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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs显示文摘CRISPR/Cas9 系统是一个有效编辑基因的方法,但是编辑基因的动物的多数显示出 mosaicism,与编辑仅仅在房间的部分发生。这里,我们证明那单个基因或多重基因能被 Cas9 mRNA 和多重邻近的单个指南的 RNA 的 zygotic 注射完全在老鼠和猴子胚胎击倒(spaced 10-200 bp 分开) 指向仅仅一把单个钥匙每基因的 exon。个别地在 Y 染色体上跟随八基因的指向的删除的 F0 老鼠的 Phenotypic 分析在产生猛烈老鼠表明了这条途径的坚韧性。重要地,这条途径在高效率交付完全的基因大美人(Arntl 上的 100% 并且 91% 在 Prrt2 上) 在猴子胚胎。最后,我们能在一个单个步骤产生一只完全的 Prrt2 猛烈猴子,表明在很快建立编辑基因的猴子模型的这条途径的实用性。 | Erwei Zuo Yi-Jun Cai Kui Li Yu Wei Bang-An Wang Yidi Sun Zhen Liu Jiwei Liu Xinde Hu Wei Wei Xiaona Huo Linyu Shi Cheng Tang Dan Liang Yan Wang Yan-Hong Nie Chen-Chen Zhang Xuan Yao Xing Wang Changyang Zhou Wenqin Ying Qifang Wang Ren-Chao Chen Qi Shen Guo-Liang Xu Jinsong Li Qiang Sun Zhi-Qi Xiong Hui Yang | 2017 | Cell Research2017，27，7： | 21 |
| 3 | Immunomodulatory effects of polysaccharides from edible fungus:a review显示文摘The polysaccharides from edible fungus showed many kinds of biological activities,including anti-tumor,immunomodulatory,anti-inflammatory,anti-diabetes,improving functional constipation activities.In particular,the immunomodulatory effects have been paid more and more attention by scholars,but there was no systematic introduction of their immunomodulatory mechanism.So,this review introduced the immunomodulatory effects and mechanism of edible fungus polysaccharides in recent years,and then the relationships between structure and immunomodulatory effect were also discussed. | Zhenghua Yin Zhenhua Liang Changqin Li Jinmei Wang Changyang Ma Wenyi Kang | 2021 | Food Science and Human Wellness2021，10，4： | 12 |
| 4 | Highly efficient base editing in human tripronuclear zygotes显示文摘 | Changyang Zhou Meiling Zhang Yu Wei Yidi Sun Yun Sun Hong Pan Ning Yao Wanxia Zhong Yixue Li Weiping Li3 Hui Yang Zi-jiang Chen | 2017 | Protein & Cell2017，8，10： | 6 |
| 5 | Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method显示文摘This study was designed to elucidate the immunoregulation of Ganoderma lucidum.HPLC fingerprint and spectrum-effect relationship of G.lucidum were established to predict the active compounds and BP neural network model was established to predict the efficacy.Then the target compounds were identified by high resolution mass spectrometry.The results indicated that there are both enhanced immunity and immunosuppressive components in G.lucidum.BP neural network was trained with the common peak area and immune effi cacy index of G.lucidum fi ngerprint as samples,and a combined evaluation system of G.lucidum fi ngerprint effi cacy was established.The correlation coeffi cient R of BP network model was 0.98643,and the error of pharmacodynamic prediction results was in the ideal range.Eight compounds were identifi ed by high resolution mass spectrometry.The compounds related to immune activity in G.lucidum were determined in this study. | Changqin Li Yiping Cui Jie Lu Lijun Meng Changyang Ma Zhenhua Liu Yan Zhang Wenyi Kang | 2021 | Food Science and Human Wellness2021，10，3： | 6 |
| 6 | Nanomaterials for radiotherapeutics-based multimodal synergistic cancer therapy显示文摘Over the past decade,numerous studies have attempted to enhance the effectiveness of radiotherapy(external beam radiotherapy and internal radioisotope therapy)for cancer treatment.However,the low radiation absorption coefficient and radiation resistance of tumors remain major critical challenges for radiotherapy in the clinic.With the development of nanomedicine,nanomaterials in combination with radiotherapy offer the possibility to improve the efficiency of radiotherapy in tumors.Nanomaterials act not only as radiosensitizers to enhance radiation energy,but also as nanocarriers to deliver therapeutic units in combating radiation resistance.In this review,we discuss opportunities for a synergistic cancer therapy by combining radiotherapy based on nanomaterials designed for chemotherapy,photodynamic therapy,photothermal therapy,gas therapy,genetic therapy,and immunotherapy.We highlight how nanomaterials can be utilized to amplify antitumor radiation responses and describe cooperative enhancement interactions among these synergistic therapies.Moreover,the potential challenges and future prospects of radio-based nanomedicine to maximize their synergistic efficiency for cancer treatment are identified. | Xi Yang Ling Gao Qing Guo Yongjiang Li Yue Ma Ju Yang Changyang Gong Cheng Yi | 2020 | Nano Research2020，13，10： | 3 |
| 7 | Recent advances in chemical durability and mechanical stability of superhydrophobic materials: Multi-strategy design and strengthening显示文摘Inspired by the lotus leaf effect, non-wetting artificial superhydrophobic surfaces demonstrate an enormous potential in numerous fields. However, limited by poor stability and durability, superhydrophobic surfaces are rarely available for practical applications. In this review, based on the wettability mechanisms and failure modes of superhydrophobic surfaces, it is proposed that the construction of highly stable superhydrophobic materials can be approached from four aspects, including structural design, chemical bonding, interfacial-strengthening of hydrophobic materials and substrates, and self-healing. We introduced in detail the design ideas, strengthening approaches, and characterization tools of highly stable superhydrophobic materials from the perspective of multi-strategy design and strengthening, and provided corresponding insights. Eventually, the development, current status, and prospects of highly stable and multifunctional superhydrophobic materials were also presented in detail. Recent advances and development prospects of durable superhydrophobic materials were summarized and discussed in this review,providing certain insights and design guidelines for the fabrication of stable superhydrophobic materials. | Peng Wang Changyang Li Dun Zhang | 2022 | Journal of Materials Science & Technology2022，，34： | 3 |
| 8 | Effects of edpetiline from Fritillaria on inflammation and oxidative stress induced by LPS stimulation in RAW264.7 macrophages显示文摘The dry bulbs of Fritillaria cirrhosa species can help resolve phlegm,soothe cough,clear heat,and moisten the lung,and the main active components responsible for these effect are its alkaloids.However,it is unclear whether or how edpetiline in Fritillaria can inhibit the excessive inflammatory response and oxidative stress.In this research,we aimed to examine this aspect using lipopolysaccharide(LPS)-stimulated RAW264.7 macrophages as an inflammatory model.The quantitative real-time polymerase chain reaction and western blot analysis results showed that edpetiline significantly inhibited the content and mRNA expression levels of proinflammatory cytokines(TNF-αand IL-6)in LPS-induced RAW264.7 cells,significantly increased the mRNA expression of IL-4(anti-inflammatory cytokine),and markedly downregulated the inflammatory mediators inductible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)mRNA and protein expression levels.The oxidative stress induced by LPS was also inhibited by edpetiline,as the level of intracellular reactive oxygen species decreased notably.Edpetiline may exert anti-inflammatory and antioxidant effects through inhibiting the phosphorylation of IκB and the nuclear transcription of nuclear transcription factor-κB p65 and decreasing the phosphorylation of p38 and ERK in the mitogen-activated protein kinase signaling pathway,without activating the JNK/mitogen-activated protein kinase signaling pathway.These findings suggest that edpetiline may be a potential therapeutic agent for the prevention or treatment of inflammation-and oxidative stress-related pathophysiological processes and diseases. | Hongli Zhang Xiaoqing Xu Zhenhua Liu Dongxiao Sun-Waterhouse Jinmei Wang Changyang Ma Geoffrey I.N.Waterhouse Wenyi Kang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，2： | 2 |
| 9 | A Retrospective Study of Treatment Efficacy of 65 Children with Ametroic Amblyopia显示文摘Purpose: To investigate relationship between treatment efficacy and the severity of ametropic amblyopia, the type of anisometropia and patient age. Methods:A total of 65 children with ametropic amblyopia undergoing clinical treatment in the ophthalmology department of Shaoguan Hygienic Hospital of Women and Children between June 2005 and November 2011 were enrolled in this study. The treatment efficacy for those subjects with different severities of ametropic amblyopia, types of anisometropia and ages was recorded. Results: The near-recovery/recovery rate, improvement rate and ineffectiveness rate were 70.8%, 16.9% and 12.3%, respectively. The recovery rates in mild-, moderate- and severe amblyopia groups were 97.1%, 61.1% and 8.3% respectively (P<0.05)..The recovery rate for patients with hyperopic-, astigmatic- and myopic anisometropia were 75.8%, 78.3% and 33.3% respectively. The recovery rates did not differ between hyperopic- and astigmatic- anisometropia children(P>0.05), whereas a statistically significant difference was noted between myopic children compared with their hyperopic and myopic-anisometropia counterparts (all P<0.05). The recovery rate for patients aged 3 to 6 years was 86.8% and 48.1% for those aged between 7 and 10 years (P<0.05). Conclusion: The treatment efficacy in ametropic amblyopia is associated with the severity of amblyopia, type of anisometropia and patient's age. Older patients with more severe amblyopia had poorer treatment efficacy. The efficacy in patients with hyperopic and astigmatic anisometropia was better than that for myopic anisometropia subjects. | Yuxiang Zhang Lihua Huang Changyang Cao Yingfang Li | 2012 | Eye Science2012，27，2： | 2 |
| 10 | Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos显示文摘Dear Editor,Newly discovered characteristics like'collateral effect'or trans-cleavage in CRISPR-Cas13 and CRISPR-Cas12 systems have enabled their usage in nucleic acid detection(Gootenberg et al.2017,2018;Chen et al.2018).The collateral RNA cleavage of Cas13a has been reported to be harmful for cell development(Wang et al.2019;Buchman et al.2020).As a representative gene editor of CRISPR-Cas12 system,CRISPR-Cas12a(Cpf1)holds great potential for therapeutic applications in the future(Zetsche et al.2015;Koo et al.2018;Campa et al.2019). | Yu Wei Yingsi Zhou Yajing Liu Wenqin Ying Ruiming Lv Qimeng Zhao Haibo Zhou Erwei Zuo Yidi Sun Hui Yang Changyang Zhou | 2021 | Protein & Cell2021，12，9： | 2 |
| 11 | CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration显示文摘RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro.In this perspective,we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macular degeneration. | Changyang Zhou Xinde Hu Cheng Tang Wenjia Liu Shaoran Wang Yingsi Zhou Qimeng Zhao Qiyu Bo Linyu Shi Xiaodong Sun Haibo Zhou Hui Yang | 2020 | National Science Review2020，7，5： | 2 |
| 12 | Frenquency-Hopping CDMA with Reed-Solomon Code Sequences in Wireless Communications 显示文摘 | Mao Fulin Guu Changyang Cheng Yuanchang | 2007 | IEEE Transactions on Communications2007，55，11： | 1 |
| 13 | Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel显示文摘 | ChangYang Gong Shuai Shi PengWei Dong Bing Kan MaLing Gou XianHuo Wang XingYi Li Feng Luo Xia Zhao YuQuan Wei ZhiYong Qian | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 14 | Self-assembled honokiol-loaded micelles based on poly(?-caprolactone)-poly(ethylene glycol)-poly(?-caprolactone) copolymer显示文摘 | XiaWei Wei ChangYang Gong Shuai Shi ShaoZhi Fu Ke Men Shi Zeng XiuLing Zheng MaLing Gou LiJuan Chen LiYan Qiu ZhiYong Qian | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 15 | A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel显示文摘 | MaLing Gou XingYi Li Mei Dai ChangYang Gong XianHuo Wang Yao Xie HongXin Deng LiJuan Chen Xia Zhao ZhiYong Qian YuQuan Wei | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 16 | Biodegradable poly ( epsilon- caprolactone) - poly ( ethylene glycol ) eopoly- mers as drug deliverysystem 显示文摘 | XiaWei Wei ChangYang Gong MaLing Gou | 2009 | International Journal of Phar- maceutics2009，381，1： | 1 |
| 17 | Structural Topology and Dynamic Response Analysis of an Electric Torque Vectoring Drive-Axle for Electric Vehicles显示文摘In-wheel motor-drive electric vehicles have the advantage of independently controllable wheel torque and the disadvantages of unsprung mass rise and power restriction.To address the disadvantages,a centralized layout electric torque vectoring drive-axle system(E-TVDS)with dual motors is proposed,which can realize arbitrary distribution of driving torque between the left and right wheels.First,the speed and torque distribution principle of E-TVDS based on velocity diagram are analyzed,and a virtual prototype of the whole vehicle with basic gear ratio relation model of the E-TVDS is built for simulation to verify the theoretical results and the basic effect of E-TVDS on the steering performance of the vehicle.Second,the charac-teristics of 36 types of the novel E-TVDS topology structure are compared and analyzed,and the optimal structure scheme is selected.Third,the accurate multiple degrees of freedom dynamic model for the optimal structure is established by using the bond graph method,and its dynamic response characteristics are analyzed.The results show that the vehicle equipped with the proposed E-TVDS can distribute the driving torque with the almost identical amount but opposite sign between the left and right wheels in any direction,and varying amount according to different chassis dynamics control requirements,and the torque response performance is great with little delay and overshoot.The function and dynamic response of the proposed E-TVDS show that it has potential application value for various performance improvements of electric vehicles. | Junnian Wang Shoulin Gao Yue Qiang Meng Xu Changyang Guan Zidong Zhou | 2022 | Automotive Innovation2022，5，2： | 1 |
| 18 | Biodegradable poly (e-caprolaction)-poly (ethylene glycol ) copolymers as drug delivery system 显示文摘 | Wei Xiawei Gong Changyang Gou Maling | 2009 | International Journal of Pharmaceutics2009，38，： | 1 |
| 19 | In Vitro Degradation Behavior of Polyesteramide Copolymer Fiber Based on 6-Aminocaproic Acid, Adipic Acid, and 1,6-Hexane Diol显示文摘 | CaiBing Liu WenJuan Jia ZhiYong Qian MeiJuan Huang YingChun Gu GuoTao Chao MaLing Gou ChangYang Gong HongXin Deng Ke Lei AnLiang Huang MingJing Tu | 2007 | Journal of Polymer Research2007，，1： | 1 |
| 20 | Immunoregulatory polysaccharides from Apocynum venetum L.flowers stimulate phagocytosis and cytokine expression via activating the NF-κB/MAPK signaling pathways in RAW264.7 cells显示文摘Two immunomodulatory polysaccharides(Vp2a-Ⅱ and Vp3) were isolated and identified from Apocynum venetum L. flowers, and their innate immune-stimulating functions and working mechanisms were evaluated in RAW264.7 cells. Both the level of released nitric oxide(NO) and expression of inducible nitric oxide synthase(iNOS) m RNA were significantly enhanced in the RAW264.7 macrophages cells treated by Vp2a-Ⅱ and Vp3. Vp2a-Ⅱ(100–800 μg/m L) and Vp3(400 μg/mL) could significantly increase the phagocytic activity of RAW264.7 cells and the secretion and m RNA expression of TNF-α and IL-6 in a concentrationdependent manner through affecting mitogen-activated protein kinase(MAPK) activity and nuclear factor κB(NF-κB) nuclear translocation. Vp2a-Ⅱ might activate the MAPK signaling pathways and induce the nuclear translocation of NF-κB p65, whilst Vp3 likely activated the NF-κB and MAPK signaling pathways without influencing the p38 MAPK route. | Honglin Wang Changyang Ma Dongxiao Sun-Waterhouse Jinmei Wang Geoffrey Ivan Neil Waterhouse Wenyi Kang | 2022 | Food Science and Human Wellness2022，11，4： | 1 |
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