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| 1 | Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor显示文摘Recent studies have shown that premature ventricular contractions(PVCs) could enlarge the heart,but its risk factors are incompletely understood as a single 24-hour recording cannot reflect the true PVC burden due to day-to-day variability.Our purpose was to investigate the effect of burden and origin sites on left ventricular(LV) function in patients with PVCs by 7-day Holter electrocardiography(ECG).From May 2012 to August2013,112 consecutive patients with PVCs were recruited from the authors' affiliated hospital.All patients received2-dimensional transthoracic echocardiography,12-lead routing ECG and 7-days Holter ECG.Serum N-terminal probrain natriuretic peptide(NT-proBNP) levels were measured.A total of 102 participants with PVCs were included in the final analysis.Origin of PVCs from the tricuspid annulus had the highest burden and NT-proBNP level.LV papillary muscle had a higher LV ejection fraction(EF) level and a lower LV end-systolic dimension(ESD) than other PVC foci(P<0.05).The high burden group had a higher LV end-diastolic dimension(EDD) and LVESD but lower LVEF than the other two groups(P<0.05).Female,older age,physical work,and history of PVCs had a significantly positive correlation with symptoms.Male,older age,physical work,and high burden were positive predictors of enlarged LVEDD,LVESD and higher serum NT-proBNP level,but lower LVEF.Seven-day dynamic ECG Holter monitor showed the true PVC burden on patients with PVCs.PVCs with a lower burden or origin from the LV papillary muscle and the fascicle were relatively benign,while PVCs with a higher burden or origin from the tricuspid annulus may lead to cardiac dysfunction. | Wenhua Xu Mingfang Li Minglong Chen Bing Yang Daowu Wang Xiangqing Kong Hongwu Chen Weizhu Ju Kai Gu Kejiang Cao Hailei Liu Qi Jiang Jiaojiao Shi Yan Cui Hong Wang | 2015 | The Journal of Biomedical Research2015，29，6： | 4 |
| 2 | Assessment of atrial electromechanical interval using echocardiography after catheter ablation in patients with persistent atrial fibrillation显示文摘We sought to investigate variation of atrial electromechanical interval after catheter ablation procedure in patients with persistent atrial fibrillation using pulse Doppler(PW) and pulse tissue Doppler imaging(PW-TDI).A total of 25 consecutive in-patients with persistent atrial fibrillation,who restored sinus rhythm after ablation procedure,were recruited in our cardiac center.Echocardiography was performed on each patient at 2 hours,1 day,5 days,1 month and 3 months after the ablation therapy,and atrial electromechanical delay was measured simultaneously by PW and PW-TDI.There was no significant difference between PW and TDI in measuring atrial electromechanical delay.However,at postoperative 2 hours,peak A detection rates were mathematically but nonsignificantly greater by PWTDI than by PW.Second,there was a significant decreasing trend in atrial electromechanical interval from postoperative 2 hours to 3 months,but only postoperative 2-hour atrial electromechanical interval was significantly greater than atrial electromechanical interval at other time.Lastly,patients without postoperative 2-hour atrial electromechanical interval had a significantly longer duration of atrial fibrillation as compared to those with postoperative 2-hour atrial electromechanical interval,by the PW or by PW-TDI,respectively.In patients with persistent atrial fibrillation,atrial electromechanical interval may decrease significantly within the first 24 hours after ablation but remain consistent later,and was significantly related to patients' duration of atrial fibrillation.Atrial electromechanical interval,as a potential predicted factor,is recommended to be measured by either PW or TDI after24 hours,when patients had recovered sinus rhythm by radiofrequency ablation. | Xiaodong Chen Minglong Chen Yingying Wang Bing Yang Weizhu Ju Fengxiang Zhang Kejiang Cao | 2016 | The Journal of Biomedical Research2016，30，6： | 2 |
| 3 | Efficient biosynthesis of 2-keto-D-gluconic acid by fed-batch culture of metabolically engineered Gluconobacter japonicus显示文摘2-keto-D-gluconic acid(2-KGA)is a key precursor for synthesising vitamin C and isovitamin C.However,phage contamination is as constant problem in industrial production of 2-KGA using Pseudomonas fluorescens.Gluconobacter holds promise for producing 2-KGA due to impressive resistance to hypertonicity and acids,and high utilisation of glucose.In this study,the 2-KGA synthesis pathway was regulated to enhance production of 2-KGA and reduce accumulation of the by-products 5-keto-D-gluconic acid(5-KGA)and D-gluconic acid(D-GA)in the 2-KGA producer Gluconobacter japonicus CGMCC 1.49.Knocking out the ga5dh-1 gene from a competitive pathway and overexpressing the ga2dh-A gene from the 2-KGA synthesis pathway via homologous recombination increased the titre of 2-KGA by 63.81%in shake flasks.Additionally,accumulation of 5-KGA was decreased by 63.52%with the resulting G.japonicas-Δga5dh-1-ga2dh-A strain.Using an intermittent fed-batch mode in a 3 L fermenter,2-KGA reached 235.3 g L^−1 with a 91.1%glucose conversion rate.Scaling up in a 15 L fermenter led to stable 2-KGA titre with productivity of 2.99 g L^−1 h^−1,11.99%higher than in the 3 L fermenter,and D-GA and 5-KGA by-products were completely converted to 2-KGA. | Weizhu Zeng Wen Cai Li Liu Guocheng Du Jian Chen Jingwen Zhou | 2019 | Synthetic and Systems Biotechnology2019，4，3： | 1 |
| 4 | Rationale and Study Design for Evaluating the Efficacy and Safety of Intracardiac Echocardiography-Guided Minimal-Fluoroscopy Ablation in Patients with Paroxysmal Atrial Fibrillation:A Non-Inferior,Multi-Center,Prospective Randomized Controlled Trial(PAF-ICE Trial)显示文摘The feasibility and safety of intracardiac echocardiography(ICE)-guided catheter ablation for atrial fibrillation(AF)using a minimal/zero-fluoroscopy approach have recently been reported.This approach helps to reduce ionizing radiation exposure and orthopedic complications resulting from using lead aprons.The objectives of this planned prospective,multicenter randomized controlled trial(RCT)(paroxysmal AF(PAF)-ICE trial;ChiCTR2000033624)are to evaluate the efficacy and safety of ICE-guided minimal-fluoroscopy ablation in patients with PAF and the impact on occupational hazards among lab staff.Patients will be randomized in a 1:1 ratio to 2 groups:minimal fluoroscopy group(n=216)and traditional approach group(n=216).In the minimal fluoroscopy group,an ICE catheter will be used for geometry/anatomic construction,transseptal puncture,catheter tracking,and effusion monitoring.Pulmonary vein isolation(PVI)will be performed using an open-irrigated radiofrequency SmartTouch Surround Flow or SmartTouch catheter(Biosense Webster,Diamond Bar,California,USA),and confirmed by a multipolar Lasso or PentaRay catheter(Biosense Webster).In the traditional approach group,an ICE catheter will not be used.Transseptal puncture will be performed under fluoroscopic guidance,with all geometries constructed by mapping the catheters.The primary efficacy endpoint is freedom from AF recurrence(without antiarrhythmic medications)at 12months after ablation.Other endpoints include duration of lead apron use,measures of intra-procedural efficiency,and peri-procedural complications.This RCT will evaluate the efficacy and safety of ICE-guided minimal-fluoroscopy ablation in patients with PAF,also evaluate the benefits to lab staff(regarding reducing occupational hazards)related to this“minimal/zero-fluoroscopy”and“leadless”mode. | Ruhong Jiang Xingpeng Liu Jidong Zhang Yu Chen Rui Wang Mengzuo Wu Deyong Long Jia Li Haixiong Wang Jie Fan Weizhu Ju Weili Ge Xu Liu Hai Deng Weijian Wang Pingzhen Yang Ding Li Xiaobo Huang Xiongtao Liu Hailong Tao Paul CZei Roderick Tung Xunzhang Wang Chenyang Jiang | 2021 | Cardiology Discovery2021，1，4： | 1 |
| 5 | The Kinematic Effects of the Defects in Liquid Crystal Dynamics显示文摘Here we investigate the kinematic transports of the defects in the nematic liquid crystal system by numerical experiments.The model is a shear flow case of the viscoelastic continuummodel simplified fromthe Ericksen-Leslie system.The numerical experiments are carried out by using a differencemethod.Based on these numerical experiments we find some interesting and important relationships between the kinematic transports and the characteristics of the flow.We present the development and interaction of the defects.These results are partly consistent with the observation from the experiments.Thus this scheme illustrates,to some extent,the kinematic effects of the defects. | Rui Chen Weizhu Bao Hui Zhang | 2016 | Communications in Computational Physics2016，20，6： | 1 |
| 6 | Comparison of UV and UV-LED activated sodium percarbonate for the degradation of O-desmethylvenlafaxine显示文摘As an active metabolite of venlafaxine and emerging antidepressant,Odesmethylvenlafaxine(ODVEN) was widely detected in different water bodies,which caused potential harm to human health and environmental safety.In this study,the comparative work on the ODVEN degradation by UV(254 nm) and UV-LED(275 nm) activated sodium percarbonate(SPC) systems was systematically performed.The higher removal rate of ODVEN can be achieved under UV-LED direct photolysis(14.99%) than UV direct photolysis(4.57%) due to the higher values of photolysis coefficient at the wavelength 275nm.Significant synergistic effects were observed in the UV/SPC(80.38%) and UV-LED/SPC(53.57%) systems and the former exhibited better performance for the elimination of ODVEN.The degradation of ODVEN all followed the pseudo-first-order kinetics well in these processes,and the pseudo-first-order rate constant(kobs) increased with increasing SPC concentration.Radicals quenching experiments demonstrated that both ·OH and CO_(3)·-were involved in the degradation of ODVEN and the second-order rate constant of ODVEN with CO_(3)·-(1.58 × 10^(8)(mol/L)-1sec-1) was reported for the first time based on competitive kinetic method.The introduction of HA,Cl-,NO_(3)-and HCO_(3)-inhibited the ODVEN degradation to varying degrees in the both processes.According to quantum chemical calculation,radical addition at the ortho-position of the phenolic hydroxyl group was confirmed to be the main reaction pathways for the oxidation of ODVEN by·OH.In addition,the oxidation of ODVEN may involve the demethylation,H-abstraction,OH^(-)addition and C-N bond cleavage.Eventually,the UV-LED/SPC process was considered to be more cost-effective compared to the UV/SPC process,although the UV/SPC process possessed a higher removal rate of ODVEN. | Jing Deng Anhong Cai Xiao Ling Qian Sun Tianxin Zhu Qingsong Li Xueyan Li Weizhu Chen | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 7 | Epicardial adipose tissue around the superior vena cava: A single center study of factors related to atrial fibrillation显示文摘The superior vena cava(SVC)is the main component of non-pulmonary vein(PV)ectopy in patients with atrial fibrillation(AF).Researchers have found that epicardial adipose tissue(EAT)volume is related to the AF substrate,which can be defined by the low voltage area(LVA).This study aimed to investigate the relationship between SVC-EAT and SVC-AF.Twenty-six patients with SVC-AF triggers were identified as the SVC-AF group.Other three groups were defined and included as the LVA-AF group(LVA>5%),non-LVA-AF group(LVA<5%),and physical examination(PE)group.EAT around left atrium(LA-EAT)and SVC-EAT volumes were obtained using a cardiac risk assessment module.According to the SVC/LA-EAT ratio,there are significant differences between the SVC-AF group and the three control groups(the SVC-AF group 0.092±0.041 vs.the LVA-AF group 0.054±0.026,the non-LVA-AF group 0.052±0.022,and the PE group 0.052±0.019,all P<0.001).Receiver operating characteristic curve analysis suggests the optimal cut-off point of SVC/LA-EAT ratio is 6.8%for detecting SVC-AF patients,with 81.1%sensitivity,73.1%specificity,and an area under the curve of 0.83(95%confidence interval,0.75-0.91).Those with SVC-AF have a higher SVC/LA-EAT ratio and empirical SVC isolation could be considered if the SVC/LA-EAT ratio was over 6.8%. | Xingxing Sun Jun Wang Qing Yan Weizhu Ju Fengxiang Zhang Gang Yang Kai Gu Hailei Liu Zidun wang Xiaohong Jiang Mingfang Li Di Xu Yi Xu Hongwu Chen Minglong Chen | 2022 | The Journal of Biomedical Research2022，36，6： | 0 |
| 8 | A nomogram predicting atrial fibrillation in patients with dilated cardiomyopathy显示文摘To the Editor:Dilated cardiomyopathy(DCM)is a type of primary myocardial disease with unknown etiology.[1]It is a disorder of the heart muscle mainly characterized by left ventricular dilation and systolic dysfunction,resulting from the response of the myocardium to genetic and environmental insults.The clinical manifestations arc progressive heart failure,arrhythmia,thromboembolism,and even sudden death. | Yangming Mao Yanmin Liu Jian Zhang Yeqian Zhu Xinguang Chen Ling Sun Yao Lu Hongwu Chen Weizhu Ju Gang Yang Pengcheng Zhao Minglong Chen Fengxiang Zhang | 2022 | Chinese Medical Journal2022，，8： | 0 |
| 9 | Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis显示文摘Methanobactins(Mbns)are a family of copper binding peptides involved in copper uptake by methanotrophs,and are potential therapeutic agents for treating diseases characterized by disordered copper accumulation.Mbns are produced via modification of MbnA precursor peptides at cysteine residues catalyzed by the core biosynthetic machinery containing MbnB,an iron-dependent enzyme,and MbnC.However,mechanistic details underlying the catalysis of the MbnBC holoenzyme remain unclear.Here,we present crystal structures of MbnABC complexes from two distinct species,revealing that the leader peptide of the substrate MbnA binds MbnC for recruitment of the MbnBC holoenzyme,while the core peptide of MbnA resides in the catalytic cavity created by the MbnB-MbnC interaction which harbors a unique tri-iron cluster.Ligation of the substrate sulfhydryl group to the tri-iron center achieves a dioxygen-dependent reaction for oxazolone thioamide installation.Structural analysis of the MbnABC complexes together with functional investigation of MbnB variants identifed a conserved catalytic aspartate residue as a general base required for MbnBC-mediated MbnA modifcation.Together,our study reveals the similar architecture and function of MbnBC complexes from different species,demonstrating an evolutionarily conserved catalytic mechanism of the MbnBC holoenzymes. | Chao Dou Zhaolin Long Shoujie Li Dan Zhou Ying Jin Li Zhang Xuan Zhang Yanhui Zheng Lin Li Xiaofeng Zhu Zheng Liu Siyu He Weizhu Yan Lulu Yang Jie Xiong Xianghui Fu Shiqian Qi Haiyan Ren She Chen Lunzhi Dai Binju Wang Wei Cheng | 2022 | Cell Research2022，32，3： | 0 |
| 10 | Elimination of ethyl carbamate in fermented foods显示文摘Ethyl carbamate (EC) is a common harmful by-product in fermented foods and can be derived from raw materials or formed during the fermentation or even in the post-treatment.Its content can be affected by temperature,microorganisms,technological processes,and other factors.In this review,we summarized the technologies and their applications for EC elimination in fermented foods in the light of upstream processes,such as raw material pretreatment,lower temperature,breeding microorganisms,and exogenous substances,to the downstream enzymatic method and physical adsorption.The review covers different strategies to eliminate EC,such as strain breeding,genetic engineering,enzyme,and physicochemical strategies.By comparing these strategies,practical strategies for the efficient elimination of EC in different fermented foods on an industrial scale have been discussed and proposed in consideration of flavor,food safety and feasibility of an industrial application. | Yu Chen Weizhu Zeng Fang Fang Shiqin Yu Jingwen Zhou | 2022 | Food Bioscience2022，47，3： | 0 |
| 11 | Rapid Determination of Tetrodotoxin in Human Plasma by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry显示文摘 | CHEN Weizhu ZHANG Yiping SUN Jipeng XIE Quanling HONG Zhuan YI Ruizao | 2018 | Chemical Research in Chinese Universities2018，34，6： | 0 |
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