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| 1 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 2 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 3 | Effects of metal lead on growth and mycorrhizae of an invasive plant species (Solidago canadensis L.)显示文摘It is less known whether and how soil metal lead (Pb) impacts the invasion of exotic plants. A greenhouse experiment was conducted to estimate the effects of lead on the growth and mycorrhizae of an invasive species (Solidago canadensis L.) in a microcosm system. Each microcosm unit was separated into HOST and TEST compartments by a replaceable mesh screen that allowed arbuscular mycorrhizal (AM) fungal hyphae rather than plant roots to grow into the TEST compartments. Three Pb levels (control, 300, and 600 mg/kg soil) were used in this study to simulate ambient soil and two pollution sites where S. canadensis grows. Mycorrhizal inoculum comprised five indigenous arbuscular mycorrhizal fungal species (Glomus mosseae, Glomus versiform, Glomus diaphanum, Glomus geosporum, and Glomus etunicatum). The 15N isotope tracer was used to quantify the mycorrhizally mediated nitrogen acquisition of plants. The results showed that S. canadensis was highly dependent on mycorrhizae. The Pb additions significantly decreased biomass and arbuscular mycorrhizal colonization (root length colonized, RLC%) but did not affect spore numbers, N (including total N and 15N) and P uptake. The facilitating efficiency of mycorrhizae on nutrient acquisition was promoted by Pb treatments. The Pb was mostly sequestered in belowground of plant (root and rhizome). The results suggest that the high efficiency of mycorrhizae on nutrient uptake might give S. canadensis a great advantage over native species in Pb polluted soils. | YANG Ruyi YU Guodong TANG Jianjun CHEN Xin | 2008 | Journal of Environmental Sciences2008，20，6： | 12 |
| 4 | Evaluating efficacy of screening for upper gastrointestinal cancer in China:a study protocol for a randomized controlled trial显示文摘Objective: To evaluate the efficacy and feasibility of screening procedure for upper gastrointestinal cancer in both high-risk and non-high-risk areas in China.Setting: Seven cities/counties, representing three economical-geographical regions(Eastern, Central and Western) in China, were selected as screening centers: three in high-risk areas and four in non-high-risk areas.Participants: Villages/communities in these seven centers regarded as clusters were randomly assigned to either intervention group(screening by endoscopic examination) or control group(with normal community care) in a 1:1ratio stratified by each center. Eligible participants are local residents aged 40–69 years in the selected villages/communities with no history of cancer or endoscopic examination in the latest 3 years who are mentally and physically competent. Those who are not willing to take endoscopic examination or are unwilling to sign the consent form are excluded from the study. Totally 140,000 participants will be enrolled.Interventions: In high-risk areas of upper gastrointestinal cancer, all subjects in screening group will be screened by endoscopy. In non-high-risk areas, 30% of the subjects in screening group, identified through a survey,will be screened by endoscopy.Primary and secondary outcome measures: The primary outcome is the mortality caused by upper gastrointestinal cancer. The secondary outcomes include detection rate, incidence rate, survival rate, and clinical stage distribution. Additional data on quality of life and cost-effectiveness will also be collected to answer important questions regarding screening effects.Conclusions: Screening strategy evaluated in those areas with positive findings may be promoted nationally and applied to the majority of Chinese people. On the other hand, negative findings will provide scientific evidence for abandoning a test and shifting resources elsewhere.Trial registration: The study has been registered with the Protocol Registration System in Chinese Clinical Trial Registry. | wanqing chen hongmei zeng ru chen ruyi xia zhixun yang changfa xia rongshou zheng wenqiang wei guihua zhuang xueqin yu jie he | 2017 | Chinese Journal of Cancer Research2017，29，4： | 11 |
| 5 | Passively mode-locked Er-doped fiber laser based on SnS2 nanosheets as a saturable absorber显示文摘In this paper, tin disulfide(SnS_2), a two-dimensional(2D) n-type direct bandgap layered metal dichalcogenide with a gap value of 2.24 eV, was employed as a saturable absorber. Its appearance and nonlinear saturable absorption characteristics were also investigated experimentally. SnS_2-PVA(polyvinyl alcohol) film was successfully prepared and employed as a mode-locker for achieving a mode-locked Er-doped fiber laser with a pulse width of 623 fs at a pulse repetition rate of 29.33 MHz. The results prove that SnS_2 nanosheets will have wide potential ultrafast photonic applications due to their suitable bandgap value and excellent nonlinear saturable absorption characteristics. | KANGDI NIU RuYI SUN QINGYUN CHEN BAOYUAN MAN AND HUANIAN ZHANG | 2018 | Photonics Research2018，6，2： | 7 |
| 6 | Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)显示文摘Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell biology.As mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ago.However,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these cells.In this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT sites.We show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP recombinase.The imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker Synaptopodin.The imPOD cells do not form tumor-like masses in vivo.We further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and Col1a1.Collectively,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions. | Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan | 2018 | Genes & Diseases2018，5，2： | 5 |
| 7 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 8 | Dynamic Distribution Adaptation Based Transfer Network for Cross Domain Bearing Fault Diagnosis显示文摘In machinery fault diagnosis,labeled data are always difficult or even impossible to obtain.Transfer learning can leverage related fault diagnosis knowledge from fully labeled source domain to enhance the fault diagnosis performance in sparsely labeled or unlabeled target domain,which has been widely used for cross domain fault diagnosis.However,existing methods focus on either marginal distribution adaptation(MDA)or conditional distribution adaptation(CDA).In practice,marginal and conditional distributions discrepancies both have significant but different influences on the domain divergence.In this paper,a dynamic distribution adaptation based transfer network(DDATN)is proposed for cross domain bearing fault diagnosis.DDATN utilizes the proposed instance-weighted dynamic maximum mean discrepancy(IDMMD)for dynamic distribution adaptation(DDA),which can dynamically estimate the influences of marginal and conditional distribution and adapt target domain with source domain.The experimental evaluation on cross domain bearing fault diagnosis demonstrates that DDATN can outperformance the state-of-the-art cross domain fault diagnosis methods. | Yixiao Liao Ruyi Huang Jipu Li Zhuyun Chen Weihua Li | 2021 | Chinese Journal of Mechanical Engineering2021，34，3： | 4 |
| 9 | Beneficial use of stainless steel EAF slag as composite cement admixture and its heavy metals leaching risk analysis显示文摘This study analyzes the feasibility of using stainless steel electric arc furnace(EAF)slag as composite cement admixture and the risk of leaching-out of heavy metals.The results show that the stainless steel EAF slag,mainly made up of Ca2SiO4,Ca3Mg(SiO4)2,some Cr-containing minerals and in small particle size,is easily ground and has cementitious activity.EAF slag,when used as cement admixture,can be added with a maximum percentage of 32%.It can meet the strength requirements of the standard P·C 32.5 cement.When the mixing percentage is decreased to 25%,the strength of the cement can be increased to that of P·C 42.5 cement.Other main quality indexes of composite cement,such as the setting time and stability,also satisfy standard requirements.The results also show that most of the heavy metals in the stainless steel EAF slag exist in a stable speciation.The concentration of heavy metals that leach out from the stainless steel EAF slag and the composite cement products is far lower than the standard limit of hazardous wastes.The main heavy metal,chromium,exists as less hazardous trivalent chromium.Therefore,the risk of heavy metals leaching out from the stainless steel EAF slag is low.The internal exposure index(IRa)and the external exposure index(Iγ)of the stainless steel EAF slag are both lower than 1.0,satisfying the standard requirements of the state for the radionuclides of building materials.Therefore,stainless steel EAF slag can be safely used as admixture to produce composite cement. | WANG Ruyi CHEN Ronghuan SHI Lei | 2009 | Baosteel Technical Research2009，3，4： | 3 |
| 10 | Plant species coexistence alleviates the impacts of lead on Zea mays L.显示文摘Whether plant coexistence can reduce the impacts of lead (Pb) on crops in agroecosystems has not been well understood. We conducted a factorial experiment to investigate the effects of weeds coexisting with maize (Zea mays L.) on Pb accumulation in maize and soil microbes at two Pb levels (ambient and 300 mg/kg). Elevated Pb tended to increase the Pb concentration in maize and decreased soil microbial activity (indicated by the average well color development, AWCD), functional group diversity, as well as arbuscular mycorrhizal (AM) colonization and vesicle number of maize. Compared to the monoculture, weeds coexisting with maize reduced the Pb concentrations in the root, leaf, sheath and stem of maize at both seedling and mature stages. In maize-weed mixtures, soil microbial activity and functional group diversity tended to increase for both Pb treatments relative to the monoculture. Furthermore, principal component analysis revealed that the soil microbial community structure changed with the introduction of weeds. The highest Pb accumulation in weeds occurred for the elevated Pb treatment in a three species mixture. The results suggest that multiple plant species coexistence could reduce lead accumulation in crop plants and alleviate the negative impacts on soil microbes in polluted land, thereby highlighting the significance of plant diversity in agroecosystems. | Ruyi Yang Ling Liu Shuting Zan Jianjun Tang Xin Chen | 2012 | Journal of Environmental Sciences2012，24，3： | 2 |
| 11 | A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state显示文摘Dopamine(DA)level in the nucleus accumbens(NAc)is critical for reward and aversion encoding.DA released from the ventral mesencephalon(VM)DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons(D1-MSNs)in the NAc to enhance DA release and augment rewards.However,how such a DA positive feedback loop is regulated to maintain DA homeostasis and reward-aversion balance remains elusive.Here we report that the ventral pallidum(VP)projection of NAc D1-MSNs(D1^(NAc-VP))is inhibited by rewarding stimuli and activated by aversive stimuli.In contrast to the VM projection of D1-MSN(D1^(NAc-VM)),activation of D1^(NAc-VP) projection induces aversion,but not reward.D1^(NAc-VP) MSNs are distinct from the D1^(NAc-VM) MSNs,which exhibit conventional functions of D1-MSNs.Activation of D1^(NAc-VP) projection stimulates VM GABAergic transmission,inhibits VM DAergic neurons,and reduces DA release into the NAc.Thus,D1^(NAc-VP) and D1^(NAc-VM) MSNs cooperatively control NAc dopamine balance and reward-aversion states. | Zhiyuan Liu Qiumin Le Yanbo Lv Xi Chen Jian Cui Yiming Zhou Deqin Cheng Chaonan Ma Xiujuan Su Lei Xiao Ruyi Yang Jiayi Zhang Lan Ma Xing Liu | 2022 | Cell Research2022，32，2： | 2 |
| 12 | Research on the use of sintering flue gas desulphurization gypsum as a cement retarder显示文摘The characteristics of the desulphurized gypsum produced in the flue gas desulphurization(FGD)process of the Baosteel sintering plant are investigated in this study.According to the technical and quality requirements of gypsum in the cement industry,the feasibility of using desulphurized gypsum as a cement retarder is also studied.The results show that desulphurized gypsum can be used as a cement retarder instead of natural gypsum. | CHEN Ronghuan WANG Ruyi SHI Lei | 2010 | Baosteel Technical Research2010，4，2： | 2 |
| 13 | Two-stage treatment process of pickling wastewater in the cold-rolling production of stainless steel显示文摘Based on the characteristics of pickling wastewater in the cold-rolling production of stainless steel,a new processing route,featuring source sludge reduction,wastewater two-stage treatment,heavy metal-contained sludge and calcium salt sludge separating recovery,was proposed.As shown by the research results,after the two-stage process treatment,the effluent water can steadily reach the emission standards,the sludge yield can be decreased by more than 8%;within the heavy metal-contained sludge,the recovery rates of Fe,Cr and Ni can either reach or surpass 95%,and the total content of F and S can drop to around 3%.Therefore,the sludge in the front part can be used as ferric dust.In the calcium salt sludge,the recovery rate of F can either reach or surpass 85%,and the total contents of Fe,Cr and Ni can fall below 0.5%.So the sludge in the rear part can be used as fluorgypsum or fluorite.Meanwhile,the results of the analysis on heavy metals leaching toxicity and morphologic distribution indicate that the two kinds of sectionalized sludge are not classified as hazardous wastes,which have a stable behavior and better utilization values compared with the former mixed-sludge. | SHI Lei CHEN Ronghuan WANG Ruyi | 2010 | Baosteel Technical Research2010，4，2： | 2 |
| 14 | Changes in peripheral perfusion index within 72h of life in a cohort of very low birth weight infants显示文摘To the Editor:The latest generation of pulse oximeters are equipped with technology allowing for monitoring of the peripheral perfusion index(PI),the percentage of the amount of light absorbed by pulsatile tissue(variable arterial blood flow)over non-pulsatile tissue(venous blood,muscle,and other tissues)at a wavelength of 940 nm as a signal. | Xiaojing Hu Conway Niu Ruyi Zheng Li Zhang Hongyan Chen Yun Cao Guoying Huang | 2022 | Chinese Medical Journal2022，，10： | 2 |
| 15 | Effect of microarc discharge surface treatment on the tensile properties of Al–Cu–Mg alloy显示文摘 | Wenbin Xue Chao Wang Yongliang Li Zhiwei Deng Ruyi Chen Tonghe Zhang | 2002 | Materials Letters2002，，5： | 2 |
| 16 | Microstructure and properties of ceramic coatings produced on 2024 aluminum alloy by microarc oxidation显示文摘 | Xue Wenbin Deng Zhiwei Chen Ruyi | 2001 | J Mater Sci2001，36，11： | 1 |
| 17 | Structure and properties characterization of ceramic coatings produced on Ti-6A1-4V alloy by microarc oxidation in aluminate solution 显示文摘 | Xue Wenbin Wang Chao Chen Ruyi | 2002 | Mater Lett2002，52，： | 1 |
| 18 | 显示文摘 | Xue Wenbin Dong Zhiwei Chen Ruyi | 2001 | Journal of Materials Science2001，36，： | 1 |
| 19 | Effects of coexisting plant species on soil microbial properties and soil enzymes in metal lead contaminated soils 显示文摘 | Yang Ruyi Tang Jianjun Chen Xin | 2007 | Applied Soil Ecology2007，37，： | 1 |
| 20 | 显示文摘 | Xue Wenbin Wang Chao Chen Ruyi | 2002 | Materials Letters2002，52，： | 1 |
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