A Family of P Systems for Solving Linear Equations显示文摘Solving linear equations is one of the fundamental problems in numerical calculation and has a wide application in many science and engineering fields. We present a family of P systems to solve linear equations in which the coefficients are real numbers. An instance is given to illustrate the feasibility and effectiveness of our designed P systems. Our work contributes to make P systems to solve more complicated computation problems effectively. | GUO Ping WEI Lijiao CHEN Haizhu LIU Ran | 2017 | Chinese Journal of Electronics2017，26，4： | 0 |
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