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| 1 | Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound显示文摘Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged inflammation.Electrospun nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled manner.Herein,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive agents.Physicochemical characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant activities.Furthermore,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue formation.The angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin��6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW. | Atta ur Rehman Khan Kai Huang Mina Shahriari Khalaji Fan Yu Xianrui Xie Tonghe Zhu Yosry Morsi Zhao Jinzhong Xiumei Mo | 2021 | Bioactive Materials2021，6，9： | 3 |
| 2 | Crimped nanofiber scaffold mimicking tendon-to-bone interface for fatty-infiltrated massive rotator cuff repair显示文摘Electrospun fibers,with proven ability to promote tissue regeneration,are widely being explored for rotator cuff repairing.However,without post treatment,the microstructure of the electrospun scaffold is vastly different from that of natural extracellular matrix(ECM).Moreover,during mechanical loading,the nanofibers slip that hampers the proliferation and differentiation of migrating stem cells.Here,electrospun nanofiber scaffolds,with crimped nanofibers and welded joints to biomimic the intricate natural microstructure of tendon-to-bone insertion,were prepared using poly(ester-urethane)urea and gelatin via electrospinning and double crosslinking by a multi-bonding network densification strategy.The crimped nanofiber scaffold(CNS)features bionic tensile stress and induces chondrogenic differentiation,laying credible basis for in vivo experimentation.After repairing a rabbit massive rotator cuff tear using a CNS for 3 months,the continuous translational tendon-to-bone interface was fully regenerated,and fatty infiltration was simultaneously inhibited.Instead of micro-CT,μCT was employed to visualize the integrity and intricateness of the three-dimensional microstructure of the CNS-induced-healed tendon-to-bone interface at an ultra-high resolution of less than 1μm.This study sheds light on the correlation between nanofiber post treatment and massive rotator cuff repair and provides a general strategy for crimped nanofiber preparation and tendon-to-bone interface imaging characterization. | Liren Wang Tonghe Zhu Yuhao Kang Jianguang Zhang Juan Du Haihan Gao Sihao Chen Jia Jiang Jinzhong Zhao | 2022 | Bioactive Materials2022，7，10： | 2 |
| 3 | Effect of microarc discharge surface treatment on the tensile properties of Al–Cu–Mg alloy显示文摘 | Wenbin Xue Chao Wang Yongliang Li Zhiwei Deng Ruyi Chen Tonghe Zhang | 2002 | Materials Letters2002，，5： | 2 |
| 4 | Electrical properties of polymer modified by metal ion implantation显示文摘 | Wu Yuguang Zhang Tonghe Zhang Huixing | 2000 | Nuclear Instrument and Methods in Physics Research2000，169，： | 1 |
| 5 | Influence of the structure of implanted steel, with Y,Y+ C and Y+Cr on the behaviors of wear, oxidation and corrosion resistance 显示文摘 | Zhang Tonghe Xie Jindong Ji chengzhou | 1995 | Surface and Coatings Technology1995，72，12： | 1 |
| 6 | A method for the fabricatien of low-noise carbon fiber nanoelectrodes显示文摘 | HuangWH PangD W TongH | | 0，，： | 1 |
| 7 | Surface modification of steel by high-dose pulse-ion implantation of titanium, tungsten, molybdenum and carbon 显示文摘 | Zhang Tonghe Ji Cbengzhou Sben Jinghua | 1991 | Nuclear Instruments and Methods in Physiscs Research1991，，5960： | 1 |
| 8 | Gprotein-coupledre-ceptorinternalizationsignalingisrequiredforcardioprotectioninischemicpreconditioning显示文摘 | TongH RockmanHA KochW J etal | 2004 | CircRes2004，94，8： | 1 |
| 9 | Early enteral feeding in cranial trauma显示文摘 | De Degne C De Tongh R Merckx L | 1998 | Ann Fr Anesth Reanim1998，17，2： | 1 |
| 10 | Growth Regularity of Ceramic Coatings Formed by Microarc Oxidation on Al-Cu-Mg Alloy 显示文摘 | XUE Wenbin DENG Zhiwei CHEN Ruyi ZHANG Tonghe | 2000 | Thin Solid Films2000，372，1： | 1 |
| 11 | NanoGphotocatalyticmaterials:possibilitiesandchallenges显示文摘 | TongH OuyangSX BiYP etal | 2012 | Advanced MaGterials2012，24，2： | 1 |
| 12 | Early enteral feeding in cranial trauma 显示文摘 | De Degne C De Tongh R Merekx L | 1998 | Ann Fr Anesth Reanim1998，17，2： | 1 |
| 13 | Effect of microarc discharge surface treatment on the tensile properties of Al–Cu–Mg alloy显示文摘 | Wenbin Xue Chao Wang Yongliang Li Zhiwei Deng Ruyi Chen Tonghe Zhang | 2002 | Materials Letters2002，，5： | 1 |
| 14 | Growth regularity of ceramic coatings formed by microarc oxidation on Al–Cu–Mg alloy显示文摘 | Wenbin Xue Zhiwei Deng Ruyi Chen Tonghe Zhang | 2000 | Thin Solid Films2000，，1： | 1 |
| 15 | Shanggu yinyunbiao gao 上古音韵表稿[Tentative archaic Chinese phonological Tables]显示文摘 | Dong Tonghe(董同酥) | 1948 | 历史语言研究所集刊1948，18，： | 1 |
| 16 | A new approachto the prediction of passenger flow in a transit system显示文摘 | ZHAO Shuzhi NI Tonghe WANG Yang | 2011 | Computers and Mathematics with Applications2011，61，： | 1 |
| 17 | Dendritic cells and NK cells aftraulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma显示文摘 | Kamath AT Sheasby CE Tongh DF | 2005 | J Immunol2005，174，2： | 1 |
| 18 | 显示文摘 | Zhang Tonghe Ji Chengzhou Shen Jinghua | 1993 | Nucl In-strum Methods1993，72，： | 1 |
| 19 | Formation of intermetallic compounds with a high flux pulse molybdenum ion beam in steel and aluminum显示文摘 | Zhang Tonghe Ji Chengzhou Yang Jianhua | 1994 | Surface and Coatings Technology1994，65，： | 1 |
| 20 | Fasl liband mediates activation-indu-cde cell death is human T lymphocyte显示文摘 | ALDERSON M R TONGH T W DAVIS S T | 1995 | J Exp Med1995，181，： | 1 |
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