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50篇 您的检索式:作者名="Yang Ruyi"
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1Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities.Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen 2018Chinese Journal of Cancer Research2018,30,4:22
2Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine.Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He 2017Genes & Diseases2017,4,2:19
3Effects of metal lead on growth and mycorrhizae of an invasive plant species (Solidago canadensis L.)显示文摘It is less known whether and how soil metal lead (Pb) impacts the invasion of exotic plants. A greenhouse experiment was conducted to estimate the effects of lead on the growth and mycorrhizae of an invasive species (Solidago canadensis L.) in a microcosm system. Each microcosm unit was separated into HOST and TEST compartments by a replaceable mesh screen that allowed arbuscular mycorrhizal (AM) fungal hyphae rather than plant roots to grow into the TEST compartments. Three Pb levels (control, 300, and 600 mg/kg soil) were used in this study to simulate ambient soil and two pollution sites where S. canadensis grows. Mycorrhizal inoculum comprised five indigenous arbuscular mycorrhizal fungal species (Glomus mosseae, Glomus versiform, Glomus diaphanum, Glomus geosporum, and Glomus etunicatum). The 15N isotope tracer was used to quantify the mycorrhizally mediated nitrogen acquisition of plants. The results showed that S. canadensis was highly dependent on mycorrhizae. The Pb additions significantly decreased biomass and arbuscular mycorrhizal colonization (root length colonized, RLC%) but did not affect spore numbers, N (including total N and 15N) and P uptake. The facilitating efficiency of mycorrhizae on nutrient acquisition was promoted by Pb treatments. The Pb was mostly sequestered in belowground of plant (root and rhizome). The results suggest that the high efficiency of mycorrhizae on nutrient uptake might give S. canadensis a great advantage over native species in Pb polluted soils.YANG Ruyi YU Guodong TANG Jianjun CHEN Xin 2008Journal of Environmental Sciences2008,20,6:12
4Evaluating efficacy of screening for upper gastrointestinal cancer in China:a study protocol for a randomized controlled trial显示文摘Objective: To evaluate the efficacy and feasibility of screening procedure for upper gastrointestinal cancer in both high-risk and non-high-risk areas in China.Setting: Seven cities/counties, representing three economical-geographical regions(Eastern, Central and Western) in China, were selected as screening centers: three in high-risk areas and four in non-high-risk areas.Participants: Villages/communities in these seven centers regarded as clusters were randomly assigned to either intervention group(screening by endoscopic examination) or control group(with normal community care) in a 1:1ratio stratified by each center. Eligible participants are local residents aged 40–69 years in the selected villages/communities with no history of cancer or endoscopic examination in the latest 3 years who are mentally and physically competent. Those who are not willing to take endoscopic examination or are unwilling to sign the consent form are excluded from the study. Totally 140,000 participants will be enrolled.Interventions: In high-risk areas of upper gastrointestinal cancer, all subjects in screening group will be screened by endoscopy. In non-high-risk areas, 30% of the subjects in screening group, identified through a survey,will be screened by endoscopy.Primary and secondary outcome measures: The primary outcome is the mortality caused by upper gastrointestinal cancer. The secondary outcomes include detection rate, incidence rate, survival rate, and clinical stage distribution. Additional data on quality of life and cost-effectiveness will also be collected to answer important questions regarding screening effects.Conclusions: Screening strategy evaluated in those areas with positive findings may be promoted nationally and applied to the majority of Chinese people. On the other hand, negative findings will provide scientific evidence for abandoning a test and shifting resources elsewhere.Trial registration: The study has been registered with the Protocol Registration System in Chinese Clinical Trial Registry.wanqing chen hongmei zeng ru chen ruyi xia zhixun yang changfa xia rongshou zheng wenqiang wei guihua zhuang xueqin yu jie he 2017Chinese Journal of Cancer Research2017,29,4:11
5Revisiting Scientific Issues for Industrial Applications of Lithium–Sulfur Batteries显示文摘Inspired by high theoretical energy density(-2600 W h kg^(-1))and cost-effectiveness of sulfur cathode,lithium–sulfur batteries are receiving great attention and considered as one of the most promising next-generation high-energy-density batteries.However,over the past decades,the energy density and reliable safety levels as well as the commercial progress of lithium-sulfur batteries are still far from satisfactory due to the disconnection and huge gap between fundamental research and practical application.Bo Liu Ruyi Fang Dong Xie Wenkui Zhang Hui Huang Yang Xia Xiuli Wang Xinhui Xia Jiangping Tu 2018Energy & Environmental Materials2018,1,4:9
6Two selenium tolerant Lysinibacillus sp. strains are capable of reducing selenite to elemental Se efficiently under aerobic conditions显示文摘Microbes play important roles in the transport and transformation of selenium(Se) in the environment, thereby influencing plant resistance to Se and Se accumulation in plant. The objectives are to characterize the bacteria with high Se tolerance and reduction capacity and explore the significance of microbial origins on their Se tolerance, reduction rate and efficiency. Two bacterial strains were isolated from a naturally occurred Se-rich soil at tea orchard in southern Anhui Province, China. The reduction kinetics of selenite was investigated and the reducing product was characterized using scanning electron microscopy and transmission electron microscopy-energy dispersive spectroscopy. The bacteria were identified as Lysinibacillus xylanilyticus and Lysinibacillus macrolides,respectively, using morphological, physiological and molecular methods. The results showed that the minimal inhibitory concentrations(MICs) of selenite for L. xylanilyticus and L. macrolides were 120 and 220 mmol/L, respectively, while MICs of selenate for L.xylanilyticus and L. macrolides were 800 and 700 mmol/L, respectively. Both strains aerobically reduced selenite with an initial concentration of 1.0 mmol/L to elemental Se nanoparticles(SeNPs) completely within 36 hr. Biogenic SeNPs were observed both inside and outside the cells suggesting either an intra-or extracellular reduction process. Our study implied that the microbes from Se-rich environments were more tolerant to Se and generally quicker and more efficient than those from Se-free habitats in the reduction of Se oxyanions. The bacterial strains with high Se reduction capacity and the biological synthesized Se NPs would have potential applications in agriculture, food, environment and medicine.Ju Zhang Yue Wang Zongyuan Shao Jing Li Shuting Zan Shoubiao Zhou Ruyi Yang 2019Journal of Environmental Sciences2019,31,3:7
7The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders.Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu 2018Genes & Diseases2018,5,1:4
8Decoding lithium batteries through advanced in situ characterization techniques显示文摘Given the energy demands of the electromobility market,the energy density and safety of lithium batteries(LBs)need to be improved,whereas its cost needs to be decreased.For the enhanced performance and decreased cost,more suitable electrode and electrolyte materials should be developed based on the improved understanding of the degradation mechanisms and structure–performance correlation in the LB system.Thus,various in situ characterization technologies have been developed during the past decades,providing abundant guidelines on the design of electrode and electrolyte materials.Here we first review the progress of in situ characterization of LBs and emphasize the feature of the multi-model coupling of different characterization techniques.Then,we systematically discuss how in situ characterization technologies reveal the electrochemical processes and fundamental mechanisms of different electrode systems based on representative electrode materials and electrolyte components.Finally,we discuss the current challenges,future opportunities,and possible directions to promote in situ characterization technologies for further improvement of the battery performance.Mei Yang Ruyi Bi Jiangyan Wang Ranbo Yu Dan Wang 2022International Journal of Minerals,Metallurgy and Materials2022,29,5:4
9Mechanical decision for a class of integral inequalities显示文摘A class of integral inequalities is transformed into homogeneous symmetric polynomial inequalities beyond Tarski model,where the number of elements of the polynomial,say n,is also a variable and the coefficients are functions of n.This is closely associated with some open problems formulated recently by Yang et al.Using Timofte's dimension-decreasing method for symmetric polynomial inequalities,combined with the inequality-proving package BOTTEMA and a program of implementing the method known as successive difference substitution,we provide a procedure for deciding the nonnegativity of the corresponding polynomial inequality such that the original integral inequality is mechanically decidable;otherwise,a counterexample will be given.The effectiveness of the algorithm is illustrated by some more examples.YANG Lu YU WenSheng YUAN RuYi 2010Science China(Information Sciences)2010,53,9:3
10A New Species of the Genus Sinomicrurus Slowinski,Boundy and Lawson,2001 (Squamata:Elapidae) from Hainan Province,China显示文摘A new species of the coral snake genus Sinomicrurus is described based on four specimens from southern Hainan Island(three specimens from Tianchi,Jianfengling National Nature Reserve,one specimen from Diaoluoshan National Nature Reserve),Hainan Province,China.Morphologically,the new species is rather similar to Sinomicrurus kelloggi.However,it is distinct from S.kelloggi by the pattern on the head,the head length,head length/width,the number of infralabial scales,number of bands on dorsal body,and number of blotches on the belly.Lifang PENG Lijun WANG Li DING Yiwu ZHU Jian LUO Diancheng YANG Ruyi HUANG Shunqing LU Song HUANG 2018Asian Herpetological Research2018,9,2:3
11A New Species of the Genus Achalinus from Huangshan, Anhui, China(Squamata: Xenodermidae)显示文摘A new species of the genus Achalinus is described based on five specimens collected from the villages of Huangjialing and Fuxi, Huangshan, Anhui, China. It can be morphologically differentia ted from all the other species in Achalinus except for A. spinalis and A. werneri by the presence of a dotted black streak in the middle of the subcaudal. It can be distinguished from A. spinalis in that its two anterior temporals are in contact with eye, and A. werneri by its light brown flanks. The phylogenetic rela tionship of Achalinus was reconstructed using the mitochondrial locus of cytochrome coxidase subunit 1(CO1). The five new specimens form a monophyletic clade with strong support. The uncorrected p-dista nces between the new species and other representatives of Achalinus range from 13.6% to 21.7%. The recognition of the new species increases the number of described Achalinus species to 14.Ruyi HUANG Lifang PENG Lei YU Tianqi HUANG Ke JIANG Li DING Jinkang CHANG Diancheng YANG Yuhao XU Song HUANG 2021Asian Herpetological Research2021,12,2:3
12The comparison of statistical features and synoptic circulations between the eastward-propagating and quasi-stationary MCSs during the warm season around the second-step terrain along the middle reaches of the Yangtze River显示文摘Mesoscale convective systems(MCSs) around the second-step terrain(106°–113°E, 28°–35°N), along the middle reaches of the Yangtze River, were detected, tracked and classified using a black body temperature(TBB) dataset during May to August 2000–2016(except 2005). The MCSs were divided into eastward-propagating(EP) and quasi-stationary(QS) types, to compare their spatial and temporal distributions and convective intensities, and to identify the favorable synoptic conditions for the formation and evolution of EP MCSs. The results showed that both MCS types occurred most often in July. The EP MCSs were mainly initiated over the eastern regions of the study area, while the QS type mainly originated in the western regions of the study area. Both MCS types mainly formed in the afternoon, but a second peak occurred in the early morning for QS MCSs. The EP MCSs had a larger cloud area at their mature stage and a lower cloud brightness temperature, indicating more intense convection. Additionally, the longer lifetime and further eastward propagation of the EP MCSs meant that they had a great influence on the precipitation over the middle and lower reaches of the Yangtze River. Synoptic circulation analysis demonstrated that the combination of the mid-level low trough east of the Tibetan Plateau(TP), and the western pacific subtropical high(WPSH), favored the formation and eastward propagation of EP MCSs. The positive vertical relative vorticity and stronger vertical wind shear provided dynamic conditions favorable for convective organization and development. Furthermore, a stronger low level jet imported warm and moist air to the eastern edge of, and the regions east of, the second-step terrain. The substantial convergence of water vapor promoted the development and long-lived maintenance of the EP MCSs.Ruyi YANG Yuanchun ZHANG Jianhua SUN Jun LI 2020Science China Earth Sciences2020,63,8:3
13Preparation and stability investigation of tamsulosin hydrochloride sustained release pellets containing acrylic resin polymers with two different techniques显示文摘The objective of this study was to prepare tamsulosin hydrochloride-sustained release(TSH-SR)pellets which showed good release stability with frame-controlled method.TSH was added to Eudragit~?NE30D and Eudragit~?L30D-55 polymers to form drug-loaded inner core.Afterwards,enteric Eudragit~?L30D-55 polymer was modified on the surface of it to the final product.Dissolution studies showed that TSH-SR pellets were more stable during the coating process,different curing temperatures and storage conditions compared with TSH pellets produced by film-controlled technique.Appearances and glass transition temperatures(Tgs)of free films and surface morphologies observed by scanning electron microscopy(SEM)of blank sustained release pellets prepared by different ratios of Eudragit~?NE30D and Eudragit~?L30D-55 further indicated that temperature and relative humidity(RH)were the key factors when Eudragit~?NE30D blended with Eudragit~?L30D-55 were applied to sustained/controlled release preparations.In addition,SEM identified the surface morphologies of TSH-SR pellets before and after dissolution,which showed intact surface structure and great correlation with release curve respectively.Rui Fan Yinghua Sun Bing Li Ruyi Yang Wenrui Ma Jin Sun 2017Asian Journal of Pharmaceutical Sciences2017,12,2:2
14Plant species coexistence alleviates the impacts of lead on Zea mays L.显示文摘Whether plant coexistence can reduce the impacts of lead (Pb) on crops in agroecosystems has not been well understood. We conducted a factorial experiment to investigate the effects of weeds coexisting with maize (Zea mays L.) on Pb accumulation in maize and soil microbes at two Pb levels (ambient and 300 mg/kg). Elevated Pb tended to increase the Pb concentration in maize and decreased soil microbial activity (indicated by the average well color development, AWCD), functional group diversity, as well as arbuscular mycorrhizal (AM) colonization and vesicle number of maize. Compared to the monoculture, weeds coexisting with maize reduced the Pb concentrations in the root, leaf, sheath and stem of maize at both seedling and mature stages. In maize-weed mixtures, soil microbial activity and functional group diversity tended to increase for both Pb treatments relative to the monoculture. Furthermore, principal component analysis revealed that the soil microbial community structure changed with the introduction of weeds. The highest Pb accumulation in weeds occurred for the elevated Pb treatment in a three species mixture. The results suggest that multiple plant species coexistence could reduce lead accumulation in crop plants and alleviate the negative impacts on soil microbes in polluted land, thereby highlighting the significance of plant diversity in agroecosystems.Ruyi Yang Ling Liu Shuting Zan Jianjun Tang Xin Chen 2012Journal of Environmental Sciences2012,24,3:2
15How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?显示文摘Cytokines are secreted by various cell types and act as critical mediators in many physiological processes,including immune response and tumor progression.Cytokines production is precisely and timely regulated by multiple mechanisms at different levels,ranging from transcriptional to post-transcriptional and posttranslational processes.Monocyte chemoattractant protein-1 induced protein 1(MCPIP1),a potent immunosuppressive protein,was first described as a transcription factor in monocytes treated with monocyte chemoattractant protein-1(MCP-1)and subsequently found to possess intrinsic RNase and deubiquitinase activities.MCPIP1 tightly regulates cytokines expression via various functions.Furthermore,cytokines such as interleukin 1 beta(IL-1B)and MCP-1 and inflammatory cytokines inducer lipopolysaccharide(LPS)strongly induce MCPIP1 expression.Mutually regulated MCPIP1 and cytokines form a complicated network in the tumor environment.In this review,we summarize how MCPIP1 and cytokines reciprocally interact and elucidate the effect of the network formed by these components in cancer-related immunity with aim of exploring potential clinical benefits of their mutual regulation.Ruyi Xu Yi Li Yang Liu Jianwei Qu Wen Cao Enfan Zhang Jingsong He Zhen Cai 2020Protein & Cell2020,11,12:2
16A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state显示文摘Dopamine(DA)level in the nucleus accumbens(NAc)is critical for reward and aversion encoding.DA released from the ventral mesencephalon(VM)DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons(D1-MSNs)in the NAc to enhance DA release and augment rewards.However,how such a DA positive feedback loop is regulated to maintain DA homeostasis and reward-aversion balance remains elusive.Here we report that the ventral pallidum(VP)projection of NAc D1-MSNs(D1^(NAc-VP))is inhibited by rewarding stimuli and activated by aversive stimuli.In contrast to the VM projection of D1-MSN(D1^(NAc-VM)),activation of D1^(NAc-VP) projection induces aversion,but not reward.D1^(NAc-VP) MSNs are distinct from the D1^(NAc-VM) MSNs,which exhibit conventional functions of D1-MSNs.Activation of D1^(NAc-VP) projection stimulates VM GABAergic transmission,inhibits VM DAergic neurons,and reduces DA release into the NAc.Thus,D1^(NAc-VP) and D1^(NAc-VM) MSNs cooperatively control NAc dopamine balance and reward-aversion states.Zhiyuan Liu Qiumin Le Yanbo Lv Xi Chen Jian Cui Yiming Zhou Deqin Cheng Chaonan Ma Xiujuan Su Lei Xiao Ruyi Yang Jiayi Zhang Lan Ma Xing Liu 2022Cell Research2022,32,2:2
17AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination显示文摘Oligodendrocytes(OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK(apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYKdeficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs.Chunxia Jiang Wanqing Yang Zhihong Fan Peng Teng Ruyi Mei Junlin Yang Aifen Yang Mengsheng Qiu Xiaofeng Zhao 2018Neuroscience Bulletin2018,34,3:2
18Phylogenetic analysis of rabbit hemorrhagic disease virus in China and the antigenic variation of new strains显示文摘Xinglong Wang Huafang Hao Li Qiu Ruyi Dang Enqi Du Shuxia Zhang Zengqi Yang 2012Archives of Virology2012,,8:1
19Effects of coexisting plant species on soil microbial properties and soil enzymes in metal lead contaminated soils 显示文摘Yang Ruyi Tang Jianjun Chen Xin 2007Applied Soil Ecology2007,37,:1
20Invasive and non-invasive plants differ in response to soil heavy metal lead 显示文摘Yang Ruyi Tang Jianjun Yang Yisong 2007Botanical Studies2007,48,4:1
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